Extended Virulence Genotypes of Escherichia coli Strains from Patients with Urosepsis in Relation to Phylogeny and Host Compromise

Johnson, James R.; Stell, Adam L.

doi:10.1086/315217

Cited by 1,269Escherichia coli research studiesUrinary Tract Infections ManagementEnterobacteriaceae and Cronobacter Research

Extended Virulence Genotypes of Escherichia coli Strains from Patients with Urosepsis in Relation to Phylogeny and Host Compromise

Johnson, James R., Stell, Adam L.·2000·The Journal of Infectious Diseases

DOI 10.1086/315217

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Abstract

Among 75 urosepsis isolates of Escherichia coli, 29 virulence factor (VF) genes were detected by use of a novel polymerase chain reaction (PCR) assay. Compared with probe hybridization, the PCR assay's specificity was 100% and sensitivity 97.1%. fyuA (yersiniabactin: overall prevalence, 93%), traT (serum resistance, 68%), and a pathogenicity-associated island marker (71%) occurred in most strains from both compromised and noncompromised hosts. Present in <20% of strains each were sfaS, focG (F1C fimbriae), afa/dra, bmaE (M fimbriae), gafD (G fimbriae), cnf1, cdtB (cytolethal distending toxin), cvaC (colicin V), and ibeA (invasion of brain endothelium). Different VFs were variously confined to virulence-associated phylogenetic group B2 (as defined by multilocus enzyme electrophoresis); concentrated in group B2, but with spread beyond; or concentrated outside of group B2. These findings provide novel insights into the VFs of extraintestinal pathogenic E. coli and demonstrate the new PCR assay's utility for molecular epidemiological studies.

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Strains responsible for extra-intestinal infection were far more likely to be members of phylogroups B2 than A.
“strains responsible for extra-intestinal infection were far more likely to be members of phylogroups B2 than A [143, 144]”
From Selection, Comparative Genomics, and Potential Probiotic Features of Escherichia coli 5C, a pks-Negative Strain Isolated from Healthy Infant Donor Feces (2026) · cites this paper as [144]

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The <scp>C</scp> lermont <scp>E</scp> scherichia coli phylo‐typing method revisited: improvement of specificity and detection of new phylo‐groups
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“…each other phylogenetically among E. coli sensu stricto [107]; that strains responsible for extra-intestinal infection were far more likely to be members of phylogroups B2 than A [143, 144]; and that the B2 phylotype is likely the colibactin-positive most virulent phylogroup among E. coli [145].”

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Authors: Johnson, J. R., & Stell, A. L.
Affiliations: University of Minnesota (US)
Corresponding author: Johnson, James R.
ORCID: Johnson, James R.
Stell, Adam L.
Venue: The Journal of Infectious Diseases
Publisher: Oxford University Press (OUP)
Published: 2000-01
Volume: 181
Issue: 1
Pages: 261-272
ISSN: 0022-1899 (ISSN-L)
1537-6613
DOI: 10.1086/315217
OpenAlex: W2138139644
Cited by: 1,269
References: 88
Citations by year: 2026: 28 · 2025: 44 · 2024: 43 · 2023: 42 · 2022: 67 · 2021: 63 · 2020: 71 · 2019: 55 · 2018: 59 · 2017: 59 · 2016: 67 · 2015: 75 · 2014: 75 · 2013: 64 · 2012: 54
FWCI: 18.94
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01dk047504-08)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 47504)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
Health Sciences › Medicine › Epidemiology › Urinary Tract Infections Management
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Enterobacteriaceae and Cronobacter Research
Keywords: Escherichia coli, urosepsis, virulence genes, extraintestinal pathogenic Escherichia coli, phylogenetic groups, fyuA, traT, serum resistance, pathogenicity islands, fimbriae, cytolethal distending toxin, PCR testing, molecular epidemiology
MeSH terms: Escherichia coli, Escherichia coli Infections, Genes, Bacterial, Genotype, Humans, Phylogeny, Urinary Tract Infections, Virulence, Washington, Polymerase Chain Reaction, Bacteremia, DNA Primers

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Extended Virulence Genotypes of Escherichia coli Strains from Patients with Urosepsis in Relation to Phylogeny and Host Compromise

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