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Pathogenic Escherichia coli

Kaper, James B., Nataro, James P., Mobley, Harry L. T.·2004·Nature Reviews Microbiology
DOI 10.1038/nrmicro818
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Abstract

Few microorganisms are as versatile as Escherichia coli. An important member of the normal intestinal microflora of humans and other mammals, E. coli has also been widely exploited as a cloning host in recombinant DNA technology. But E. coli is more than just a laboratory workhorse or harmless intestinal inhabitant; it can also be a highly versatile, and frequently deadly, pathogen. Several different E. coli strains cause diverse intestinal and extraintestinal diseases by means of virulence factors that affect a wide range of cellular processes.

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Metadata

Authors
Kaper, J. B., Nataro, J. P., & Mobley, H. L. T.
Affiliations
University of Maryland, Baltimore (US)
Corresponding author
Kaper, James B.
ORCID
Venue
Nature Reviews Microbiology
Publisher
Springer Science and Business Media LLC
Published
2004-02
Volume
2
Issue
2
Pages
123-140
ISSN
  • 1740-1526 (ISSN-L)
  • 1740-1534
DOI
10.1038/nrmicro818
OpenAlex
W1966597734
Cited by
5,583
References
0
Citations by year
2026: 269 · 2025: 345 · 2024: 385 · 2023: 396 · 2022: 458 · 2021: 329 · 2020: 310 · 2019: 268 · 2018: 256 · 2017: 284 · 2016: 276 · 2015: 298 · 2014: 301 · 2013: 245 · 2012: 244
FWCI
8.88
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Nature Reviews Microbiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Allergy and Infectious Diseases (R37AI021657)
Topics
  • Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Life Sciences › Immunology and Microbiology › Microbiology › Enterobacteriaceae and Cronobacter Research
Keywords
pathogenic Escherichia coli, virulence factors, extraintestinal infections, intestinal diseases, bacterial pathogenesis, host-pathogen interaction, enteric pathogens
MeSH terms
Animals, Bacterial Adhesion, Diarrhea, Escherichia coli, Humans, Urinary Tract Infections, Gene Expression Regulation, Bacterial, Meningitis, Bacterial, Shiga Toxins, Virulence Factors

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