Cited by 1,676Neutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stressNitric Oxide and Endothelin Effects

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Antimicrobial reactive oxygen and nitrogen species: concepts and controversies

Fang, Ferric C.·2004·Nature Reviews Microbiology

DOI 10.1038/nrmicro1004

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Abstract

Phagocyte-derived reactive oxygen and nitrogen species are of crucial importance for host resistance to microbial pathogens. Decades of research have provided a detailed understanding of the regulation, generation and actions of these molecular mediators, as well as their roles in resisting infection. However, differences of opinion remain with regard to their host specificity, cell biology, sources and interactions with one another or with myeloperoxidase and granule proteases. More than a century after Metchnikoff first described phagocytosis, and more than four decades after the discovery of the burst of oxygen consumption that is associated with microbial killing, the seemingly elementary question of how phagocytes inhibit, kill and degrade microorganisms remains controversial. This review updates the reader on these concepts and the topical questions in the field.

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Authors: Fang, F. C.
Affiliations: University of Washington (US)
Corresponding author: Fang, Ferric C.
ORCID: Fang, Ferric C.
Venue: Nature Reviews Microbiology
Publisher: Springer Science and Business Media LLC
Published: 2004-10
Volume: 2
Issue: 10
Pages: 820-832
ISSN: 1740-1526 (ISSN-L)
1740-1534
DOI: 10.1038/nrmicro1004
OpenAlex: W2066515050
Cited by: 1,676
References: 245
Citations by year: 2026: 56 · 2025: 73 · 2024: 81 · 2023: 72 · 2022: 89 · 2021: 129 · 2020: 104 · 2019: 113 · 2018: 83 · 2017: 88 · 2016: 110 · 2015: 70 · 2014: 93 · 2013: 79 · 2012: 90
FWCI: 2.90
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Microbiology (publishedVersion)
PubMed (publishedVersion)
Funders: Fonds De La Recherche Scientifique - FNRS
Topics: Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: reactive oxygen species, reactive nitrogen species, phagocytes, antimicrobial host defense, phagocytosis, myeloperoxidase, microbial killing, host specificity, respiratory burst
MeSH terms: Granulomatous Disease, Chronic, Humans, Immunity, Innate, Phagocytes, Polymorphism, Genetic, Cytokines, Reactive Oxygen Species, Nitric Oxide Synthase, Reactive Nitrogen Species, Nitric Oxide Synthase Type II

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