The DOI matches its Crossref record; 200 of the 200 references it cites were found in a registry or an index.
Waves of resistance: Staphylococcus aureus in the antibiotic era
Open accessAbstract
Staphylococcus aureus is notorious for its ability to become resistant to antibiotics. Infections that are caused by antibiotic-resistant strains often occur in epidemic waves that are initiated by one or a few successful clones. Methicillin-resistant S. aureus (MRSA) features prominently in these epidemics. Historically associated with hospitals and other health care settings, MRSA has now emerged as a widespread cause of community infections. Community or community-associated MRSA (CA-MRSA) can spread rapidly among healthy individuals. Outbreaks of CA-MRSA infections have been reported worldwide, and CA-MRSA strains are now epidemic in the United States. Here, we review the molecular epidemiology of the epidemic waves of penicillin- and methicillin-resistant strains of S. aureus that have occurred since 1940, with a focus on the clinical and molecular epidemiology of CA-MRSA.
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“These events culminate with the production of PBP2a, which is the hallmark of methicillin resistance in S. aureus (70).”
From Mechanisms of Antibiotic Resistance (2016) · cites this paper as [70]
In the citing paper
“Indeed, community-associated MRSA strains appear to harbor shorter SCCmec cassettes (e.g SCCmec type IV) and carry less antibiotic resistance determinants, whereas hospital-associated (HA) isolates possess longer elements (e.g. SCCmec type II) and are usually multidrug resistant (70).”
From Mechanisms of Antibiotic Resistance (2016) · cites this paper as [70]
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Cites
Staphylococcus aureus Infections
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Tong, S. Y. C., Davis, J. S., Eichenberger, E., Holland, T. L., & Fowler, V. G. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00134-14 · Cited by 5,192
Antimicrobial resistance: a global multifaceted phenomenon
Prestinaci, F., Pezzotti, P., & Pantosti, A. (2015) · Pathogens and Global Health · doi:10.1179/2047773215y.0000000030 · Cited by 3,296
Mechanisms of Antibiotic Resistance
Munita, J. M., & Arias, C. A. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.vmbf-0016-2015 · Cited by 2,782
Mobile Genetic Elements Associated with Antimicrobial Resistance
Partridge, S. R., Kwong, S. M., Firth, N., & Jensen, S. O. (2018) · Clinical Microbiology Reviews · doi:10.1128/cmr.00088-17 · Cited by 2,751
Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology
Lakhundi, S., & Zhang, K. (2018) · Clinical Microbiology Reviews · doi:10.1128/cmr.00020-18 · Cited by 1,762
Metadata
- Authors
- Chambers, H. F., & DeLeo, F. R.
- Affiliations
- San Francisco General Hospital (US)
- National Institutes of Health (US)
- Corresponding author
- Chambers, Henry F.
- Venue
- Nature Reviews Microbiology
- Published
- 2009-09
- Volume
- 7
- Issue
- 9
- Pages
- 629-641
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- PMC
- PMC2871281
- OpenAlex
- W2151150074
- Cited by
- 2,718
- References
- 198
- Citations by year
- 2026: 132 · 2025: 170 · 2024: 172 · 2023: 192 · 2022: 220 · 2021: 200 · 2020: 194 · 2019: 175 · 2018: 185 · 2017: 159 · 2016: 176 · 2015: 130 · 2014: 138 · 2013: 162 · 2012: 132
- FWCI
- 12.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Microbiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (R01AI070289, T32AI007641)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Health Sciences › Medicine › Infectious Diseases › Antibiotic Use and Resistance
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Keywords
- Staphylococcus aureus, antibiotic resistance, community-associated methicillin-resistant Staphylococcus aureus, penicillin resistance, methicillin resistance, epidemic waves, molecular epidemiology, MRSA outbreak, clonal spread, nosocomial infections
- MeSH terms
- Anti-Bacterial Agents, Cross Infection, Disease Outbreaks, Humans, Penicillin Resistance, Staphylococcal Infections, Staphylococcus aureus, Methicillin Resistance, Community-Acquired Infections, Molecular Epidemiology
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