Cited by 1,159Neuroscience and Neuropharmacology ResearchPharmacological Receptor Mechanisms and EffectsReceptor Mechanisms and Signaling

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Neurosteroids: endogenous regulators of the GABAA receptor

Belelli, Delia, Lambert, Jeremy J.·2005·Nature reviews. Neuroscience

DOI 10.1038/nrn1703

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Abstract

GABA(A) (gamma-aminobutyric acid type A) receptors mediate most of the 'fast' synaptic inhibition in the mammalian brain and are targeted by many clinically important drugs. Certain naturally occurring pregnane steroids can potently and specifically enhance GABA(A) receptor function in a nongenomic (direct) manner, and consequently have anxiolytic, analgesic, anticonvulsant, sedative, hypnotic and anaesthetic properties. These steroids not only act as remote endocrine messengers, but also can be synthesized in the brain, where they modify neuronal activity locally by modulating GABA(A) receptor function. Such 'neurosteroids' can influence mood and behaviour in various physiological and pathophysiological situations, and might contribute to the behavioural effects of psychoactive drugs.

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International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
Catterall, W. A., Chandy, K. G., Clapham, D. E., Gutman, G. A., Hofmann, F., Harmar, A. J., Abernethy, D. R., & Spedding, M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.5 · Cited by 7,126
Excitatory actions of gaba during development: the nature of the nurture
Ben-Ari, Y. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn920 · Cited by 2,448
Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors
Farrant, M., & Nusser, Z. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1625 · Cited by 2,081
Neuroactive steroids
Paul, S. M., & Purdy, R. H. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.6.1347506 · Cited by 1,413
International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function.
Barnard, E. A., Skolnick, P., Olsen, R. W., Möhler, H., Sieghart, W., Biggio, G., Bræstrup, C., Bateson, A. N., & Langer, S. Z. (1998) · PubMed · Cited by 1,204
Is there more to gaba than synaptic inhibition?
Owens, D. F., & Kriegstein, A. R. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn919 · Cited by 1,172
Receptor trafficking and synaptic plasticity
Collingridge, G. L., Isaac, J. T. R., & Wang, Y. T. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1556 · Cited by 1,046
Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain.
Purdy, R. H., Morrow, A. L., Moore, P. H., & Paul, S. M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.10.4553 · Cited by 951
Subunit Composition, Distribution and Function of GABA-A Receptor Subtypes
Sieghart, W., & Sperk, G. (2002) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026023393507 · Cited by 914
Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by δ subunit-containing GABA A receptors
Stell, B. M., Brickley, S. G., Tang, C., Farrant, M., & Módy, I. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2435457100 · Cited by 799

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Melcangi, R. C., Magnaghi, V., Galbiati, M. & Martini, L. in Neurosteroid and Brain Function (eds Biggio, G. & Purdy, R. H.) 146–176 (Academic, San Diego, 2001).
Sundstrom-Poromaa, I. in Neurosteroid Effects in the Central Nervous System: the Role of the GABAA Receptor (ed. Smith, S. S.) 291–304 (CRC, New York, 2004).
Mtchedlishvili, Z. & Kapur, J. in Neurosteroid Effects in the Central Nervous System: the Role of the GABAA Receptor (ed. Smith, S. S.) 305–316 (CRC, New York, 2004).
Gibbs, T. T. & Farb, D. H. in Neurosteroid Effects in the Central Nervous System: the Role of the GABAA Receptor (ed. Smith S. S.) 339–358 (CRC, New York, 2004).

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Authors: Belelli, D., & Lambert, J. J.
Affiliations: University of Dundee (GB)
Corresponding author: Lambert, Jeremy J.
ORCID: Belelli, Delia
Lambert, Jeremy J.
Venue: Nature reviews. Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2005-06-15
Volume: 6
Issue: 7
Pages: 565-575
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn1703
OpenAlex: W2070510853
Semantic Scholar: 1e15686792dd96994a0bd1337b50f1e4448b7965
Cited by: 1,159
References: 123
Citations by year: 2026: 32 · 2025: 40 · 2024: 45 · 2023: 51 · 2022: 49 · 2021: 52 · 2020: 53 · 2019: 49 · 2018: 54 · 2017: 43 · 2016: 57 · 2015: 57 · 2014: 71 · 2013: 64 · 2012: 55
FWCI: 5.43
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Discovery Research Portal (University of Dundee) (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Receptor Mechanisms and Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: neurosteroids, GABAA receptor, pregnane steroids, non-genomic steroid action, synaptic inhibition, anxiolytic effects, anticonvulsant activity, anesthesia, psychoactive substances
MeSH terms: Animals, Brain, Humans, Models, Biological, Neural Inhibition, Synaptic Transmission, Pregnanes, Receptors, GABA-A, Antipsychotic Agents, Mood Disorders

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Neurosteroids: endogenous regulators of the GABAA receptor

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