The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Using movies to analyse gene circuit dynamics in single cells
Open accessAbstract
Many bacterial systems rely on dynamic genetic circuits to control crucial biological processes. A major goal of systems biology is to understand these behaviours in terms of individual genes and their interactions. However, traditional techniques based on population averages 'wash out' crucial dynamics that are either unsynchronized between cells or are driven by fluctuations, or 'noise', in cellular components. Recently, the combination of time-lapse microscopy, quantitative image analysis and fluorescent protein reporters has enabled direct observation of multiple cellular components over time in individual cells. In conjunction with mathematical modelling, these techniques are now providing powerful insights into genetic circuit behaviour in diverse microbial systems.
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Cites
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Self-citationBacterial Persistence as a Phenotypic Switch
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Cited by
Microbial single-cell RNA sequencing by split-pool barcoding
Kuchina, A., Brettner, L. M., Paleologu, L., Roco, C. M., Rosenberg, A. B., Carignano, A., Kibler, R., Hirano, M., DePaolo, R. W., & Seelig, G. (2021) · Science · doi:10.1126/science.aba5257 · Cited by 340
Impulse Control: Temporal Dynamics in Gene Transcription
Yosef, N., & Regev, A. (2011) · Cell · doi:10.1016/j.cell.2011.02.015 · Cited by 258
Skandamis, P. N., & Jeanson, S. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01178 · Cited by 66
Beyond Homeostasis: A Predictive-Dynamic Framework for Understanding Cellular Behavior
Freddolino, L., & Tavazoie, S. (2012) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154129 · Cited by 65
Single-cell analysis of circadian dynamics in tissue explants
Lande-Diner, L., Stewart-Ornstein, J., Weitz, C. J., & Lahav, G. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-06-0403 · Cited by 22
Metadata
- Authors
- Locke, J. C. W., & Elowitz, M. B.
- Venue
- Nature Reviews Microbiology
- Published
- 2009-05
- Volume
- 7
- Issue
- 5
- Pages
- 383-392
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W1997057704
- Cited by
- 238
- References
- 12
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
