The DOI matches its Crossref record; 76 of the 77 references it cites were found in a registry or an index.
Persister cells, dormancy and infectious disease
Abstract
Several well-recognized puzzles in microbiology have remained unsolved for decades. These include latent bacterial infections, unculturable microorganisms, persister cells and biofilm multidrug tolerance. Accumulating evidence suggests that these seemingly disparate phenomena result from the ability of bacteria to enter into a dormant (non-dividing) state. The molecular mechanisms that underlie the formation of dormant persister cells are now being unravelled and are the focus of this Review.
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“Persistence is always linked to cell dormancy, a state in which the cellular metabolism temporarily ceases [111,123,124].”
From Insight into the Mechanisms and Clinical Relevance of Antifungal Heteroresistance (2025) · cites this paper as [124]
In the citing paper
“In contrast, resistance is linked to specific molecular mechanisms and can be stably inherited by progeny [15,17–19].”
From Antifungal persistence: Clinical relevance and mechanisms (2025) · cites this paper as [18]
In the citing paper
“Thirdly, antifungal persistence is non-heritable, although the progeny of persisters may still divide into persistent subpopulations and non-persistent subpopulations.”
From Antifungal persistence: Clinical relevance and mechanisms (2025) · cites this paper as [18]
In the citing paper
“It has been well studied that dormant state reduces the exposure of antibiotic targets and helps bacterial cells tolerate a variety of antibiotics, a process linked to the toxin-antitoxin system [18,54].”
From Antifungal persistence: Clinical relevance and mechanisms (2025) · cites this paper as [18]
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Metadata
- Authors
- Lewis, K.
- Affiliations
- Northeastern University (US)
- Corresponding author
- Lewis, Kim
- ORCID
- Lewis, Kim
- Venue
- Nature Reviews Microbiology
- Published
- 2006-12-04
- Volume
- 5
- Issue
- 1
- Pages
- 48-56
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W2045825103
- Cited by
- 2,052
- References
- 77
- Citations by year
- 2026: 101 · 2025: 98 · 2024: 104 · 2023: 116 · 2022: 126 · 2021: 129 · 2020: 127 · 2019: 132 · 2018: 122 · 2017: 100 · 2016: 120 · 2015: 130 · 2014: 94 · 2013: 104 · 2012: 108
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Keywords
- persister cells, bacterial dormancy, antibiotic tolerance, persistent infection, unculturable microorganisms, multidrug tolerance
- MeSH terms
- Adaptation, Physiological, Anti-Bacterial Agents, Bacteria, Bacterial Infections, Drug Tolerance, Genes, Bacterial, Humans, Gene Expression Regulation, Bacterial, Bacterial Physiological Phenomena, Biofilms, Drug Resistance, Multiple, Bacterial, Microbial Viability
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