The DOI matches its Crossref record; 180 of the 180 references it cites were found in a registry or an index.
Enriched environments, experience-dependent plasticity and disorders of the nervous system
Abstract
Behavioural, cellular and molecular studies have revealed significant effects of enriched environments on rodents and other species, and provided new insights into mechanisms of experience-dependent plasticity, including adult neurogenesis and synaptic plasticity. The demonstration that the onset and progression of Huntington's disease in transgenic mice is delayed by environmental enrichment has emphasized the importance of understanding both genetic and environmental factors in nervous system disorders, including those with Mendelian inheritance patterns. A range of rodent models of other brain disorders, including Alzheimer's disease and Parkinson's disease, fragile X and Down syndrome, as well as various forms of brain injury, have now been compared under enriched and standard housing conditions. Here, we review these findings on the environmental modulators of pathogenesis and gene-environment interactions in CNS disorders, and discuss their therapeutic implications.
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“Studies in animal models report an increase in brain BDNF levels when aged animals are submitted to protocols such as long-term environmental enrichment [47–49] or physical activity [50, 51].”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [47]
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A JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
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Metadata
- Authors
- Nithianantharajah, J., & Hannan, A. J.
- Affiliations
- The University of Melbourne (AU)
- Corresponding author
- Hannan, Anthony J.
- Venue
- Nature Reviews Neuroscience
- Published
- 2006-09
- Volume
- 7
- Issue
- 9
- Pages
- 697-709
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2054282296
- Cited by
- 1,771
- References
- 180
- Citations by year
- 2026: 61 · 2025: 74 · 2024: 78 · 2023: 89 · 2022: 109 · 2021: 113 · 2020: 113 · 2019: 106 · 2018: 125 · 2017: 82 · 2016: 95 · 2015: 101 · 2014: 95 · 2013: 88 · 2012: 95
- FWCI
- 3.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health and Medical Research Council
- National Medical Research Council
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- environmental enrichment, experience-dependent plasticity, neuroplasticity, adult neurogenesis, synaptic plasticity, Huntington's disease, Alzheimer's disease, Parkinson's disease, fragile X syndrome, Down syndrome, brain injury, gene-environment interaction, central nervous system disorders, treatment options, rodent models
- MeSH terms
- Animals, Cell Survival, Disease Models, Animal, Environment Design, Humans, Nervous System Malformations, Neuronal Plasticity, Rodentia, Sensory Deprivation, Neurodegenerative Diseases, Recovery of Function
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