Cited by 2,052Bacterial Genetics and BiotechnologyBacterial biofilms and quorum sensingAntimicrobial Resistance in Staphylococcus

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Persister cells, dormancy and infectious disease

Lewis, Kim·2007·Nature Reviews Microbiology

DOI 10.1038/nrmicro1557

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Abstract

Several well-recognized puzzles in microbiology have remained unsolved for decades. These include latent bacterial infections, unculturable microorganisms, persister cells and biofilm multidrug tolerance. Accumulating evidence suggests that these seemingly disparate phenomena result from the ability of bacteria to enter into a dormant (non-dividing) state. The molecular mechanisms that underlie the formation of dormant persister cells are now being unravelled and are the focus of this Review.

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Authors: Lewis, K.
Affiliations: Northeastern University (US)
Corresponding author: Lewis, Kim
ORCID: Lewis, Kim
Venue: Nature Reviews Microbiology
Publisher: Springer Science and Business Media LLC
Published: 2006-12-04
Volume: 5
Issue: 1
Pages: 48-56
ISSN: 1740-1526 (ISSN-L)
1740-1534
DOI: 10.1038/nrmicro1557
OpenAlex: W2045825103
Cited by: 2,052
References: 77
Citations by year: 2026: 101 · 2025: 98 · 2024: 104 · 2023: 116 · 2022: 126 · 2021: 129 · 2020: 127 · 2019: 132 · 2018: 122 · 2017: 100 · 2016: 120 · 2015: 130 · 2014: 94 · 2013: 104 · 2012: 108
FWCI: 5.90
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Microbiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
Keywords: persister cells, bacterial dormancy, antibiotic tolerance, persistent infection, unculturable microorganisms, multidrug tolerance
MeSH terms: Adaptation, Physiological, Anti-Bacterial Agents, Bacteria, Bacterial Infections, Drug Tolerance, Genes, Bacterial, Humans, Gene Expression Regulation, Bacterial, Bacterial Physiological Phenomena, Biofilms, Drug Resistance, Multiple, Bacterial, Microbial Viability

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