The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Within-host evolution of bacterial pathogens
Open accessAbstract
Whole-genome sequencing has opened the way for investigating the dynamics and genomic evolution of bacterial pathogens during the colonization and infection of humans. The application of this technology to the longitudinal study of adaptation in an infected host — in particular, the evolution of drug resistance and host adaptation in patients who are chronically infected with opportunistic pathogens — has revealed remarkable patterns of convergent evolution, suggestive of an inherent repeatability of evolution. In this Review, we describe how these studies have advanced our understanding of the mechanisms and principles of within-host genome evolution, and we consider the consequences of findings such as a potent adaptive potential for pathogenicity. Finally, we discuss the possibility that genomics may be used in the future to predict the clinical progression of bacterial infections and to suggest the best option for treatment.
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Cites
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Cited by
Staphylococcus aureus host interactions and adaptation
Howden, B. P., Giulieri, S. G., Wong Fok Lung, T., Baines, S. L., Sharkey, L. K., Lee, J. Y. H., Hachani, A., Monk, I. R., & Stinear, T. P. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-023-00852-y · Cited by 689
Co-occurrence of antibiotic and metal resistance genes revealed in complete genome collection
Li, L.-G., Xia, Y., & Zhang, T. (2017) · The ISME Journal · doi:10.1038/ismej.2016.155 · Cited by 528
Diversity within Species: Interpreting Strains in Microbiomes
Van Rossum, T., Ferretti, P., Maistrenko, O. M., & Bork, P. (2020) · Nature Reviews Microbiology · doi:10.1038/s41579-020-0368-1 · Cited by 441
Adaptive Evolution within Gut Microbiomes of Healthy People
Zhao, S., Lieberman, T. D., Poyet, M., Kauffman, K. M., Gibbons, S. M., Groussin, M., Xavier, R. J., & Alm, E. J. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.03.007 · Cited by 434
When are pathogen genome sequences informative of transmission events?
Campbell, F., Strang, C., Ferguson, N., Cori, A., & Jombart, T. (2018) · PLOS Pathogens · doi:10.1371/journal.ppat.1006885 · Cited by 199
Metadata
- Authors
- Didelot, X., Walker, A. S., Peto, T. E., Crook, D. W., & Wilson, D. J.
- Venue
- Nature Reviews Microbiology
- Published
- 2016-01-19
- Volume
- 14
- Issue
- 3
- Pages
- 150-162
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W2273624252
- Cited by
- 483
- References
- 13
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- green
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- Didelot, X., Walker, A. S., Peto, T. E., Crook, D. W., & Wilson, D. J. (2016). Within-host evolution of bacterial pathogens. Nature Reviews Microbiology. https://doi.org/10.1038/nrmicro.2015.13
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