The molecular basis for calcium-dependent axon pathfinding
Abstract
Ca(2+) signals have profound and varied effects on growth cone motility and guidance. Modulation of Ca(2+) influx and release from stores by guidance cues shapes Ca(2+) signals, which determine the activation of downstream targets. Although the precise molecular mechanisms that underlie distinct Ca(2+)-mediated effects on growth cone behaviours remain unclear, recent studies have identified important players in both the regulation and targets of Ca(2+) signals in growth cones.
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Cytosolic calcium plays a critical role in controlling axonal and dendritic growth and arborization.
“Cytosolic calcium plays a critical role in controlling axonal and dendritic growth and arborization75–79.”
From CYFIP1 governs the development of cortical axons by modulating calcium availability (2025) · cites this paper as [75]
Cites
Turning of nerve growth cones induced by neurotransmitters
Zheng, J. Q., Felder, M., Connor, J. A., & Poo, M.-M. (1994) · Nature · doi:10.1038/368140a0 · Cited by 580 · see citing works
Self-citationFunctional Implications of the Subunit Composition of Neuronal CaM Kinase II
Brocke, L., Chiang, L. W., Wagner, P. D., & Schulman, H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.32.22713 · Cited by 161 · cited 1× · see citing works
“Importantly, the concentration of Ca 2+ /CaM required for β-CaMKII activation is several orders of magnitude less than that required for the α-isofor”
BackgroundCiccolini, F., Collins, T. J., Sudhoelter, J., Lipp, P., Berridge, M. J., & Bootman, M. D. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00103.2003 · Cited by 135 · cited 1× · see citing works
“However, other studies have found that elevating [Ca 2+ ] i in growth cones promotes neurite outgrowt”
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Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling
Burgoyne, R. D. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2093 · Cited by 527 · see citing works
Liao, C.-Y., Li, X.-Y., Wu, B., Duan, S., & Jiang, G.-B. (2008) · Environmental Science & Technology · doi:10.1021/es800018k · Cited by 96 · see citing works
Leiper, L. J., Walczysko, P., Kucerova, R., Ou, J., Shanley, L. J., Lawson, D., Forrester, J. V., McCaig, C. D., Zhao, M., & Collinson, J. M. (2006) · BMC Biology · doi:10.1186/1741-7007-4-27 · Cited by 83 · see citing works
CYFIP1 governs the development of cortical axons by modulating calcium availability
Ricci, C., Midroit, M. J., Caicci, F., Achsel, T., Domínguez-Iturza, N., & Bagni, C. (2025) · Nature Communications · doi:10.1038/s41467-025-65801-0 · Cited by 1 · see citing works
- Authors
- Gomez, T. M., & Zheng, J. Q.
- Affiliations
- University of Medicine and Dentistry of New Jersey (US)
- ORCID
- Zheng, James Q.
- Venue
- Nature Reviews Neuroscience
- Published
- 2006-02
- Volume
- 7
- Issue
- 2
- Pages
- 115-125
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2106820442
- Cited by
- 330
- References
- 3
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 9 · 2023: 9 · 2022: 8 · 2021: 2 · 2020: 9 · 2019: 7 · 2018: 8 · 2017: 12 · 2016: 12 · 2015: 16 · 2014: 19 · 2013: 32 · 2012: 24
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- National Institute of Neurological Disorders and Stroke (R01NS041564)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- calcium signaling, axon guidance, growth cone motility, growth cone guidance, intracellular calcium stores, calcium influx, guidance cues
- MeSH terms
- Animals, Axons, Calcium, Humans, Models, Neurological, Neurons, Calcium Signaling, Growth Cones
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