The DOI matches its Crossref record; 203 of the 203 references it cites were found in a registry or an index.
A day in the life of the spliceosome
Open accessAbstract
One of the most amazing findings in molecular biology was the discovery that eukaryotic genes are discontinuous, with coding DNA being interrupted by stretches of non-coding sequence. The subsequent realization that the intervening regions are removed from pre-mRNA transcripts via the activity of a common set of small nuclear RNAs (snRNAs), which assemble together with associated proteins into a complex known as the spliceosome, was equally surprising. How do cells coordinate the assembly of this molecular machine? And how does the spliceosome accurately recognize exons and introns to carry out the splicing reaction? Insights into these questions have been gained by studying the life cycle of spliceosomal snRNAs from their transcription, nuclear export and re-import to their dynamic assembly into the spliceosome. This assembly process can also affect the regulation of alternative splicing and has implications for human disease.
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“Alternative splicing patterns (BOX 1) are regulated by specialized pre-mRNA binding proteins that alter spliceosome assembly at specific splice sites5–8”
From The neurogenetics of alternative splicing (2016) · cites this paper as [6]
In the citing paper
“U2 snRNA binds to the branch point during spliceosome assembly and then forms base pairs with the U6 snRNA to become a key portion of the spliceosome catalytic centre for all major class introns6,8,183,184”
From The neurogenetics of alternative splicing (2016) · cites this paper as [6]
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Cites
Expansion of the eukaryotic proteome by alternative splicing
Nilsen, T. W., & Graveley, B. R. (2010) · Nature · doi:10.1038/nature08909 · Cited by 2,270
CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals
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Spliceosome Structure and Function
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Are snRNPs involved in splicing?
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U1 snRNP regulates cancer cell migration and invasion in vitro
Oh, J.-M., Venters, C. C., Di, C., Pinto, A. M., Wan, L., Younis, I., Cai, Z., Arai, C., So, B. R., Duan, J., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-13993-7 · Cited by 7,157
A brave new world of RNA-binding proteins
Hentze, M. W., Castello, A., Schwarzl, T., & Preiss, T. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.130 · Cited by 1,821
Robust transcriptome-wide discovery of RNA-binding protein binding sites with enhanced CLIP (eCLIP)
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Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors
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Goodall, G. J., & Wickramasinghe, V. O. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-00306-0 · Cited by 1,090
Metadata
- Authors
- Matera, A. G., & Wang, Z.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Matera, A. Gregory
- Wang, Zefeng
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2014-01-23
- Volume
- 15
- Issue
- 2
- Pages
- 108-121
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- PMC
- PMC4060434
- OpenAlex
- W2009221497
- Cited by
- 1,074
- References
- 203
- Citations by year
- 2026: 56 · 2025: 92 · 2024: 95 · 2023: 83 · 2022: 94 · 2021: 122 · 2020: 102 · 2019: 90 · 2018: 85 · 2017: 86 · 2016: 79 · 2015: 65 · 2014: 23
- FWCI
- 8.01
- Type
- journal article
- Language
- en
- Update notices
- erratum (2014-03-11)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01ns041617-13, 5r01gm053034-18)
- National Cancer Institute (R01CA158283)
- National Institute of General Medical Sciences (R01‑GM053034)
- National Institute of Neurological Disorders and Stroke (R01‑NS041617)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R21AR061640)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- spliceosome assembly, small nuclear RNA, alternative splicing, pre-mRNA splicing, intron removal, nuclear export, splicing regulation, gene expression regulation, human disease
- MeSH terms
- Exons, Gene Expression Regulation, Humans, Introns, RNA Precursors, RNA, Small Nuclear, Spliceosomes, Alternative Splicing, Multiprotein Complexes
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