Spliceosome Structure and Function

Lysine acetylation targets protein complexes and co-regulates major cellular functions

Choudhary, C., Kumar, C., Gnad, F., Nielsen, M. L., Rehman, M., Walther, T. C., Olsen, J. V., & Mann, M. (2009) · Science · doi:10.1126/science.1175371 · Cited by 4,040 · see citing works

Mechanisms of Alternative Pre-Messenger RNA Splicing

Black, D. L. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161720 · Cited by 2,704 · see citing works

The Spliceosome: Design Principles of a Dynamic RNP Machine

Wahl, M. C., Will, C. L., & Lührmann, R. (2009) · Cell · doi:10.1016/j.cell.2009.02.009 · Cited by 2,665 · see citing works

Expansion of the eukaryotic proteome by alternative splicing

Nilsen, T. W., & Graveley, B. R. (2010) · Nature · doi:10.1038/nature08909 · Cited by 2,172 · see citing works

Understanding alternative splicing: towards a cellular code

Matlin, A. J., Clark, F., & Smith, C. W. J. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1645 · Cited by 1,299 · see citing works

Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches

Chen, M., & Manley, J. L. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2777 · Cited by 1,284 · see citing works

An extensive network of coupling among gene expression machines

Maniatis, T., & Reed, R. (2002) · Nature · doi:10.1038/416499a · Cited by 1,148 · see citing works

Mechanical Devices of the Spliceosome: Motors, Clocks, Springs, and Things

Staley, J. P., & Guthrie, C. (1998) · Cell · doi:10.1016/s0092-8674(00)80925-3 · Cited by 1,127 · see citing works

Exon Recognition in Vertebrate Splicing

Berget, S. M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.6.2411 · Cited by 1,090 · see citing works

Splicing regulation: From a parts list of regulatory elements to an integrated splicing code

Wang, Z., & Burge, C. B. (2008) · RNA · doi:10.1261/rna.876308 · Cited by 1,076 · see citing works

Pre-mRNA Splicing

Jurica, M. S., & Moore, M. J. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00270-3 · Cited by 963 · see citing works

Alternative pre-mRNA splicing: the logic of combinatorial control

Smith, C. W. J., & Valcárcel, J. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01604-2 · Cited by 901 · see citing works

Crystal structure at 1.92 Å resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin

Oubridge, C., Ito, N., Evans, P. R., Teo, C.-H., & Nagai, K. (1994) · Nature · doi:10.1038/372432a0 · Cited by 832 · see citing works

GraFix: sample preparation for single-particle electron cryomicroscopy

Kastner, B., Fischer, N., Golas, M. M., Sander, B. O., Dube, P., Boehringer, D., Hartmuth, K., Deckert, J., Hauer, F., Wolf, E., et al. (2007) · Nature Methods · doi:10.1038/nmeth1139 · Cited by 578 · see citing works

How did alternative splicing evolve?

Ast, G. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1451 · Cited by 544 · see citing works

20 Splicing of Precursors to mRNAs by the Spliceosomes

Burge, C. B., Tuschl, T., & Sharp, P. A. (1999) · doi:10.1101/087969589.37.525 · Cited by 538 · see citing works

Crystal Structure of a Self-Spliced Group II Intron

Toor, N., Keating, K. S., Taylor, S. D., & Pyle, A. M. (2008) · Science · doi:10.1126/science.1153803 · Cited by 498 · see citing works

Splicing double: insights from the second spliceosome

Patel, A. A., & STEITZ, J. A. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1259 · Cited by 479 · see citing works

Crystal Structures of Two Sm Protein Complexes and Their Implications for the Assembly of the Spliceosomal snRNPs

Kambach, C., Walke, S., Young, R., Avis, J. M., Fortelle, E. D. L., Raker, V. A., Lührmann, R., Li, J., & Nagai, K. (1999) · Cell · doi:10.1016/s0092-8674(00)80550-4 · Cited by 475 · see citing works

A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome

Madhani, H. D., & Guthrie, C. (1992) · Cell · doi:10.1016/0092-8674(92)90556-r · Cited by 438 · see citing works

Jmjd6 Catalyses Lysyl-Hydroxylation of U2AF65, a Protein Associated with RNA Splicing

Webby, C. J., Wolf, A., Gromak, N., Dreger, M., Kramer, H., Kessler, B. M., Nielsen, M. L., Schmitz, C., Butler, D. S., Yates, J. R., et al. (2009) · Science · doi:10.1126/science.1175865 · Cited by 423 · see citing works

Intron—exon structures of eukaryotic model organisms

Long, M., & Deutsch, M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.15.3219 · Cited by 417 · see citing works

The pathobiology of splicing

Ward, A. J., & Cooper, T. A. (2009) · The Journal of Pathology · doi:10.1002/path.2649 · Cited by 415 · see citing works

Genomewide Analysis of mRNA Processing in Yeast Using Splicing-Specific Microarrays

Clark, T. A., Sugnet, C. W., & Ares, M. (2002) · Science · doi:10.1126/science.1069415 · Cited by 411 · see citing works

Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing.Preprint

Xiao, S.-H., & Manley, J. L. (1997) · Genes & Development · doi:10.1101/gad.11.3.334 · Cited by 397 · see citing works

Isolation of an active step I spliceosome and composition of its RNP core

Bessonov, S., Anokhina, M. M., Will, C. L., Urlaub, H., & Lührmann, R. (2008) · Nature · doi:10.1038/nature06842 · Cited by 390 · see citing works

Prp8 protein: At the heart of the spliceosome

Grainger, R. J. R., & Beggs, J. D. (2005) · RNA · doi:10.1261/rna.2220705 · Cited by 374 · see citing works

Allosteric Cascade of Spliceosome Activation

Brow, D. A. (2002) · Annual Review of Genetics · doi:10.1146/annurev.genet.36.043002.091635 · Cited by 372 · see citing works

Crystal structure of human spliceosomal U1 snRNP at 5.5 Å resolution

Krummel, D. P., Oubridge, C., Leung, A. K.-W., Li, J., & Nagai, K. (2009) · Nature · doi:10.1038/nature07851 · Cited by 358 · see citing works

Crystal structure of the spliceosomal U2B″–U2A′ protein complex bound to a fragment of U2 small nuclear RNA

Price, S. R., Evans, P. R., & Nagai, K. (1998) · Nature · doi:10.1038/29234 · Cited by 356 · see citing works

An RNA Switch at the 5′ Splice Site Requires ATP and the DEAD Box Protein Prp28p

Staley, J. P., & Guthrie, C. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80174-4 · Cited by 339 · see citing works

The Prp19p-Associated Complex in Spliceosome Activation

Chan, S., Kao, D.-I., Tsai, W.-Y., & Cheng, S.-C. (2003) · Science · doi:10.1126/science.1086602 · Cited by 323 · see citing works

The Evolutionarily Conserved Core Design of the Catalytic Activation Step of the Yeast Spliceosome

Fabrizio, P., Dannenberg, J., Dube, P., Kastner, B., Stark, H., Urlaub, H., & Lührmann, R. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.040 · Cited by 313 · see citing works

13 Splicing of Precursors to mRNA by the SpliceosomePreprint

Moore, M. J., Query, C. C., & Sharp, P. A. (1993) · Cold Spring Harbor Monograph Archive · doi:10.1101/087969380.24.303 · Cited by 309 · see citing works

Protein Composition and Electron Microscopy Structure of Affinity-Purified Human Spliceosomal B Complexes Isolated under Physiological Conditions

Deckert, J., Hartmuth, K., Boehringer, D., Behzadnia, N., Will, C. L., Kastner, B., Stark, H., Urlaub, H., & Lührmann, R. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00582-06 · Cited by 301 · see citing works

Identification of alternative splicing regulators by RNA interference in Drosophila

Park, J. W., Parisky, K. M., Celotto, A. M., Reenan, R. A., & Graveley, B. R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407004101 · Cited by 290 · see citing works

Crystal Structure of the Spliceosomal 15.5kD Protein Bound to a U4 snRNA Fragment

Vidovic, I., Nottrott, S., Hartmuth, K., Lührmann, R., & Ficner, R. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00131-3 · Cited by 289 · see citing works

Interaction of U2AF 65 RS Region with Pre-mRNA of Branch Point and Promotion Base Pairing with U2 snRNA

Valcárcel, J., Gaur, R. K., Singh, R., & Green, M. R. (1996) · Science · doi:10.1126/science.273.5282.1706 · Cited by 288 · see citing works

Molecular Architecture of the Multiprotein Splicing Factor SF3b

Golas, M. M., Sander, B. O., Will, C. L., Lührmann, R., & Stark, H. (2003) · Science · doi:10.1126/science.1084155 · Cited by 277 · see citing works

Composition and Functional Characterization of the Yeast Spliceosomal Penta-snRNP

Stevens, S. W., Ryan, D. E., Ge, H. Y., Moore, R. E., Young, M. K., Lee, T. D., & Abelson, J. N. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00436-7 · Cited by 273 · see citing works

The architecture of pre-mRNAs affects mechanisms of splice-site pairing

Fox-Walsh, K. L., Dou, Y., Lam, B. J., Hung, S., Baldi, P., & Hertel, K. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508489102 · Cited by 267 · see citing works

Mechanisms of fidelity in pre-mRNA splicing

Reed, R. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00097-1 · Cited by 253 · see citing works

Arrangement of RNA and proteins in the spliceosomal U1 small nuclear ribonucleoprotein particle

Stark, H., Dube, P., Lührmann, R., & Kastner, B. (2001) · Nature · doi:10.1038/35054102 · Cited by 253 · see citing works

Structural Basis for Recognition of the Intron Branch Site RNA by Splicing Factor 1

Liu, Z., Luyten, I., Bottomley, M. J., Messias, A. C., Houngninou-Molango, S., Sprangers, R., Zanier, K., Krämer, A., & Sattler, M. (2001) · Science · doi:10.1126/science.1064719 · Cited by 244 · see citing works

U1 snRNP targets an essential splicing factor, U2AF65, to the 3' splice site by a network of interactions spanning the exon.Preprint

Hoffman, B. E., & Grabowski, P. J. (1992) · Genes & Development · doi:10.1101/gad.6.12b.2554 · Cited by 226 · see citing works

Splicing-related catalysis by protein-free snRNAs

Valadkhan, S., & Manley, J. L. (2001) · Nature · doi:10.1038/35099500 · Cited by 222 · see citing works

Composition and three‐dimensional EM structure of double affinity‐purified, human prespliceosomal A complexes

Behzadnia, N., Golas, M. M., Hartmuth, K., Sander, B. O., Kastner, B., Deckert, J., Dube, P., Will, C. L., Urlaub, H., Stark, H., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601631 · Cited by 218 · see citing works

Structural Basis for the Molecular Recognition between Human Splicing Factors U2AF65 and SF1/mBBP

Selenko, P., Gregorovic, G., Sprangers, R., Stier, G., Rhani, Z., Krämer, A., & Sattler, M. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00115-1 · Cited by 212 · see citing works

Deletion of MUD2, the yeast homolog of U2AF65, can bypass the requirement for Sub2, an essential spliceosomal ATPasePreprint

Kistler, A. L. (2001) · Genes & Development · doi:10.1101/gad.851301 · Cited by 207 · see citing works

A Novel Peptide Recognition Mode Revealed by the X-Ray Structure of a Core U2AF35/U2AF65 Heterodimer

Kielkopf, C. L., Rodionova, N. A., Green, M. R., & Burley, S. K. (2001) · Cell · doi:10.1016/s0092-8674(01)00480-9 · Cited by 203 · see citing works

Transcript Specificity in Yeast Pre-mRNA Splicing Revealed by Mutations in Core Spliceosomal Components

Pleiss, J. A., Whitworth, G. B., Bergkessel, M., & Guthrie, C. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050090 · Cited by 199 · see citing works

A Pathway of Sequential Arginine-Serine-Rich Domain-Splicing Signal Interactions during Mammalian Spliceosome Assembly

Shen, H., & Green, M. R. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.10.021 · Cited by 199 · see citing works

Specific Alterations of U1-C Protein or U1 Small Nuclear RNA Can Eliminate the Requirement of Prp28p, an Essential DEAD Box Splicing Factor

Chen, J. Y., Stands, L., Staley, J. P., Jackups, R., Latus, L. J., & Chang, T. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00170-8 · Cited by 199 · see citing works

The EF-G-like GTPase Snu114p Regulates Spliceosome Dynamics Mediated by Brr2p, a DExD/H Box ATPase

Small, E. C., Leggett, S. R., Winans, A. A., & Staley, J. P. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.05.043 · Cited by 194 · see citing works

A novel U2-U6 snRNA structure is necessary for mammalian mRNA splicing.Preprint

Sun, J., & Manley, J. L. (1995) · Genes & Development · doi:10.1101/gad.9.7.843 · Cited by 193 · see citing works

Both phosphorylation and dephosphorylation of ASF/SF2 are required for pre-mRNA splicing in vitro.

Cao, W., Jamison, S. F., & García-Blanco, M. A. (1997) · PubMed · Cited by 193 · see citing works

Phosphorylation of spliceosomal protein SAP 155 coupled with splicing catalysisPreprint

Wang, C., Chua, K. F., Seghezzi, W., Lees, E. M., Gozani, O., & Reed, R. (1998) · Genes & Development · doi:10.1101/gad.12.10.1409 · Cited by 187 · see citing works

Structural Basis for Polypyrimidine Tract Recognition by the Essential Pre-mRNA Splicing Factor U2AF65

Sickmier, E. A., Frato, K. E., Shen, H., Paranawithana, S. R., Green, M. R., & Kielkopf, C. L. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.05.025 · Cited by 187 · see citing works

Exon ligation is proofread by the DExD/H-box ATPase Prp22p

Mayas, R. M., Maita, H., & Staley, J. P. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1093 · Cited by 183 · see citing works

A mechanism to enhance mRNA splicing fidelity: The RNA-dependent ATPase Prp16 governs usage of a discard pathway for aberrant lariat intermediates

Burgess, S. M., & Guthrie, C. (1993) · Cell · doi:10.1016/0092-8674(93)90363-u · Cited by 178 · see citing works

Polypyrimidine tract binding protein controls the transition from exon definition to an intron defined spliceosome

Sharma, S., Kohlstaedt, L. A., Damianov, A., Rio, D. C., & Black, D. L. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1375 · Cited by 177 · see citing works

RBM5/Luca-15/H37 Regulates Fas Alternative Splice Site Pairing after Exon Definition

Bonnal, S., Martínez, C., Förch, P., Bachi, A., Wilm, M. S., & Valcárcel, J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.08.008 · Cited by 176 · see citing works

Conservation of the Protein Composition and Electron Microscopy Structure of Drosophila melanogaster and Human Spliceosomal Complexes

Herold, N., Will, C. L., Wolf, E., Kastner, B., Urlaub, H., & Lührmann, R. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01415-08 · Cited by 176 · see citing works

Spliceosome disassembly catalyzed by Prp43 and its associated components Ntr1 and Ntr2Preprint

Tsai, R.-T., Fu, R., Yeh, F.-L., Tseng, C. K., Lin, Y. J., Huang, Y.-H., & Cheng, S.-C. (2005) · Genes & Development · doi:10.1101/gad.1377405 · Cited by 173 · see citing works

Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components

Warkocki, Z., Odenwälder, P., Schmitzová, J., Platzmann, F., Stark, H., Urlaub, H., Ficner, R., Fabrizio, P., & Lührmann, R. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1729 · Cited by 172 · see citing works

Ntr1 activates the Prp43 helicase to trigger release of lariat-intron from the spliceosomePreprint

Tanaka, N., Aronova, A., & Schwer, B. (2007) · Genes & Development · doi:10.1101/gad.1580507 · Cited by 159 · see citing works

Assembly of ribosomes and spliceosomes: complex ribonucleoprotein machines

Staley, J. P., & Woolford, J. L. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.01.003 · Cited by 157 · see citing works

RS domains contact splicing signals and promote splicing by a common mechanism in yeast through humansPreprint

Shen, H., & Green, M. R. (2006) · Genes & Development · doi:10.1101/gad.1422106 · Cited by 153 · see citing works

Thiophosphorylation of U1-70K protein inhibits pre-mRNA splicing

Tazi, J., Kornstädt, U., Rossi, F., Jeanteur, P., Cathala, G., Brunel, C., & Lührmann, R. (1993) · Nature · doi:10.1038/363283a0 · Cited by 149 · see citing works

Structure and assembly of the spliceosomal small nuclear ribonucleoprotein particles

Kambach, C., Walket, S., & Nagai, K. (1999) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(99)80032-3 · Cited by 149 · see citing works

“Nought May Endure but Mutability”: Spliceosome Dynamics and the Regulation of Splicing

Smith, D. J., Query, C. C., & Konarska, M. M. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.04.013 · Cited by 149 · see citing works

Binding of the Human Prp31 Nop Domain to a Composite RNA-Protein Platform in U4 snRNP

Liu, S., Li, P., Dybkov, O., Nottrott, S., Hartmuth, K., Lührmann, R., Carlomagno, T., & Wahl, M. C. (2007) · Science · doi:10.1126/science.1137924 · Cited by 149 · see citing works

snRNAs as the catalysts of pre-mRNA splicing

Valadkhan, S. (2005) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2005.10.008 · Cited by 147 · see citing works

The second catalytic step of pre-mRNA splicing.

Umen, J., & Guthrie, C. (1995) · PubMed · Cited by 145 · see citing works

Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome

Mathew, R. S., Hartmuth, K., Möhlmann, S., Urlaub, H., Ficner, R., & Lührmann, R. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1415 · Cited by 145 · see citing works

Suppression of Multiple Substrate Mutations by Spliceosomal prp8 Alleles Suggests Functional Correlations with Ribosomal Ambiguity Mutants

Query, C. C., & Konarska, M. M. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00217-5 · Cited by 144 · see citing works

A structural analysis of the group II intron active site and implications for the spliceosome

Keating, K. S., Toor, N., Perlman, P. S., & Pyle, A. M. (2009) · RNA · doi:10.1261/rna.1791310 · Cited by 143 · see citing works

U2–U6 RNA folding reveals a group II intron-like domain and a four-helix junction

Sashital, D. G., Cornilescu, G., & Butcher, S. E. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb863 · Cited by 139 · see citing works

13 Spliceosome Structure and FunctionPreprint

Will, C. L., & Lührmann, R. (2006) · Cold Spring Harbor Monograph Archive · doi:10.1101/087969739.43.369 · Cited by 138 · see citing works

A Conformational Rearrangement in the Spliceosome Sets the Stage for Prp22-Dependent mRNA Release

Schwer, B. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.05.003 · Cited by 136 · see citing works

RNA-RNA Interactions in Nuclear Pre-mRNA SplicingPreprint

Nilsen, T. W. (1998) · Cold Spring Harbor Monograph Archive · doi:10.1101/087969509.35.279 · Cited by 135 · see citing works

A role for ubiquitin in the spliceosome assembly pathway

Bellare, P., Small, E. C., Huang, X., Wohlschlegel, J. A., Staley, J. P., & Sontheimer, E. J. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1401 · Cited by 134 · see citing works

Self-splicing group II and nuclear pre-mRNA introns: how similar are they?

Jacquier, A. (1990) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(90)90075-m · Cited by 132 · see citing works

Structure of a Multipartite Protein-Protein Interaction Domain in Splicing Factor Prp8 and Its Link to Retinitis Pigmentosa

Peña, V., Liu, S., Bujnicki, J. M., Lührmann, R., & Wahl, M. C. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.01.023 · Cited by 132 · see citing works

PP1/PP2A Phosphatases Are Required for the Second Step of Pre-mRNA Splicing and Target Specific snRNP Proteins

Shi, Y., Reddy, B. D., & Manley, J. L. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.07.022 · Cited by 130 · see citing works

Competition between the ATPase Prp5 and Branch Region-U2 snRNA Pairing Modulates the Fidelity of Spliceosome Assembly

Xu, Y., & Query, C. C. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.09.022 · Cited by 129 · see citing works

ATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the C terminus of Prp8

Maeder, C., Kutach, A. K., & Guthrie, C. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1535 · Cited by 128 · see citing works

Rearrangement of competing U2 RNA helices within the spliceosome promotes multiple steps in splicingPreprint

Perriman, R., & Ares, M. (2007) · Genes & Development · doi:10.1101/gad.1524307 · Cited by 124 · see citing works

RNA splicing: What has phosphorylation got to do with it?

Misteli, T. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80128-6 · Cited by 122 · see citing works

The Prp19-associated Complex Is Required for Specifying Interactions of U5 and U6 with Pre-mRNA during Spliceosome Activation

Chan, S., & Cheng, S.-C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505060200 · Cited by 122 · see citing works

Repositioning of the Reaction Intermediate within the Catalytic Center of the Spliceosome

Konarska, M. M., Vilardell, J., & Query, C. C. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.01.017 · Cited by 120 · see citing works

Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation

Schneider, M., Hsiao, H., Will, C. L., Giet, R., Urlaub, H., & Lührmann, R. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1718 · Cited by 115 · see citing works

Interaction between a G-Patch Protein and a Spliceosomal DEXD/H-Box ATPase That Is Critical for Splicing

Silverman, E. J., Maeda, A., Wei, J., Smith, P., Beggs, J. D., & Lin, R.-J. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.23.10101-10110.2004 · Cited by 115 · see citing works

Both Catalytic Steps of Nuclear Pre-mRNA Splicing Are Reversible

Tseng, C. K., & Cheng, S.-C. (2008) · Science · doi:10.1126/science.1158993 · Cited by 112 · see citing works

U2 toggles iteratively between the stem IIa and stem IIc conformations to promote pre-mRNA splicingPreprint

Hilliker, A. K., Mefford, M. A., & Staley, J. P. (2007) · Genes & Development · doi:10.1101/gad.1536107 · Cited by 109 · see citing works

Exon Definition Complexes Contain the Tri-snRNP and Can Be Directly Converted into B-like Precatalytic Splicing Complexes

Schneider, M., Will, C. L., Anokhina, M. M., Tazi, J., Urlaub, H., & Lührmann, R. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.02.027 · Cited by 104 · see citing works

Structure and function of an RNase H domain at the heart of the spliceosome

Peña, V., Rozov, A., Fabrizio, P., Lührmann, R., & Wahl, M. C. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.209 · Cited by 101 · see citing works

Distinct activities of the DExD/H-box splicing factor hUAP56 facilitate stepwise assembly of the spliceosomePreprint

Shen, H., Zheng, X., Shen, J., Zhang, L., Zhao, R., & Green, M. R. (2008) · Genes & Development · doi:10.1101/gad.1657308 · Cited by 100 · see citing works

An exonic splicing silencer represses spliceosome assembly after ATP-dependent exon recognition

House, A. E., & Lynch, K. W. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1149 · Cited by 98 · see citing works

CRYO-ELECTRON MICROSCOPY OF SPLICEOSOMAL COMPONENTS

Stark, H., & Lührmann, R. (2006) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.35.040405.101953 · Cited by 97 · see citing works

Visualizing the splicing of single pre-mRNA molecules in whole cell extract

Crawford, D. J., Hoskins, A. A., Friedman, L. J., Gelles, J., & Moore, M. J. (2007) · RNA · doi:10.1261/rna.794808 · Cited by 97 · see citing works

Stalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation

Kuhn, A. N., van Santen, M. A., Schwienhorst, A., Urlaub, H., & Lührmann, R. (2008) · RNA · doi:10.1261/rna.1332609 · Cited by 95 · see citing works

Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2

Zhang, L., Xu, T., Maeder, C., Bud, L.-O., Shanks, J., Nix, J. C., Guthrie, C., Pleiss, J. A., & Zhao, R. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1625 · Cited by 93 · see citing works

Biochemical and NMR analyses of an SF3b155–p14–U2AF-RNA interaction network involved in branch point definition during pre-mRNA splicing

Spadaccini, R., Reidt, U., Dybkov, O., Will, C. L., Frank, R., Stier, G., Corsini, L., Wahl, M. C., Lührmann, R., & Sattler, M. (2006) · RNA · doi:10.1261/rna.2271406 · Cited by 92 · see citing works

Opposing classes of prp8 alleles modulate the transition between the catalytic steps of pre-mRNA splicing

Liu, L., Query, C. C., & Konarska, M. M. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1240 · Cited by 91 · see citing works

Spliceosome Assembly and Composition

Matlin, A. J., & Moore, M. J. (2007) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-77374-2_2 · Cited by 88 · see citing works

The ribosomal translocase homologue Snu114p is involved in unwinding U4/U6 RNA during activation of the spliceosome

Bartels, C., Klatt, C., Lührmann, R., & Fabrizio, P. (2002) · EMBO Reports · doi:10.1093/embo-reports/kvf172 · Cited by 88 · see citing works

Beat the clock: paradigms for NTPases in the maintenance of biological fidelity

Burgess, S. M., & Guthrie, C. (1993) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(93)90094-4 · Cited by 88 · see citing works

Three-dimensional structure of C complex spliceosomes by electron microscopy

Jurica, M. S., Sousa, D. R., Moore, M. J., & Grigorieff, N. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb728 · Cited by 85 · see citing works

Organization of Core Spliceosomal Components U5 snRNA Loop I and U4/U6 Di-snRNP within U4/U6.U5 Tri-snRNP as Revealed by Electron Cryomicroscopy

Sander, B. O., Golas, M. M., Makarov, E. M., Brahms, H., Kastner, B., Lührmann, R., & Stark, H. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.08.021 · Cited by 85 · see citing works

Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p

Bellare, P., Kutach, A. K., Rines, A. K., Guthrie, C., & Sontheimer, E. J. (2006) · RNA · doi:10.1261/rna.2152306 · Cited by 84 · see citing works

Dynamic Interactions of Ntr1-Ntr2 with Prp43 and with U5 Govern the Recruitment of Prp43 To Mediate Spliceosome Disassembly

Tsai, R.-T., Tseng, C. K., Lee, P.-J., Chen, H.-C., Fu, R., Chang, K.-J., Yeh, F.-L., & Cheng, S.-C. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01213-07 · Cited by 84 · see citing works

Common Design Principles in the Spliceosomal RNA Helicase Brr2 and in the Hel308 DNA Helicase

Peña, V., Mozaffari‐Jovin, S., Fabrizio, P., Orlowski, J., Bujnicki, J. M., Lührmann, R., & Wahl, M. C. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.08.006 · Cited by 83 · see citing works

Major Conformational Change in the Complex SF3b upon Integration into the Spliceosomal U11/U12 di-snRNP as Revealed by Electron Cryomicroscopy

Golas, M. M., Sander, B. O., Will, C. L., Lührmann, R., & Stark, H. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.02.016 · Cited by 82 · see citing works

Three-dimensional structure of a pre-catalytic human spliceosomal complex B

Boehringer, D., Makarov, E. M., Sander, B. O., Makarova, O. V., Kastner, B., Lührmann, R., & Stark, H. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb761 · Cited by 81 · see citing works

Evidence that U2/U6 helix I promotes both catalytic steps of pre-mRNA splicing and rearranges in between these steps

Mefford, M. A., & Staley, J. P. (2009) · RNA · doi:10.1261/rna.1582609 · Cited by 81 · see citing works

Cwc25 Is a Novel Splicing Factor Required after Prp2 and Yju2 To Facilitate the First Catalytic Reaction

Chiu, Y.-F., Liu, Y.-C., Chiang, T.-W. W., Yeh, T.-C., Tseng, C. K., Wu, N.-Y., & Cheng, S.-C. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00773-09 · Cited by 80 · see citing works

Genetic Analysis Reveals a Role for the C Terminus of the Saccharomyces cerevisiae GTPase Snu114 During Spliceosome Activation

Brenner, T. J., & Guthrie, C. (2005) · Genetics · doi:10.1534/genetics.105.042044 · Cited by 79 · see citing works

Commitment to Splice Site Pairing Coincides with A Complex Formation

Lim, S. R., & Hertel, K. J. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.06.025 · Cited by 76 · see citing works

Protein-free small nuclear RNAs catalyze a two-step splicing reaction

Valadkhan, S., Mohammadi, A., Jaladat, Y., & Geisler, S. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902020106 · Cited by 76 · see citing works

A Novel Splicing Factor, Yju2, Is Associated with NTC and Acts after Prp2 in Promoting the First Catalytic Reaction of Pre-mRNA Splicing

Liu, Y.-C., Chen, H.-C., Wu, N.-Y., & Cheng, S.-C. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00346-07 · Cited by 76 · see citing works

Inhibition of a spliceosome turnover pathway suppresses splicing defects

Pandit, S., Lynn, B. C., & Rymond, B. C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603188103 · Cited by 75 · see citing works

Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy

Häcker, I., Sander, B. O., Golas, M. M., Wolf, E., Karagöz, G. E., Kastner, B., Stark, H., Fabrizio, P., & Lührmann, R. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1506 · Cited by 75 · see citing works

Crystal structure of a core spliceosomal protein interface

Schellenberg, M. J., Edwards, R. A., Ritchie, D. B., Kent, O. A., Golas, M. M., Stark, H., Lührmann, R., Glover, J. N. M., & MacMillan, A. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508048103 · Cited by 75 · see citing works

Crystal structure of the β-finger domain of Prp8 reveals analogy to ribosomal proteins

Yang, K., Zhang, L., Xu, T., Heroux, A., & Zhao, R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805960105 · Cited by 75 · see citing works

Three-Dimensional Structure of the Native Spliceosome by Cryo-Electron Microscopy

Azubel, M., Wolf, S. G., Sperling, J. M., & Sperling, R. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.07.022 · Cited by 73 · see citing works

Structural elucidation of a PRP8 core domain from the heart of the spliceosome

Ritchie, D. B., Schellenberg, M. J., Gesner, E. M., Raithatha, S. A., Stuart, D. T., & MacMillan, A. M. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1505 · Cited by 73 · see citing works

Insights into the mechanisms of splicing: more lessons from the ribosome: Figure 1.Preprint

Konarska, M. M., & Query, C. C. (2005) · Genes & Development · doi:10.1101/gad.1363105 · Cited by 70 · see citing works

Solution structure of human U1 snRNA. Derivation of a possible three-dimensional model

Krol, A., Westhof, É., Bach, M. A., Lührmann, R., Ebel, J., & Carbon, P. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.13.3803 · Cited by 67 · see citing works

Single-molecule analysis of protein-free U2–U6 snRNAs

Guo, Z., Karunatilaka, K. S., & Rueda, D. S. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1672 · Cited by 64 · see citing works

Coevolutionary networks of splicing cis -regulatory elements

Xiao, X. G., Wang, Z., Jang, M., & Burge, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707349104 · Cited by 61 · see citing works

Spatial mapping of splicing factor complexes involved in exon and intron definition

Ellis, J. D., Llères, D., Denegri, M., Lamond, A. I., & Cáceres, J. F. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200710051 · Cited by 60 · see citing works

Crystal structure of the C‐terminal domain of splicing factor Prp8 carrying retinitis pigmentosa mutants

Zhang, L., Shen, J., Guarnieri, M. T., Heroux, A., Yang, K., & Zhao, R. (2007) · Protein Science · doi:10.1110/ps.072872007 · Cited by 58 · see citing works

Proximity of conserved U6 and U2 snRNA elements to the 5′ splice site region in activated spliceosomes

Rhode, B. M., Hartmuth, K., Westhof, É., & Lührmann, R. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601134 · Cited by 56 · see citing works

Early organization of pre-mRNA during spliceosome assembly

Kent, O. A., & MacMillan, A. M. (2002) · Nature Structural Biology · doi:10.1038/nsb822 · Cited by 54 · see citing works

Structural characterization of the fission yeast U5.U2/U6 spliceosome complex

Ohi, M. D., Ren, L., Wall, J. S., Gould, K. L., & Walz, T. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611591104 · Cited by 54 · see citing works

The 5′ End of U2 snRNA Is in Close Proximity to U1 and Functional Sites of the Pre-mRNA in Early Spliceosomal Complexes

Dönmez, G., Hartmuth, K., Kastner, B., Will, C. L., & Lührmann, R. (2007) · Molecular Cell · doi:10.1016/j.molcel.2006.12.019 · Cited by 53 · see citing works

Spliceosome structure: Piece by piece

Ritchie, D. B., Schellenberg, M. J., & MacMillan, A. M. (2009) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2009.08.010 · Cited by 53 · see citing works

Exon, intron and splice site locations in the spliceosomal B complex

Wolf, E., Kastner, B., Deckert, J., Merz, C., Stark, H., & Lührmann, R. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.171 · Cited by 51 · see citing works

Splicing of mRNA precursors: the role of RNAs and proteins in catalysis

Wachtel, C., & Manley, J. L. (1900) · Molecular BioSystems · doi:10.1039/b820828j · Cited by 49 · see citing works

RS domain–splicing signal interactions in splicing of U12-type and U2-type introns

Shen, H., & Green, M. R. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1263 · Cited by 49 · see citing works

Splicing Factors SF1 and U2AF Associate in Extraspliceosomal Complexes

Rino, J., Desterro, J. M. P., Pacheco, T. R., Gadella, T. W. J., & Carmo‐Fonseca, M. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.02015-07 · Cited by 49 · see citing works

Splicing regulation: From a parts list of regulatory elements to an integrated splicing code

Burge, C. B., & Wang, Z. (2020) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/bzpx-7662 · Cited by 49 · see citing works

Is the spliceosome a ribonucleoprotein enzyme?

Abelson, J. N. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1208-1235 · Cited by 47 · see citing works

Protein-free spliceosomal snRNAs catalyze a reaction that resembles the first step of splicing

Valadkhan, S., Mohammadi, A., Wachtel, C., & Manley, J. L. (2007) · RNA · doi:10.1261/rna.626207 · Cited by 47 · see citing works

Pre-mRNA Missplicing as a Cause of Human Disease

Novoyatleva, T., Tang, Y., Rafalska, I., & Stamm, S. (2006) · Progress in molecular and subcellular biology · doi:10.1007/978-3-540-34449-0_2 · Cited by 44 · see citing works

The Prp18 protein stabilizes the interaction of both exons with the U5 snRNA during the second step of pre-mRNA splicingPreprint

Crotti, L. B., Bačíková, D., & Horowitz, D. S. (2007) · Genes & Development · doi:10.1101/gad.1538207 · Cited by 44 · see citing works

Functional interactions between Prp8, Prp18, Slu7, and U5 snRNA during the second step of pre-mRNA splicing

Aronova, A., Bačíková, D., Crotti, L. B., Horowitz, D. S., & Schwer, B. (2007) · RNA · doi:10.1261/rna.572807 · Cited by 40 · see citing works

Genetic interactions between the yeast RNA helicase homolog Prp16 and spliceosomal snRNAs identify candidate ligands for the Prp16 RNA-dependent ATPase.

Madhani, H. D., & Guthrie, C. (1994) · Genetics · doi:10.1093/genetics/137.3.677 · Cited by 39 · see citing works

Structural mapping of spliceosomes by electron microscopy

Lührmann, R., & Stark, H. (2009) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2009.01.001 · Cited by 39 · see citing works

Phosphorylation-Dependent Control of the Pre-mRNA Splicing Machinery

Soret, J., & Tazi, J. (2003) · Progress in molecular and subcellular biology · doi:10.1007/978-3-662-09728-1_4 · Cited by 38 · see citing works

Roles of the U5 snRNP in spliceosome dynamics and catalysis

Turner, I. A., Norman, C. M., Churcher, M. J., & Newman, A. J. (2004) · Biochemical Society Transactions · doi:10.1042/bst0320928 · Cited by 38 · see citing works

Structure of yeast U6 snRNPs: Arrangement of Prp24p and the LSm complex as revealed by electron microscopy

Karaduman, R., Dube, P., Stark, H., Fabrizio, P., Kastner, B., & Lührmann, R. (2008) · RNA · doi:10.1261/rna.1369808 · Cited by 30 · see citing works

A protein-based EM label for RNA identifies the location of exons in spliceosomes

Alcid, E. A., & Jurica, M. S. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1378 · Cited by 25 · see citing works

A critical assessment of the utility of protein-free splicing systems

Smith, D. J., & Konarska, M. M. (2008) · RNA · doi:10.1261/rna.1322709 · Cited by 23 · see citing works

trans-Splicing to Spliceosomal U2 snRNA Suggests Disruption of Branch Site-U2 Pairing during Pre-mRNA Splicing

Smith, D. J., Query, C. C., & Konarska, M. M. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.020 · Cited by 19 · see citing works

Crystal Structure of Human Spliceosomal U1 snRNP

Krummel, D. A. P., Oubridge, C., Leung, A. K.-W., Li, J., & Nagai, K. (2008) · Worldwide Protein Data Bank · doi:10.2210/pdb3cw1/pdb · Cited by 10 · see citing works

Crystal structure of human spliceosomal U1 snRNP at 5.5 Å resolution

Krummel, D. P., Oubridge, C., Leung, A. K.-W., Li, J., & Nagai, K. (2009) · Acta Crystallographica Section A Foundations of Crystallography · doi:10.1107/s0108767309099772 · Cited by 9 · see citing works

Identification and characterization of a short 2′–3′ bond-forming ribozyme

Smith, D. J., & Konarska, M. M. (2008) · RNA · doi:10.1261/rna.1321909 · Cited by 5 · see citing works

Common Design Principles in the Spliceosomal RNA Helicase Brr2 and in the Hel308 DNA Helicase

Peña, V., Mozaffari‐Jovin, S., Fabrizio, P., Orlowski, J., Bujnicki, J. M., Lührmann, R., & Wahl, M. C. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.01.018 · Cited by 5 · see citing works

The Spliceosome: Design Principles of a Dynamic RNP Machine

Wahl, M. C., Will, C. L., & Lührmann, R. (2009) · Cell · doi:10.1016/j.cell.2009.02.009 · Cited by 2,665 · see citing works

Mechanisms and Regulation of Alternative Pre-mRNA Splicing

Lee, Y., & Rio, D. C. (2015) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-034316 · Cited by 1,291 · see citing works

A day in the life of the spliceosome

Matera, A. G., & Wang, Z. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3742 · Cited by 1,074 · see citing works

RNA in cancer

Goodall, G. J., & Wickramasinghe, V. O. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-00306-0 · Cited by 1,070 · see citing works

Complexity of the Alternative Splicing Landscape in Plants

Reddy, A. S. N., Márquez, Y., Kalyna, M., & Barta, A. (2013) · The Plant Cell · doi:10.1105/tpc.113.117523 · Cited by 849 · see citing works

Alternative Splicing at the Intersection of Biological Timing, Development, and Stress Responses

Staiger, D., & Brown, J. W. S. (2013) · The Plant Cell · doi:10.1105/tpc.113.113803 · Cited by 690 · see citing works

A Protein Complex Network of Drosophila melanogaster

Guruharsha, K. G., Rual, J.-F. M., Zhai, B., Mintseris, J., Vaidya, P., Vaidya, N., Beekman, C. N., Wong, C. S. F., Rhee, D. Y., Cenaj, O., et al. (2011) · Cell · doi:10.1016/j.cell.2011.08.047 · Cited by 654 · see citing works

Long Non-Coding RNAs in the Regulation of Gene Expression: Physiology and Disease

Fernandes, J. C. R., Acuña, S. M., Aoki, J. I., Floeter‐Winter, L. M., & Muxel, S. M. (2019) · Non-Coding RNA · doi:10.3390/ncrna5010017 · Cited by 647 · see citing works

Splice-switching antisense oligonucleotides as therapeutic drugs

Havens, M. A., & Hastings, M. L. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw533 · Cited by 541 · see citing works

N6-methyladenosine links RNA metabolism to cancer progression

Dai, D., Wang, H., Zhu, L., Jin, H., & Wang, X. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0129-x · Cited by 466 · see citing works

Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes

Sveen, A., Kilpinen, S. K., Ruusulehto, A., Lothe, R. A., & Skotheim, R. I. (2015) · Oncogene · doi:10.1038/onc.2015.318 · Cited by 463 · see citing works

The ‘how’ and ‘where’ of plant micro RNA s

Yu, Y., Jia, T., & Chen, X. (2017) · New Phytologist · doi:10.1111/nph.14834 · Cited by 462 · see citing works

Insights into circular RNA biology

Ebbesen, K. K., Hansen, T. B., & Kjems, J. (2016) · RNA Biology · doi:10.1080/15476286.2016.1271524 · Cited by 454 · see citing works

Deep intronic mutations and human disease

Vaz‐Drago, R., Custódio, N., & Carmo‐Fonseca, M. (2017) · Human Genetics · doi:10.1007/s00439-017-1809-4 · Cited by 448 · see citing works

A View of Pre-mRNA Splicing from RNase R Resistant RNAs

Suzuki, H., & Tsukahara, T. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15069331 · Cited by 428 · see citing works

Molecular genetics and emerging therapies for retinitis pigmentosa: Basic research and clinical perspectives

Dias, M. F., Joo, K., Kemp, J. A., Fialho, S. L., Silva‐Cunha, A., Woo, S. J., & Kwon, Y. J. (2017) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2017.10.004 · Cited by 420 · see citing works

The spliceosome as a target of novel antitumour drugs

Bonnal, S., Vigevani, L., & Valcárcel, J. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3823 · Cited by 403 · see citing works

Physiologic Expression of Sf3b1(K700E) Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation

Obeng, E. A., Chappell, R. J., Seiler, M., Chen, M. C., Campagna, D. R., Schmidt, P. J., Schneider, R. K., Lord, A. M., Wang, L., Gambe, R. G., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.08.006 · Cited by 380 · see citing works

Splicing and transcription touch base: co-transcriptional spliceosome assembly and function

Herzel, L., Ottoz, D. S. M., Alpert, T., & Neugebauer, K. M. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.63 · Cited by 356 · see citing works

The neurogenetics of alternative splicing

Vuong, C. K., Black, D. L., & Zheng, S. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.27 · Cited by 340 · see citing works

The significant other: splicing by the minor spliceosome

Turunen, J. J., Niemelä, E. H., Verma, B., & Frilander, M. J. (2012) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1141 · Cited by 349 · see citing works

Structure of a yeast spliceosome at 3.6-angstrom resolution

Yan, C., Hang, J., Wan, R., Huang, M., Wong, C. C. L., & Shi, Y. (2015) · Science · doi:10.1126/science.aac7629 · Cited by 334 · see citing works

Exon and intron definition in pre‐mRNA splicing

Conti, L. D., Baralle, M., & Buratti, E. (2012) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1140 · Cited by 331 · see citing works

Functional complexity and regulation through RNA dynamics

Dethoff, E. A., Chugh, J., Mustoe, A. M., & Al‐Hashimi, H. M. (2012) · Nature · doi:10.1038/nature10885 · Cited by 331 · see citing works

The exon junction complex as a node of post-transcriptional networks

Hir, H. L., Saulière, J., & Wang, Z. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2015.7 · Cited by 280 · see citing works

Human branch point consensus sequence is yUnAy

Gao, K., Masuda, A., Matsuura, T., & Ohno, K. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn073 · Cited by 284 · see citing works

An Atomic Structure of the Human Spliceosome

Zhang, X., Yan, C., Hang, J., Finci, L. I., Lei, J., & Shi, Y. (2017) · Cell · doi:10.1016/j.cell.2017.04.033 · Cited by 268 · see citing works

FTO controls reversible m6Am RNA methylation during snRNA biogenesis

Mauer, J., Sindelar, M., Despic, V., Guez, T., Hawley, B. R., Vasseur, J., Rentmeister, A., Gross, S. S., Pellizzoni, L., Debart, F., et al. (2019) · Nature Chemical Biology · doi:10.1038/s41589-019-0231-8 · Cited by 270 · see citing works

Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5′ splice site recognition

Kondo, Y., Oubridge, C., van Roon, A. M., & Nagai, K. (2015) · eLife · doi:10.7554/elife.04986 · Cited by 249 · see citing works

Genome-wide discovery of human splicing branchpointsPreprint

Mercer, T. R., Clark, M. B., Andersen, S. B., Brunck, M. E. G., Haerty, W., Crawford, J., Taft, R. J., Nielsen, L. K., Dinger, M. E., & Mattick, J. S. (2015) · Genome Research · doi:10.1101/gr.182899.114 · Cited by 244 · see citing works

Cyclin-Dependent Kinases (CDK) and Their Role in Diseases Development–Review

Łukasik, P., Załuski, M., & Gutowska, I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062935 · Cited by 256 · see citing works

Alternative mRNA splicing in cancer immunotherapy

Frankiw, L., Baltimore, D., & Li, G. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0195-7 · Cited by 248 · see citing works

The RNA Worlds in Context

Cech, T. R. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a006742 · Cited by 244 · see citing works

Structural Insights into Nuclear pre-mRNA Splicing in Higher EukaryotesPreprint

Kastner, B., Will, C. L., Stark, H., & Lührmann, R. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a032417 · Cited by 240 · see citing works

The architecture of the spliceosomal U4/U6.U5 tri-snRNP

Nguyen, T. H. D., Galej, W. P., Bai, X., Savva, C. G., Newman, A. J., Scheres, S. H. W., & Nagai, K. (2015) · Nature · doi:10.1038/nature14548 · Cited by 240 · see citing works

U1 snRNP regulates chromatin retention of noncoding RNAs

Yin, Y., Lu, J., Zhang, X., Shao, W., Xu, Y., Li, P., Hong, Y., Cui, L., Shan, G., Tian, B., et al. (2020) · Nature · doi:10.1038/s41586-020-2105-3 · Cited by 224 · see citing works

Cryo-EM structure of the spliceosome immediately after branching

Galej, W. P., Wilkinson, M. E., Fica, S. M., Oubridge, C., Newman, A. J., & Nagai, K. (2016) · Nature · doi:10.1038/nature19316 · Cited by 235 · see citing works

Targeting tumour-supportive cellular machineries in anticancer drug development

Dobbelstein, M., & Moll, U. M. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4201 · Cited by 229 · see citing works

ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP

Sun, S., Ling, S., Qiu, J., de Albuquerque, C. P., Zhou, Y., Tokunaga, S., Li, H., Qiu, H., Bui, A., Yeo, G. W.-M., et al. (2015) · Nature Communications · doi:10.1038/ncomms7171 · Cited by 229 · see citing works

Predicting the structure of large protein complexes using AlphaFold and Monte Carlo tree search

(2022) · doi:10.1038/s41467-022-33729-4 · Cited by 226 · see citing works

Mouse totipotent stem cells captured and maintained through spliceosomal repression

Shen, H., Yang, M., Li, S., Zhang, J., Peng, B., Wang, C., Chang, Z., Ong, J., & Du, P. (2021) · Cell · doi:10.1016/j.cell.2021.04.020 · Cited by 216 · see citing works

Structure of a pre-catalytic spliceosome

Plaschka, C., Lin, P.-C., & Nagai, K. (2017) · Nature · doi:10.1038/nature22799 · Cited by 217 · see citing works

RRM–RNA recognition: NMR or crystallography…and new findings

Daubner, G. M., Cléry, A., & Allain, F. H. ‐. (2012) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2012.11.006 · Cited by 219 · see citing works

Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution

Nguyen, T. H. D., Galej, W. P., Bai, X., Oubridge, C., Newman, A. J., Scheres, S. H. W., & Nagai, K. (2016) · Nature · doi:10.1038/nature16940 · Cited by 215 · see citing works

SF3B1, a splicing factor is frequently mutated in refractory anemia with ring sideroblasts

Visconte, V., Makishima, H., Jankowska, A. M., Szpurka, H., Traina, F., Jerez, A., O'Keefe, C., Rogers, H. J., Sekeres, M. A., Maciejewski, J. P., et al. (2011) · Leukemia · doi:10.1038/leu.2011.232 · Cited by 212 · see citing works

Splice site m6A methylation prevents binding of U2AF35 to inhibit RNA splicing

Mendel, M., Delaney, K., Pandey, R. R., Chen, K., Wenda, J. M., Vågbø, C. B., Steiner, F. A., Homolka, D., & Pillai, R. S. (2021) · Cell · doi:10.1016/j.cell.2021.03.062 · Cited by 200 · see citing works

Alternative splicing in plants: directing traffic at the crossroads of adaptation and environmental stress

Filichkin, S. A., Priest, H. D., Megraw, M. S., & Mockler, T. C. (2015) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2015.02.008 · Cited by 208 · see citing works

Alternative Splicing and Protein Diversity: Plants Versus Animals

Chaudhary, S., Khokhar, W., Jabre, I., Reddy, A. S. N., Byrne, L. J., Wilson, C. M., & Syed, N. H. (2019) · Frontiers in Plant Science · doi:10.3389/fpls.2019.00708 · Cited by 204 · see citing works

The Dengue Virus NS5 Protein Intrudes in the Cellular Spliceosome and Modulates Splicing

Maio, F. A. D., Risso, G. J., Iglesias, N. G., Shah, P. S., Pozzi, B., Gebhard, L. G., Mammi, P., Mancini, E., Yanovsky, M. J., Andino, R., et al. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005841 · Cited by 198 · see citing works

Regulation of alternative splicing of CD44 in cancer

Procházka, L., Tesařı́k, R., & Tuřánek, J. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.07.011 · Cited by 196 · see citing works

Tau-mediated disruption of the spliceosome triggers cryptic rna splicing and neurodegeneration in Alzheimer's Disease

Hsieh, Y.-C., Guo, C., Yalamanchili, H. K., Abreha, M., Al-Ouran, R., Li, Y., Dammer, E. B., Lah, J. J., Levey, A. I., Bennett, D. A., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.08.104 · Cited by 196 · see citing works

The EF-G-like GTPase Snu114p Regulates Spliceosome Dynamics Mediated by Brr2p, a DExD/H Box ATPase

Small, E. C., Leggett, S. R., Winans, A. A., & Staley, J. P. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.05.043 · Cited by 194 · see citing works

Evolution of group II introns

Zimmerly, S., & Semper, C. (2015) · Mobile DNA · doi:10.1186/s13100-015-0037-5 · Cited by 189 · see citing works

Proteogenomic analysis reveals alternative splicing and translation as part of the abscisic acid response in Arabidopsis seedlings

Zhu, F., Chen, M., Ye, N., Shi, L., Ma, K., Yang, J., Cao, Y., Zhang, Y., Yoshida, T., Fernie, A. R., et al. (2017) · The Plant Journal · doi:10.1111/tpj.13571 · Cited by 193 · see citing works

Transcriptomic characterization of cold acclimation in larval zebrafish

Long, Y., Song, G., Yan, J., He, X., Li, Q. X., & Cui, Z. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-612 · Cited by 192 · see citing works

Structural basis of splicing modulation by antitumor macrolide compounds

Cretu, C., Agrawal, A. A., Cook, A., Will, C. L., Fekkes, P., Smith, P. G., Lührmann, R., Larsen, N., Buonamici, S., & Pena, V. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.03.011 · Cited by 174 · see citing works

Dynamic imaging of nascent RNA reveals general principles of transcription dynamics and stochastic splice site selection

Wan, Y., Anastasakis, D. G., Rodriguez, J., Palangat, M., Gudla, P. R., Zaki, G., Tandon, M., Pegoraro, G., Chow, C. C., Hafner, M., et al. (2021) · Cell · doi:10.1016/j.cell.2021.04.012 · Cited by 188 · see citing works

New connections between splicing and human disease

Padgett, R. A. (2012) · Trends in Genetics · doi:10.1016/j.tig.2012.01.001 · Cited by 183 · see citing works

How do cells cope with RNA damage and its consequences?

Yan, L. L., & Zaher, H. S. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.006513 · Cited by 185 · see citing works

Genome organization around nuclear speckles drives mRNA splicing efficiency

Bhat, P., Chow, A. Y., Emert, B. L., Ettlin, O., Quinodoz, S. A., Strehle, M. M., Takei, Y., Burr, A., Goronzy, I. N., Chen, A. W., et al. (2024) · Nature · doi:10.1038/s41586-024-07429-6 · Cited by 182 · see citing works

RBM5/Luca-15/H37 Regulates Fas Alternative Splice Site Pairing after Exon Definition

Bonnal, S., Martínez, C., Förch, P., Bachi, A., Wilm, M. S., & Valcárcel, J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.08.008 · Cited by 176 · see citing works

Structure of a yeast catalytic step I spliceosome at 3.4 Å resolution

Wan, R., Yan, C., Bai, R., Huang, G., & Shi, Y. (2016) · Science · doi:10.1126/science.aag2235 · Cited by 173 · see citing works

Oogenesis and Egg Quality in Finfish: Yolk Formation and Other Factors Influencing Female Fertility

Reading, B. J., Andersen, L. K., Ryu, Y., Mushirobira, Y., Todo, T., & Hiramatsu, N. (2018) · Fishes · doi:10.3390/fishes3040045 · Cited by 175 · see citing works

Live-Cell Visualization of Pre-mRNA Splicing with Single-Molecule Sensitivity

Martin, R. M., Rino, J., Carvalho, C., Kirchhausen, T., & Carmo-Fonseca, M. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.08.013 · Cited by 173 · see citing works

Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components

Warkocki, Z., Odenwälder, P., Schmitzová, J., Platzmann, F., Stark, H., Urlaub, H., Ficner, R., Fabrizio, P., & Lührmann, R. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1729 · Cited by 172 · see citing works

The importance of DNA methylation of exons on alternative splicing

Shayevitch, R., Askayo, D., Keydar, I., & Ast, G. (2018) · RNA · doi:10.1261/rna.064865.117 · Cited by 171 · see citing works

Chromatin-associated RNA sequencing (ChAR-seq) maps genome-wide RNA-to-DNA contacts

Bell, J. C., Jukam, D., Teran, N. A., Risca, V. I., Smith, O. K., Johnson, W. L., Skotheim, J. M., Greenleaf, W. J., & Straight, A. F. (2018) · eLife · doi:10.7554/elife.27024 · Cited by 170 · see citing works

CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion

Tien, J. F., Mazloomian, A., Cheng, S., Hughes, C. S., Chow, C. C. T., Canapi, L. T., Oloumi, A., Trigo‐Gonzalez, G., Bashashati, A., Xu, J., et al. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx187 · Cited by 165 · see citing works

Dysregulation and therapeutic targeting of RNA splicing in cancer

Stanley, R. F., & Abdel-Wahab, O. I. (2022) · Nature Cancer · doi:10.1038/s43018-022-00384-z · Cited by 160 · see citing works

The 3.8 Å structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis

Wan, R., Yan, C., Bai, R., Wang, L., Huang, M., Wong, C. C. L., & Shi, Y. (2016) · Science · doi:10.1126/science.aad6466 · Cited by 160 · see citing works

Prespliceosome structure provides insights into spliceosome assembly and regulation

Plaschka, C., Lin, P.-C., Charenton, C., & Nagai, K. (2018) · Nature · doi:10.1038/s41586-018-0323-8 · Cited by 154 · see citing works

The pathogenicity of splicing defects: mechanistic insights into pre‐mRNA processing inform novel therapeutic approaches

Daguenet, É., Dujardin, G., & Valcárcel, J. (2015) · EMBO Reports · doi:10.15252/embr.201541116 · Cited by 151 · see citing works

De novo variants in the RNU4-2 snRNA cause a frequent neurodevelopmental syndrome

Chen, Y., Dawes, R., Kim, H. C., Ljungdahl, A., Stenton, S. L., Walker, S., Lord, J., Lemire, G., Martin-Geary, A. C., Ganesh, V. S., et al. (2024) · Nature · doi:10.1038/s41586-024-07773-7 · Cited by 155 · see citing works

EBV Noncoding RNA Binds Nascent RNA to Drive Host PAX5 to Viral DNA

Lee, N., Moss, W. N., Yario, T. A., & STEITZ, J. A. (2015) · Cell · doi:10.1016/j.cell.2015.01.015 · Cited by 154 · see citing works

Pre-mRNA alternative splicing as a modulator for heat stress response in plants

Ling, Y., Mahfouz, M. M., & Zhou, S. (2021) · Trends in Plant Science · doi:10.1016/j.tplants.2021.07.008 · Cited by 151 · see citing works

Role of DNA methylation in imprinting disorders: an updated review

Elhamamsy, A. R. (2017) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-017-0895-5 · Cited by 150 · see citing works

Alternative splicing: Human disease and quantitative analysis from high-throughput sequencing

Jiang, W., & Chen, L. (2020) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2020.12.009 · Cited by 154 · see citing works

Mobile Bacterial Group II Introns at the Crux of Eukaryotic Evolution

Lambowitz, A. M., & Belfort, M. (2015) · Microbiology Spectrum · doi:10.1128/microbiolspec.mdna3-0050-2014 · Cited by 149 · see citing works

RNA components of the spliceosome regulate tissue- and cancer-specific alternative splicingPreprint

Dvinge, H., Guenthoer, J., Porter, P. L., & Bradley, R. K. (2019) · Genome Research · doi:10.1101/gr.246678.118 · Cited by 143 · see citing works

RNA helicases in splicing

Cordin, O., & Beggs, J. D. (2012) · RNA Biology · doi:10.4161/rna.22547 · Cited by 144 · see citing works

Splicing and beyond: The many faces of the Prp19 complex

Chanarat, S., & Sträßer, K. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.05.023 · Cited by 149 · see citing works

Molecular Architecture of the Human Prp19/CDC5L Complex

Grote, M., Wolf, E., Will, C. L., Lemm, I., Agafonov, D. E., Schomburg, A., Fischle, W., Urlaub, H., & Lührmann, R. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01505-09 · Cited by 142 · see citing works

Spliceosome Database: a tool for tracking components of the spliceosome

Cvitkovic, I., & Jurica, M. S. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks999 · Cited by 139 · see citing works

Phosphorylation-Mediated Regulation of Alternative Splicing in Cancer

Naro, C., & Sette, C. (2013) · International Journal of Cell Biology · doi:10.1155/2013/151839 · Cited by 138 · see citing works

Structure of a transcribing RNA polymerase II–U1 snRNP complex

Zhang, S., Aibara, S., Vos, S. M., Agafonov, D. E., Lührmann, R., & Cramer, P. (2021) · Science · doi:10.1126/science.abf1870 · Cited by 138 · see citing works

A Conformational Rearrangement in the Spliceosome Sets the Stage for Prp22-Dependent mRNA Release

Schwer, B. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.05.003 · Cited by 136 · see citing works

Structure of a yeast step II catalytically activated spliceosome

Yan, C., Wan, R., Bai, R., Huang, G., & Shi, Y. (2016) · Science · doi:10.1126/science.aak9979 · Cited by 138 · see citing works

Emerging roles for RNA-binding proteins as effectors and regulators of cardiovascular disease

de Bruin, R. G., Rabelink, T. J., van Zonneveld, A. J., & van der Veer, E. P. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw567 · Cited by 129 · see citing works

Post-Transcriptional Regulation of Anti-Apoptotic BCL2 Family Members

Cui, J., & Placzek, W. J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19010308 · Cited by 135 · see citing works

Structure of a Multipartite Protein-Protein Interaction Domain in Splicing Factor Prp8 and Its Link to Retinitis Pigmentosa

Peña, V., Liu, S., Bujnicki, J. M., Lührmann, R., & Wahl, M. C. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.01.023 · Cited by 132 · see citing works

Disordered Proteinaceous Machines

Fuxreiter, M., Tóth-Petróczy, Á., Kraut, D. A., Matouschek, A. T., Lim, R. Y. H., Xue, B., Kurgan, L., & Uversky, V. N. (2014) · Chemical Reviews · doi:10.1021/cr4007329 · Cited by 133 · see citing works

Splicing factor gene mutations in hematologic malignancies

Sáez, B., Walter, M. J., & Graubert, T. A. (2016) · Blood · doi:10.1182/blood-2016-10-692400 · Cited by 130 · see citing works

Modifications in small nuclear RNAs and their roles in spliceosome assembly and function

Bohnsack, M. T., & Sloan, K. E. (2018) · Biological Chemistry · doi:10.1515/hsz-2018-0205 · Cited by 130 · see citing works

Modulation of the Apoptosis Gene Bcl-x Function Through Alternative Splicing

Stevens, M., & Oltean, S. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00804 · Cited by 130 · see citing works

Emerging roles of spliceosome in cancer and immunity

Yang, H., Beutler, B., & Zhang, D. (2021) · Protein & Cell · doi:10.1007/s13238-021-00856-5 · Cited by 134 · see citing works

Plant Small Non-coding RNAs and Their Roles in Biotic Stresses

Brant, E. J., & Budak, H. (2018) · Frontiers in Plant Science · doi:10.3389/fpls.2018.01038 · Cited by 127 · see citing works

Transcriptome Maps of mRNP Biogenesis Factors Define Pre-mRNA Recognition

Baejen, C., Torkler, P., Gressel, S., Essig, K., Söding, J., & Cramer, P. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.005 · Cited by 127 · see citing works

An oomycete plant pathogen reprograms host pre-mRNA splicing to subvert immunity

Huang, J., Gu, L., Zhang, Y., Yan, T., Kong, G., Kong, L., Guo, B., Qiu, M., Wang, Y., Jing, M., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02233-5 · Cited by 125 · see citing works

Targeting RNA in mammalian systems with small molecules

Donlic, A., & Hargrove, A. E. (2018) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1477 · Cited by 122 · see citing works

Role of Rad51 and DNA repair in cancer: A molecular perspective

Laurini, E., Marson, D., Fermeglia, A., Aulić, S., Fermeglia, M., & Pricl, S. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107492 · Cited by 128 · see citing works

The Spliceosome: Design Principles of a Dynamic RNP Machine

Wahl, M. C., Will, C. L., & Lührmann, R. (2009) · Cell · doi:10.1016/j.cell.2009.02.009 · Cited by 2,665 · see citing works

Structural analyses of the pre‐mRNA splicing machinery

Zhang, L., Li, X., & Zhao, R. (2013) · Protein Science · doi:10.1002/pro.2266 · Cited by 14 · see citing works

Structural Insights into Nuclear pre-mRNA Splicing in Higher EukaryotesPreprint

Kastner, B., Will, C. L., Stark, H., & Lührmann, R. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a032417 · Cited by 240 · see citing works

Structure of a yeast spliceosome at 3.6-angstrom resolution

Yan, C., Hang, J., Wan, R., Huang, M., Wong, C. C. L., & Shi, Y. (2015) · Science · doi:10.1126/science.aac7629 · Cited by 334 · see citing works

Biochemical and structural characterization of spliceosomes purified at defined stages of assembly from the yeast S. cerevisiae

Dannenberg, J. (2013) · doi:10.53846/goediss-4039 · Cited by 1 · see citing works