The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Precise Quantitation of the Latent HIV-1 Reservoir: Implications for Eradication Strategies
Open accessAbstract
The quantitative viral outgrowth assay (QVOA) provides a precise minimal estimate of the reservoir of resting CD4(+) T-cell infection (resting cell infection [RCI]). However, the variability of RCI over time during antiretroviral therapy (ART), relevant to assess potential effects of latency-reversing agents or other interventions, has not been fully described. We performed QVOA on resting CD4(+) T cells obtained via leukapheresis from 37 human immunodeficiency virus (HIV)-infected patients receiving stable suppressive ART for a period of 6 years. Patients who started ART during acute (n = 17) or chronic (n = 20) HIV infection were studied once HIV RNA levels were <50 copies/mL for ≥ 6 months. Using random effects analysis of 160 RCI measurements, we found that RCI declined significantly over time (P < .001), with an estimated mean half-life of 3.6 years (95% confidence interval, 2.3-8.1 years), remarkably consistent with findings of prior studies. There was no evidence of more rapid decay in acute versus chronic HIV infection (P = .99) for patients suppressed ≥ 6 months. RCI was reliably estimated with longitudinal measurements generally showing < 2-fold variation from the previous measure. When QVOA is performed in this format, RCI decreases of >6-fold were rare. We suggest that a 6-fold decline is a relevant threshold to reliably identify effects of antilatency interventions on RCI.
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Defective proviruses rapidly accumulate during acute HIV-1 infection
Bruner, K. M., Murray, A. J., Pollack, R. A., Soliman, M. G., Laskey, S. B., Capoferri, A. A., Lai, J., Strain, M. C., Lada, S. M., Hoh, R., et al. (2016) · Nature Medicine · doi:10.1038/nm.4156 · Cited by 737
A quantitative approach for measuring the reservoir of latent HIV-1 proviruses
Bruner, K. M., Wang, Z., Simonetti, F. R., Bender, A. M., Kwon, K. J., Sengupta, S., Fray, E. J., Beg, S. A., Antar, A. A. R., Jenike, K. M., et al. (2019) · Nature · doi:10.1038/s41586-019-0898-8 · Cited by 718
Pollack, R. A., Jones, R. B., Pertea, M., Bruner, K. M., Martin, A. R., Thomas, A. S., Capoferri, A. A., Beg, S. A., Huang, S.-H., Karandish, S., et al. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.03.008 · Cited by 370
Abrahams, M.-R., Joseph, S. B., Garrett, N., Tyers, L., Moeser, M., Archin, N., Council, O. D., Matten, D., Zhou, S., Doolabh, D., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw5589 · Cited by 196
Self-citationLu, C.-L., Pai, J. A., Nogueira, L., Mendoza, P., Gruell, H., Oliveira, T. Y., Barton, J., Lorenzi, J. C. C., Cohen, Y. Z., Cohn, L. B., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1813512115 · Cited by 77
Metadata
- Authors
- Crooks, A. M., Bateson, R., Cope, A. B., Dahl, N. P., Griggs, M. K., Kuruc, J. D., Gay, C. L., Eron, J. J., Margolis, D. M., Bosch, R. J., & Archin, N. M.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-04-15
- Volume
- 212
- Issue
- 9
- Pages
- 1361-1365
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2144549163
- Cited by
- 406
- References
- 28
- FWCI
- 19.21
- Type
- journal article
- Language
- en
- Open access
- green
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- Crooks, A. M., Bateson, R., Cope, A. B., Dahl, N. P., Griggs, M. K., Kuruc, J. D., Gay, C. L., Eron, J. J., Margolis, D. M., Bosch, R. J., & Archin, N. M. (2015). Precise Quantitation of the Latent HIV-1 Reservoir: Implications for Eradication Strategies. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jiv218
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
