Cited by 527S100 Proteins and AnnexinsIon channel regulation and functionIon Channels and Receptors

Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling

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Burgoyne, Robert D.·2007·Nature Reviews Neuroscience

Abstract

In neurons, intracellular calcium signals have crucial roles in activating neurotransmitter release and in triggering alterations in neuronal function. Calmodulin has been widely studied as a Ca(2+) sensor that has several defined roles in neuronal Ca(2+) signalling, but members of the neuronal calcium sensor protein family have also begun to emerge as key components in a number of regulatory pathways and have increased the diversity of neuronal Ca(2+) signalling pathways. The differing properties of these proteins allow them to have discrete, non-redundant functions.

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  • Postsynaptic calcium helps regulate long-term potentiation and depression; calcium accumulation controls CaMKII, calcineurin, and protein phosphatase 1, which persistently alter synaptic strength by changing AMPAR number or conductance.

    “The calcium inside the postsynaptic membrane also plays important regulating roles in long-term potentiation and depression where Ca 2+ accumulation is necessary to regulate enzymes, i.e.Ca 2+ /calmodulindependent protein kinase II (CaMKII), calcineurin, and protein phosphatase 1 42,43,46,47 , which in turn triggers rapid and persistent modification of synaptic strengths by changing the number and”

    From Memristors with diffusive dynamics as synaptic emulators for neuromorphic computing (2017) · cites this paper as [42]

    The 'Different signals, diverse outcomes' section says postsynaptic Ca2+ signals can trigger LTP or LTD, and 'Ca2+ sensor proteins: calmodulin' links Ca2+/calmodulin to CaMKII and identifies calcineurin as a calmodulin target (page numbers unavailable). The paper does not establish the claimed pathway through protein phosphatase 1 or say that these enzymes persistently change synaptic strength by altering AMPAR number or conductance. Its References discuss possible AMPA-receptor endocytosis in LTD through hippocalcin, a different mechanism. (LLM, conf=0.87)

    Experimental — accuracy not yet measured
  • At chemical synapses, calcium concentration is balanced by entry through VSCCs and NMDARs and removal by PMCA and NCE, which returns internal calcium to baseline.

    “In chemical synapses, the dynamical balance of the Ca 2+ concentration is shaped by both influx via voltage-sensitive calcium channels (VSCC) and N-methyl-D-aspartate receptors (NMDAR) 42,43 , and extrusion via the plasma membrane Ca 2+ -ATPase (PMCA) and Na + /Ca 2+ exchanger (NCE) 43,44 that restores [Ca 2+ ]i to the basal concentration.”

    From Memristors with diffusive dynamics as synaptic emulators for neuromorphic computing (2017) · cites this paper as [42]

    The “Changes in Ca2+ concentration” section says neuronal calcium can enter through voltage-gated calcium channels or NMDA receptors and identifies a resting intracellular concentration. It does not identify PMCA or the Na+/Ca2+ exchanger as the means of extrusion or say that they restore calcium to baseline. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

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Authors
Burgoyne, R. D.
Affiliations
University of Liverpool (GB)
Corresponding author
Burgoyne, Robert D.
Venue
Nature Reviews Neuroscience
Published
2007-03
Volume
8
Issue
3
Pages
182-193
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
OpenAlex
W2031781678
Cited by
527
References
156
Citations by year
2026: 14 · 2025: 6 · 2024: 23 · 2023: 17 · 2022: 17 · 2021: 25 · 2020: 32 · 2019: 35 · 2018: 21 · 2017: 26 · 2016: 28 · 2015: 23 · 2014: 28 · 2013: 31 · 2012: 58
FWCI
2.72
Type
journal article
Language
en
Open access
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
Wellcome Trust (072514)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords
neuronal calcium sensor proteins, calmodulin, intracellular calcium, neurotransmitter release, calcium signalling pathway, non-redundant function
MeSH terms
Animals, Brain, Calcium, Humans, Models, Molecular, Models, Neurological, Neurons, Calcium Signaling, Neuronal Calcium-Sensor Proteins

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