Neurosteroids: endogenous regulators of the GABAA receptor

International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels

Catterall, W. A., Chandy, K. G., Clapham, D. E., Gutman, G. A., Hofmann, F., Harmar, A. J., Abernethy, D. R., & Spedding, M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.5 · Cited by 7,126

Excitatory actions of gaba during development: the nature of the nurture

Ben-Ari, Y. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn920 · Cited by 2,448

Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors

Farrant, M., & Nusser, Z. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1625 · Cited by 2,081

Neuroactive steroids

Paul, S. M., & Purdy, R. H. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.6.1347506 · Cited by 1,413

International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function.

Barnard, E. A., Skolnick, P., Olsen, R. W., Möhler, H., Sieghart, W., Biggio, G., Bræstrup, C., Bateson, A. N., & Langer, S. Z. (1998) · PubMed · Cited by 1,204

Is there more to gaba than synaptic inhibition?

Owens, D. F., & Kriegstein, A. R. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn919 · Cited by 1,172

Receptor trafficking and synaptic plasticity

Collingridge, G. L., Isaac, J. T. R., & Wang, Y. T. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1556 · Cited by 1,046

Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain.

Purdy, R. H., Morrow, A. L., Moore, P. H., & Paul, S. M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.10.4553 · Cited by 951

Subunit Composition, Distribution and Function of GABA-A Receptor Subtypes

Sieghart, W., & Sperk, G. (2002) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026023393507 · Cited by 914

Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by δ subunit-containing GABA A receptors

Stell, B. M., Brickley, S. G., Tang, C., Farrant, M., & Módy, I. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2435457100 · Cited by 799

Mutations at the M2 and M3 Transmembrane Helices of the GABAARs α1 and β2 Subunits Affect Primarily Late Gating Transitions Including Opening/Closing and Desensitization

Terejko, K., Michałowski, M. A., Iżykowska, I., Dominik, A., Brzóstowicz, A., & Mozrzymas, J. W. (2021) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00151 · Cited by 10

Medroxyprogesterone acetate positively modulates specific GABAA-receptor subtypes - affecting memory and cognition

Das, R., Ragagnin, G., Sjöstedt, J., Johansson, M., Haage, D., Druzin, M., Johansson, S., & Bäckström, T. C. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105754 · Cited by 10

Modulation of GABAA receptors by neurosteroids. A new concept to improve cognitive and motor alterations in hepatic encephalopathy

Agustí, A., Llansola, M., Hernández‐Rabaza, V., Cabrera‐Pastor, A., Montoliu, C., & Felipo, V. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.08.020 · Cited by 10

Neurosteroid allopregnanolone reduces ipsilateral visual cortex potentiation following unilateral optic nerve injury

Sergeeva, E. G., Espinosa‐García, C., Atif, F., Pardue, M. T., & Stein, D. G. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.05.005 · Cited by 10

Inhibitable photolabeling by neurosteroid diazirine analog in the β3-Subunit of human hetereopentameric type A GABA receptors

Wu, B., Jayakar, S. S., Zhou, X., Titterton, K., Chiara, D. C., Szabo, A. L., Savechenkov, P. Y., Kent, D. E., Cohen, J. B., Forman, S. A., et al. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.11.019 · Cited by 10

Sexually divergent changes in select brain proteins and neurosteroid levels after a history of ethanol drinking and intermittent PTSD-like stress exposure in adult C57BL/6J mice

Devaud, L. L., Alavi, M., Jensen, J. P., Helms, M. L., Nipper, M. A., & Finn, D. A. (2018) · Alcohol · doi:10.1016/j.alcohol.2018.12.001 · Cited by 10

Endogenous neurosteroids pregnanolone and pregnanolone sulfate potentiate presynaptic glutamate release through distinct mechanisms

Smejkalová, T., Kořı́nek, M., Krůšek, J., Krausová, B. H., Candelas, M., Hajdukovic, D., Kudová, E., Chodounská, H., & Vyklický, L. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15529 · Cited by 9

Lost in promiscuity? An evolutionary and biochemical evaluation of HSD10 function in cardiolipin metabolism

Wohlfarter, Y., Eidelpes, R., Yu, R. D., Sailer, S., Koch, J. M., Karall, D., Scholl‐Bürgi, S., Amberger, A., Hillen, H. S., Zschocke, J., et al. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04579-6 · Cited by 10

Effects of acute microinjections of thyroid hormone to the preoptic region of euthyroid adult male rats on sleep and motor activity

Martin, J. V., Giannopoulos, P. F., Moffett, S. X., & James, T. D. (2013) · Brain Research · doi:10.1016/j.brainres.2013.01.032 · Cited by 10

The Combination of Metyrapone and Oxazepam for the Treatment of Cocaine and Other Drug Addictions

Goeders, N. E., Guerin, G. F., & Schmoutz, C. D. (2014) · Advances in pharmacology · doi:10.1016/b978-0-12-420118-7.00011-1 · Cited by 10

Functional Relevance of GABAA-Receptor Subtypes

Möhler, H. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-465-0_2 · Cited by 10

New insights into the mechanisms and prevention of central nervous system oxygen toxicity: A prospective review

Groborz, O., Maršálek, P., & Šefc, L. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123169 · Cited by 9

The impact of pharmacotherapy for premenstrual dysphoric disorder on sleep

Meth, E. M. S., Nôga, D. A., Dubol, M., Xue, P., Poromaa, I. S., & Benedict, C. (2025) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2025.102069 · Cited by 10

Acute stress impairs sensorimotor gating via the neurosteroid allopregnanolone in the prefrontal cortex

Cadeddu, R., Mosher, L. J., Nordkild, P., Gaikwad, N. W., Ratto, G. M., Scheggi, S., & Bortolato, M. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100489 · Cited by 10

Neurosteroid Modulation of Synaptic and Extrasynaptic GABAA Receptors of the Mouse Nucleus Accumbens

Mitchell, S. J., Phillips, G., Tench, B., Li, Y., Belelli, D., Martin, S. J., Swinny, J. D., Kelly, L., Atack, J. R., Paradowski, M., et al. (2024) · Biomolecules · doi:10.3390/biom14040460 · Cited by 9

Differentiation-dependent progesterone synthesis and metabolism in NT2-N human neurons

Pistritto, G., Papacleovoulou, G., Ragone, G., Cesare, S. D., Papaleo, V., Mason, J. I., & Barbaccia, M. L. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.03.008 · Cited by 9

Multiple roles for the first transmembrane domain of GABAA receptor subunits in neurosteroid modulation and spontaneous channel activity

Baker, C. N., Sturt, B. L., & Bamber, B. A. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.02.058 · Cited by 10

Involvement of GABAA receptors in 5-HT1A and σ1 receptor synergism on prefrontal dopaminergic transmission under circulating neurosteroid deficiency

Ago, Y., Hasebe, S., Hiramatsu, N., Mori, K., Watabe, Y., Onaka, Y., Hashimoto, H., Takuma, K., & Matsuda, T. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4353-3 · Cited by 9

Analgesic Effect of 17β-Estradiol on Nucleus Paragigantocellularis Lateralis of Male Rats Mediated Via GABAA Receptors

Khakpay, R., Azaddar, M., Khakpai, F., & Nemati, H. H. (2017) · Basic and Clinical Neuroscience Journal · doi:10.15412/j.bcn.03080107 · Cited by 9

Key players in progesterone and testosterone action: the metabolizing enzymes

Giatti, S., Diviccaro, S., & Melcangi, R. C. (2022) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2022.100319 · Cited by 9

Functional Alternatives to Alcohol

Nutt, D., Tyacke, R. J., Spriggs, M. J., Jacoby, V., Borthwick, A. D., & Belelli, D. (2022) · Nutrients · doi:10.3390/nu14183761 · Cited by 11

Neurosteroids as stress modulators and neurotherapeutics: lessons from the retina

Zorumski, C. F., Izumi, Y., Ishikawa, M., Nakazawa, T., Kunikata, H., Sato, K., & Covey, D. F. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.355752 · Cited by 10

Complex Metabolism of the Novel Neurosteroid, Ganaxolone, in Humans: A Unique Challenge for Metabolites in Safety Testing Assessment

Fitch, W. L., Smith, S. M., Saporito, M. S., Busse, G., Zhang, M., Ren, J., Fitzsimmons, M. E., Yi, P. C., English, S., Carter, A. N., et al. (2023) · Drug Metabolism and Disposition · doi:10.1124/dmd.122.001218 · Cited by 9

Neurosteroid modulation of arterial baroreflex function in the rostral ventrolateral medulla

Heesch, C. M. (2010) · Autonomic Neuroscience · doi:10.1016/j.autneu.2010.10.002 · Cited by 9

Localization of brain 5α-reductase messenger RNA in mice selectively bred for high chronic alcohol withdrawal severity

Roselli, C. E., Finn, T. J., Ronnekleiv‐Kelly, S. M., Tanchuck, M. A., Kaufman, K. R., & Finn, D. A. (2011) · Alcohol · doi:10.1016/j.alcohol.2011.08.002 · Cited by 9

Influence of gender and estrous cycle in the forced swim test in rats.

Gouvêia, A., Afonseca, T. L., Maximino, C., Domı́nguez, R., & Morato, S. (2008) · Psychology & Neuroscience · doi:10.3922/j.psns.2008.2.012 · Cited by 9

The metabolic fate and receptor interaction of 16α-hydroxyprogesterone and its 5α-reduced metabolite, 16α-hydroxy-dihydroprogesterone

van Rooyen, D., du Toit, T., Toit, R. L.-D., Africander, D., Swart, P., & Swart, A. C. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.09.025 · Cited by 9

Effects of perfluoroalkyl substances on neurosteroid synthetic enzymes in the rat

Xu, R.-A., Shen, Q., Li, S., Li, X., Li, H., Lu, Y. P., Lian, Q., & Ge, R. (2017) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.05.017 · Cited by 9

Effects of Fungicides on Rat’s Neurosteroid Synthetic Enzymes

Shen, X., Chen, F., Chen, L., Su, Y., Huang, P. C., & Ge, R. (2017) · BioMed Research International · doi:10.1155/2017/5829756 · Cited by 9

Neuroactive Steroids and Sex-Dimorphic Nervous Damage Induced by Diabetes Mellitus

Giatti, S., Diviccaro, S., & Melcangi, R. C. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-018-0613-6 · Cited by 9

Enhanced hippocampal type II theta activity AND altered theta architecture in mice lacking the Cav3.2 T-type voltage-gated calcium channel

Arshaad, M. I., Siwek, M. E., Henseler, C., Daubner, J., Ehninger, D., Hescheler, J., Sachinidis, A., Broich, K., Papazoglou, A., & Weiergräber, M. (2021) · Scientific Reports · doi:10.1038/s41598-020-79763-4 · Cited by 8

Comparative non-radioactive RT-PCR assay: An approach to study the neurosteroids biosynthetic pathway in humans

Luchetti, S., di Michele, F., Romeo, E., Brusa, L., Bernardi, G., Cummings, B. J., & Longone, P. (2005) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2005.11.005 · Cited by 9

Distinct mechanisms of allopregnanolone and diazepam underlie neuronal oscillations and differential antidepressant effect

Takasu, K., Yawata, Y., Tashima, R., Aritomi, H., Shimada, S., Onodera, T., Taishi, T., & Ogawa, K. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1274459 · Cited by 9

CGP7930 - An allosteric modulator of GABABRs, GABAARs and inwardly-rectifying potassium channels

Hannan, S. B., Penzinger, R., Mickute, G., & Smart, T. G. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109644 · Cited by 8

Allopregnanolone pleiotropic action in neurons and astrocytes: calcium signaling as a unifying mechanism

Wang, T., Chen, S., Mao, Z., Shang, Y., & Brinton, R. D. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1286931 · Cited by 8

17-β-estradiol potentiates the neurotrophic and neuroprotective effects mediated by the dopamine D3/acetylcholine nicotinic receptor heteromer in dopaminergic neurons

Sbrini, G., Mutti, V., Bono, F., Tomasoni, Z., Fadel, D., Missale, C., & Fiorentini, C. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176678 · Cited by 8

Lorediplon: A New GABAA Modulator Drug for Treatment of Insomnia

Aniello, F. D., Santos, B., & Guglietta, A. (2014) · Milestones in drug therapy · doi:10.1007/978-3-319-11514-6_6 · Cited by 8

Precise and accurate assay of pregnenolone and five other neurosteroids in monkey brain tissue by LC–MS/MS

Dury, A. Y., Ke, Y., & Labrie, F. (2016) · Steroids · doi:10.1016/j.steroids.2016.06.011 · Cited by 8

Hormones and Steroids as Neurotransmitters

Marwein, S., Biswal, S., & Acharya, P. C. (2020) · Springer eBooks · doi:10.1007/978-981-15-3556-7_14 · Cited by 8

Recent advances in the psychopharmacology of major depressive disorder

Alexander, L., & Young, A. H. (2022) · BJPsych Advances · doi:10.1192/bja.2022.14 · Cited by 8

Preclinical assessment of abuse liability of biologics: In defense of current regulatory control policies

Gauvin, D. V., Zimmermann, Z. J., & Baird, T. J. (2015) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2015.06.009 · Cited by 8

The use of symmetry in enantioselective synthesis: Four pairs of chrysene enantiomers prepared from 19-nortestosterone

Kudová, E., Rath, N. P., & Covey, D. F. (2011) · Organic & Biomolecular Chemistry · doi:10.1039/c1ob05385j · Cited by 8

Influences of non-canonical neurosteroid signaling on developing neural circuits

London, S. E. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.06.018 · Cited by 8

Pharmacological characterization of the excitatory ‘Cys‐loop’ GABA receptor family inCaenorhabditis elegans

Nicholl, G. C. B., Jawad, A. K., Weymouth, R., Zhang, H., & Beg, A. A. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13736 · Cited by 9

Design of a randomized controlled trial examining the efficacy and biological mechanisms of web-prolonged exposure and present-centered therapy for PTSD among active-duty military personnel and veterans

McLean, C. P., Rauch, S. A. M., Foa, E. B., Sripada, R. K., Tannahill, H. S., Mintz, J., Yarvis, J. S., Young‐McCaughan, S., Dondanville, K. A., Hall‐Clark, B. N., et al. (2017) · Contemporary Clinical Trials · doi:10.1016/j.cct.2017.11.008 · Cited by 9

Preemptive Analgesic Effect of Intrathecal Applications of Neuroactive Steroids in a Rodent Model of Post-Surgical Pain: Evidence for the Role of T-Type Calcium Channels

Tat, Q. L., Joksimovic, S. M., Krishnan, K., Covey, D. F., Todorovic, S. M., & Jevtović‐Todorović, V. (2020) · Cells · doi:10.3390/cells9122674 · Cited by 8

BST2 Suppresses LINE-1 Retrotransposition by Reducing the Promoter Activity of LINE-1 5′ UTR

Zhao, Y., Du, J., Wang, Y., Wang, Q., Wang, S., & Zhao, K. (2021) · Journal of Virology · doi:10.1128/jvi.01610-21 · Cited by 8

Brain allopregnanolone induces marked scratching behaviour in diet-induced atopic dermatitis mouse model

Fujii, M., Ohgami, S., Asano, E., Nakayama, T., Toda, T., Nabe, T., & Ohya, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-38858-3 · Cited by 8

Suppression of neurotransmission on gonadotropin-releasing hormone neurons in letrozole-induced polycystic ovary syndrome: A mouse model

Bhattarai, P., Rijal, S., Bhattarai, J. P., Cho, D. H., & Han, S. K. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1059255 · Cited by 7

Functional role of translocator protein and its ligands in ocular diseases (Review)

Yu, M., & Zhao, S. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13157 · Cited by 9

Positive association between dehydroepiandrosterone (DHEA) and gene expression of the gamma-aminobutyric acid (GABA-A) receptor δ subunit

Hamidovic, A., Cho, S., & Davis, J. M. (2024) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2024.106525 · Cited by 7

Identification of amino acids involved in histamine potentiation of GABAA receptors

Thiel, U., Platt, S. J., Wolf, S., Hatt, H. H., & Gisselmann, G. ⁄. N. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00106 · Cited by 7

Phasic GABAA‐mediated inhibition

Cherubini, E. (2010) · Epilepsia · doi:10.1111/j.1528-1167.2010.02799.x · Cited by 7

Regional Fos-expression induced by γ-hydroxybutyrate (GHB): Comparison with γ-butyrolactone (GBL) and effects of co-administration of the GABAB antagonist SCH 50911 and putative GHB antagonist NCS-382

Nieuwenhuijzen, P. S. V., McGregor, I. S., Chebib, M., & Hunt, G. E. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.07.056 · Cited by 7

Steroid hormone activation of wandering in the isolated nervous system of Manduca sexta

Miller, J. E., & Levine, R. B. (2006) · Journal of Comparative Physiology A · doi:10.1007/s00359-006-0143-4 · Cited by 6

A role of progesterone and its metabolites in regulation functions of the brain

Ivanova, G. P., Николаевна, Г. Л., Литвинов, А. В., Сергеевич, Б. В., & Василенко, Л. М. (2018) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro201811851129 · Cited by 7

A Benzodiazepine Ligand with Improved GABAA Receptor α5-Subunit Selectivity Driven by Interactions with Loop C

Simeone, X., Koniuszewski, F., Müllegger, M., Smetka, A., Steudle, F., Puthenkalam, R., Ernst, M. C., & Scholze, P. (2020) · Molecular Pharmacology · doi:10.1124/molpharm.120.000067 · Cited by 8

Different roles of T-type calcium channel isoforms in hypnosis induced by an endogenous neurosteroid epipregnanolone

Coulter, I. C., Stamenić, T. T., Eggan, P., Fine-Raquet, B., Corrigan, T., Covey, D. F., Yang, L., Pan, J. Q., & Todorovic, S. M. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108739 · Cited by 7

Hydroxylated biphenyl derivatives are positive modulators of human GABAA receptors

Mascia, M. P., Fabbri, D., Dettori, M. A., Ledda, G., Delogu, G., & Biggio, G. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.07.048 · Cited by 7

Fetal Hypothalamus-Pituitary-Adrenal Responses to Estradiol Sulfate

Wood, C. E. (2011) · Endocrinology · doi:10.1210/en.2011-0284 · Cited by 7

Interaction of diazepam and swim stress

Peričić, D., Štrac, D. Š., & Vlainić, J. (2007) · Brain Research · doi:10.1016/j.brainres.2007.09.039 · Cited by 7

17β-Nitro-5α-androstan-3α-ol and its 3β-methyl derivative: Neurosteroid analogs with potent anticonvulsant and anxiolytic activities

Runyon, S. P., Orr, M. D., Navarro, H. A., Kepler, J. A., Rogawski, M. A., Kaminski, R. M., & Cook, C. E. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.06.052 · Cited by 7

Neurosteroids and the Nervous System

King, S. R. (2012) · SpringerBriefs in neuroscience · doi:10.1007/978-1-4614-5559-2_1 · Cited by 7

Neurotransmitters

Wilkinson, M., & Brown, R. E. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9781139045803.006 · Cited by 7

Glia-Neuron Interactions: Neurosteroids and Epileptogenesis

Biagini, G., Marinelli, C., Panuccio, G., Puia, G., & Avoli, M. (2012) · IRIS UNIMORE (University of Modena and Reggio Emilia) · Cited by 7

Sterol regulatory element binding protein‐1C knockout mice show altered neuroactive steroid levels in sciatic nerve

Mitro, N., Cermenati, G., Audano, M., Giatti, S., Pesaresi, M., Pedretti, S., Spezzano, R., Caruso, D., & Melcangi, R. C. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14063 · Cited by 7

Pregnenolone does not interfere with the effects of cannabinoids on synaptic transmission in the cerebellum and the nucleus accumbens

Krohmer, A., Brehm, M., Auwärter, V., & Szabó, B. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.04.032 · Cited by 9

Neuroactive Steroids in Anxiety and Stress

Finn, D. A., & Purdy, R. H. (2007) · Wiley eBooks · doi:10.1002/9780470101001.hcn026 · Cited by 7

Key mRNAs and lncRNAs of pituitary that affect the reproduction of FecB + + small tail han sheep

Yang, J., Tang, J., He, X., Di, R., Zhang, X., Zhang, J., Guo, X., Hu, W., & Chu, M. (2024) · BMC Genomics · doi:10.1186/s12864-024-10191-8 · Cited by 6

Neuroactive steroids fluctuate with regional specificity in the central and peripheral nervous system across the rat estrous cycle

Cioffi, L., Diviccaro, S., Chrostek, G., Caruso, D., García‐Segura, L. M., Melcangi, R. C., & Giatti, S. (2024) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2024.106590 · Cited by 6

Neurosteroids and neurological disorders

Park, G., Kim, H., Won, S., Kim, N. H., & Choi, S. (2025) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.24.353 · Cited by 7

Quantification of ONO-2952 Occupancy of 18-kDaTranslocator Protein in Conscious Monkey Brains using Positron Emission Tomography

Mitsui, K., Morimoto, N., Niwa, T., Yamaura, Y., Ohba, H., Tsukada, H., & Katsumata, S. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.238568 · Cited by 6

Steroidogenesis and the initiation of parturition

Conley, A. J., & Reynolds, L. P. (2019) · Bioscientifica Proceedings · doi:10.1530/biosciprocs.8.028 · Cited by 6

Widespread Cortical Thickness Is Associated With Neuroactive Steroid Levels

Morey, R. A., Davis, S. L., Haswell, C. C., Naylor, J. C., Kilts, J. D., Szabo, S. T., Shampine, L. J., Parke, G. J., Sun, D., Swanson, C. A., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01118 · Cited by 6

Pharmacological administration of 3α,5α‐THP into the nucleus accumbens core increases 3α,5α‐THP expression and reduces alcohol self‐administration

Ornelas, L. C., Boero, G., Voorhies, K. V., O’Buckley, T. K., Besheer, J., & Morrow, A. L. (2023) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.15008 · Cited by 7

Early conversion of maternal androgens affects the embryo already in the first week of development

Wang, Y., Riedstra, B., Hulst, R., Noordhuis, R., & Groothuis, T. G. G. (2023) · Biology Letters · doi:10.1098/rsbl.2022.0593 · Cited by 6

Pregnenolone sulfate analogues differentially modulate GABAA receptor closed/desensitised states

Mortensen, M., Xu, Y., Shehata, M. A., Krall, J., Ernst, M. C., Frølund, B., & Smart, T. G. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16143 · Cited by 6

Isoallopregnanolone Inhibits Estrus Cycle-Dependent Aggressive Behavior

Bäckström, T. C., Bengtsson, S. K. S., Sjöstedt, J., Malinina, E., Johansson, M., Ragagnin, G., Ekberg, K., & Lundgren, P. (2023) · Biomolecules · doi:10.3390/biom13061017 · Cited by 6

Extra-Synaptic GABAA Receptor Potentiation and Neurosteroid-Induced Learning Deficits Are Inhibited by GR3027, a GABAA Modulating Steroid Antagonist

Bengtsson, S. K. S., Sjöstedt, J., Malinina, E., Das, R., Doverskog, M., Johansson, M., Haage, D., & Bäckström, T. C. (2023) · Biomolecules · doi:10.3390/biom13101496 · Cited by 6

Local effect of allopregnanolone in rat ovarian steroidogenesis, follicular and corpora lutea development

Cáceres, A. R. R., Cardone, D. A., Sanhueza, M. D. L. Á., Bosch, I. M., Cuello-Carrión, F. D., Rodriguez, G. B., Scotti, L., Parborell, F., Halperín, J., & Laconi, M. R. (2024) · Scientific Reports · doi:10.1038/s41598-024-57102-1 · Cited by 6

Direct measurements of neurosteroid binding to specific sites on GABAA receptors

Chintala, S. M., Tateiwa, H., Qian, M., Xu, Y., Amtashar, F. S., Chen, Z., Kirkpatrick, C. C., Bracamontes, J. R., Germann, A. L., Akk, G., et al. (2024) · British Journal of Pharmacology · doi:10.1111/bph.16490 · Cited by 6

Differential interactions engendered by benzodiazepine and neuroactive steroid combinations on schedule-controlled responding in rats

Gunter, B. W., Platt, D. M., & Rowlett, J. K. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.08.003 · Cited by 6

Acute effects of neurosteroids in a rodent model of primary paroxysmal dystonia

Hamann, M., Richter, F., & Richter, A. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.04.006 · Cited by 6

Genotype Differences in Sensitivity to the Anticonvulsant Effect of the Synthetic Neurosteroid Ganaxolone during Chronic Ethanol Withdrawal

Nipper, M. A., Jensen, J. P., Helms, M. L., Ford, M. M., Crabbe, J. C., Rossi, D. J., & Finn, D. A. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.11.045 · Cited by 6

Animal Model Approaches to Understanding the Neurobiology of Suicidal Behavior

Romay-Tallón, R., & Pinna, G. (2022) · Neuromethods · doi:10.1007/978-1-0716-2083-0_6 · Cited by 6

Aging Is Associated With Lower Neuroactive Steroids and Worsened Outcomes Following Cerebral Ischemia in Male Mice

Fernandez, N., Petit, A., Pianos, A., Haddad, L., Schumacher, M., Lière, P., & Guennoun, R. (2022) · Endocrinology · doi:10.1210/endocr/bqac183 · Cited by 6

Analysis of ketone‐based neurosteroids by reactive low‐temperature plasma mass spectrometry

Ding, X., Garikapati, V., Spengler, B., & Heiles, S. (2018) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.8180 · Cited by 6

Molecular-Cellular Targets of the Pathogenetic Action of Ethanol in the Human Brain in Ontogenesis and the Possibility of Targeted Therapy Aimed at Correcting the Effect of Pathogenic Factors

Шушпанова, Т. В., Солонский, А. В., & Shushpanova, O. V. (2018) · InTech eBooks · doi:10.5772/intechopen.73333 · Cited by 6

Superior mesenteric ganglion neural modulation of ovarian angiogenesis, apoptosis and proliferation by the neuroactive steroid allopregnanolone

Cáceres, A. R. R., Arboccó, F. C. V., Cardone, D. A., Sanhueza, M. D. L. Á., Casais, M., Orozco, A. S. V., & Laconi, M. R. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.13056 · Cited by 6

Neuronal Signaling Molecules and Leydig Cells

Mayerhofer, A. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-453-7_20 · Cited by 6

A 17β‐derivative of allopregnanolone is a neurosteroid antagonist at a cerebellar subpopulation of GABAAreceptors with nanomolar affinity

Maksay, G., Fodor, L., Bı́ró, T., Avlonitis, N., & Calogeropoulou, T. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707316 · Cited by 6

Steroid Receptor Isoform Expression in Drosophila Nociceptor Neurons Is Required for Normal Dendritic Arbor and Sensitivity

McParland, A., Follansbee, T., Vesenka, G. D., Panaitiu, A. E., & Ganter, G. K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140785 · Cited by 6

A New Look at the 5á-Reductase Inhibitor Finasteride

Finn, D. A., Beadles-Bohling, A. S., Beckley, E. H., Ford, M. M., Gililland, K. R., Gorin-Meyer, R. E., & Wiren, K. M. (2006) · Cited by 6

Cross-talk between Peptide Neurotransmitters and their Role in Homeostasis of Brain, Behavior, and Immunity

Rani, S., Yadav, S., & Ghorai, S. M. (2023) · Current Psychiatry Research and Reviews · doi:10.2174/0126660822262191231024081805 · Cited by 5

Identification of New Antiseizure Medication Candidates in Preclinical Animal Studies

Yang, C.-S., Wu, M.-C., Lai, M., Wu, S., & Huang, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713143 · Cited by 6

Drug repurposing reveals posaconazole as a CYP11A1 inhibitor enhancing anti-tumor immunity

Pramanik, J., Shaji, S. K., Zaman, M., Brown, B., Zhang, B., Yamashita-Kanemaru, Y., Homer, N. Z. M., Hussein, H. A. M., Zhao, Q., Okkenhaug, K., et al. (2025) · iScience · doi:10.1016/j.isci.2025.112488 · Cited by 5

Effects of gallates on 5α-reductase type 1: structure-activity relationship and implications for neurosteroid balance in neuropsychiatric disorders

Zhang, P., Li, W., Lu, X., Qi, S., Fang, H., Chen, J., Mao, B., Ge, R., & Wang, Y. (2025) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2025.111650 · Cited by 5

GABA Receptors in the Medial Preoptic Area Modulate the Onset of Oestradiol‐Induced Maternal Behaviour in Hysterectomised‐Ovariectomised, Pregnant Rats

Gómora‐Arrati, P., Dominguez, G., & Ågmo, A. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12434 · Cited by 5

Trajectories of Allopregnanolone and Allopregnanolone to Progesterone Ratio across the Six Subphases of Menstrual Cycle

Hamidovic, A., Davis, J. M., Soumare, F., Datta, A., & Naveed, A. (2023) · Biomolecules · doi:10.3390/biom13040652 · Cited by 5

Advances in steroid research from the pioneering neurosteroid concept to metabolomics: New insights into pregnenolone function

Vallée, M. (2023) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2023.101113 · Cited by 5

Neurosteroid modulation of recombinant and synaptic GABAA receptors

Lambert, J. J., Harney, S. C., Belelli, D., & Peters, J. A. (2001) · International review of neurobiology · doi:10.1016/s0074-7742(01)46063-6 · Cited by 42

Modulation of native and recombinant GABAA receptors by endogenous and synthetic neuroactive steroids

Lambert, J. J., Belelli, D., Harney, S. C., Peters, J. A., & Frenguelli, B. G. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00124-2 · Cited by 164

Neurosteroid modulation of synaptic and extrasynaptic GABAA receptors

Herd, M. B., Belelli, D., & Lambert, J. J. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.03.007 · Cited by 206

Neurosteroid modulation of GABAA receptors

Lambert, J. J., Belelli, D., Peden, D. R., Vardy, A., & Peters, J. A. (2003) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2003.09.001 · Cited by 498

Neurosteroids and GABA-A Receptor Function

Wang, M. (2011) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00044 · Cited by 207