The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
HIV reservoirs: what, where and how to target them
Open accessAbstract
One of the main challenges in the fight against HIV infection is to develop strategies that are able to eliminate the persistent viral reservoir that harbours integrated, replication-competent provirus within host cellular DNA. This reservoir is resistant to antiretroviral therapy (ART) and to clearance by the immune system of the host; viruses originating from this reservoir lead to rebound viraemia once treatment is stopped, giving rise to new rounds of infection. Several studies have focused on elucidating the cells and tissues that harbour persistent virus, the true size of the reservoir and how best to target it, but these topics are the subject of ongoing debate. In this Viewpoint article, several experts in the field discuss the constitution of the viral reservoir, how best to measure it and the best ways to target this source of persistent infection.
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Cites
Glass, J. D., Fedor, H., Wesselingh, S. L., & McArthur, J. C. (1995) · Annals of Neurology · doi:10.1002/ana.410380510 · Cited by 662
Precise Quantitation of the Latent HIV-1 Reservoir: Implications for Eradication Strategies
Crooks, A. M., Bateson, R., Cope, A. B., Dahl, N. P., Griggs, M. K., Kuruc, J. D., Gay, C. L., Eron, J. J., Margolis, D. M., Bosch, R. J., et al. (2015) · Journal of Infectious Diseases · doi:10.1093/infdis/jiv218 · Cited by 406
Self-citationCanestri, A., Lescure, F., Jaureguiberry, S., Moulignier, A., Amiel, C., Marcelin, A. G., Peytavin, G., Tubiana, R., Pialoux, G., & Katlama, C. (2010) · Clinical Infectious Diseases · doi:10.1086/650538 · Cited by 405
Extensive astrocyte infection is prominent in human immunodeficiency virus–associated dementia
Churchill, M. J., Wesselingh, S. L., Cowley, D., Pardo, C. A., McArthur, J. C., Brew, B. J., & Gorry, P. R. (2009) · Annals of Neurology · doi:10.1002/ana.21697 · Cited by 339
Self-citationInduction of IL-17 and nonclassical T-cell activation by HIV-Tat protein
Johnson, T. P., Patel, K., Johnson, K. R., Maric, D., Calabresi, P. A., Hasbun, R., & Nath, A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308673110 · Cited by 265
Peluso, M. J., Ferretti, F., Peterson, J., Lee, E., Fuchs, D., Boschini, A., Gisslén, M., Angoff, N., Price, R. W., Cinque, P., et al. (2012) · AIDS · doi:10.1097/qad.0b013e328355e6b2 · Cited by 252
Churchill, M. J., Gorry, P. R., Cowley, D., Lal, L., Sonza, S., Purcell, D. F., Thompson, K. A., Gabuzda, D., McArthur, J. C., Pardo, C. A., et al. (2006) · Journal of Neurovirology · doi:10.1080/13550280600748946 · Cited by 221
Self-citationPeripheral Vγ9Vδ2 T Cells Are a Novel Reservoir of Latent HIV Infection
Soriano-Sarabia, N., Archin, N. M., Bateson, R., Dahl, N., Crooks, A. M., Kuruc, J. D., Garrido, C., & Margolis, D. M. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005201 · Cited by 77
Self-citationGray, L. R., Cowley, D., Welsh, C., Lu, H. K., Brew, B. J., Lewin, S. R., Wesselingh, S. L., Gorry, P. R., & Churchill, M. J. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.111 · Cited by 43
Self-citation
Cited by
Pathogenesis of HIV-1 and Mycobacterium tuberculosis co-infection
Bell, L. C. K., & Noursadeghi, M. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.128 · Cited by 389
HIV Reservoirs and Treatment Strategies toward Curing HIV Infection
Matsuda, K., & Maeda, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052621 · Cited by 43
Metadata
- Authors
- Churchill, M. J., Deeks, S. G., Margolis, D. M., Siliciano, R. F., & Swanstrom, R.
- Venue
- Nature Reviews Microbiology
- Published
- 2015-11-30
- Volume
- 14
- Issue
- 1
- Pages
- 55-60
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W2184875956
- Cited by
- 313
- References
- 9
- FWCI
- 14.64
- Type
- journal article
- Language
- en
- Open access
- green
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- Churchill, M. J., Deeks, S. G., Margolis, D. M., Siliciano, R. F., & Swanstrom, R. (2016). HIV reservoirs: what, where and how to target them. Nature Reviews Microbiology. https://doi.org/10.1038/nrmicro.2015.5
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
