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Pathogenic Escherichia coli

Kaper, James B., Nataro, James P., Mobley, Harry L. T.·2004·Nature Reviews Microbiology
DOI 10.1038/nrmicro818
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Abstract

Few microorganisms are as versatile as Escherichia coli. An important member of the normal intestinal microflora of humans and other mammals, E. coli has also been widely exploited as a cloning host in recombinant DNA technology. But E. coli is more than just a laboratory workhorse or harmless intestinal inhabitant; it can also be a highly versatile, and frequently deadly, pathogen. Several different E. coli strains cause diverse intestinal and extraintestinal diseases by means of virulence factors that affect a wide range of cellular processes.

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  1. Sweeney, N. J. et al. The Escherichia coli K-12 gntP gene allows E. coli F-18 to occupy a distinct nutritional niche in the streptomycin-treated mouse large intestine. Infect. Immun. 64, 3497–3503 (1996). · DOI
  2. Nataro, J. P. & Kaper, J. B. Diarrheagenic Escherichia coli. Clin. Microbiol. Rev. 11, 142–201 (1998). A comprehensive review of the pathogenesis, epidemiology, diagnosis and clinical aspects of diarrhoeagenic E. coli. · DOI
  3. Russo, T. A. & Johnson, J. R. Proposal for a new inclusive designation for extraintestinal pathogenic isolates of Escherichia coli: ExPEC. J. Infect. Dis. 181, 1753–1754 (2000). · DOI
  4. Whittam, T. S. in Escherichia coli and Salmonella (eds Neidhardt, F. C. et al.) 2708–2720 (ASM Press, Washington DC, USA, 1996).
  5. Cassels, F. J. & Wolf, M. K. Colonization factors of diarrheagenic E. coli and their intestinal receptors. J. Ind. Microbiol. 15, 214–226 (1995). · DOI
  6. Keller, R. et al. Afa, a diffuse adherence fibrillar adhesin associated with enteropathogenic Escherichia coli. Infect. Immun. 70, 2681–2689 (2002). · DOI
  7. Tieng, V. et al. Binding of Escherichia coli adhesin AfaE to CD55 triggers cell-surface expression of the MHC class I-related molecule MICA. Proc. Natl Acad. Sci. USA 99, 2977–2982 (2002). · DOI
  8. Goldberg, M. B. & Theriot, J. A. Shigella flexneri surface protein IcsA is sufficient to direct actin-based motility. Proc. Natl Acad. Sci. USA 92, 6572–6576 (1995). · DOI
  9. Tapping, R. I., Akashi, S., Miyake, K., Godowski, P. J. & Tobias, P. S. Toll-like receptor 4, but not toll-like receptor 2, is a signaling receptor for Escherichia and Salmonella lipopolysaccharides. J. Immunol. 165, 5780–5787 (2000). · DOI
  10. Hayashi, F. et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 410, 1099–1103 (2001). · DOI
  11. Sears, C. L. & Kaper, J. B. Enteric bacterial toxins: mechanisms of action and linkage to intestinal secretion. Microbiol. Rev. 60, 167–215 (1996). · DOI
  12. Melton-Celsa, A. R. & O'Brien, A. D. in Escherichia coli O157:H7 and Other Shiga Toxin-Producing E. coli Strains (eds Kaper, J. B. & O'Brien, A. D.) 121–128 (ASM Press, Washington DC, USA, 1998).
  13. De Rycke, J. & Oswald, E. Cytolethal distending toxin (CDT): a bacterial weapon to control host cell proliferation? FEMS Microbiol Lett. 203, 141–148 (2001). · DOI
  14. Marches, O. et al. Enteropathogenic and enterohaemorrhagic Eschericha coli deliver a novel effector called Cif, which blocks cell cycle G2/M transition. Mol. Microbiol 50, 1553–1567 (2003). · DOI
  15. Lerm, M. et al. Deamidation of Cdc42 and Rac by Escherichia coli cytotoxic necrotizing factor 1: activation of c-Jun N-terminal kinase in HeLa cells. Infect. Immun. 67, 496–503 (1999). · DOI
  16. Kenny, B. et al. Co-ordinate regulation of distinct host cell signalling pathways by multifunctional enteropathogenic Escherichia coli effector molecules. Mol. Microbiol. 44, 1095–1107 (2002). · DOI
  17. Tauschek, M., Gorrell, R. J., Strugnell, R. A. & Robins-Browne, R. M. Identification of a protein secretory pathway for the secretion of heat-labile enterotoxin by an enterotoxigenic strain of Escherichia coli. Proc. Natl Acad. Sci. USA 99, 7066–7071 (2002). · DOI
  18. Henderson, I. R., Navarro-Garcia, F. & Nataro, J. P. The great escape: structure and function of the autotransporter proteins. Trends Microbiol. 6, 370–378 (1998). · DOI
  19. Hueck, C. J. Type III protein secretion systems in bacterial pathogens of animals and plants. Microbiol. Mol. Biol. Rev. 62, 379–433 (1998). · DOI
  20. Balakrishnan, L., Hughes, C. & Koronakis, V. Substrate-triggered recruitment of the TolC channel-tunnel during type I export of hemolysin by Escherichia coli. J. Mol. Biol. 313, 501–510 (2001). · DOI
  21. McDaniel, T. K., Jarvis, K. G., Donnenberg, M. S. & Kaper, J. B. A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens. Proc. Natl Acad. Sci. USA 92, 1664–1668 (1995). The first description of a pathogenicity island in enteric E. coli pathotypes. · DOI
  22. Jerse, A. E., Yu, J., Tall, B. D. & Kaper, J. B. A genetic locus of enteropathogenic Escherichia coli necessary for the production of attaching and effacing lesions on tissue culture cells. Proc. Natl Acad. Sci. USA 87, 7839–7843 (1990). · DOI
  23. Higgins, L. M. et al. Role of bacterial intimin in colonic hyperplasia and inflammation. Science 285, 588–591 (1999). · DOI
  24. Kenny, B. et al. Enteropathogenic E. coli (EPEC) transfers its receptor for intimate adherence into mammalian cells. Cell 91, 511–520 (1997). The first report of a bacterium translocating its receptor into mammalian cells by a type III secretion system. · DOI
  25. Muza-Moons, M. M., Koutsouris, A. & Hecht, G. Disruption of cell polarity by enteropathogenic Escherichia coli enables basolateral membrane proteins to migrate apically and to potentiate physiological consequences. Infect. Immun. 71, 7069–7078 (2003). · DOI
  26. Sinclair, J. F. & O'Brien, A. D. Cell surface-localized nucleolin is a eukaryotic receptor for the adhesin intimin-γ of enterohemorrhagic Escherichia coli O157:H7. J. Biol. Chem. 277, 2876–2885 (2002). · DOI
  27. Kalman, D. et al. Enteropathogenic E. coli acts through WASP and Arp2/3 complex to form actin pedestals. Nature Cell Biol. 1, 389–391 (1999). · DOI
  28. Campellone, K. G. & Leong, J. M. Tails of two Tirs: actin pedestal formation by enteropathogenic E. coli and enterohemorrhagic E. coli O157:H7. Curr. Opin. Microbiol. 6, 82–90 (2003). · DOI
  29. Vallance, B. A. & Finlay, B. B. Exploitation of host cells by enteropathogenic Escherichia coli. Proc. Natl Acad. Sci. USA 97, 8799–8806 (2000). · DOI
  30. Sanger, J. M., Chang, R., Ashton, F., Kaper, J. B. & Sanger, J. W. Novel form of actin-based motility transports bacteria on the surface of infected cells. Cell Motil. Cytoskeleton 34, 279–287 (1996). · DOI
  31. Crane, J. K., McNamara, B. P. & Donnenberg, M. S. Role of EspF in host cell death induced by enteropathogenic Escherichia coli. Cell Microbiol. 3, 197–211 (2001). · DOI
  32. McNamara, B. P. et al. Translocated EspF protein from enteropathogenic Escherichia coli disrupts host intestinal barrier function. J. Clin. Invest. 107, 621–629 (2001). · DOI
  33. Klapproth, J. M. et al. A large toxin from pathogenic Escherichia coli strains that inhibits lymphocyte activation. Infect. Immun. 68, 2148–2155 (2000). · DOI
  34. Nicholls, L., Grant, T. H. & Robins-Browne, R. M. Identification of a novel genetic locus that is required for in vitro adhesion of a clinical isolate of enterohaemorrhagic Escherichia coli to epithelial cells. Mol. Microbiol. 35, 275–288 (2000). · DOI
  35. Tobe, T. et al. Complete DNA sequence and structural analysis of the enteropathogenic Escherichia coli adherence factor plasmid. Infect. Immun. 67, 5455–5462 (1999). · DOI
  36. Girón, J. A., Ho, A. S. Y. & Schoolnik, G. K. An inducible bundle-forming pilus of enteropathogenic Escherichia coli. Science 254, 710–713 (1991). · DOI
  37. Trabulsi, L. R., Keller, R. & Tardelli Gomes, T. A. Typical and atypical enteropathogenic Escherichia coli. Emerg. Infect. Dis. 8, 508–513 (2002). · DOI
  38. Hecht, G. Microbes and microbial toxins: paradigms for microbial–mucosal interactions. VII. Enteropathogenic Escherichia coli: physiological alterations from an extracellular position. Am. J. Physiol Gastrointest. Liver Physiol. 281, G1–G7 (2001). · DOI
  39. Frankel, G. et al. Enteropathogenic and enterohaemorrhagic Escherichia coli: more subversive elements. Mol. Microbiol. 30, 911–921 (1998). · DOI
  40. Kenny, B. Mechanism of action of EPEC type III effector molecules. Int. J. Med. Microbiol. 291, 469–477 (2002). · DOI
  41. Hecht, G. et al. Pathogenic Escherichia coli increase Cl− secretion from intestinal epithelia by upregulating galanin-1 receptor expression. J. Clin. Invest. 104, 253–262 (1999). · DOI
  42. Varma, J. K. et al. An outbreak of Escherichia coli O157 infection following exposure to a contaminated building. JAMA 290, 2709–2712 (2003). · DOI
  43. Andreoli, S. P., Trachtman, H., Acheson, D. W., Siegler, R. L. & Obrig, T. G. Hemolytic uremic syndrome: epidemiology, pathophysiology, and therapy. Pediatr. Nephrol. 17, 293–298 (2002). · DOI
  44. Jones, N. L. et al. Escherichia coli Shiga toxins induce apoptosis in epithelial cells that is regulated by the Bcl-2 family. Am. J. Physiol. Gastrointest. Liver Physiol. 278, G811–G819 (2000). · DOI
  45. Reid, S. D., Herbelin, C. J., Bumbaugh, A. C., Selander, R. K. & Whittam, T. S. Parallel evolution of virulence in pathogenic Escherichia coli. Nature 406, 64–67 (2000). · DOI
  46. Tatsuno, I. et al. toxB gene on pO157 of enterohemorrhagic Escherichia coli O157:H7 is required for full epithelial cell adherence phenotype. Infect. Immun. 69, 6660–6669 (2001). · DOI
  47. Burland, V. et al. The complete DNA sequence and analysis of the large virulence plasmid of Escherichia coli O157:H7. Nucleic Acids Res. 26, 4196–4204 (1998). · DOI
  48. Lathem, W. W. et al. StcE, a metalloprotease secreted by Escherichia coli O157:H7, specifically cleaves C1 esterase inhibitor. Mol. Microbiol. 45, 277–288 (2002). · DOI
  49. Perna, N. T. et al. Genome sequence of enterohaemorrhagic Escherichia coli O157:H7. Nature 409, 529–533 (2001). The first reported genome sequence for a pathogenic E. coli strain. · DOI
  50. Heimer, S. R. et al. Urease of enterohemorrhagic Escherichia coli: evidence for regulation by fur and a trans-acting factor. Infect. Immun. 70, 1027–1031 (2002). · DOI
  51. Wolf, M. K. Occurrence, distribution, and associations of O and H serogroups, colonization factor antigens, and toxins of enterotoxigenic Escherichia coli. Clin. Microbiol. Rev. 10, 569–584 (1997). · DOI
  52. Spangler, B. D. Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin. Microbiol. Rev. 56, 622–647 (1992). · DOI
  53. Pizza, M. et al. Mucosal vaccines: non-toxic derivatives of LT and CT as mucosal adjuvants. Vaccine 19, 2534–2541 (2001). · DOI
  54. Currie, M. G. et al. Guanylin: an endogenous activator of intestinal guanylate cyclase. Proc. Natl Acad. Sci. USA 89, 947–951 (1992). This paper suggests that STa evolved as a molecular mimic of an endogenous ligand. This model is necessary, not only to understand ETEC pathogenesis and evolution, but also to provide a context for future studies of microbial evolution. · DOI
  55. Dubreuil, J. D. Escherichia coli STb enterotoxin. Microbiology 143, 1783–1795 (1997). · DOI
  56. Pitari, G. M. et al. Bacterial enterotoxins are associated with resistance to colon cancer. Proc. Natl Acad. Sci. USA 100, 2695–2699 (2003). · DOI
  57. Nataro, J. P., Steiner, T. S. & Guerrant, R. L. Enteroaggregative Escherichia coli. Emerg. Infect. Dis. 4, 251–261 (1998). · DOI
  58. Hicks, S., Candy, D. C. A. & Phillips, A. D. Adhesion of enteroaggregative Escherichia coli to pediatric intestinal mucosa in vitro. Infect. Immun. 64, 4751–4760 (1996). · DOI
  59. Vial, P. A. et al. Characterization of enteroadherent-aggregative Escherichia coli, a putative agent of diarrheal disease. J. Infect. Dis. 158, 70–79 (1988). · DOI
  60. Benjamin, P., Federman, M. & Wanke, C. A. Characterization of an invasive phenotype associated with enteroaggregative Escherichia coli. Infect. Immun. 63, 3417–3421 (1995). · DOI
  61. Abe, C. M., Knutton, S., Pedroso, M. Z., Freymuller, E. & Gomes, T. A. An enteroaggregative Escherichia coli strain of serotype O111:H12 damages and invades cultured T84 cells and human colonic mucosa. FEMS Microbiol. Lett. 203, 199–205 (2001). · DOI
  62. Czeczulin, J. R. et al. Aggregative adherence fimbria II, a second fimbrial antigen mediating aggregative adherence in enteroaggregative Escherichia coli. Infect. Immun. 65, 4135–4145 (1997). · DOI
  63. Nataro, J. P., Yikang, D., Yingkang, D. & Walker, K. AggR, a transcriptional activator of aggregative adherence fimbria I expression in enteroaggregative Escherichia coli. J. Bacteriol. 176, 4691–4699 (1994). Describes the emergence of AggR as a global regulator of virulence genes in EAEC · DOI
  64. Sheikh, J. et al. A novel dispersin protein in enteroaggregative Escherichia coli. J. Clin. Invest. 110, 1329–1337 (2002). · DOI
  65. Steiner, T. S., Nataro, J. P., Poteet-Smith, C. E., Smith, J. A. & Guerrant, R. L. Enteroaggregative Escherichia coli expresses a novel flagellin that causes IL-8 release from intestinal epithelial cells. J. Clin. Invest 105, 1769–1777 (2000). The pathogenesis of EAEC is not completely understood, but inflammation might be an important component. · DOI
  66. Henderson, I. R., Czeczulin, J., Eslava, C., Noriega, F. & Nataro, J. P. Characterization of Pic, a secreted protease of Shigella flexneri and enteroaggregative Escherichia coli. Infect. Immun. 67, 5587–5596 (1999). · DOI · Paper page
  67. Noriega, F. R., Liao, F. M., Formal, S. B., Fasano, A. & Levine, M. M. Prevalence of Shigella enterotoxin 1 among Shigella clinical isolates of diverse serotypes. J. Infect. Dis. 172, 1408–1410 (1995). · DOI
  68. Savarino, S. J. et al. Enteroaggregative Escherichia coli heat-stable enterotoxin 1 represents another subfamily of E. coli heat-stable toxin. Proc. Natl Acad. Sci. USA 90, 3093–3097 (1993). · DOI
  69. Menard, L. P. & Dubreuil, J. D. Enteroaggregative Escherichia coli heat-stable enterotoxin 1 (EAST1): a new toxin with an old twist. Crit. Rev. Microbiol. 28, 43–60 (2002). · DOI
  70. Navarro-Garcia, F. et al. In vitro effects of a high-molecular weight heat-labile enterotoxin from enteroaggregative Escherichia coli. Infect. Immun. 66, 3149–3154 (1998). · DOI
  71. Jiang, Z. D., Greenberg, D., Nataro, J. P., Steffen, R. & DuPont, H. L. Rate of occurrence and pathogenic effect of enteroaggregative Escherichia coli virulence factors in international travelers. J. Clin. Microbiol. 40, 4185–4190 (2002). · DOI
  72. Wei, J. et al. Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T. Infect. Immun. 71, 2775–2786 (2003). · DOI
  73. Pupo, G. M., Lan, R. & Reeves, P. R. Multiple independent origins of Shigella clones of Escherichia coli and convergent evolution of many of their characteristics. Proc. Natl Acad. Sci. USA 97, 10567–10572 (2000). This paper suggests that Shigella should be considered within the species Escherichia coli , and that their evolution represents adaptation to a specific pathogenetic niche, a phenomenon that has occurred on several occasions over many years. · DOI
  74. Sansonetti, P. Host–pathogen interactions: the seduction of molecular cross talk. Gut 50, Suppl. 3 S2–S8 (2002).
  75. Zychlinsky, A., Prevost, M. C. & Sansonetti, P. J. Shigella flexneri induces apoptosis in infected macrophages. Nature 358, 167–169 (1992). · DOI
  76. Buchrieser, C. et al. The virulence plasmid pWR100 and the repertoire of proteins secreted by the type III secretion apparatus of Shigella flexneri. Mol. Microbiol. 38, 760–771 (2000). · DOI
  77. Egile, C. et al. Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin- based motility. J. Cell Biol. 146, 1319–1332 (1999). · DOI
  78. Sansonetti, P. J. et al. Caspase-1 activation of IL-1β and IL-18 are essential for Shigella flexneri-induced inflammation. Immunity. 12, 581–590 (2000). The pathogenesis of Shigella infection represents a complex manipulation of the immune response, in ways that are beneficial to both pathogen and host. · DOI
  79. Tran Van Nhieu, G., Bourdet-Sicard, R., Dumenil, G., Blocker, A. & Sansonetti, P. J. Bacterial signals and cell responses during Shigella entry into epithelial cells. Cell. Microbiol. 2, 187–193 (2000). · DOI
  80. Niebuhr, K. et al. Conversion of PtdIns(4,5)P2 into PtdIns5P by the S. flexneri effector IpgD reorganizes host cell morphology. EMBO J. 21, 5069–5078 (2002). · DOI
  81. Scaletsky, I. C. et al. Diffusely adherent Escherichia coli as a cause of acute diarrhea in young children in northeast Brazil: a case-control study. J. Clin. Microbiol. 40, 645–648 (2002). · DOI
  82. Bilge, S. S., Clausen, C. R., Lau, W. & Moseley, S. L. Molecular characterization of a fimbrial adhesin, F1845, mediating diffuse adherence of diarrhea-associated Escherichia coli to HEp-2 cells. J. Bacteriol. 171, 4281–4289 (1989). · DOI
  83. Hasan, R. J. et al. Structure–function analysis of decayaccelerating factor: identification of residues important for binding of the Escherichia coli Dr adhesin and complement regulation. Infect. Immun. 70, 4485–4493 (2002). · DOI
  84. Bernet-Camard, M. F., Coconnier, M. H., Hudault, S. & Servin, A. L. Pathogenicity of the diffusely adhering strain Escherichia coli C1845: F1845 adhesin-decay accelerating factor interaction, brush border microvillus injury, and actin disassembly in cultured human intestinal epithelial cells. Infect. Immun. 64, 1918–1928 (1996). · DOI
  85. Peiffer, I., Servin, A. L. & Bernet-Camard, M. F. Piracy of decay-accelerating factor (CD55) signal transduction by the diffusely adhering strain Escherichia coli C1845 promotes cytoskeletal F-actin rearrangements in cultured human intestinal INT407 cells. Infect. Immun. 66, 4036–4042 (1998). DAEC exhibits a unique pathogenetic scheme that includes cytoskeletal sabotage. · DOI
  86. Peiffer, I., Bernet-Camard, M. F., Rousset, M. & Servin, A. L. Impairments in enzyme activity and biosynthesis of brush border-associated hydrolases in human intestinal Caco-2/TC7 cells infected by members of the Afa/Dr family of diffusely adhering Escherichia coli. Cell. Microbiol. 3, 341–357 (2001). · DOI
  87. Phillips, I. et al. Epidemic multiresistant Escherichia coli infection in West Lambeth Health District. Lancet 1, 1038–1041 (1988). · DOI
  88. Manges, A. R. et al. Widespread distribution of urinary tract infections caused by a multidrug-resistant Escherichia coli clonal group. N. Engl. J. Med. 345, 1007–1013 (2001). This work identified specific clonal groups of E. coli that cause widespread antibiotic resistant bacteria. · DOI
  89. Nowicki, B., Svanborg-Eden, C., Hull, R. & Hull, S. Molecular analysis and epidemiology of the Dr hemagglutinin of uropathogenic Escherichia coli. Infect. Immun. 57, 446–451 (1989). · DOI
  90. Johnson, J. R. Virulence factors in Escherichia coli urinary tract infection. Clin. Microbiol. Rev. 4, 80–128 (1991). · DOI
  91. Johnson, J. R. & Stell, A. L. Extended virulence genotypes of Escherichia coli strains from patients with urosepsis in relation to phylogeny and host compromise. J. Infect. Dis. 181, 261–272 (2000). · DOI · Paper page
  92. Welch, R. A. et al. Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli. Proc. Natl Acad. Sci. USA 99, 17020–17024 (2002). The first complete nucleotide sequence of a representative uropathogenic strain of E. coli and shows that EHEC, UPEC and E. coli K-12 share only 39.2% of the combined set of predicted proteins. · DOI
  93. Bahrani-Mougeot, F. K. et al. Type 1 fimbriae and extracellular polysaccharides are preeminent uropathogenic Escherichia coli virulence determinants in the murine urinary tract. Mol. Microbiol. 45, 1079–1093 (2002). · DOI
  94. Gunther, N. W., Lockatell, V., Johnson, D. E. & Mobley, H. L. In vivo dynamics of type 1 fimbria regulation in uropathogenic Escherichia coli during experimental urinary tract infection. Infect. Immun. 69, 2838–2846 (2001). · DOI
  95. Connell, I. et al. Type 1 fimbrial expression enhances Escherichia coli virulence for the urinary tract. Proc. Natl Acad. Sci. USA 93, 9827–9832 (1996). Demonstrates that type 1 fimbriae satisfies molecular Koch's postulates. · DOI
  96. Mulvey, M. A. et al. Induction and evasion of host defenses by type 1-piliated uropathogenic Escherichia coli. Science 282, 1494–1497 (1998). · DOI
  97. Anderson, G. G. et al. Intracellular bacterial biofilm-like pods in urinary tract infections. Science 301, 105–107 (2003). · DOI
  98. Svanborg-Eden, C. & Hansson, H. A. Escherichia coli pili as possible mediators of attachment to human urinary tract epithelial cells. Infect. Immun. 21, 229–237 (1978). · DOI
  99. Korhonen, T. K., Virkola, R. & Holthofer, H. Localization of binding sites for purified Escherichia coli P fimbriae in the human kidney. Infect. Immun. 54, 328–332 (1986). · DOI
  100. Trifillis, A. L. et al. Binding to and killing of human renal epithelial cells by hemolytic P-fimbriated E. coli. Kidney Int. 46, 1083–1091 (1994). · DOI
  101. Uhlen, P. et al. α-haemolysin of uropathogenic E. coli induces Ca2+ oscillations in renal epithelial cells. Nature 405, 694–697 (2000). · DOI
  102. Guyer, D. M., Henderson, I. R., Nataro, J. P. & Mobley, H. L. Identification of Sat, an autotransporter toxin produced by uropathogenic Escherichia coli. Mol. Microbiol. 38, 53–66 (2000). Describes the identification of a new toxin of uropathogenic E. coli · DOI
  103. Unhanand, M., Mustafa, M. M., McCracken, G. H. Jr & Nelson, J. D. Gram-negative enteric bacillary meningitis: a twenty-one-year experience. J. Pediatr. 122, 15–21 (1993). · DOI
  104. Dawson, K. G., Emerson, J. C. & Burns, J. L. Fifteen years of experience with bacterial meningitis. Pediatr. Infect. Dis. J. 18, 816–822 (1999). · DOI
  105. Stoll, B. J. et al. Changes in pathogens causing early-onset sepsis in very-low-birth-weight infants. N. Engl. J. Med. 347, 240–247 (2002). · DOI
  106. Dietzman, D. E., Fischer, G. W. & Schoenknecht, F. D. Neonatal Escherichia coli septicemia-bacterial counts in blood. J. Pediatr. 85, 128–130 (1974). · DOI
  107. Stins, M. F., Badger, J. L. & Kim, K. S. Bacterial invasion and transcytosis in transfected human brain microvascular endothelial cells. Microb. Pathog. 30, 19–28 (2001). · DOI
  108. Stins, M. F., Nemani, P. V., Wass, C. & Kim, K. S. Escherichia coli binding to and invasion of brain microvascular endothelial cells derived from humans and rats of different ages. Infect. Immun. 67, 5522–5525 (1999). · DOI
  109. Kim, K. S. et al. The K1 capsule is the critical determinant in the development of Escherichia coli meningitis in the rat. J. Clin. Invest. 90, 897–905 (1992). Recognition of the importance of capsule for virulence of MNEC. · DOI
  110. Rode, C. K., Melkerson-Watson, L. J., Johnson, A. T. & Bloch, C. A. Type-specific contributions to chromosome size differences in Escherichia coli. Infect. Immun. 67, 230–236 (1999). · DOI
  111. Bonacorsi, S. P. et al. Identification of regions of the Escherichia coli chromosome specific for neonatal meningitis-associated strains. Infect. Immun. 68, 2096–2101 (2000). · DOI
  112. Badger, J. L., Wass, C. A., Weissman, S. J. & Kim, K. S. Application of signature-tagged mutagenesis for identification of Escherichia coli K1 genes that contribute to invasion of human brain microvascular endothelial cells. Infect. Immun. 68, 5056–5061 (2000). · DOI
  113. Parkkinen, J., Korhonen, T. K., Pere, A., Hacker, J. & Soinila, S. Binding sites in the rat brain for Escherichia coli S fimbriae associated with neonatal meningitis. J. Clin. Invest 81, 860–865 (1988). · DOI
  114. Prasadarao, N. V., Wass, C. A. & Kim, K. S. Endothelial cell GlcNAc β,1-4GlcNAc epitopes for outer membrane protein A enhance traversal of Escherichia coli across the blood–brain barrier. Infect. Immun. 64, 154–160 (1996). · DOI
  115. Kim, K. S. Escherichia coli translocation at the blood–brain barrier. Infect. Immun. 69, 5217–5222 (2001). · DOI
  116. Badger, J. L. & Kim, K. S. Environmental growth conditions influence the ability of Escherichia coli K1 to invade brain microvascular endothelial cells and confer serum resistance. Infect. Immun. 66, 5692–5697 (1998). · DOI
  117. Hoffman, J. A., Wass, C., Stins, M. F. & Kim, K. S. The capsule supports survival but not traversal of Escherichia coli K1 across the blood–brain barrier. Infect. Immun. 67, 3566–3570 (1999). · DOI
  118. Reddy, M. A., Wass, C. A., Kim, K. S., Schlaepfer, D. D. & Prasadarao, N. V. Involvement of focal adhesion kinase in Escherichia coli invasion of human brain microvascular endothelial cells. Infect. Immun. 68, 6423–6430 (2000). · DOI
  119. Khan, M. A. & Isaacson, R. E. Identification of Escherichia coli genes that are specifically expressed in a murine model of septicemic infection. Infect. Immun. 70, 3404–3412 (2002). · DOI
  120. Darfeuille-Michaud, A. Adherent-invasive Escherichia coli: a putative new E. coli pathotype associated with Crohn's disease. Int. J. Med. Microbiol. 292, 185–193 (2002). · DOI
  121. Panigrahi, P., Bamford, P., Horvath, K., Morris, J. G. Jr & Gewolb, I. H. Escherichia coli transcytosis in a Caco-2 cell model: implications in neonatal necrotizing enterocolitis. Pediatr. Res. 40, 415–421 (1996). · DOI
  122. De Rycke, J., Milon, A. & Oswald, E. Necrotoxic Escherichia coli (NTEC): two emerging categories of human and animal pathogens. Vet. Res. 30, 221–233 (1999).
  123. Elliott, S. J. et al. Characterization of the roles of hemolysin and other toxins in enteropathy caused by α-hemolytic Escherichia coli linked to human diarrhea. Infect. Immun. 66, 2040–2051 (1998). · DOI
  124. Toth, I., Herault, F., Beutin, L. & Oswald, E. Production of cytolethal distending toxins by pathogenic Escherichia coli strains isolated from human and animal sources: establishment of the existence of a new cdt variant (type IV). J. Clin. Microbiol. 41, 4285–4291 (2003). · DOI
  125. Janka, A. et al. Cytolethal distending toxin gene cluster in enterohemorrhagic Escherichia coli O157:H- and O157:H7: characterization and evolutionary considerations. Infect. Immun. 71, 3634–3638 (2003). · DOI
  126. Otto, B. R., van Dooren, S. J., Dozois, C. M., Luirink, J. & Oudega, B. Escherichia coli hemoglobin protease autotransporter contributes to synergistic abscess formation and heme-dependent growth of Bacteroides fragilis. Infect. Immun. 70, 5–10 (2002). · DOI
  127. McVeigh, A. et al. IS 1414, an Escherichia coli insertion sequence with a heat-stable enterotoxin gene embedded in a transposase-like gene. Infect. Immun. 68, 5710–5715 (2000). · DOI
  128. Hacker, J. & Kaper, J. B. Pathogenicity islands and the evolution of microbes. Annu. Rev. Microbiol. 54, 641–679 (2000). · DOI
  129. Dobrindt, U. et al. Genetic structure and distribution of four pathogenicity islands (PAI I(536) to PAI IV(536)) of uropathogenic Escherichia coli strain 536. Infect. Immun. 70, 6365–6372 (2002). · DOI
  130. Tauschek, M., Strugnell, R. A. & Robins-Browne, R. M. Characterization and evidence of mobilization of the LEE pathogenicity island of rabbit-specific strains of enteropathogenic Escherichia coli. Mol. Microbiol. 44, 1533–1550 (2002). · DOI
  131. Torres, A. G. & Kaper, J. B. Pathogenicity islands of intestinal E. coli. Curr. Top. Microbiol. Immunol. 264, 31–48 (2002).
  132. Ingersoll, M., Groisman, E. A. & Zychlinsky, A. Pathogenicity islands of Shigella. Curr. Top. Microbiol. Immunol. 264, 49–65 (2002).
  133. Redford, P. & Welch, R. A. Extraintestinal Escherichia coli as a model system for the study of pathogenicity islands. Curr. Top. Microbiol. Immunol. 264, 15–30 (2002).
  134. Schubert, S., Cuenca, S., Fischer, D. & Heesemann, J. High-pathogenicity island of Yersinia pestis in enterobacteriaceae isolated from blood cultures and urine samples: prevalence and functional expression. J. Infect. Dis. 182, 1268–1271 (2000). · DOI
  135. Maurelli, A. T., Fernández, R. E., Bloch, C. A., Rode, C. K. & Fasano, A. 'Black holes' and bacterial pathogenicity: a large genomic deletion that enhances the virulence of Shigella spp. and enteroinvasive Escherichia coli. Proc. Natl Acad. Sci. USA 95, 3943–3948 (1998). · DOI
  136. Casalino, M., Latella, M. C., Prosseda, G. & Colonna, B. CadC is the preferential target of a convergent evolution driving enteroinvasive Escherichia coli toward a lysine decarboxylase-defective phenotype. Infect. Immun. 71, 5472–5479 (2003). · DOI
  137. Weissman, S. J., Moseley, S. L., Dykhuizen, D. E. & Sokurenko, E. V. Enterobacterial adhesins and the case for studying SNPs in bacteria. Trends Microbiol. 11, 115–117 (2003). · DOI
  138. Dobrindt, U. et al. Analysis of genome plasticity in pathogenic and commensal Escherichia coli isolates by use of DNA arrays. J. Bacteriol. 185, 1831–1840 (2003). · DOI
  139. Mellies, J. L., Elliott, S. J., Sperandio, V., Donnenberg, M. S. & Kaper, J. B. The Per regulon of enteropathogenic Escherichia coli: identification of a regulatory cascade and a novel transcriptional activator, the locus of enterocyte effacement (LEE)-encoded regulator (Ler). Mol. Microbiol. 33, 296–306 (1999). · DOI
  140. Xia, Y., Gally, D., Forsman-Semb, K. & Uhlin, B. E. Regulatory cross-talk between adhesin operons in Escherichia coli: inhibition of type 1 fimbriae expression by the PapB protein. EMBO J. 19, 1450–1457 (2000). · DOI
  141. Wagner, P. L. et al. Bacteriophage control of Shiga toxin 1 production and release by Escherichia coli. Mol. Microbiol. 44, 957–970 (2002). · DOI
  142. Zhang, X. et al. Quinolone antibiotics induce Shiga toxin-encoding bacteriophages, toxin production, and death in mice. J. Infect. Dis. 181, 664–670 (2000). · DOI
  143. Sperandio, V., Mellies, J. L., Nguyen, W., Shin, S. & Kaper, J. B. Quorum sensing controls expression of the type III secretion gene transcription and protein secretion in enterohemorrhagic and enteropathogenic Escherichia coli. Proc. Natl Acad. Sci. USA 96, (1999). First report that enteric bacterial virulence factors are regulated by quorum sensing. · DOI
  144. Sperandio, V., Torres, A. G., Jarvis, B., Nataro, J. P. & Kaper, J. B. Bacteria–host communication: the language of hormones. Proc. Natl Acad. Sci. USA 100, 8951–8956 (2003). · DOI · Paper page
  145. Abraham, J. M., Freitag, C. S., Clements, J. R. & Eisenstein, B. I. An invertible element of DNA controls phase variation of type 1 fimbriae of Escherichia coli. Proc. Natl Acad. Sci. USA 82, 5724–5727 (1985). · DOI
  146. Kuehn, M. J., Heuser, J., Normark, S. & Hultgren, S. J. P pili in uropathogenic E. coli are composite fibres with distinct fibrillar adhesive tips. Nature 356, 252–255 (1992). · DOI
  147. Bustamante, V. H., Santana, F. J., Calva, E. & Puente, J. L. Transcriptional regulation of type III secretion genes in enteropathogenic Escherichia coli: Ler antagonizes H-NS-dependent repression. Mol. Microbiol. 39, 664–678 (2001). · DOI
  148. Friedberg, D., Umanski, T., Fang, Y. & Rosenshine, I. Hierarchy in the expression of the locus of enterocyte effacement genes of enteropathogenic Escherichia coli. Mol. Microbiol. 34, 941–952 (1999). · DOI
  149. Goldberg, M. D., Johnson, M., Hinton, J. C. & Williams, P. H. Role of the nucleoid-associated protein Fis in the regulation of virulence properties of enteropathogenic Escherichia coli. Mol. Microbiol. 41, 549–559 (2001). · DOI
  150. Grant, A. J. et al. Co-ordination of pathogenicity island expression by the BipA GTPase in enteropathogenic Escherichia coli (EPEC). Mol. Microbiol. 48, 507–521 (2003). · DOI
  151. Sperandio, V., Li, C. C. & Kaper, J. B. Quorum-sensing Escherichia coli regulator A: a regulator of the LysR family involved in the regulation of the locus of enterocyte effacement pathogenicity island in enterohemorrhagic E. coli. Infect. Immun. 70, 3085–3093 (2002). · DOI
  152. Sperandio, V., Torres, A. G. & Kaper, J. B. Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli. Mol. Microbiol. 43, 809–821 (2002). · DOI
  153. Gómez-Duarte, O. G. & Kaper, J. B. A plasmid-encoded regulatory region activates chromosomal eaeA expression in enteropathogenic Escherichia coli. Infect. Immun. 63, 1767–1776 (1995). · DOI
  154. Tobe, T., Schoolnik, G. K., Sohel, I., Bustamante, V. H. & Puente, J. L. Cloning and characterization of bfpTVW, genes required for the transcriptional activation of bfpA in enteropathogenic Escherichia coli. Mol. Microbiol. 21, 963–975 (1996). · DOI
  155. Shin, S. et al. An activator of glutamate decarboxylase genes regulates the expression of enteropathogenic Escherichia coli virulence genes through control of the plasmid-encoded regulator, Per. Mol. Microbiol. 41, 1133–1150 (2001). · DOI
  156. Mellies, J. L. et al. espC pathogenicity island of enteropathogenic Escherichia coli encodes an enterotoxin. Infect. Immun. 69, 315–324 (2001) · DOI

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Metadata

Authors
Kaper, J. B., Nataro, J. P., & Mobley, H. L. T.
Affiliations
University of Maryland, Baltimore (US)
Corresponding author
Kaper, James B.
ORCID
Venue
Nature Reviews Microbiology
Publisher
Springer Science and Business Media LLC
Published
2004-02
Volume
2
Issue
2
Pages
123-140
ISSN
  • 1740-1526 (ISSN-L)
  • 1740-1534
DOI
10.1038/nrmicro818
OpenAlex
W1966597734
Cited by
5,583
References
0
Citations by year
2026: 269 · 2025: 345 · 2024: 385 · 2023: 396 · 2022: 458 · 2021: 329 · 2020: 310 · 2019: 268 · 2018: 256 · 2017: 284 · 2016: 276 · 2015: 298 · 2014: 301 · 2013: 245 · 2012: 244
FWCI
8.88
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Nature Reviews Microbiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Allergy and Infectious Diseases (R37AI021657)
Topics
  • Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Life Sciences › Immunology and Microbiology › Microbiology › Enterobacteriaceae and Cronobacter Research
Keywords
pathogenic Escherichia coli, virulence factors, extraintestinal infections, intestinal diseases, bacterial pathogenesis, host-pathogen interaction, enteric pathogens
MeSH terms
Animals, Bacterial Adhesion, Diarrhea, Escherichia coli, Humans, Urinary Tract Infections, Gene Expression Regulation, Bacterial, Meningitis, Bacterial, Shiga Toxins, Virulence Factors

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