The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Extensive astrocyte infection is prominent in human immunodeficiency virus–associated dementia
Abstract
Astrocyte infection with human immunodeficiency virus (HIV) is considered rare, so astrocytes are thought to play a secondary role in HIV neuropathogenesis. By combining double immunohistochemistry, laser capture microdissection, and highly sensitive multiplexed polymerase chain reaction to detect HIV DNA in single astrocytes in vivo, we showed that astrocyte infection is extensive in subjects with HIV‐associated dementia, occurring in up to 19% of GFAP+ cells. In addition, astrocyte infection frequency correlated with the severity of neuropathological changes and proximity to perivascular macrophages. Our data indicate that astrocytes can be extensively infected with HIV, and suggest an important role for HIV‐infected astrocytes in HIV neuropathogenesis. Ann Neurol 2009;66:253–258
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Updated research nosology for HIV-associated neurocognitive disorders
Antinori, A., Arendt, G., Becker, J. T., Brew, B. J., Byrd, D. A., Cherner, M., Clifford, D. B., Cinque, P., Epstein, L. G., Goodkin, K., et al. (2007) · Neurology · doi:10.1212/01.wnl.0000287431.88658.8b · Cited by 2,630
Self-citationNew roles for astrocytes: redefining the functional architecture of the brain.
Nedergaard, M., Ransom, B., & Goldman, S. A. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.08.008 · Cited by 1,334
Cosenza;, M. A., Zhao;, M., Si;, Q., & Lee, S. C. (2002) · Brain Pathology · doi:10.1111/j.1750-3639.2002.tb00461.x · Cited by 238
Cited by
Towards an HIV cure: a global scientific strategy
The International AIDS Society Scientific Working Group on HIV Cure (2012) · Nature Reviews Immunology · doi:10.1038/nri3262 · Cited by 554
HIV reservoirs: what, where and how to target them
Churchill, M. J., Deeks, S. G., Margolis, D. M., Siliciano, R. F., & Swanstrom, R. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2015.5 · Cited by 313
Self-citationCurrent understanding of HIV-associated neurocognitive disorders pathogenesis
Gannon, P., Khan, M. Z., & Kolson, D. L. (2011) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32834695fb · Cited by 271
General Pathophysiology of Astroglia
Verkhratsky, A., Ho, M. S., Vardjan, N., Zorec, R., & Parpura, V. (2019) · Advances in Experimental Medicine and Biology · doi:10.1007/978-981-13-9913-8_7 · Cited by 66
Characterization of HIV-1 Infection in Microglia-Containing Human Cerebral Organoids
Gumbs, S. B. H., Berdenis van Berlekom, A., Kübler, R., Schipper, P. J., Gharu, L., Boks, M. P., Ormel, P. R., Wensing, A. M. J., de Witte, L. D., & Nijhuis, M. (2022) · Viruses · doi:10.3390/v14040829 · Cited by 65
Metadata
- Authors
- Churchill, M. J., Wesselingh, S. L., Cowley, D., Pardo, C. A., McArthur, J. C., Brew, B. J., & Gorry, P. R.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2009-08
- Volume
- 66
- Issue
- 2
- Pages
- 253-258
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2015983043
- Cited by
- 339
- References
- 3
- FWCI
- 7.19
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Extensive astrocyte infection is prominent in human immunodeficiency virus–associated dementia. https://app.cochat.ai/papers/10.1002/ana.21697
- The paper
- Churchill, M. J., Wesselingh, S. L., Cowley, D., Pardo, C. A., McArthur, J. C., Brew, B. J., & Gorry, P. R. (2009). Extensive astrocyte infection is prominent in human immunodeficiency virus–associated dementia. Annals of Neurology. https://doi.org/10.1002/ana.21697
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
