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Cited by 517

The DOI matches its Crossref record; 130 of the 130 references it cites were found in a registry or an index.

HIV and antiretroviral therapy in the brain: neuronal injury and repair

Ellis, Ronald, Langford, Dianne, Masliah, Eliezer·2007·Nature Reviews Neuroscience

Abstract

Approximately 40 million people worldwide are infected with human immunodeficiency virus (HIV). Despite HIV's known propensity to infect the CNS and cause neurological disease, HIV neurocognitive disorders remain under-recognized. Although combination antiretroviral therapy has improved the health of millions of those living with HIV, the penetration into the CNS of many such therapies is limited, and patients' quality of life continues to be diminished by milder, residual neurocognitive impairment. Synaptodendritic neuronal injury is emerging as an important mediator of such deficits in HIV. By carefully selecting specific antiretrovirals and supplementing them with neuroprotective agents, physicians might be able to facilitate innate CNS repair, promoting enhanced synaptodendritic plasticity, neural function and clinical neurological status.

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Metadata

Authors
Ellis, R., Langford, D., & Masliah, E.
Venue
Nature Reviews Neuroscience
Published
2007-01
Volume
8
Issue
1
Pages
33-44
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
OpenAlex
W1976434061
Cited by
517
References
130
FWCI
1.03
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: HIV and antiretroviral therapy in the brain: neuronal injury and repair. https://app.cochat.ai/papers/10.1038/nrn2040
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Ellis, R., Langford, D., & Masliah, E. (2007). HIV and antiretroviral therapy in the brain: neuronal injury and repair. Nature Reviews Neuroscience. https://doi.org/10.1038/nrn2040

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