The DOI matches its Crossref record; 172 of the 173 references it cites were found in a registry or an index.
New insights into symptoms and neurocircuit function of anorexia nervosa
Open accessAbstract
Individuals with anorexia nervosa have a relentless preoccupation with dieting and weight loss that results in severe emaciation and sometimes death. It is controversial whether such symptoms are secondary to psychosocial influences, are a consequence of obsessions and anxiety or reflect a primary disturbance of brain appetitive circuits. New brain imaging technology provides insights into ventral and dorsal neural circuit dysfunction - perhaps related to altered serotonin and dopamine metabolism - that contributes to the puzzling symptoms found in people with eating disorders. For example, altered insula activity could explain interoceptive dysfunction, and altered striatal activity might shed light on altered reward modulation in people with anorexia nervosa.
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“There are preclinical and human studies pointing at an implication of the serotonin (5HT) system dysfunction in a broad range of psychiatric diseases (Kaye, Fudge, & Paulus, 2009).”
From Can epigenetics shine a light on the biological pathways underlying major mental disorders? (2022) · cites this paper as Kaye, Fudge, & Paulus, 2009
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“Interoceptive processing occurs across all major biological systems involved in maintaining bodily homeostasis, including the cardiovascular (9,10), pulmonary (11), gastrointestinal (12,13), genitourinary (14), nociceptive (15), chemosensory (16), osmotic (17), thermoregulatory (18), visceral1 (19), immune (20,21), and autonomic systems (22,23) (Table 1).”
From Interoception and Mental Health: A Roadmap. (2018) · cites this paper as [13]
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Cites
Diagnostic and Statistical Manual of Mental Disorders
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How do you feel — now? The anterior insula and human awareness
(Bud) Craig, A. D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2555 · Cited by 6,657 · cited 2×
“…of the entire body 143 and is crucial for the instantiation of the ‘self’ because it provides the link between cognitive and affective processes and the current body state 140–142, It is thought that altered interoceptive awareness might be a precipitating and reinforcing factor in AN 10,146–148 .”
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
How do you feel? Interoception: The sense of the physiological condition of the body
Craig, A. D. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn894 · Cited by 6,006
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
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Neural systems supporting interoceptive awareness
Critchley, H. D., Wiens, S., Rotshtein, P., Öhman, A., & Dolan, R. J. (2004) · Nature Neuroscience · doi:10.1038/nn1176 · Cited by 3,406 · cited 2×
“…of the entire body 143 and is crucial for the instantiation of the ‘self’ because it provides the link between cognitive and affective processes and the current body state 140–142, It is thought that altered interoceptive awareness might be a precipitating and reinforcing factor in AN 10,146–148 .”
Contributions of anterior cingulate cortex to behaviour
Devinsky, O., Morrell, M. J., & Vogt, B. A. (1995) · Brain · doi:10.1093/brain/118.1.279 · Cited by 3,377
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Anterior Cingulate Conflict Monitoring and Adjustments in Control
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Gut feelings: the emerging biology of gut-brain communication
Mayer, E. A. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3071 · Cited by 1,726
Interoception and Mental Health: A Roadmap.
Khalsa, S. S., Adolphs, R., Cameron, O. G., Critchley, H. D., Davenport, P. W., Feinstein, J. S., Feusner, J. D., Garfinkel, S. N., Lane, R. D., Mehling, W. E., et al. (2018) · Biological psychiatry. Cognitive neuroscience and neuroimaging · doi:10.1016/j.bpsc.2017.12.004 · Cited by 1,453
Self-citationThe tempted brain eats: Pleasure and desire circuits in obesity and eating disorders
Berridge, K. C., Ho, C.-Y., Richard, J. M., & DiFeliceantonio, A. G. (2010) · Brain Research · doi:10.1016/j.brainres.2010.04.003 · Cited by 873
Treasure, J. L., Claudino, A. M., & Zucker, N. L. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61748-7 · Cited by 661
Nothing tastes as good as skinny feels: the neurobiology of anorexia nervosa
Kaye, W. H., Wierenga, C. E., Bailer, U. F., Simmons, A. N., & Bischoff‐Grethe, A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.01.003 · Cited by 566
Self-citation
Metadata
- Authors
- Kaye, W. H., Fudge, J. L., & Paulus, M.
- Affiliations
- University of California San Diego (US)
- University of Rochester Medicine (US)
- Corresponding author
- Kaye, Walter H.
- Venue
- Nature Reviews Neuroscience
- Published
- 2009-07-15
- Volume
- 10
- Issue
- 8
- Pages
- 573-584
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC13038070
- OpenAlex
- W2067637201
- Cited by
- 843
- References
- 173
- Citations by year
- 2026: 38 · 2025: 37 · 2024: 38 · 2023: 38 · 2022: 45 · 2021: 47 · 2020: 49 · 2019: 58 · 2018: 43 · 2017: 59 · 2016: 57 · 2015: 52 · 2014: 58 · 2013: 77 · 2012: 45
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- green
- pmc.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Louis and Harold Price Foundation
- Wellcome Trust (066122)
- U.S. Public Health Service (018307, 001894, 020687, 016663, 046001, 063291, 042984)
- National Institute of Mental Health (R01MH063291)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Keywords
- anorexia nervosa, eating disorders, neurocircuitry, neurotransmitter systems, serotonin, dopamine, reward processing, interoception, insula, striatum, appetite regulation, neuroimaging
- MeSH terms
- Animals, Anorexia Nervosa, Brain, Brain Mapping, Diagnostic Imaging, Dopamine, Humans, Neural Pathways, Serotonin
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