Neurosteroids: endogenous regulators of the GABAA receptor

International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels

Catterall, W. A., Chandy, K. G., Clapham, D. E., Gutman, G. A., Hofmann, F., Harmar, A. J., Abernethy, D. R., & Spedding, M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.5 · Cited by 7,126

Excitatory actions of gaba during development: the nature of the nurture

Ben-Ari, Y. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn920 · Cited by 2,448

Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors

Farrant, M., & Nusser, Z. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1625 · Cited by 2,081

Neuroactive steroids

Paul, S. M., & Purdy, R. H. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.6.1347506 · Cited by 1,413

International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function.

Barnard, E. A., Skolnick, P., Olsen, R. W., Möhler, H., Sieghart, W., Biggio, G., Bræstrup, C., Bateson, A. N., & Langer, S. Z. (1998) · PubMed · Cited by 1,204

Is there more to gaba than synaptic inhibition?

Owens, D. F., & Kriegstein, A. R. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn919 · Cited by 1,172

Receptor trafficking and synaptic plasticity

Collingridge, G. L., Isaac, J. T. R., & Wang, Y. T. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1556 · Cited by 1,046

Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain.

Purdy, R. H., Morrow, A. L., Moore, P. H., & Paul, S. M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.10.4553 · Cited by 951

Subunit Composition, Distribution and Function of GABA-A Receptor Subtypes

Sieghart, W., & Sperk, G. (2002) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026023393507 · Cited by 914

Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by δ subunit-containing GABA A receptors

Stell, B. M., Brickley, S. G., Tang, C., Farrant, M., & Módy, I. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2435457100 · Cited by 799

Synthesis and pharmacological evaluation of neurosteroid photoaffinity ligands

Savechenkov, P. Y., Chiara, D. C., Desai, R., Stern, A. T., Zhou, X., Ziemba, A. M., Szabo, A. L., Zhang, Y., Cohen, J. B., Forman, S. A., et al. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.04.043 · Cited by 15

Current Perspectives for the use of Gonane Progesteronergic Drugs in the Treatment of Central Hypoventilation Syndromes

Loiseau, C., Cayetanot, F., Joubert, F., Perrin‐Terrin, A., Cardot, P., Fiamma, M., Frugière, A., Straus, C., & Bodineau, L. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170719104605 · Cited by 18

Expression and purification of a functional heteromeric GABAA receptor for structural studies

Claxton, D. P., & Gouaux, E. (2018) · PLoS ONE · doi:10.1371/journal.pone.0201210 · Cited by 15

Effects of paroxetine treatment and its withdrawal on neurosteroidogenesis

Giatti, S., Diviccaro, S., Cioffi, L., Falvo, E., Caruso, D., & Melcangi, R. C. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105364 · Cited by 16

Non-sedative cortical EEG signatures of allopregnanolone and functional comparators

Lambert, P. M., Ni, R., Benz, A. M., Rensing, N. R., Wong, M., Zorumski, C. F., & Mennerick, S. J. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01450-x · Cited by 16

Cholesterol metabolite cholestane-3β,5α,6β-triol suppresses epileptic seizures by negative modulation of voltage-gated sodium channels

Tang, L., Wang, Y., Leng, T., Sun, H., Zhou, Y., Zhu, W., Qiu, P., Zhang, J., Lu, B., Yan, M., et al. (2015) · Steroids · doi:10.1016/j.steroids.2014.12.025 · Cited by 15

GABAergic compensation in connexin36 knock-out mice evident during low-magnesium seizure-like event activity

Voss, L. J., Melin, S., Jacobson, G. M., & Sleigh, J. W. (2010) · Brain Research · doi:10.1016/j.brainres.2010.09.002 · Cited by 15

Alcohol Exposure During Late Adolescence Increases Drinking in Adult Wistar Rats, an Effect that is not Reduced by Finasteride

Milivojevic, V., & Covault, J. (2012) · Alcohol and Alcoholism · doi:10.1093/alcalc/ags105 · Cited by 15

During postnatal development endogenous neurosteroids influence GABA-ergic neurotransmission of mouse cortical neurons

Brown, A. R., Mitchell, S. J., Peden, D. R., Herd, M. B., Seifi, M., Swinny, J. D., Belelli, D., & Lambert, J. J. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.11.019 · Cited by 15

Exploring the molecular basis of neurosteroid binding to the β3 homopentameric GABAA receptor

Álvarez, L. D., & Estrin, D. A. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.07.012 · Cited by 15

Behavioral and electromyographic assessment of oxaliplatin-induced motor dysfunctions: Evidence for a therapeutic effect of allopregnanolone

Taleb, O., Bouzobra, F., Tekin-Pala, H., Meyer, L., Mensah‐Nyagan, A. G., & Patte‐Mensah, C. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.10.040 · Cited by 18

Endogenous neurosteroids influence synaptic GABAAreceptors during postnatal development

Belelli, D., Brown, A. R., Mitchell, S. J., Gunn, B. G., Herd, M. B., Phillips, G. D., Seifi, M., Swinny, J. D., & Lambert, J. J. (2017) · Journal of Neuroendocrinology · doi:10.1111/jne.12537 · Cited by 15

Functional coupling of GABAA/Breceptors and the channel TRPV4 mediates rapid progesterone signaling in the oviduct

Jung, C., Fernández‐Dueñas, V., Plata, C., García-Elías, A., Ciruela, F., Fernández‐Fernández, J. M., & Valverde, M. A. (2018) · Science Signaling · doi:10.1126/scisignal.aam6558 · Cited by 15

Neuroprotective actions of cerebellar and pineal allopregnanolone on Purkinje cells

Tsutsui, K., & Haraguchi, S. (2020) · FASEB BioAdvances · doi:10.1096/fba.2019-00055 · Cited by 15

The Anaesthetic Steroid Alphaxalone Positively Modulates α1-Glycine Receptor Function

Ahrens, J., Leuwer, M., Demir, R., Krampfl, K., Foadi, N., & Haeseler, G. (2008) · Pharmacology · doi:10.1159/000156489 · Cited by 15

Anticonvulsant doses of ganaxolone do not compromise motor performance in immature rats

Mareš, P., & Stehlíková, M. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.12.037 · Cited by 15

Induction of Akt by endogenous neurosteroids and calcium sequestration in P19 derived neurons

Xilouri, M., & Papazafiri, P. (2008) · Neurotoxicity Research · doi:10.1007/bf03033504 · Cited by 15

The effects of acute, chronic and withdrawn progesterone in male and female Mongolian gerbils (Meriones unguiculatus) in two tests of anxiety

Starkey, N. J., & Bridges, N. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.10.039 · Cited by 14

Ethanol Modulates the Interaction of the Endogenous Neurosteroid Allopregnanolone with the α1β2γ2L GABAA Receptor

Akk, G., Li, P., Manion, B. D., Evers, A. S., & Steinbach, J. H. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.029942 · Cited by 15

Neurosteroids as Selective Inhibitors of Glycine Receptor Activity: Structure-Activity Relationship Study on Endogenous Androstanes and Androstenes

Bukanova, J. V., Solntseva, E. I., & Kudová, E. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00044 · Cited by 14

Diabetic Encephalopathy in a Preclinical Experimental Model of Type 1 Diabetes Mellitus: Observations in Adult Female Rat

Falvo, E., Giatti, S., Diviccaro, S., Cioffi, L., Herian, M., Brivio, P., Calabrese, F., Caruso, D., & Melcangi, R. C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021196 · Cited by 14

Effects of Pregnanolone Glutamate and Its Metabolites on GABA A and NMDA Receptors and Zebrafish Behavior

Abramova, V., Alvarado, V. L., Hill, M., Smejkalová, T., Malý, M., Valeš, K., Dittert, I., Božíková, P., Kysilov, B., Krausová, B. H., et al. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00131 · Cited by 14

Local Effects of Steroid Hormones within the Bone Microenvironment

Sandor, L. F., Ragacs, R., & Győri, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417482 · Cited by 14

Effect of maternal administration of allopregnanolone before birth asphyxia on neonatal hippocampal function in the spiny mouse

Fleiss, B., Parkington, H. C., Coleman, H. A., Dickinson, H., Yawno, T., Castillo-Meléndez, M., Hirst, J. J., & Walker, D. W. (2011) · Brain Research · doi:10.1016/j.brainres.2011.11.035 · Cited by 14

Temporal lobe epilepsy exacerbation during pharmacological inhibition of endogenous neurosteroid synthesis

Pugnaghi, M., Monti, G., Biagini, G., & Meletti, S. (2013) · BMJ Case Reports · doi:10.1136/bcr-2012-008204 · Cited by 14

Increased Superoxide Dismutase 2 by Allopregnanolone Ameliorates ROS-Mediated Neuronal Death in Mice with Pilocarpine-Induced Status Epilepticus

Cho, I., Kim, W., Kim, H., Heo, K., Lee, B., & Cho, Y.-J. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2561-4 · Cited by 13

Allopregnanolone Protects Against Dopamine‐Induced Striatal Damage After In Vitro Ischaemia via Interaction at GABAA Receptors

Knight, S. R., Davidson, C., Young, A. M. J., & Gibson, C. L. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02319.x · Cited by 14

GABAA Receptor-Mediated Tonic Depolarization in Developing Neural Circuits

Lu, J., Hsiao, Y., Chiang, C.-W., & Wang, C. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8548-x · Cited by 14

Benzodiazepine and neuroactive steroid combinations in rats: anxiolytic-like and discriminative stimulus effects

Gunter, B. W., Jones, S. A., Paul, I. A., Platt, D. M., & Rowlett, J. K. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4369-8 · Cited by 14

Dehydroepiandrosterone and Pregnenolone Alterations in Schizophrenia

Ritsner, M. S., Gibel, A., Ratner, Y., & Weizman, A. (2008) · Springer eBooks · doi:10.1007/978-1-4020-6854-6_14 · Cited by 14

Investigation of the anticonvulsive effect of acute immobilization stress in anxious Balb/cByJ mice using GABAA-related mechanistic probes

Verleye, M., Heulard, I., & Gillardin, J. (2008) · Psychopharmacology · doi:10.1007/s00213-007-1066-7 · Cited by 14

Neurosteroid analogues. Part 13: Synthetic methods for the preparation of 2β-hydroxygonane derivatives as structural mimics of ent-3α-hydroxysteroid modulators of GABAA receptors

Wang, C., Rath, N. P., & Covey, D. F. (2007) · Tetrahedron · doi:10.1016/j.tet.2007.05.068 · Cited by 14

Neurosteroid Replacement Therapy for Catamenial Epilepsy

Reddy, D. S., & Rogawski, M. A. (2010) · Epilepsy · doi:10.1201/9781420085594-c28 · Cited by 14

GABA-B1 Receptor-Null Schwann Cells Exhibit Compromised In Vitro Myelination

Faroni, A., Melfi, S., Castelnovo, L. F., Bonalume, V., Colleoni, D., Magni, P., Araúzo-Bravo, M. J., Reinbold, R. A., & Magnaghi, V. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1158-x · Cited by 13

Cocaine Exposure Increases Excitatory Synaptic Transmission and Intrinsic Excitability in the Basolateral Amygdala in Male and Female Rats and Across the Estrous Cycle

Corbett, C. M., Miller, E. N., Wannen, E. E., Rood, B. D., Chandler, D. J., & Loweth, J. A. (2023) · Neuroendocrinology · doi:10.1159/000531351 · Cited by 13

Allopregnanolone and its antagonist modulate neuroinflammation and neurological impairment

Bäckström, T. C., Doverskog, M., Blackburn, T. P., Scharschmidt, B. F., & Felipo, V. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105668 · Cited by 14

Expanding the therapeutic potential of neuro(active)steroids: a promising strategy for hyperdopaminergic behavioral phenotypes

Scheggi, S., Concas, L., Corsi, S., Carta, M., Melis, M., & Frau, R. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105842 · Cited by 13

Pharmacokinetics of hard micronized progesterone capsules via vaginal or oral route compared with soft micronized capsules in healthy postmenopausal women: a randomized open-label clinical study

Wang, H., Liu, M., Fu, Q., & Deng, C. (2019) · Drug Design Development and Therapy · doi:10.2147/dddt.s204624 · Cited by 13

Lithium ion adduction enables UPLC-MS/MS-based analysis of multi-class 3-hydroxyl group-containing keto-steroids

Wang, Q., Shimizu, K., Maehata, K., Pan, Y., Sakurai, K., Hikida, T., Fukada, Y., & Takao, T. (2020) · Journal of Lipid Research · doi:10.1194/jlr.d119000588 · Cited by 13

Neuroendocrine biomarkers of prolonged exposure treatment response in military-related PTSD

Rauch, S. A. M., Sripada, R. K., Burton, M. S., Michopoulos, V., Kerley, K. A., Marx, C. E., Kilts, J. D., Naylor, J. C., ROTHBAUM, B. O., McLean, C. P., et al. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104749 · Cited by 13

Augmentation of endogenous neurosteroid synthesis alters experimental status epilepticus dynamics

Lucchi, C., Costa, A., Senn, L., Messina, S., Rustichelli, C., & Biagini, G. (2020) · Epilepsia · doi:10.1111/epi.16654 · Cited by 13

Preventing Phosphorylation of the GABAAR β3 Subunit Compromises the Behavioral Effects of Neuroactive Steroids

Vien, T. N., Ackley, M. A., Doherty, J., Moss, S. J., & Davies, P. A. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.817996 · Cited by 13

Gut Inflammation Induced by Finasteride Withdrawal: Therapeutic Effect of Allopregnanolone in Adult Male Rats

Diviccaro, S., Giatti, S., Cioffi, L., Falvo, E., Herian, M., Caruso, D., & Melcangi, R. C. (2022) · Biomolecules · doi:10.3390/biom12111567 · Cited by 16

Neurosteroids as positive and negative allosteric modulators of ligand-gated ion channels: P2X receptor perspective

Sivcev, S., Kudová, E., & Zemkova, H. W. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109542 · Cited by 15

The GABA system, a new target for medications against cognitive impairment—Associated with neuroactive steroids

Bäckström, T. C., Türkmen, Ş., Das, R., Doverskog, M., & Blackburn, T. P. (2023) · Journal of Internal Medicine · doi:10.1111/joim.13705 · Cited by 14

Retrochalcone derivatives are positive allosteric modulators at synaptic and extrasynaptic GABAA receptors in vitro

Jiang, R., Miyamoto, A., Martz, A., Specht, A., Ishibashi, H., Kueny‐Stotz, M., Chassaing, S., Brouillard, R., de Carvalho, L. P., Goeldner, M. P., et al. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01142.x · Cited by 13

Sex differences in acute ethanol withdrawal severity after adrenalectomy and gonadectomy in Withdrawal Seizure-Prone and Withdrawal Seizure-Resistant mice

Strong, M. N., Kaufman, K. R., Crabbe, J. C., & Finn, D. A. (2009) · Alcohol · doi:10.1016/j.alcohol.2009.07.001 · Cited by 13

Neurosteroids increase tonic GABAergic inhibition in the lateral section of the central amygdala in mice

Parra, H. R., Blaesse, P., Sosulina, L., & Pape, H. (2015) · Journal of Neurophysiology · doi:10.1152/jn.00045.2015 · Cited by 13

GABAA receptor-mediated tonic currents in substantia gelatinosa neurons of rat spinal trigeminal nucleus pars caudalis

Han, S.-M., & Youn, D. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.06.048 · Cited by 13

Anti-anhedonic effect of selective serotonin reuptake inhibitors with affinity for sigma-1 receptors in picrotoxin-treated mice

Hasebe, S., Ago, Y., Watabe, Y., Oka, S., Hiramatsu, N., Tanaka, T., Umehara, C., Hashimoto, H., Takuma, K., & Matsuda, T. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13692 · Cited by 13

Calcium-engaged Mechanisms of Nongenomic Action of Neurosteroids

Rębas, E., Radzik, T., Boczek, T., & Żylińska, L. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170329091935 · Cited by 16

Isotope Dilution-Based Targeted and Nontargeted Carbonyl Neurosteroid/Steroid Profiling

Sharp, S., Mitchell, S. J., Vallée, M., Kuzmanova, E., Cooper, M. A., Belelli, D., Lambert, J. J., & Huang, J. T.-J. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b00055 · Cited by 13

Modulation of GABA and glycine receptors in rat pyramidal hippocampal neurones by 3α5β-pregnanolone derivatives

Bukanova, J. V., Solntseva, E. I., Kolbaev, S. N., & Kudová, E. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.06.002 · Cited by 13

Inhibition of multiple voltage-gated calcium channels may contribute to spinally mediated analgesia by epipregnanolone in a rat model of surgical paw incision

Joksimovic, S. L., Donald, R., Park, J.-Y., & Todorovic, S. M. (2019) · Channels · doi:10.1080/19336950.2018.1564420 · Cited by 13

GABAA receptors in GtoPdb v.2021.3

Belelli, D., Hales, T. G., Lambert, J. J., Lüscher, B., Olsen, R. W., Peters, J. A., Rudolph, U., & Sieghart, W. (2021) · IUPHAR/BPS Guide to Pharmacology CITE · doi:10.2218/gtopdb/f72/2021.3 · Cited by 12

Neonatal allopregnanolone or finasteride administration modifies hippocampal K+ Cl− co-transporter expression during early development in male rats

Mòdol, L., Casas, C., Llidó, A., Navarro, X., Pallarés, M., & Darbra, S. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.05.002 · Cited by 13

Testosterone and Myelin Regeneration in the Central Nervous System

Schumacher, M., Ghoumari, A. M., Mattern, C., Bougneres, P. F., & Traiffort, É. (2021) · Androgens Clinical Research and Therapeutics · doi:10.1089/andro.2021.0023 · Cited by 14

Sedative and hypnotic effects of the saponins from a traditional edible plant Liriope spicata Lour. in PCPA-induced insomnia mice

Li, Y.-M., Shen, C., & Jiang, J. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118049 · Cited by 14

Neuroactive steroid exposure impacts neurodevelopment: Comparison of human and rodent placental contribution

Vacher, C., Tsompanidis, A., Firestein, M. R., & Penn, A. A. (2025) · Journal of Neuroendocrinology · doi:10.1111/jne.13489 · Cited by 13

Transcription of GABAA receptor subunits in circulating monocytes and association to emotional brain function in premenstrual dysphoric disorder

Stiernman, L., Comasco, E., Johansson, M., & Bixo, M. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03465-6 · Cited by 13

Rescue of deficient amygdala tonic γ‐aminobutyric acidergic currents in theFmr–/ymouse model of fragile X syndrome by a novel γ‐aminobutyric acid type A receptor‐positive allosteric modulator

Martin, B. S., Martínez-Botella, G., Loya, C. M., Salituro, F. G., Robichaud, A. J., Huntsman, M. M., Ackley, M. A., Doherty, J., & Corbin, J. G. (2015) · Journal of Neuroscience Research · doi:10.1002/jnr.23632 · Cited by 13

Self-tuning interfacial architecture for Estradiol detection by surface plasmon resonance biosensor

Boltovets, P., Shinkaruk, S., Vellutini, L., & Снопок, Б. А. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.11.017 · Cited by 12

Allopregnanolone suppresses mechanical allodynia and internalization of neurokinin-1 receptors at the spinal dorsal horn in a rat postoperative pain model

Fujita, M., Fukuda, T., Sato, Y., Takasusuki, T., & Tanaka, M. (2018) · The Korean journal of pain · doi:10.3344/kjp.2018.31.1.10 · Cited by 12

The novel rapid-acting neurosteroid-based antidepressant generation

Günay, A., & Pinna, G. (2022) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2022.100340 · Cited by 12

The Mitochondrial Enzyme 17βHSD10 Modulates Ischemic and Amyloid-β-Induced Stress in Primary Mouse Astrocytes

Metodieva, V., Smith, T., & Gunn‐Moore, F. J. (2022) · eNeuro · doi:10.1523/eneuro.0040-22.2022 · Cited by 15

Biomarkers and treatments for mood disorders encompassing the neurosteroid and endocannabinoid systems

Pinna, G. (2022) · Journal of Neuroendocrinology · doi:10.1111/jne.13226 · Cited by 12

What is special about the adolescent (JME) brain?

Craiu, D. (2013) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2012.12.008 · Cited by 12

Role of Acetaldehyde in Ethanol‐Induced Elevation of the Neuroactive Steroid 3α‐Hydroxy‐5α‐Pregnan‐20‐One in Rats

Boyd, K. N., O’Buckley, T. K., & Morrow, A. L. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00762.x · Cited by 12

Dynamic Adaptation in Neurosteroid Networks in Response to Alcohol

Finn, D. A., & Jimenez, V. A. (2017) · Handbook of experimental pharmacology · doi:10.1007/164_2017_82 · Cited by 13

Neuromodulation of Hippocampal Cells and Circuits

Cobb, S., & Lawrence, J. J. (2010) · Springer eBooks · doi:10.1007/978-1-4419-0996-1_7 · Cited by 13

Elucidating GABAB and GABAB Receptor Functions in Anxiety Using the Stress-Induced Hyperthermia Paradigm: A Review

Vinkers, C. H., Cryan, J. F., Olivier, B., & Groenink, L. (2010) · The Open Pharmacology Journal · doi:10.2174/1874143601004010001 · Cited by 12

Cellular localization of 5α-reductase in the rat cerebellum

Kiyokage, E., Toida, K., Suzuki-Yamamoto, T., & Ishimura, K. (2014) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2014.04.002 · Cited by 13

Regulation of α3-containing GABAA receptors in guinea-pig adrenal medullary cells by adrenal steroids

Inoue, M., Harada, K., Nakamura, J., & Matsuoka, H. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.046 · Cited by 10

Changes in ventral respiratory column GABAaR ε- and δ-subunits during hibernation mediate resistance to depression by EtOH and pentobarbital

Hengen, K. B., Gómez, T. M., Stang, K., Johnson, S. M., & Behan, M. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00607.2010 · Cited by 12

Replacement with GABAergic steroid precursors restores the acute ethanol withdrawal profile in adrenalectomy/gonadectomy mice

Kaufman, K. R., Tanchuck, M. A., Strong, M. N., & Finn, D. A. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.11.075 · Cited by 12

Synthesis and GABAA receptor activity of A-homo analogues of neuroactive steroids

Dansey, M. V., Chenna, P. H. D., Veleiro, A. S., Krištofíková, Z., Chodounská, H., Kasal, A., & Burton, G. (2010) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2010.03.037 · Cited by 12

A controlled randomized clinical trial to assess postoperative analgesia after thiopental–isoflurane anaesthesia or total intravenous anaesthesia with alfaxalone in dogs

Bennell, P. M., Whittem, T., & Tudor, E. M. (2019) · Journal of Veterinary Pharmacology and Therapeutics · doi:10.1111/jvp.12740 · Cited by 12

Neurosteroids: a lifelong impact on brain health

Walton, N. L., & Maguire, J. L. (2025) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2025.1644615 · Cited by 11

Upregulation of HSD11B1 promotes cortisol production and inhibits NK cell activation in pancreatic adenocarcinoma

Zhang, H., Liu, A., Bo, W., Zhang, M., Wang, H., Feng, X., & Wu, Y. (2024) · Molecular Immunology · doi:10.1016/j.molimm.2024.08.005 · Cited by 11

The role of neuroactive steroids in psychiatric and neurological disorders: Neurobiology and therapeutic perspectives

Pinna, G., & Bortolato, M. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106438 · Cited by 12

Local Changes in Neurosteroid Levels in the Substantia Nigra Reticulata and the Ventral Tegmental Area Alter Chronic Ethanol Withdrawal Severity in Male Withdrawal Seizure‐Prone Mice

Tanchuck, M. A., Cozzoli, D. K., He, I., Kaufman, K. R., Snelling, C., Crabbe, J. C., Mark, G. P., & Finn, D. A. (2012) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12027 · Cited by 11

Inhibition of 5α-reductase alters pregnane metabolism in the late pregnant mare

Wynn, M. A. A., Ball, B. A., Legacki, E. L., Conley, A. J., Loux, S. C., May, J. B., Esteller‐Vico, A., Stanley, S. D., Scoggin, K. E. S., Squires, E. L., et al. (2018) · Reproduction · doi:10.1530/rep-17-0380 · Cited by 11

Neurosteroid allopregnanolone inhibits glutamate release from rat cerebrocortical nerve terminals

Chang, Y., Hsieh, H. L., Huang, S.-K., & Wang, S. (2018) · Synapse · doi:10.1002/syn.22076 · Cited by 11

Therapeutic Potential of GABAergic Signaling in Myelin Plasticity and Repair

Reyes‐Haro, D., Cisneros-Mejorado, A., & Arellano, R. O. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.662191 · Cited by 11

Null Mutation of 5α-Reductase Type I Gene Alters Ethanol Consumption Patterns in a Sex-Dependent Manner

Ford, M. M., Nickel, J. D., Kaufman, M. N., & Finn, D. A. (2014) · Behavior Genetics · doi:10.1007/s10519-014-9694-2 · Cited by 11

Interactions of L-3,5,3'-Triiodothyronine, Allopregnanolone, and Ivermectin with the GABAA Receptor: Evidence for Overlapping Intersubunit Binding Modes

Westergard, T., Salari, R., Martin, J. V., & Brannigan, G. H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139072 · Cited by 12

Effects ofGabra2Point Mutations on Alcohol Intake: Increased Binge‐Like and Blunted Chronic Drinking by Mice

Newman, E. L., Gunner, G., Huynh, P., Gachette, D., Moss, S. J., Smart, T. G., Rudolph, U., DeBold, J. F., & Miczek, K. A. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13215 · Cited by 11

Residence Time, a New parameter to Predict Neurosteroidogenic Efficacy of Translocator Protein (TSPO) Ligands: the Case Study of N,N‐Dialkyl‐2‐arylindol‐3‐ylglyoxylamides

Costa, B., Taliani, S., Pozzo, E. D., Barresi, E., Robello, M., Cavallini, C., Cosconati, S., Settimo, F. D., Novellino, E., & Martini, C. (2017) · ChemMedChem · doi:10.1002/cmdc.201700220 · Cited by 13

Discovery of neurosteroid glucuronides in mouse brain

Kallonen, S., Tammimäki, A., Piepponen, P. T., Raattamaa, H., Ketola, R. A., & Kostiainen, R. K. (2009) · Analytica Chimica Acta · doi:10.1016/j.aca.2009.07.059 · Cited by 11

Phasic GABAA-Mediated Inhibition

Cherubini, E. (2012) · Oxford University Press eBooks · doi:10.1093/med/9780199746545.003.0008 · Cited by 12

GABA and Sleep: Molecular, Functional and Clinical Aspects

Reite, M. L. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11010133 · Cited by 11

GABAA Receptor

Olsen, R. W., & Li, G.-D. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-378630-2.00339-x · Cited by 11

Pre- and postsynaptic modulation of hippocampal inhibitory synaptic transmission by pregnenolone sulphate

Seljeset, S., Liebowitz, S., Bright, D. P., & Smart, T. G. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109530 · Cited by 11

The extra-adrenal effects of metyrapone and oxazepam on ongoing cocaine self-administration

Guerin, G. F., Schmoutz, C. D., & Goeders, N. E. (2014) · Brain Research · doi:10.1016/j.brainres.2014.05.039 · Cited by 10

Neurosteroidal modulation of in vitro epileptiform activity is enhanced in pilocarpine-treated epileptic rats

Shiri, Z., Herrington, R., Lévesque, M., & Avoli, M. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.03.020 · Cited by 10

Effect of neurosteroids on a model lipid bilayer including cholesterol: An Atomic Force Microscopy study

Sacchi, M., Balleza, D., Vena, G., Puia, G., Facci, P., & Alessandrini, A. (2015) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2015.01.002 · Cited by 10

Ethanol withdrawal-induced dysregulation of neurosteroid levels in plasma, cortex, and hippocampus in genetic animal models of high and low withdrawal

Jensen, J. P., Nipper, M. A., Helms, M. L., Ford, M. M., Crabbe, J. C., Rossi, D. J., & Finn, D. A. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4671-0 · Cited by 10

Using the NGF/IL-6 ratio as a reliable criterion to show the beneficial effects of progesterone after experimental diffuse brain injury

Shirazpour, S., Khaksari, M., Nader, S., Iranpour, M., Shahryari, M., Jafari, E., & Salmani, N. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e03844 · Cited by 10

Neuroactive Type-A γ-Aminobutyric Acid Receptor Allosteric Modulator Steroids from the Hypobranchial Gland of Marine Mollusk, Conus geographus

Niu, C., Leavitt, L. S., Lin, Z., Paguigan, N. D., Sun, L., Zhang, J., Torres, J. P., Raghuraman, S., Chase, K., Cadeddu, R., et al. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00562 · Cited by 10

Neurosteroid modulation of recombinant and synaptic GABAA receptors

Lambert, J. J., Harney, S. C., Belelli, D., & Peters, J. A. (2001) · International review of neurobiology · doi:10.1016/s0074-7742(01)46063-6 · Cited by 42

Modulation of native and recombinant GABAA receptors by endogenous and synthetic neuroactive steroids

Lambert, J. J., Belelli, D., Harney, S. C., Peters, J. A., & Frenguelli, B. G. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00124-2 · Cited by 164

Neurosteroid modulation of synaptic and extrasynaptic GABAA receptors

Herd, M. B., Belelli, D., & Lambert, J. J. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.03.007 · Cited by 206

Neurosteroid modulation of GABAA receptors

Lambert, J. J., Belelli, D., Peden, D. R., Vardy, A., & Peters, J. A. (2003) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2003.09.001 · Cited by 498

Neurosteroids and GABA-A Receptor Function

Wang, M. (2011) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00044 · Cited by 207