Cited by 1,676Neutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stressNitric Oxide and Endothelin Effects

The DOI matches its Crossref record; 244 of the 245 references it cites were found in a registry or an index.

Antimicrobial reactive oxygen and nitrogen species: concepts and controversies

Fang, Ferric C.·2004·Nature Reviews Microbiology

DOI 10.1038/nrmicro1004

Open this paper in CoChat — free account

Abstract

Phagocyte-derived reactive oxygen and nitrogen species are of crucial importance for host resistance to microbial pathogens. Decades of research have provided a detailed understanding of the regulation, generation and actions of these molecular mediators, as well as their roles in resisting infection. However, differences of opinion remain with regard to their host specificity, cell biology, sources and interactions with one another or with myeloperoxidase and granule proteases. More than a century after Metchnikoff first described phagocytosis, and more than four decades after the discovery of the burst of oxygen consumption that is associated with microbial killing, the seemingly elementary question of how phagocytes inhibit, kill and degrade microorganisms remains controversial. This review updates the reader on these concepts and the topical questions in the field.

Integrity signals

Registry

Crossref · 10.1038/nrmicro1004

Cites

244 of 244 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

The large-conductance Ca2+-activated K+ channel is essential for innate immunity
Ahluwalia, J., Tinker, A., Clapp, L. H., Duchen, M. R., Abramov, A. Y., Pope, S. A. S., Nobles, M., & Segal, A. W. (2004) · Nature · doi:10.1038/nature02356 · Cited by 206
Retracted
Nitric oxide synthases: Roles, tolls, and controls
Nathan, C., & Xie, Q. W. (1994) · Cell · doi:10.1016/0092-8674(94)90266-6 · Cited by 2,920
Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase.
Xie, Q. W., Kashiwabara, Y., & Nathan, C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37600-7 · Cited by 2,212 · cited 1×
“together with signalling from proinflammatory cytokines (such as IFNs, IL-1β and TNF-α) triggers signalling cascades that lead to iNOS transcription, including the p38 mitogen-activated protein kinase (MAPK), NF-κB and Janus-activated kinase–signal transducer and activator of transcription–interferon regulatory factor…”
Background
Pathways of Oxidative Damage
Imlay, J. A. (2003) · Annual Review of Microbiology · doi:10.1146/annurev.micro.57.030502.090938 · Cited by 2,201
DNA damage and oxygen radical toxicity
Imlay, J. A., & Linn, S. (1988) · Science · doi:10.1126/science.3287616 · Cited by 1,974
Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
Eiserich, J. P., Hristova, M., Cross, C. E., Jones, A. D., Freeman, B. A., Halliwell, B., & van der Vliet, A. (1998) · Nature · doi:10.1038/34923 · Cited by 1,496
Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens
Nathan, C., & Shiloh, M. U. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.16.8841 · Cited by 1,469
Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase
MacMicking, J. D., Nathan, C., Hom, G. J., Chartrain, N. A., Fletcher, D. S., Trumbauer, M. E., Stevens, K. A., Xie, Q. W., Sokol, K. A., Hutchinson, N. I., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90085-3 · Cited by 1,445
TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection.
Serbina, N., Salazar-Mather, T. P., Biron, C., Kuziel, W., & Pamer, E. (2003) · Immunity · doi:10.1016/s1074-7613(03)00171-7 · Cited by 1,293
Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions.
Daugherty, A., Dunn, J. L., Rateri, D. L., & Heinecke, J. W. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117342 · Cited by 1,269

Flagged first, then by citations

Show all 245 references

1 of the 245 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

Gaston, B. & Stamler, J. S. in Nitric Oxide and Infection (ed. Fang, F. C.) 37–55 (Kluwer Academic/Plenum Publishers, New York, 1999).
De Groote, M. A. & Fang, F. C. in Nitric Oxide and Infection (ed. Fang, F. C.) 231–261 (Kluwer Academic/Plenum Publishers, New York, 1999).
Fang, F. C. Nitric Oxide and Infection 517 (Kluwer Academic/Plenum Publishers, New York, 1999). A comprehensive examination of the many roles of NO˙ in infection.

Sorted by citations

Items 301–400 of 1,001

Optimized polymeric film-based nitric oxide delivery inhibits bacterial growth in a mouse burn wound model
Brisbois, E. J., Bayliss, J. M., Wu, J., Major, T. C., Xi, C., Wang, S. C., Bartlett, R. H., Handa, H., & Meyerhoff, M. E. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.06.032 · Cited by 87
l-Arginine and COVID-19: An Update
Adebayo, A., Varzideh, F., Wilson, S. M., Gambardella, J., Eacobacci, M., Jankauskas, S. S., Donkor, K., Kansakar, U., Trimarco, V., Mone, P., et al. (2021) · Nutrients · doi:10.3390/nu13113951 · Cited by 91
The Multidrug Efflux Pump MdtEF Protects against Nitrosative Damage during the Anaerobic Respiration in Escherichia coli
Zhang, Y., Xiao, M., Horiyama, T., Zhang, Y., Li, X., Nishino, K., & Yan, A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.243261 · Cited by 87
Mechanisms of group A Streptococcus resistance to reactive oxygen species
Henningham, A., Döhrmann, S., Nizet, V., & Cole, J. N. (2015) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuu009 · Cited by 92
Reactive oxygen species in development and infection processes
Marschall, R., & Tudzynski, P. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.03.020 · Cited by 87
Nitric Oxide-Releasing Quaternary Ammonium-Modified Poly(amidoamine) Dendrimers as Dual Action Antibacterial Agents
Worley, B. V., Slomberg, D. L., & Schoenfisch, M. H. (2014) · Bioconjugate Chemistry · doi:10.1021/bc5000719 · Cited by 87
Reactive species and pathogen antioxidant networks during phagocytosis
Piacenza, L., Trujillo, M., & Radí, R. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20181886 · Cited by 100
Stress-induced adaptations in Salmonella: A ground for shaping its pathogenesis
Pradhan, D., & Negi, V. D. (2019) · Microbiological Research · doi:10.1016/j.micres.2019.126311 · Cited by 92
Stromal IFN-γR-Signaling Modulates Goblet Cell Function During Salmonella Typhimurium Infection
Songhet, P., Barthel, M., Stecher, B., Müller, A. J., Kremer, M., Hansson, G. C., & Hardt, W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022459 · Cited by 86
Redox Sensing by Fe 2+ in Bacterial Fur Family Metalloregulators
Pinochet-Barros, A., & Helmann, J. D. (2018) · Antioxidants & Redox Signaling · doi:10.1089/ars.2017.7359 · Cited by 85
Anti-biofilm action of nitric oxide-releasing alkyl-modified poly(amidoamine) dendrimers against Streptococcus mutans
Backlund, C. J., Worley, B. V., & Schoenfisch, M. H. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.10.021 · Cited by 85
Surface Dielectric Barrier Discharge plasma: a suitable measure against fungal plant pathogens
Ambrico, P. F., Šimek, M., Rotolo, C., Morano, M., Minafra, A., Ambrico, M., Pollastro, S., Gerin, D., Faretra, F., & Angelini, R. M. D. M. (2020) · Scientific Reports · doi:10.1038/s41598-020-60461-0 · Cited by 85
The roles of NO in microbial symbioses
Wang, Y., & Ruby, E. G. (2011) · Cellular Microbiology · doi:10.1111/j.1462-5822.2011.01576.x · Cited by 86
Micro‐/Nanorobots in Antimicrobial Applications: Recent Progress, Challenges, and Opportunities
Zhang, Z., Wang, L., Chan, T. K. F., Chen, Z., Ip, M., Chan, P. K. S., Sung, J. J. �., & Zhang, L. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202101991 · Cited by 84
Basidiomycota Fungi and ROS: Genomic Perspective on Key Enzymes Involved in Generation and Mitigation of Reactive Oxygen Species
Mattila, H., Österman, J., Mali, T., & Lundell, T. (2022) · Frontiers in Fungal Biology · doi:10.3389/ffunb.2022.837605 · Cited by 88
Posttranslational, Translational, and Transcriptional Responses to Nitric Oxide Stress in Cryptococcus neoformans : Implications for Virulence
Missall, T. A., Pusateri, M. E., Donlin, M. J., Chambers, K. T., Corbett, J. A., & Lodge, J. K. (2006) · Eukaryotic Cell · doi:10.1128/ec.5.3.518-529.2006 · Cited by 87
Neisseria gonorrhoeae suppresses the oxidative burst of human polymorphonuclear leukocytes
Criss, A. K., & Seifert, H. S. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2008.01205.x · Cited by 83
Xanthine oxidase-lactoperoxidase system and innate immunity: Biochemical actions and physiological roles
Al-Shehri, S. S., Duley, J. A., & Bansal, N. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101524 · Cited by 82
An ESIPT based fluorescence probe for ratiometric monitoring of nitric oxide
Chen, L., Wu, D., & Yoon, J. (2017) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2017.12.073 · Cited by 84
Chitosan-graft-PAMAM loading nitric oxide for efficient antibacterial application
Li, G., Yu, S., Xue, W., Ma, D., & Zhang, W. (2018) · Chemical Engineering Journal · doi:10.1016/j.cej.2018.04.159 · Cited by 82
Reactive Oxygen Species Regulate Neutrophil Recruitment and Survival in Pneumococcal Pneumonia
Marriott, H. M., Jackson, L. E., Wilkinson, T. S., Simpson, A. J., Mitchell, T. J., Buttle, D. J., Cross, S. S., Ince, P. G., Hellewell, P. G., Whyte, M. K. B., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200707-990oc · Cited by 84
A two-photon fluorescent probe for ratiometric visualization of hypochlorous acid in live cells and animals based on a selenide oxidation/elimination tandem reaction
Xie, X., Wu, T., Wang, X., Li, Y., Wang, K., Zhao, Z., Jiao, X., & Tang, B. (2018) · Chemical Communications · doi:10.1039/c8cc07312k · Cited by 81
Cyanine‐Dyad Molecular Probe for the Simultaneous Profiling of the Evolution of Multiple Radical Species During Bacterial Infections
Wang, Z., Cong, T. D., Zhong, W., Lau, J. W., Kwek, G., Chan‐Park, M. B. E., & Xing, B. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202104100 · Cited by 81
Differential Metabolomics for Quantitative Assessment of Oxidative Stress with Strenuous Exercise and Nutritional Intervention: Thiol-Specific Regulation of Cellular Metabolism with N-Acetyl- l -Cysteine Pretreatment
Lee, R., West, D. W. D., Phillips, S. M., & Britz‐McKibbin, P. (2010) · Analytical Chemistry · doi:10.1021/ac9029746 · Cited by 82
Vibrio fischeri flavohaemoglobin protects against nitric oxide during initiation of the squid-Vibrio symbiosis
Wang, Y., Dunn, A. K., Wilneff, J., McFall‐Ngai, M., Spiro, S., & Ruby, E. G. (2010) · Molecular Microbiology · doi:10.1111/j.1365-2958.2010.07376.x · Cited by 81
L-carnitine regulated Nrf2/Keap1 activation in vitro and in vivo and protected oxidized fish oil-induced inflammation response by inhibiting the NF-κB signaling pathway in Rhynchocypris lagowski Dybowski
Zhang, D., Guo, Z., Zhao, Y., Wang, Q., Gao, Y.-S., Yu, T. Y., Chen, Y., Chen, X., & Wang, G. (2019) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2019.08.041 · Cited by 81
Macrophage Interaction with Paracoccidioides brasiliensis Yeast Cells Modulates Fungal Metabolism and Generates a Response to Oxidative Stress
Parente-Rocha, J. A., Parente, A. F. A., Baeza, L. C., Bonfim, S. M. R. C., Hernández, O., McEwen, J. G., Bailão, A. M., Taborda, C. P., Borges, C. L., & Soares, C. M. D. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137619 · Cited by 82
Advances in fluorescence sensing enabled by lanthanide-doped upconversion nanophosphors
Sun, C., & Gradzielski, M. (2021) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2021.102579 · Cited by 80
ROS-deficient monocytes have aberrant gene expression that correlates with inflammatory disorders of chronic granulomatous disease
Brown, K. L., Bylund, J., MacDonald, K. L., Song-Zhao, G. X., Elliott, M. R., Falsafi, R., Hancock, R. E. W., & Speert, D. P. (2008) · Clinical Immunology · doi:10.1016/j.clim.2008.06.005 · Cited by 81
Identification ofHistoplasma capsulatumTranscripts Induced in Response to Reactive Nitrogen Species
Nittler, M. P., Murray, D. H., Foo, C. K., & Sil, A. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-05-0434 · Cited by 80
Local Delivery of GM-CSF Protects Mice from Lethal Pneumococcal Pneumonia
Steinwede, K., Tempelhof, O., Bolte, K., Maus, R., Bohling, J., Ueberberg, B., Länger, F. P., Christman, J. W., Paton, J. C., Ask, K., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101413 · Cited by 80
Nfu facilitates the maturation of iron‐sulfur proteins and participates in virulence in S taphylococcus aureus
Mashruwala, A. A., Pang, Y. Y., Rosario‐Cruz, Z., Chahal, H. K., Benson, M. A., Mike, L. A., Skaar, E. P., Torres, V. J., Nauseef, W. M., & Boyd, J. M. (2015) · Molecular Microbiology · doi:10.1111/mmi.12860 · Cited by 79
Light-Triggered Eradication of Acinetobacter baumannii by Means of NO Delivery from a Porous Material with an Entrapped Metal Nitrosyl
Heilman, B. J., John, J. S., Oliver, S. R. J., & Mascharak, P. K. (2012) · Journal of the American Chemical Society · doi:10.1021/ja3022736 · Cited by 79
The NsrR regulon in nitrosative stress resistance of Salmonella enterica serovar Typhimurium
Karlinsey, J. E., Bang, I. S., Becker, L. A., Frawley, E. R., Porwollik, S., Robbins, H. F., Thomas, V. C., Urbano, R., McClelland, M., & Fang, F. C. (2012) · Molecular Microbiology · doi:10.1111/j.1365-2958.2012.08167.x · Cited by 79
Self-citation
Daylight-Induced Antibacterial and Antiviral Nanofibrous Membranes Containing Vitamin K Derivatives for Personal Protective Equipment
Zhang, Z., El-Moghazy, A. Y., Wisuthiphaet, N., Nitin, N., Castillo, D., Murphy, B. G., & Sun, G. Z. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c14883 · Cited by 78
Resistance ofNeisseria gonorrhoeaeto non-oxidative killing by adherent human polymorphonuclear leucocytes
Criss, A. K., Katz, B. Z., & Seifert, H. S. (2009) · Cellular Microbiology · doi:10.1111/j.1462-5822.2009.01308.x · Cited by 78
MHC genes and oxidative stress in sticklebacks: an immuno-ecological approach
Kurtz, J., Wegner, K. M., Kalbe, M., Reusch, T. B. H., Schaschl, H., Hasselquist, D., & Milinski, M. (2006) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2005.3450 · Cited by 78
The immunomodulation of a novel tumor necrosis factor (CgTNF-1) in oyster Crassostrea gigas
Sun, Y., Zhou, Z., Wang, L., Yang, C., Jianga, S., & Song, L. (2014) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2014.03.007 · Cited by 77
The insulin signaling cascade from nematodes to mammals: Insights into innate immunity of Anopheles mosquitoes to malaria parasite infection
Luckhart, S., & Riehle, M. A. (2006) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2006.10.005 · Cited by 77
Mineralogical variables that control the antibacterial effectiveness of a natural clay deposit
Morrison, K. D., Underwood, J. C., Metge, D. W., Eberl, D. D., & Williams, L. B. (2013) · Environmental Geochemistry and Health · doi:10.1007/s10653-013-9585-0 · Cited by 77
Hemoglobin: A Nitric-Oxide Dioxygenase
Gardner, P. R. (2012) · Scientifica · doi:10.6064/2012/683729 · Cited by 80
Biological activities and biomedical potential of sea cucumber (Stichopus japonicus): a review
Oh, G., Ko, S., Lee, D. H., Heo, S., & Jung, W. (2017) · Fisheries and aquatic sciences · doi:10.1186/s41240-017-0071-y · Cited by 78
A highly sensitive and rapidly responding fluorescent probe based on a rhodol fluorophore for imaging endogenous hypochlorite in living mice
Zhang, Y., Ma, L., Tang, C., Pan, S., Shi, D., Wang, S., Li, M., & Guo, Y. (2018) · Journal of Materials Chemistry B · doi:10.1039/c7tb02862h · Cited by 76
Resistance of Neisseria Gonorrhoeae to Neutrophils
Johnson, M. B., & Criss, A. K. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00077 · Cited by 76
Mode of Nitric Oxide Delivery Affects Antibacterial Action
Hall, J. R., Rouillard, K. R., Suchyta, D. J., Brown, M. D., Ahonen, M. J. R., & Schoenfisch, M. H. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b01384 · Cited by 75
Nanomaterials: The New Antimicrobial Magic Bullet
Ndayishimiye, J., Kumeria, T., Popat, A., Falconer, J. R., & Blaskovich, M. A. T. (2022) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.1c00660 · Cited by 75
Oxidative Stress in Tropical Marine Ecosystems
Lesser, M. P. (2011) · Wiley eBooks · doi:10.1002/9781444345988.ch1 · Cited by 75
Yersiniabactin Reduces the Respiratory Oxidative Stress Response of Innate Immune Cells
Paauw, A., Hall, M. A. L., van Kessel, K. P. M., Verhoef, J., & Fluit, A. C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008240 · Cited by 74
Analysis of the Effects of Cigarette Smoke on Staphylococcal Virulence Phenotypes
McEachern, E. K., Hwang, J. H., Sladewski, K. M., Nicatia, S., Dewitz, C., Mathew, D. P., Nizet, V., & Alexander, L. E. C. (2015) · Infection and Immunity · doi:10.1128/iai.00303-15 · Cited by 75
The opportunistic pathogen Enterococcus faecalis resists phagosome acidification and autophagy to promote intracellular survival in macrophages
Zou, J., & Shankar, N. (2015) · Cellular Microbiology · doi:10.1111/cmi.12556 · Cited by 76
Anisakis pegreffii (Nematoda: Anisakidae) products modulate oxidative stress and apoptosis-related biomarkers in human cell lines
Messina, C. M., Pizzo, F., Santulli, A., Bušelić, I., Boban, M., Orhanović, S., & Mladineo, I. (2016) · Parasites & Vectors · doi:10.1186/s13071-016-1895-5 · Cited by 75
Antiseptic mouthwash, the nitrate–nitrite–nitric oxide pathway, and hospital mortality: a hypothesis generating review
Blot, S. (2021) · Intensive Care Medicine · doi:10.1007/s00134-020-06276-z · Cited by 73
Nitroaromatic Antibiotics as Nitrogen Oxide Sources
Rice, A. M., Long, Y., & King, S. B. (2021) · Biomolecules · doi:10.3390/biom11020267 · Cited by 73
Recent advances in fluorescent probes of peroxynitrite: Structural, strategies and biological applications
Sun, J., Cao, X., Lu, W., Wei, Y., Kong, L., Chen, W., Shao, X., & Wang, Y. (2023) · Theranostics · doi:10.7150/thno.80529 · Cited by 73
Anti-Biofilm Efficacy of Dual-Action Nitric Oxide-Releasing Alkyl Chain Modified Poly(amidoamine) Dendrimers
Worley, B. V., Schilly, K. M., & Schoenfisch, M. H. (2015) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00006 · Cited by 73
An essential role for bacterial nitric oxide synthase in Staphylococcus aureus electron transfer and colonization
Kinkel, T. L., Ramos‐Montañez, S., Pando, J. M., Tadeo, D. V., Strom, E. N., Libby, S. J., & Fang, F. C. (2016) · Nature Microbiology · doi:10.1038/nmicrobiol.2016.224 · Cited by 73
Self-citation
Imaging of Hypochlorous Acid by Fluorescence and Applications in Biological Systems
Yudhistira, T., Mulay, S. V., Kim, Y., Halle, M. B., & Churchill, D. G. (2019) · Chemistry - An Asian Journal · doi:10.1002/asia.201900672 · Cited by 73
Differential nitric oxide synthesis and host apoptotic events correlate with bleaching susceptibility in reef corals
Hawkins, T. D., Krueger, T., Becker, S., Fisher, P. L., & Davy, S. K. (2014) · Coral Reefs · doi:10.1007/s00338-013-1103-4 · Cited by 72
Impact of remnant surface polarization on photocatalytic and antibacterial performance of BaTiO3
Kumar, S., Sharma, M., Powar, S., Кабачков, Е. Н., & Vaish, R. (2019) · Journal of the European Ceramic Society · doi:10.1016/j.jeurceramsoc.2019.03.029 · Cited by 72
A novel reaction-based fluorescence probe for rapid imaging of HClO in live cells, animals, and injured liver tissues
Deng, Y., Feng, S., Xia, Q., Gong, S., & Feng, G. (2020) · Talanta · doi:10.1016/j.talanta.2020.120901 · Cited by 72
Nitric Oxide: A Neglected Driver for the Conjugative Transfer of Antibiotic Resistance Genes among Wastewater Microbiota
Huang, H., Feng, G., Wang, M., Liu, C., Wu, Y., Dong, L., Feng, L., Zheng, X., & Chen, Y. (2022) · Environmental Science & Technology · doi:10.1021/acs.est.2c01889 · Cited by 74
Structure of coenzyme F420H2 oxidase (FprA), a di‐iron flavoprotein from methanogenic Archaea catalyzing the reduction of O2 to H2O
Seedorf, H., Hagemeier, C. H., Shima, S., Thauer, R. K., Warkentin, E., & Ermler, U. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.05706.x · Cited by 72
Candida albicans Induces Arginine Biosynthetic Genes in Response to Host-Derived Reactive Oxygen Species
Jiménez-López, C., Collette, J. R., Brothers, K. M., Shepardson, K. M., Cramer, R. A., Wheeler, R. T., & Lorenz, M. C. (2012) · Eukaryotic Cell · doi:10.1128/ec.00290-12 · Cited by 73
Recent Progress in Metal–Organic Framework (MOF) Based Luminescent Chemodosimeters
Hao, Y., Chen, S., Zhou, Y., Zhang, Y., & Xu, M. (2019) · Nanomaterials · doi:10.3390/nano9070974 · Cited by 72
Escherichia coli induced ferroptosis in red blood cells of grass carp (Ctenopharyngodon idella)
Yang, M., Lu, Z., Li, F., Shi, F., Zhan, F., Zhao, L., Li, Y., Li, J., Lin, L., & Qin, Z. (2020) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2020.09.036 · Cited by 72
The Base Excision Repair System of Salmonella enterica serovar Typhimurium Counteracts DNA Damage by Host Nitric Oxide
Richardson, A. R., Soliven, K. C., Castor, M. E., Barnes, P. D., Libby, S. J., & Fang, F. C. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000451 · Cited by 72
Self-citation
Decomposition of reactive oxygen species by copper(II) bis(1-pyrazolyl)methane complexes
Schepetkin, I. A., Potapov, А. S., Khlebnikov, А. I., Korotkova, E. I., Lukina, A. N., Malovichko, G. I., Kirpotina, L. N., & Quinn, M. T. (2006) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-006-0101-1 · Cited by 71
The Campylobacter jejuni Transcriptional Regulator Cj1556 Plays a Role in the Oxidative and Aerobic Stress Response and Is Important for Bacterial SurvivalIn Vivo
Gundogdu, O., Mills, D. C., Elmi, A., Martin, M. J., Wren, B. W., & Dorrell, N. (2011) · Journal of Bacteriology · doi:10.1128/jb.05189-11 · Cited by 70
Reactive nitrogen species in host–bacterial interactions
Fang, F. C., & Vázquez‐Torres, A. (2019) · Current Opinion in Immunology · doi:10.1016/j.coi.2019.05.008 · Cited by 70
Self-citation
Futile cycling increases sensitivity toward oxidative stress in Escherichia coli
Adolfsen, K. J., & Brynildsen, M. P. (2015) · Metabolic Engineering · doi:10.1016/j.ymben.2015.02.006 · Cited by 70
A ratiometric fluorescent probe for rapid and sensitive visualization of hypochlorite in living cells
Zha, J., Fu, B., Qin, C., Zeng, L., & Hu, X. (2014) · RSC Advances · doi:10.1039/c4ra07009g · Cited by 70
Repression of SPI2 transcription by nitric oxide-producing, IFNγ-activated macrophages promotes maturation ofSalmonellaphagosomes
McCollister, B. D., Bourret, T. J., Gill, R. E., Jones‐Carson, J., & Vázquez‐Torres, A. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050246 · Cited by 70
A water-soluble, highly sensitive and ultrafast fluorescence probe for imaging of mitochondrial hypochlorous acid
Bao, X., Cao, X., Yuan, Y. C., Zhou, B., & Huo, C. (2021) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2021.130210 · Cited by 69
The Role of Macrophages in the Innate Immune Response to Streptococcus pneumoniae and Staphylococcus aureus
Cole, J., Aberdein, J., Jubrail, J., & Dockrell, D. H. (2014) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/bs.ampbs.2014.08.004 · Cited by 71
The hmp gene encoding the NO-inducible flavohaemoglobin in Escherichia coli confers a protective advantage in resisting killing within macrophages, but not in vitro: Links with swarming motility
Stevanin, T. M., Read, R. C., & Poole, R. K. (2007) · Gene · doi:10.1016/j.gene.2007.03.021 · Cited by 69
The rational design of a highly sensitive and selective fluorogenic probe for detecting nitric oxide
Ma, S., Fang, D., Ning, B., Li, M., He, L., & Gong, B. (2014) · Chemical Communications · doi:10.1039/c4cc01142b · Cited by 70
Improved Bioactivity of Antimicrobial Peptides by Addition of Amino‐Terminal Copper and Nickel (ATCUN) Binding Motifs
Libardo, M. D. J., Cervantes, J., Salazar, J. C., & Angeles-Boza, A. M. (2014) · ChemMedChem · doi:10.1002/cmdc.201402033 · Cited by 68
Mechanisms of Adaptation to Nitrosative Stress inBacillus subtilis
Rogstam, A., Larsson, J. T., Kjelgaard, P., & von Wachenfeldt, C. (2007) · Journal of Bacteriology · doi:10.1128/jb.01782-06 · Cited by 68
Intrapulmonary Administration of Leukotriene B4 Augments Neutrophil Accumulation and Responses in the Lung to Klebsiella Infection in CXCL1 Knockout Mice
Batra, S., Cai, S., Balamayooran, G., & Jeyaseelan, S. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1101985 · Cited by 68
Molecular visualizing and quantifying immune-associated peroxynitrite fluxes in phagocytes and mouse inflammation model
Li, Z., Yan, S., Chen, C., Geng, Z., Chang, J., Chen, C., Huang, B., & Wang, Z.-L. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.11.036 · Cited by 67
Exposure to diesel exhaust particles results in altered lung microbial profiles, associated with increased reactive oxygen species/reactive nitrogen species and inflammation, in C57Bl/6 wildtype mice on a high-fat diet
Daniel, S., Phillippi, D., Schneider, L. J., Nguyen, K. N., Mirpuri, J., & Lund, A. K. (2021) · Particle and Fibre Toxicology · doi:10.1186/s12989-020-00393-9 · Cited by 67
An Acid-Enhanced OFF-ON Fluorescent Probe for the Detection of Hypochlorous Acid in Rheumatoid Arthritis
Wu, P., & Xiong, H. (2022) · Talanta · doi:10.1016/j.talanta.2022.123584 · Cited by 67
MicroRNA-155 induction by Mycobacterium bovis BCG enhances ROS production through targeting SHIP1
Wang, J., Wu, M., Wen, J., Yang, K., Li, M., Zhan, X., Feng, L., Li, M., & Huang, X. (2014) · Molecular Immunology · doi:10.1016/j.molimm.2014.05.012 · Cited by 67
Identification of a Denitrase Activity against Calmodulin in Activated Macrophages Using High-Field Liquid Chromatography−FTICR Mass Spectrometry
Smallwood, H. S., Lourette, N. M., Boschek, C. B., Bigelow, D. J., Smith, R. D., Paša‐Tolić, L., & Squier, T. C. (2007) · Biochemistry · doi:10.1021/bi7009713 · Cited by 67
MglA Regulates Francisella tularensis subsp. novicida ( Francisella novicida ) Response to Starvation and Oxidative Stress
Guina, T., Radulovic, D., Bahrami, A. J., Bolton, D. L., Rohmer, L., Jones-Isaac, K. A., Chen, J., Gallagher, L. A., Gallis, B. M., Ryu, S., et al. (2007) · Journal of Bacteriology · doi:10.1128/jb.00809-07 · Cited by 67
Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils
Han, H., Stessin, A. M., Roberts, J., Hess, K. C., Gautam, N., Kamenetsky, M., Lou, O., Hyde, E., Nathan, N., Müller, W. A., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050778 · Cited by 67
Antimicrobial Action of Copper Is Amplified via Inhibition of Heme Biosynthesis
Djoko, K. Y., & McEwan, A. G. (2013) · ACS Chemical Biology · doi:10.1021/cb4002443 · Cited by 66
Anaerobic nitrate reduction divergently governs population expansion of the enteropathogen Vibrio cholerae
Bueno, E., Sit, B., Waldor, M. K., & Cava, F. (2018) · Nature Microbiology · doi:10.1038/s41564-018-0253-0 · Cited by 66
Recent advances in diverse nanosystems for nitric oxide delivery in cancer therapy
Gao, D., Asghar, S., Hu, R., Chen, S., Niu, R., Liu, J., Chen, Z., & Xiao, Y. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.11.016 · Cited by 67
Evolution of tuberculosis diagnostics: From molecular strategies to nanodiagnostics
Mukherjee, S., Perveen, S., Negi, A., & Sharma, R. (2023) · Tuberculosis · doi:10.1016/j.tube.2023.102340 · Cited by 69
Inducible NO synthase and antibacterial host defence in times of Th17/Th22/T22 immunity
Mühl, H., Bachmann, M., & Pfeilschifter, J. M. (2010) · Cellular Microbiology · doi:10.1111/j.1462-5822.2010.01559.x · Cited by 66
Caenorhabditis elegans: a model to investigate oxidative stress and metal dyshomeostasis in Parkinson's disease
Chege, P. M., & McColl, G. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00089 · Cited by 68
Inactivation of the sodA gene of Streptococcus suis type 2 encoding superoxide dismutase leads to reduced virulence to mice
Tang, Y., Zhang, X., Wu, W., Lu, Z., & Fang, W. (2012) · Veterinary Microbiology · doi:10.1016/j.vetmic.2012.02.028 · Cited by 66
Nanosensor detection of reactive oxygen and nitrogen species leakage in frustrated phagocytosis of nanofibres
Qi, Y.-T., Zhang, F.-L., Tian, S.-Y., Wu, H.-Q., Zhao, Y., Zhang, X.-W., Liu, Y.-L., Fu, P., Amatore, C., & Huang, W.-H. (2024) · Nature Nanotechnology · doi:10.1038/s41565-023-01575-0 · Cited by 65
An ESIPT fluorescent probe for ultrarapid HClO detection during reagent-stimulated oxidative stress in cells and zebrafish
Chen, M., Chen, X., Wang, Y., Fan, X., Chen, T., & Liang, Z. (2022) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2022.132545 · Cited by 65
Ag-MXene as peroxidase-mimicking nanozyme for enhanced bacteriocide and cholesterol sensing
Chen, Y., Rong, C., Gao, W., Luo, S., Guo, Y., Gu, Y., Yang, G., Xu, W., Zhu, C., & Qu, L. (2023) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2023.09.097 · Cited by 65
Nitric Oxide–Containing Nanoparticles as an Antimicrobial Agent and Enhancer of Wound Healing
Weller, R. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.149 · Cited by 65
The Oxidative Stress Agent Hypochlorite Stimulates c-di-GMP Synthesis and Biofilm Formation in Pseudomonas aeruginosa
Strempel, N., Nusser, M., Neidig, A., Brenner‐Weiß, G., & Overhage, J. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02311 · Cited by 65
Accurate construction of NIR probe for visualizing HClO fluctuations in type I, type II diabetes and diabetic liver disease assisted by theoretical calculation
Fan, G., Zhang, B., Wang, N., Wang, N., Qin, S., Zhao, W., & Zhang, J. (2023) · Talanta · doi:10.1016/j.talanta.2023.125298 · Cited by 64
Reactive oxygen species are the major antibacterials against Salmonella Typhimurium purine auxotrophs in the phagosome of RAW 264.7 cells
Mantena, R. K. R., Wijburg, O. L. C., Vindurampulle, C. J., Bennett-Wood, V. R., Walduck, A. K., Drummond, G. R., Davies, J. K., Robins-Browne, R. M., & Strugnell, R. A. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.01105.x · Cited by 64

Authors: Fang, F. C.
Affiliations: University of Washington (US)
Corresponding author: Fang, Ferric C.
ORCID: Fang, Ferric C.
Venue: Nature Reviews Microbiology
Publisher: Springer Science and Business Media LLC
Published: 2004-10
Volume: 2
Issue: 10
Pages: 820-832
ISSN: 1740-1526 (ISSN-L)
1740-1534
DOI: 10.1038/nrmicro1004
OpenAlex: W2066515050
Cited by: 1,676
References: 245
Citations by year: 2026: 56 · 2025: 73 · 2024: 81 · 2023: 72 · 2022: 89 · 2021: 129 · 2020: 104 · 2019: 113 · 2018: 83 · 2017: 88 · 2016: 110 · 2015: 70 · 2014: 93 · 2013: 79 · 2012: 90
FWCI: 2.90
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Microbiology (publishedVersion)
PubMed (publishedVersion)
Funders: Fonds De La Recherche Scientifique - FNRS
Topics: Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: reactive oxygen species, reactive nitrogen species, phagocytes, antimicrobial host defense, phagocytosis, myeloperoxidase, microbial killing, host specificity, respiratory burst
MeSH terms: Granulomatous Disease, Chronic, Humans, Immunity, Innate, Phagocytes, Polymorphism, Genetic, Cytokines, Reactive Oxygen Species, Nitric Oxide Synthase, Reactive Nitrogen Species, Nitric Oxide Synthase Type II

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Antimicrobial reactive oxygen and nitrogen species: concepts and controversies

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks