The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
The type II secretion system: biogenesis, molecular architecture and mechanism
Open accessAbstract
Many Gram-negative bacteria use the sophisticated type II secretion system (T2SS) to translocate a wide range of proteins from the periplasm across the outer membrane. The inner-membrane platform of the T2SS is the nexus of the system and orchestrates the secretion process through its interactions with the periplasmic filamentous pseudopilus, the dodecameric outer-membrane complex and a cytoplasmic secretion ATPase. Here, recent structural and biochemical information is reviewed to describe our current knowledge of the biogenesis and architecture of the T2SS and its mechanism of action.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The complete general secretory pathway in gram-negative bacteria
Pugsley, A. P. (1993) · Microbiological Reviews · doi:10.1128/mmbr.57.1.50-108.1993 · Cited by 1,774
Pilus retraction powers bacterial twitching motility
Merz, A. J., So, M., & Sheetz, M. P. (2000) · Nature · doi:10.1038/35024105 · Cited by 828
Role of a Highly Conserved Bacterial Protein in Outer Membrane Protein Assembly
Voulhoux, R., Bos, M. P., Geurtsen, J., Mols, M., & Tommassen, J. (2003) · Science · doi:10.1126/science.1078973 · Cited by 742
Leiman, P. G., Basler, M., Ramagopal, U. A., Bonanno, J. B., Sauder, J. M., Pukatzki, S., Burley, S. K., Almo, S. C., & Mekalanos, J. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813360106 · Cited by 658
Structure and function of KH domains
Valverde, R., Edwards, L., & Regan, L. (2008) · The FEBS Journal · doi:10.1111/j.1742-4658.2008.06411.x · Cited by 506
Sandkvist, M. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02403.x · Cited by 416
Self-citationCraig, L., Volkmann, N., Arvai, A. S., Pique, M. E., Yeager, M., Egelman, E. H., & Tainer, J. A. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.07.004 · Cited by 414
Structure of the Aeromonas toxin proaerolysin in its water-soluble and membrane-channel states
Parker, M. W., Buckley, J. T., Postma, J. P. M., Tucker, A. D., Leonard, K., Pattus, F., & Tsernoglou, D. (1994) · Nature · doi:10.1038/367292a0 · Cited by 414
Structure of the cell-puncturing device of bacteriophage T4
Kanamaru, S., Leiman, P. G., Kostyuchenko, V. A., Chipman, P. R., Mesyanzhinov, V. V., Arisaka, F., & Rossmann, M. G. (2002) · Nature · doi:10.1038/415553a · Cited by 391
Hobbs, M., & Mattick, J. S. (1993) · Molecular Microbiology · doi:10.1111/j.1365-2958.1993.tb01949.x · Cited by 371
Cited by
Secretion systems in Gram-negative bacteria: Structural and mechanistic insights
Costa, T. R. D., Felisberto-Rodrigues, C., Meir, A., Prevost, M. S., Redzej, A., Trokter, M., & Waksman, G. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro3456 · Cited by 1,132
A comprehensive review of signal peptides: Structure, roles, and applications
Owji, H., Nezafat, N., Negahdaripour, M., Hajiebrahimi, A., & Ghasemi, Y. (2018) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2018.06.003 · Cited by 523
Nesta, B., Valeri, M., Spagnuolo, A., Rosini, R., Mora, M., Donato, P., Alteri, C. J., Del Vecchio, M., Buccato, S., Pezzicoli, A., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004124 · Cited by 68
The structural basis for deubiquitination by the fingerless USP-type effector TssM
Hermanns, T., Uthoff, M., Baumann, U., & Hofmann, K. (2024) · Life Science Alliance · doi:10.26508/lsa.202302422 · Cited by 7
Arnoux, J. (2026) · Thèse de doctorat, Université Paris-Saclay / PPanGGOLiN · doi:10.70675/eee354d9zf63dz48ebz9444zd1809f8fb74d
Metadata
- Authors
- Korotkov, K. V., Sandkvist, M., & Hol, W. G. J.
- Venue
- Nature Reviews Microbiology
- Published
- 2012-04-02
- Volume
- 10
- Issue
- 5
- Pages
- 336-351
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W2004745913
- Cited by
- 549
- References
- 110
- FWCI
- 4.98
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The type II secretion system: biogenesis, molecular architecture and mechanism. https://app.cochat.ai/papers/10.1038/nrmicro2762
- The paper
- Korotkov, K. V., Sandkvist, M., & Hol, W. G. J. (2012). The type II secretion system: biogenesis, molecular architecture and mechanism. Nature Reviews Microbiology. https://doi.org/10.1038/nrmicro2762
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
