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A brave new world of RNA-binding proteins

Hentze, Matthias W., Castello, Alfredo, Schwarzl, Thomas, Preiss, Thomas·2018·Nature Reviews Molecular Cell Biology
DOI 10.1038/nrm.2017.130
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  • RNA binding proteins are post-transcriptional regulators of protein expression that bind RNA recognition motifs within the 5'UTR, coding region, or 3'UTR of target genes to facilitate alternative splicing, RNA export, translation, and stabilization or degradation of RNA transcripts.

    “RNA binding proteins (RBPs) are post-transcriptional regulators of protein expression that bind RNA recognition motifs within the 5’UTR, coding region (intron or exon), or 3’UTR of target genes to facilitate a variety of functions including alternative splicing, RNA export from the nucleus, translation, and stabilization or degradation of RNA transcripts58,59.”

    From Pathways and Molecular Mechanisms Governing LDL Receptor Regulation (2025) · cites this paper as [58]

  • A summary of multiple RNA interactome capture studies identified 1,914 and 1,393 RBPs in mice and humans, respectively.

    “A summary of multiple RNA interactome capture studies identified 1,914 and 1,393 RBPs in mice and humans, respectively58, making them much more abundant than transcription factors.”

    From Pathways and Molecular Mechanisms Governing LDL Receptor Regulation (2025) · cites this paper as [58]

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Metadata

Authors
Hentze, M. W., Castello, A., Schwarzl, T., & Preiss, T.
Venue
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2018-01-17
Volume
19
Issue
5
Pages
327-341
ISSN
  • 1471-0072
  • 1471-0080
DOI
10.1038/nrm.2017.130
Cited by
1,821
References
10
Language
en
Licence
www.springer.com/tdm (tdm)

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