The tempted brain eats: Pleasure and desire circuits in obesity and eating disorders
Open accessAbstract
What we eat, when and how much, all are influenced by brain reward mechanisms that generate "liking" and "wanting" for foods. As a corollary, dysfunction in reward circuits might contribute to the recent rise of obesity and eating disorders. Here we assess brain mechanisms known to generate "liking" and "wanting" for foods and evaluate their interaction with regulatory mechanisms of hunger and satiety, relevant to clinical issues. "Liking" mechanisms include hedonic circuits that connect together cubic-millimeter hotspots in forebrain limbic structures such as nucleus accumbens and ventral pallidum (where opioid/endocannabinoid/orexin signals can amplify sensory pleasure). "Wanting" mechanisms include larger opioid networks in nucleus accumbens, striatum, and amygdala that extend beyond the hedonic hotspots, as well as mesolimbic dopamine systems, and corticolimbic glutamate signals that interact with those systems. We focus on ways in which these brain reward circuits might participate in obesity or in eating disorders.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Berridge and colleagues demonstrated narrowly circumscribed, μ-opioid receptor-mediated pleasure ("liking") hotspots in the nucleus accumbens shell and ventral pallidum.
“Using this method, Berridge and colleagues ([12](#B12), [122](#B122)) have demonstrated narrowly circumscribed, μ-opioid receptor-mediated pleasure (“liking”) hotspots in the nucleus accumbens shell and ventral pallidum.”
From Food reward, hyperphagia, and obesity (2011) · cites this paper as [12]
Eating disorders such as anorexia nervosa and bulimia nervosa are characterized by disturbances in behavioral and neurobiological responses to food rewards.
“Eating disorders, such as anorexia nervosa (AN) and bulimia nervosa (BN), are characterized by disturbances in behavioral and neurobiological responses to food rewards (82).”
From A transdiagnostic perspective on social anhedonia (2019) · cites this paper as [82]
Some forms of eating disorders may be associated with normal levels of wanting but low levels of liking food, while bulimia nervosa may be associated with an excessive wanting of food that is not followed by a typical sense of pleasure.
“Some forms of eating disorders may be associated with normal levels of wanting but low levels of liking food, while BN may be associated with an excessive wanting of food that is not followed by a typical sense of pleasure (82).”
From A transdiagnostic perspective on social anhedonia (2019) · cites this paper as [82]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346 · see citing works
How do you feel? Interoception: The sense of the physiological condition of the body
Craig, A. D. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn894 · Cited by 6,006 · see citing works
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405 · see citing works
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127 · see citing works
Self-citationNeural systems of reinforcement for drug addiction: from actions to habits to compulsion
Everitt, B. J., & Robbins, T. W. (2005) · Nature Neuroscience · doi:10.1038/nn1579 · Cited by 3,785 · see citing works
Neurons containing hypocretin (orexin) project to multiple neuronal systems
Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09996.1998 · Cited by 3,466 · see citing works
JAMES, W. (1884) · Mind · doi:10.1093/mind/os-ix.34.188 · Cited by 3,446 · see citing works
Lewis, M., & Haviland, J. M. (1993) · Cited by 3,308 · see citing works
The Neural Basis of Addiction: A Pathology of Motivation and Choice
Kalivas, P. W., & Volkow, N. D. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.8.1403 · Cited by 2,757 · see citing works
James, W. (2005) · Williams & Wilkins eBooks · doi:10.1037/10735-001 · Cited by 2,221 · see citing works
The human orbitofrontal cortex: linking reward to hedonic experience
Kringelbach, M. L. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1747 · Cited by 2,180 · see citing works
Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex
Cardinal, R. N., Parkinson, J. A., Hall, J., & Everitt, B. J. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(02)00007-6 · Cited by 2,129 · see citing works
Abstract reward and punishment representations in the human orbitofrontal cortex
O'Doherty, J., Kringelbach, M. L., Rolls, E. T., Hornak, J., & Andrews, C. (2001) · Nature Neuroscience · doi:10.1038/82959 · Cited by 2,003 · see citing works
The molecular logic of endocannabinoid signalling
Piomelli, D. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1247 · Cited by 1,957 · see citing works
Wang, G.-J., Volkow, N. D., Logan, J., Pappas, N. R., Wong, C. T., Zhu, W., Netusll, N., & Fowler, J. S. (2001) · The Lancet · doi:10.1016/s0140-6736(00)03643-6 · Cited by 1,864 · see citing works
The incentive sensitization theory of addiction: some current issues
Robinson, T. E., & Berridge, K. C. (2008) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0093 · Cited by 1,717 · see citing works
Self-citationBehavioral Theories and the Neurophysiology of Reward
Schultz, W. (2006) · Annual Review of Psychology · doi:10.1146/annurev.psych.56.091103.070229 · Cited by 1,637 · see citing works
Cabanac, M. (1971) · Science · doi:10.1126/science.173.4002.1103 · Cited by 1,521 · see citing works
Robinson, T. E., & Berridge, K. C. (2003) · Annual Review of Psychology · doi:10.1146/annurev.psych.54.101601.145237 · Cited by 1,509 · see citing works
Self-citationDopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats
Johnson, P. M., & Kenny, P. J. (2010) · Nature Neuroscience · doi:10.1038/nn.2519 · Cited by 1,495 · see citing works
Neuronal Coding of Prediction Errors
Schultz, W., & Dickinson, A. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.473 · Cited by 1,427 · see citing works
The Role of the Dorsal Striatum in Reward and Decision-Making: Figure 1.
Balleine, B. W., Delgado, M. R., & Hikosaka, O. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1554-07.2007 · Cited by 1,390 · see citing works
Preliminary validation of the Yale Food Addiction Scale
Gearhardt, A. N., Corbin, W. R., & Brownell, K. D. (2009) · Appetite · doi:10.1016/j.appet.2008.12.003 · Cited by 1,369 · see citing works
Chronic stress and obesity: a new view of “comfort food”
Dallman, M. F., Pecoraro, N., Akana, S. F., la Fleur, S. E., Gomez, F., Houshyar, H., Bell, M. E., Bhatnagar, S., Laugero, K. D., & Manalo, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1934666100 · Cited by 1,369 · see citing works
Avena, N. M., Rada, P., & Hoebel, B. G. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.04.019 · Cited by 1,358 · see citing works
A role for lateral hypothalamic orexin neurons in reward seeking
Harris, G. C., Wimmer, M., & Aston-Jones, G. (2005) · Nature · doi:10.1038/nature04071 · Cited by 1,311 · see citing works
Affective neuroscience of pleasure: reward in humans and animals
Berridge, K. C., & Kringelbach, M. L. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1099-6 · Cited by 1,254 · see citing works
Self-citationThe taste reactivity test. I. Mimetic responses to gustatory stimuli in neurologically normal rats
Grill, H. J., & Norgren, R. (1978) · Brain Research · doi:10.1016/0006-8993(78)90568-1 · Cited by 1,203 · see citing works
Changes in brain activity related to eating chocolate: From pleasure to aversion
Small, D. M. (2001) · Brain · doi:10.1093/brain/124.9.1720 · Cited by 1,179 · cited 7× · see citing works
“…the anterior cingulate cortex and the anterior insula cortex (de Araujo et al., 2003; Kringelbach, 2004; Kringelbach, 2005; Kringelbach, 2010; O'Doherty et al., 2001; Petrovich and Gallagher, 2007; Rolls, 2006; Rolls et al., 2003; Small and Veldhuizen, 2010; Small et al., 2001; Small et al., 2003).”
Influential“Liking” and “wanting” food rewards: Brain substrates and roles in eating disorders
Berridge, K. C. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.02.044 · Cited by 1,147 · see citing works
Self-citationHow can drug addiction help us understand obesity?
Volkow, N. D., & Wise, R. A. (2005) · Nature Neuroscience · doi:10.1038/nn1452 · Cited by 1,089 · see citing works
Neural responses during anticipation of a primary taste reward
O'Doherty, J. P., Deichmann, R., Critchley, H. D., & Dolan, R. J. (2002) · Neuron · doi:10.1016/s0896-6273(02)00603-7 · Cited by 1,076 · see citing works
Nucleus accumbens shell and core dopamine: differential role in behavior and addiction
Di Chiara, G. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00286-3 · Cited by 996 · see citing works
Computational roles for dopamine in behavioural control
Montague, P. R., Hyman, S. E., & Cohen, J. D. (2004) · Nature · doi:10.1038/nature03015 · Cited by 966 · see citing works
Kelley, A. E. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.11.015 · Cited by 942 · see citing works
Leptin Receptor Signaling in Midbrain Dopamine Neurons Regulates Feeding
Hommel, J. D., Trinko, R., Sears, R. M., Georgescu, D., Liu, Z.-W., Gao, X.-B., Thurmon, J. J., Marinelli, M., & DiLeone, R. J. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.023 · Cited by 902 · see citing works
Teitelbaum, P., & Epstein, A. N. (1962) · Psychological Review · doi:10.1037/h0039285 · Cited by 884 · see citing works
Stress dysregulation of drug reward pathways, and the transition to drug dependence
Koob, & Kreek, M. J. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.05030503 · Cited by 868 · see citing works
New insights into symptoms and neurocircuit function of anorexia nervosa
Kaye, W. H., Fudge, J. L., & Paulus, M. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2682 · Cited by 843 · see citing works
Kringelbach, M. L. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.10.1064 · Cited by 824 · see citing works
Stress-induced obesity and the emotional nervous system
Dallman, M. F. (2010) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2009.10.004 · Cited by 814 · see citing works
Overlapping neuronal circuits in addiction and obesity: evidence of systems pathology
Volkow, N. D., Wang, G.-J., Fowler, J. S., & Telang, F. (2008) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0107 · Cited by 809 · see citing works
Kirkham, T. C., Williams, C. M., Fezza, F., & Marzo, V. D. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704767 · Cited by 788 · see citing works
Wyvell, C. L., & Berridge, K. C. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-21-08122.2000 · Cited by 764 · cited 2× · see citing works
“Similar elevations of 'wanting' without 'liking' have also been produced in ordinary rats by amphetamine-induced elevation in dopamine release, and by long term drug-sensitization of mesolimbic systems (Peciña et al., 2003; Tindell et al., 2005; Wyvell and Berridge, 2000).”
Self-citationCorticostriatal-hypothalamic circuitry and food motivation: Integration of energy, action and reward
Kelley, A. E., Baldo, B. A., Pratt, W. E., & Will, M. J. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.08.066 · Cited by 752 · see citing works
Steiner, J. E., Glaser, D., Hawilo, M. E., & Berridge, K. C. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00051-8 · Cited by 752 · see citing works
Hedonic hunger: A new dimension of appetite?
Lowe, M. R., & Butryn, M. L. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.04.006 · Cited by 739 · see citing works
How adaptive behavior is produced: a perceptual-motivational alternative to response reinforcements
Bindra, D. (1978) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00059380 · Cited by 732 · see citing works
Berridge, K. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00072-x · Cited by 721 · see citing works
Self-citationDopamine operates as a subsecond modulator of food seeking
Roitman, M. F., Stuber, G. D., Phillips, P. E. M., Wightman, R. M., & Carelli, R. M. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3823-03.2004 · Cited by 718 · see citing works
Predictability modulates human brain response to reward
Berns, G. S., McClure, S. M., Pagnoni, G., & Montague, P. R. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02793.2001 · Cited by 711 · see citing works
Berridge, K. C. (2003) · Brain and Cognition · doi:10.1016/s0278-2626(03)00014-9 · Cited by 694 · see citing works
Self-citationPeciña, S., & Berridge, K. C. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2329-05.2005 · Cited by 671 · see citing works
Self-citationImages of desire: food-craving activation during fMRI
Pelchat, M. L., Johnson, A., Chan, R., Valdez, J., & Ragland, J. D. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.08.023 · Cited by 667 · see citing works
The Brain, Appetite, and Obesity
Berthoud, H., & Morrison, C. D. (2007) · Annual Review of Psychology · doi:10.1146/annurev.psych.59.103006.093551 · Cited by 661 · see citing works
Leptin Regulation of the Mesoaccumbens Dopamine Pathway
Fulton, S., Pissios, P., Manchon, R. P., Stiles, L., Frank, L., Pothos, E. N., Maratos-Flier, E., & Flier, J. S. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.006 · Cited by 644 · see citing works
De Araujo, I. E. T., Rolls, E. T., Kringelbach, M. L., McGlone, F., & Phillips, N. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02915.x · Cited by 642 · see citing works
How the Brain Translates Money into Force: A Neuroimaging Study of Subliminal Motivation
Pessiglione, M., Schmidt, L., Draganski, B., Kalisch, R., Lau, H., Dolan, R. J., & Frith, C. D. (2007) · Science · doi:10.1126/science.1140459 · Cited by 634 · see citing works
Small, D. M., Jones-Gotman, M., & Dagher, A. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00253-2 · Cited by 632 · see citing works
Leptin Regulates Striatal Regions and Human Eating Behavior
Farooqi, I. S., Bullmore, E., Keogh, J., Gillard, J., O'Rahilly, S., & Fletcher, P. C. (2007) · Science · doi:10.1126/science.1144599 · Cited by 622 · see citing works
Individual Differences in Reward Drive Predict Neural Responses to Images of Food
Beaver, J. D., Lawrence, A. D., van Ditzhuijzen, J., Davis, M. H., Woods, A., & Calder, A. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0350-06.2006 · Cited by 594 · see citing works
Excitation of Ventral Tegmental Area Dopaminergic and Nondopaminergic Neurons by Orexins/Hypocretins
Korotkova, T. M., Sergeeva, O. A., Eriksson, K. S., Haas, H. L., & Brown, R. E. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00007.2003 · Cited by 583 · see citing works
Different representations of pleasant and unpleasant odours in the human brain
Rolls, E. T., Kringelbach, M. L., & de Araújo, I. E. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02779.x · Cited by 566 · see citing works
Arousal and reward: a dichotomy in orexin function
Harris, G. C., & Aston‐Jones, G. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.08.002 · Cited by 565 · see citing works
Castellanos, E. H., Charboneau, E., Dietrich, M. S., Park, S., Bradley, B. P., Mogg, K., & Cowan, R. L. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.138 · Cited by 564 · see citing works
Flagel, S. B., Akil, H., & Robinson, T. E. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.027 · Cited by 561 · see citing works
Schachter, S. (1968) · Science · doi:10.1126/science.161.3843.751 · Cited by 561 · see citing works
Hyperdopaminergic mutant mice have higher "wanting" but not "liking" for sweet rewards
Peciña, S., Cagniard, B., Berridge, K. C., Aldridge, J. W., & Zhuang, X. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-28-09395.2003 · Cited by 551 · see citing works
Self-citationVentral pallidum roles in reward and motivation
Smith, K. S., Tindell, A. J., Aldridge, J. W., & Berridge, K. C. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.09.038 · Cited by 548 · see citing works
Self-citationOpioid modulation of taste hedonics within the ventral striatum
Kelley, A. E., Bakshi, V. P., Haber, S. N., Steininger, T. L., Will, M. J., & Zhang, M. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00751-5 · Cited by 526 · see citing works
Increased food energy supply is more than sufficient to explain the US epidemic of obesity
Swinburn, B., Sacks, G., & Ravussin, E. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28595 · Cited by 526 · see citing works
Limbic and Motor Circuitry Underlying Footshock-Induced Reinstatement of Cocaine-Seeking Behavior
McFarland, K., Davidge, S. B., Lapish, C. C., & Kalivas, P. W. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4177-03.2004 · Cited by 524 · see citing works
Wang, G.-J., Volkow, N. D., Thanos, P. K., & Fowler, J. S. (2004) · Journal of Addictive Diseases · doi:10.1300/j069v23n03_04 · Cited by 502 · see citing works
Roles for nigrostriatal—not just mesocorticolimbic—dopamine in reward and addiction
Wise, R. A. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.06.004 · Cited by 500 · see citing works
THE FORM OF THE AUTO‐SHAPED RESPONSE WITH FOOD OR WATER REINFORCERS1
Jenkins, H. M., & Moore, B. R. (1973) · Journal of the Experimental Analysis of Behavior · doi:10.1901/jeab.1973.20-163 · Cited by 492 · see citing works
Compulsive overeating as an addiction disorder. A review of theory and evidence
Davis, C. A., & Carter, J. C. (2009) · Appetite · doi:10.1016/j.appet.2009.05.018 · Cited by 479 · see citing works
Leyton, M. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00366-4 · Cited by 476 · see citing works
Excessive sugar intake alters binding to dopamine and mu-opioid receptors in the brain
Colantuoni, C., Schwenker, J., McCarthy, J., Rada, P., Ladenheim, B., Cadet, J.-L., Schwartz, G. J., Moran, T. H., & Hoebel, B. G. (2001) · Neuroreport · doi:10.1097/00001756-200111160-00035 · Cited by 471 · see citing works
Is dopamine a physiologically relevant mediator of feeding behavior?
Palmiter, R. D. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.06.004 · Cited by 469 · see citing works
Volkow, N. D., Wang, G., Fowler, J. S., Logan, J., Jayne, M., Franceschi, D., Wong, C., Gatley, S. J., Gifford, A. N., Ding, Y., et al. (2002) · Synapse · doi:10.1002/syn.10075 · Cited by 452 · see citing works
Smith, K. S., & Berridge, K. C. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4205-06.2007 · Cited by 450 · see citing works
Self-citationNijs, I. M. T., Muris, P., Euser, A. S., & Franken, I. H. A. (2009) · Appetite · doi:10.1016/j.appet.2009.11.004 · Cited by 448 · see citing works
Hedonic Hot Spots in the Brain
Peciña, S., Smith, K. S., & Berridge, K. C. (2006) · The Neuroscientist · doi:10.1177/1073858406293154 · Cited by 441 · see citing works
Self-citationCabanac, M. (1979) · The Quarterly Review of Biology · doi:10.1086/410981 · Cited by 441 · see citing works
Wyvell, C. L., & Berridge, K. C. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07831.2001 · Cited by 436 · see citing works
Self-citation(2006) · Neuroscience · doi:10.1016/s0306-4522(05)01473-9 · Cited by 427 · see citing works
Chronically Decerebrate Rats Demonstrate Satiation But Not Bait Shyness
Grill, H. J., & Norgren, R. (1978) · Science · doi:10.1126/science.663655 · Cited by 423 · see citing works
Leinninger, G. M., Jo, Y.-H., Leshan, R. L., Louis, G. W., Yang, H., Barrera, J. G., Wilson, H., Opland, D. M., Faouzi, M. A., Gong, Y., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.06.011 · Cited by 412 · see citing works
A General Theory of Aversion Learning a
García, J., Lasiter, P. S., Bermúdez‐Rattoni, F., & Deems, D. A. (1985) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1985.tb27060.x · Cited by 405 · see citing works
Deficits of mesolimbic dopamine neurotransmission in rat dietary obesity
Geiger, B. M., Haburcak, M., Avena, N. M., Moyer, M. C., Hoebel, B. G., & Pothos, E. N. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.02.007 · Cited by 403 · see citing works
Exposure to appetitive food stimuli markedly activates the human brain
Wang, G.-J., Volkow, N. D., Telang, F., Jayne, M., Ma, J., Rao, M., Zhu, W., Wong, C. T., Pappas, N. R., Geliebter, A., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.11.026 · Cited by 402 · see citing works
Choline transporters, cholinergic transmission and cognition
Sarter, M. F., & Parikh, V. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1588 · Cited by 400 · see citing works
Prelude to Passion: Limbic Activation by “Unseen” Drug and Sexual Cues
Childress, A. R., Ehrman, R. N., Wang, Z., Li, Y., Sciortino, N., Hakun, J. G., Jens, W., Suh, J. J., Listerud, J., Marquez, K., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001506 · Cited by 395 · see citing works
The Ventral Pallidum and Hedonic Reward: Neurochemical Maps of Sucrose “Liking” and Food Intake
Smith, K. S., & Berridge, K. C. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1902-05.2005 · Cited by 391 · see citing works
Self-citationReexamination of the role of the hypothalamus in motivation.
Valenstein, E. S., Cox, V. C., & Kakolewski, J. W. (1970) · Psychological Review · doi:10.1037/h0028581 · Cited by 390 · see citing works
The Role of Learning in the Operation of Motivational Systems
Dickinson, A., & Balleine, B. W. (2002) · Wiley eBooks · doi:10.1002/0471214426.pas0312 · Cited by 387 · see citing works
Lateral hypothalamic orexin/hypocretin neurons: A role in reward-seeking and addiction
Aston‐Jones, G., Smith, R. J., Sartor, G. C., Moorman, D. E., Massi, L., Tahsili‐Fahadan, P., & Richardson, K. A. (2009) · Brain Research · doi:10.1016/j.brainres.2009.09.106 · Cited by 386 · see citing works
Mela, D. J. (2006) · Appetite · doi:10.1016/j.appet.2006.02.006 · Cited by 382 · see citing works
Regulation of Human Affective Responses by Anterior Cingulate and Limbic µ-Opioid Neurotransmission
Zubieta, J., Ketter, T. A., Bueller, J. A., Xu, Y., Kilbourn, M. R., Young, E. A., & Koeppe, R. A. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.11.1145 · Cited by 378 · see citing works
Psychophysics of sweet and fat perception in obesity: problems, solutions and new perspectives
Bartoshuk, L. M., Duffy, V. B., Hayes, J. E., MOSKOWITZ, H. R., & Snyder, D. J. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1853 · Cited by 378 · see citing works
Sensitivity to reward: implications for overeating and overweight
Davis, C. A., Strachan, S. M., & Berkson, M. (2003) · Appetite · doi:10.1016/j.appet.2003.07.004 · Cited by 378 · see citing works
Mahler, S. V., Smith, K. S., & Berridge, K. C. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301376 · Cited by 377 · see citing works
Liking vs. wanting food: Importance for human appetite control and weight regulation
Finlayson, G., King, N. A., & Blundell, J. E. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.03.004 · Cited by 376 · see citing works
The limbic lobe and its output channels: implications for emotional functions and adaptive behavior
Heimer, L., & Van Hoesen, G. W. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.06.006 · Cited by 366 · see citing works
Refined food addiction: A classic substance use disorder
Ifland, J., Preuss, H. G., Marcus, M. T., Rourke, K. M., Taylor, W. C., Burau, K. D., Jacobs, W. S., Kadish, W., & Manso, G. (2009) · Medical Hypotheses · doi:10.1016/j.mehy.2008.11.035 · Cited by 364 · see citing works
Dopamine Production in the Caudate Putamen Restores Feeding in Dopamine-Deficient Mice
Szczypka, M. S., Kwok, K., Brot, M. D., Marck, B. T., Matsumoto, A. M., Donahue, B. A., & Palmiter, R. D. (2001) · Neuron · doi:10.1016/s0896-6273(01)00319-1 · Cited by 354 · see citing works
Kelley, A. E., Baldo, B. A., & Pratt, W. E. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20769 · Cited by 352 · see citing works
Food Craving and Food “Addiction”
Rogers, P. J., & Smit, H. J. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00197-0 · Cited by 347 · see citing works
Neurobiology of Feeding and Energy Expenditure
Gao, Q., & Horvath, T. L. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094324 · Cited by 346 · see citing works
Baldo, B. A., Daniel, R. A., Berridge, C. W., & Kelley, A. E. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10783 · Cited by 346 · see citing works
Real-time chemical responses in the nucleus accumbens differentiate rewarding and aversive stimuli
Roitman, M. F., Wheeler, R. A., Wightman, R. M., & Carelli, R. M. (2008) · Nature Neuroscience · doi:10.1038/nn.2219 · Cited by 343 · see citing works
Orexin A/Hypocretin-1 Selectively Promotes Motivation for Positive Reinforcers
Borgland, S. L., Chang, S., Bowers, M. S., Thompson, J. L., Vittoz, N. M., Floresco, S., Chou, J., Chen, B. T., & Bonci, A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.6096-08.2009 · Cited by 341 · see citing works
Leptin: a pivotal regulator of human energy homeostasis
Farooqi, I. S., & O’Rahilly, S. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26788c · Cited by 333 · see citing works
Cannabinoids, opioids and eating behavior: The molecular face of hedonism?
Cota, D., Tschöp, M. H., Horvath, T. L., & Levine, A. S. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.10.004 · Cited by 330 · see citing works
The gustofacial response: observation on normal and anencephalic newborn infants.
Steiner, J. E. (1973) · PubMed · Cited by 326 · see citing works
Opioid peptides and the control of human ingestive behaviour
Yeomans, M. R., & Gray, R. W. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(02)00041-6 · Cited by 317 · see citing works
Davis, C. A., Levitan, R. D., Reid, C., Carter, J. C., Kaplan, A. S., Patte, K. A., King, N., Curtis, C., & Kennedy, J. L. (2009) · Obesity · doi:10.1038/oby.2009.52 · Cited by 314 · see citing works
Geier, A. B., Rozin, P. N., & Doros, G. D. (2006) · Psychological Science · doi:10.1111/j.1467-9280.2006.01738.x · Cited by 313 · see citing works
Baldo, B. A., & Kelley, A. E. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0741-z · Cited by 312 · see citing works
Wake-promoting and sleep-suppressing actions of hypocretin (orexin): basal forebrain sites of action
España, R. A., Baldo, B. A., Kelley, A. E., & Berridge, C. W. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00319-0 · Cited by 311 · see citing works
Piazza, P. V., Deroche‐Gamonet, V., Deminière, J.-M., Maccari, S., Moal, M. L., & Simon, H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.24.11738 · Cited by 310 · see citing works
Berridge, K. C., & Valenstein, E. S. (1991) · Behavioral Neuroscience · doi:10.1037/0735-7044.105.1.3 · Cited by 302 · cited 2× · see citing works
“Our first discovery of enhanced 'wanting'-without-'liking' came two decades ago from a study on eating evoked by electrical stimulation of the lateral hypothalamus in rats, conducted collaboratively with Elliot Valenstein (Berridge and Valenstein, 1991).”
Self-citationBerridge, K. C., & Valenstein, E. S. (1991) · Behavioral Neuroscience · doi:10.1037//0735-7044.105.1.3 · Cited by 302 · see citing works
Self-citationAugmentation of drug reward by chronic food restriction
Carr, K. D. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00759-x · Cited by 300 · see citing works
A Neural Computational Model of Incentive Salience
Zhang, J., Berridge, K. C., Tindell, A. J., Smith, K. S., & Aldridge, J. W. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000437 · Cited by 299 · see citing works
Self-citationThe Geometry of Leptin Action in the Brain: More Complicated Than a Simple ARC
Myers, M. G., Münzberg, H., Leinninger, G. M., & Leshan, R. L. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.001 · Cited by 294 · see citing works
A diet promoting sugar dependency causes behavioral cross-sensitization to a low dose of amphetamine
Avena, N. M., & Hoebel, B. G. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00502-5 · Cited by 284 · see citing works
Cannon, C. M., & Palmiter, R. D. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-34-10827.2003 · Cited by 280 · see citing works
Tindell, A. J., Berridge, K. C., Zhang, J., Peciña, S., & Aldridge, J. W. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04411.x · Cited by 268 · see citing works
Self-citationZhang, M., & Kelley, A. E. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00198-6 · Cited by 260 · see citing works
Opioids for hedonic experience and dopamine to get ready for it
Barbano, M. F., & Cador, M. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0521-1 · Cited by 257 · see citing works
Modulation of taste affect by hunger, caloric satiety, and sensory-specific satiety in the rat
Berridge, K. C. (1991) · Appetite · doi:10.1016/0195-6663(91)90036-r · Cited by 253 · see citing works
Self-citationZheng, H., Patterson, L. M., & Berthoud, H.-R. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3542-07.2007 · Cited by 248 · see citing works
Brain mechanisms underlying flavour and appetite
Rolls, E. T. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1852 · Cited by 248 · see citing works
Distinguishing whether dopamine regulates liking, wanting, and/or learning about rewards
Robinson, S., Sandstrom, S. M., Denenberg, V. H., & Palmiter, R. D. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.1.5 · Cited by 247 · see citing works
Reynolds, S. M., & Berridge, K. C. (2008) · Nature Neuroscience · doi:10.1038/nn2061 · Cited by 244 · see citing works
Self-citationVentral pallidum firing codes hedonic reward: when a bad taste turns good
Tindell, A. J., Smith, K. S., Peciña, S., Berridge, K. C., & Aldridge, J. W. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00576.2006 · Cited by 241 · see citing works
Self-citationFood for thought: hedonic experience beyond homeostasis in the human brain
Kringelbach, M. L. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.04.035 · Cited by 236 · see citing works
The End of Overeating: Taking Control of the Insatiable American Appetite
Kessler, D. A. (2009) · Cited by 235 · see citing works
Rewarding drugs produce taste avoidance, but not taste aversion
Parker, L. A. (1995) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(94)00028-y · Cited by 233 · see citing works
Choi, D. L., Davis, J. F., Fitzgerald, M. E., & Benoit, S. C. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.02.002 · Cited by 229 · see citing works
Mahler, S. V., & Berridge, K. C. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3875-08.2009 · Cited by 223 · see citing works
Self-citationEndocannabinoids in the regulation of appetite and body weight
Kirkham, T. C. (2005) · Behavioural Pharmacology · doi:10.1097/00008877-200509000-00004 · Cited by 220 · see citing works
Cromwell, H. C., & Berridge, K. C. (1993) · Brain Research · doi:10.1016/0006-8993(93)90053-p · Cited by 220 · see citing works
Self-citationAlterations of Central Dopamine Receptors Before and After Gastric Bypass Surgery
Steele, K. E., Prokopowicz, G. P., Schweitzer, M. A., Magunsuon, T. H., Lidor, A. O., Kuwabawa, H., Kumar, A., Brasic, J., & Wong, D. F. (2010) · Obesity Surgery · doi:10.1007/s11695-009-0015-4 · Cited by 213 · see citing works
Insulin, leptin, and food reward: update 2008
Figlewicz, D. P., & Benoit, S. C. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90725.2008 · Cited by 202 · see citing works
Reward sensitivity and the D2 dopamine receptor gene: A case-control study of binge eating disorder
Davis, C., Levitan, R. D., Kaplan, A. S., Carter, J., Reid, C., Curtis, C., Patte, K., Hwang, R., & Kennedy, J. L. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.09.024 · Cited by 200 · see citing works
Glucocorticoids, chronic stress, and obesity
Dallman, M. F., Pecoraro, N. C., La Fleur, S. E., Warne, J. P., Ginsberg, A. B., Akana, S. F., Laugero, K. C., Houshyar, H., Strack, A. M., Bhatnagar, S., et al. (2006) · Progress in Brain Research · doi:10.1016/s0079-6123(06)53004-3 · Cited by 198 · see citing works
Peciña, S., Schulkin, J., & Berridge, K. C. (2006) · BMC Biology · doi:10.1186/1741-7007-4-8 · Cited by 194 · see citing works
Self-citationHigh Dose Pimozide Does Not Block Amphetamine-Induced Euphoria in Normal Volunteers
Brauer, L. H. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00240-7 · Cited by 194 · see citing works
Faure, A., Reynolds, S. M., Richard, J. M., & Berridge, K. C. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4961-07.2008 · Cited by 193 · see citing works
Self-citationA Role for Hypocretin (Orexin) in Male Sexual Behavior
Muschamp, J. W., Dominguez, J. M., Sato, S. M., Shen, R., & Hull, E. M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4121-06.2007 · Cited by 192 · see citing works
CRF system recruitment mediates dark side of compulsive eating
Cottone, P., Sabino, V., Roberto, M., Bajo, M., Pockros, L., Frihauf, J. B., Fekete, E. M., Steardo, L., Rice, K. C., Grigoriadis, D. E., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908789106 · Cited by 192 · see citing works
Matsui-Sakata, A., Ohtani, H., & Sawada, Y. (2005) · Drug Metabolism and Pharmacokinetics · doi:10.2133/dmpk.20.368 · Cited by 191 · see citing works
Molecular and neural mediators of leptin action
Robertson, S., Leinninger, G. M., & Myers, M. G. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.04.005 · Cited by 186 · see citing works
Food Restriction Enhances the Central Rewarding Effect of Abused Drugs
de Vaca, S. C., & Carr, K. D. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-18-07502.1998 · Cited by 185 · see citing works
Obesity, food deprivation, and supermarket shopping behavior.
Nisbett, R. E., & Kanouse, D. E. (1969) · Journal of Personality and Social Psychology · doi:10.1037/h0027799 · Cited by 182 · see citing works
Gustatory reward and the nucleus accumbens
Norgren, R., Hajnal, A., & Mungarndee, S. S. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.05.024 · Cited by 181 · see citing works
Chronic food restriction: Enhancing effects on drug reward and striatal cell signaling
Carr, K. D. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.09.021 · Cited by 180 · see citing works
Symposium overview–food addiction: fact or fiction?
Corwin, R. L., & Grigson, P. S. (2009) · The Journal of Nutrition · doi:10.3945/jn.108.097691 · Cited by 175 · see citing works
Hypocretin/orexin in arousal and stress
Berridge, C. W., España, R. A., & Vittoz, N. M. (2009) · Brain Research · doi:10.1016/j.brainres.2009.09.019 · Cited by 172 · see citing works
The Salted Food Addiction Hypothesis may explain overeating and the obesity epidemic
Cocores, J. A., & Gold, M. S. (2009) · Medical Hypotheses · doi:10.1016/j.mehy.2009.06.049 · Cited by 172 · see citing works
Avena, N. M., & Hoebel, B. G. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)01050-x · Cited by 170 · see citing works
Sugars: hedonic aspects, neuroregulation, and energy balance
Levine, A. S., Kotz, C. M., & Gosnell, B. A. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.4.834s · Cited by 170 · see citing works
The anhedonia hypothesis: mark III.
Wise, R. A. (1985) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00020306 · Cited by 169 · see citing works
Ahn, S., & Phillips, A. G. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-19-j0003.1999 · Cited by 160 · see citing works
Wolterink, G., Phillips, G., Cador, M., Donselaar-Wolterink, I., Robbins, T. W., & Everitt, B. J. (1993) · Psychopharmacology · doi:10.1007/bf02251293 · Cited by 158 · see citing works
Taste-related activity in the human dorsolateral prefrontal cortex
Kringelbach, M. L., de Araújo, I. E., & Rolls, E. T. (2003) · NeuroImage · doi:10.1016/j.neuroimage.2003.09.063 · Cited by 156 · see citing works
Higgs, S., Williams, C. M., & Kirkham, T. C. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1263-3 · Cited by 154 · see citing works
Disgust sensitivity predicts the insula and pallidal response to pictures of disgusting foods.
Calder, A. J., Beaver, J. D., Davis, M. H., Van Ditzhuijzen, J., Keane, J., & Lawrence, A. D. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05604.x · Cited by 154 · see citing works
Pelchat, M. L. (2009) · Journal of Nutrition · doi:10.3945/jn.108.097816 · Cited by 154 · see citing works
The Neurochemistry of Behavior
Panksepp, J. (1986) · Annual Review of Psychology · doi:10.1146/annurev.ps.37.020186.000453 · Cited by 154 · see citing works
Endogenous cannabinoids and appetite
Kirkham, T. C., & Williams, C. M. (2001) · Nutrition Research Reviews · doi:10.1079/095442201108729141 · Cited by 152 · see citing works
Modulation of food reward by adiposity signals
Figlewicz, D. P., Naleid, A. M., & Sipols, A. J. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.10.008 · Cited by 149 · see citing works
Peciña, S. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)00044-0 · Cited by 148 · see citing works
Pain modulating and reward systems: A single brain mechanism?
Magnen, J. L., Marfaing-Jallat, P., Miceli, D., & Devos, M. (1980) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(80)90157-4 · Cited by 144 · see citing works
The Need for Bold Action to Prevent Adolescent Obesity
Brownell, K. D., Schwartz, M. B., Puhl, R. M., Henderson, K. E., & Harris, J. L. (2009) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2009.03.004 · Cited by 140 · see citing works
β-Endorphin: cellular localization, electrophysiological and behavioral effects
Bloom, F. E., Rossier, J., Battenberg, E. L. F., Bayón, A., French, E. D., Henriksen, S. J., Siggins, G. R., LING, N. C., & Guillemin, R. (1979) · Palgrave Macmillan UK eBooks · doi:10.1007/978-1-349-04015-5_2 · Cited by 139 · see citing works
Locating Reward Cue at Response Manipulandum (CAM) Induces Symptoms of Drug Abuse
Tomie, A. (1996) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(95)00023-2 · Cited by 138 · see citing works
Opioids as agents of reward-related feeding: a consideration of the evidence
Levine, A. S., & Billington, C. J. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.04.032 · Cited by 138 · see citing works
Wachtel, S. R., Ortengren, A., & Wit, H. D. (2002) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(02)00104-7 · Cited by 138 · see citing works
Leptin and the systems neuroscience of meal size control
Grill, H. J. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.10.005 · Cited by 137 · see citing works
Berridge, K. C. (1990) · Behaviour · doi:10.1163/156853990x00428 · Cited by 137 · see citing works
Self-citationCiccocioppo, R., Fedeli, A., Economidou, D., Policani, F., Weiss, F., & Massi, M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-28-09445.2003 · Cited by 137 · see citing works
Endogenous cannabinoids and appetite.
Kirkham, F. J., & Williams, C. M. (2001) · PubMed · doi:10.1079/nrr200118 · Cited by 133 · see citing works
A neural systems analysis of the potentiation of feeding by conditioned stimuli.
Holland, P., & Petrovich, G. (2005) · Physiology and Behavior · doi:10.1016/j.physbeh.2005.08.062 · Cited by 132 · see citing works
Opioid reward ‘liking’ and ‘wanting’ in the nucleus accumbens
Peciña, S. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.04.006 · Cited by 132 · see citing works
AppetiteNeural and Behavioural Bases
Legg, C. R., & Booth, D. (1994) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780198547877.001.0001 · Cited by 130 · see citing works
Baldo, B. A., Gual‐Bonilla, L., Sijapati, K. S., Daniel, R. A., Landry, C. F., & Kelley, A. E. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03093.x · Cited by 130 · see citing works
Grigson, P. S. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00758-8 · Cited by 130 · see citing works
The evolving theory of basal forebrain functional—anatomical ‘macrosystems’
Zahm, D. S. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.06.003 · Cited by 128 · see citing works
Ventral Pallidal Representation of Pavlovian Cues and Reward: Population and Rate Codes
Tindell, A. J., Berridge, K. C., & Aldridge, J. W. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1437-03.2004 · Cited by 128 · see citing works
Self-citationPalatability shift of a salt-associated incentive during sodium depletion.
Berridge, K. C., & Schulkin, J. A. (1989) · PubMed · Cited by 127 · see citing works
Self-citationBell, S. M., Stewart, R. B., Thompson, S. C., & Meisch, R. A. (1997) · Psychopharmacology · doi:10.1007/s002130050258 · Cited by 127 · see citing works
Dynamic Computation of Incentive Salience: “Wanting” What Was Never “Liked”
Tindell, A. J., Smith, K. S., Berridge, K. C., & Aldridge, J. W. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.2499-09.2009 · Cited by 124 · see citing works
Self-citationContextual control of trigeminal sensorimotor function
Berridge, K. C., & Fentress, J. C. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-02-00325.1986 · Cited by 122 · see citing works
Self-citationModulation of feeding by hypothalamic paraventricular nucleus α1- and α2-adrenergic receptors
Wellman, P. J., Davies, B. T., Morien, A., & McMahon, L. R. (1993) · Life Sciences · doi:10.1016/0024-3205(93)90243-v · Cited by 121 · see citing works
Postingestive alliesthesia: The rat tells the same story
Cabanac, M., & Lafrance, L. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90123-l · Cited by 120 · see citing works
Anhedonia After a Selective Bilateral Lesion of the Globus Pallidus
Miller, J. M., Vorel, S. R., Tranguch, A. J., Kenny, E. T., Mazzoni, P., van Gorp, W. G., & Kleber, H. D. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.5.786 · Cited by 120 · see citing works
Flagged first, then by citations
Research works printed but not linked: 5
- Aldridge JW Berridge KC Kringelbach ML Berridge KC 2010 Neural Coding of Pleasure: “Rose-Tinted Glasses” of the Ventral Pallidum Pleasures of the Brain Oxford University Press Oxford 62 73
- Cabanac M Kringelbach ML Berridge KC 2010 The dialectics of pleasure Pleasures of the brain Oxford University Press Oxford, U.K 113 124
- Kringelbach ML Berridge KC 2010 Pleasures of the Brain Oxford University Press Oxford 343
- Rolls ET 2005 Emotion explained Series in affective science Oxford University Press Oxford; New York xvii 606
- Small D Veldhuizen M Kringelbach ML Berridge KC 2010 Human crossmodal studies of taste and smell\ Pleasures of the brain Oxford University Press Oxford, U.K 320 336
Cited by
Sorted by citations
Depression and obesity: evidence of shared biological mechanisms
Milaneschi, Y., Simmons, W. K., van Rossum, E. F. C., & Penninx, B. W. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0017-5 · Cited by 1,073 · see citing works
Neural correlates of food addiction
Gearhardt, A. N. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.32 · Cited by 707 · see citing works
From prediction error to incentive salience: mesolimbic computation of reward motivation.
Berridge, K. C. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.07990.x · Cited by 700 · see citing works
Self-citationTomiyama, A. J. (2019) · Annual Review of Psychology · doi:10.1146/annurev-psych-010418-102936 · Cited by 695 · see citing works
“…of addictive-like behavior is wanting (i.e., motivation or desire for a substance) and intake of a substance in the absence of liking (i.e., enjoyment in consuming a substance; Berridge et al. 2010), and acute stress increases both food wanting and food intake in humans (Lemmens et al. 2011).”
BackgroundBlaming the brain for obesity: integration of hedonic and homeostatic mechanisms
Berthoud, H.-R., Münzberg, H., & Morrison, C. D. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.12.050 · Cited by 445 · see citing works
Neural correlates of long-term intense romantic love
Acevedo, B. P., Aron, A., Fisher, H. E., & Brown, L. L. (2012) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsq092 · Cited by 441 · see citing works
“, 1997; Napier and Mitrovic, 1999) and has been identified as a ‘hedonic hotspot’, mediating both ‘liking’ and ‘wanting’ for primary rewards (Berridge et al., 2010; Smith et al., 2010).”
Background“Liking” and “wanting” in eating and food reward: Brain mechanisms and clinical implications
Morales, I., & Berridge, K. C. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113152 · Cited by 346 · see citing works
Self-citationDrewnowski, A., Mennella, J. A., Johnson, S. L., & Bellisle, F. (2012) · The Journal of Nutrition · doi:10.3945/jn.111.149575 · Cited by 328 · see citing works
“The emotions or affects experienced upon tasting something sweet are complex processes that are phylogenetically remarkably well conserved (19).”
BackgroundAnorexia nervosa and obesity are associated with opposite brain reward response
Frank, G. K. W., Reynolds, J. R., Shott, M. E., Jappe, L., Yang, T. T., Tregellas, J. R., & O'Reilly, R. C. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.51 · Cited by 311 · see citing works
Food reward, hyperphagia, and obesity
Berthoud, H.-R., Lenard, N. R., & Shin, A. C. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00028.2011 · Cited by 275 · see citing works
The impact of sugar consumption on stress driven, emotional and addictive behaviors
Jacques, A., Chaaya, N., Beecher, K., Ali, S. A., Belmer, A., & Bartlett, S. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.05.021 · Cited by 271 · see citing works
Roles of "wanting" and "liking" in motivating behavior: gambling, food, and drug addictions
Robinson, M. J. F., Fischer, A. M., Ahuja, A., Lesser, E. N., & Maniates, H. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_387 · Cited by 247 · see citing works
Lawrence, N. S., Hinton, E. C., Parkinson, J. A., & Lawrence, A. D. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.06.070 · Cited by 242 · see citing works
Building a neuroscience of pleasure and well-being
Berridge, K. C., & Kringelbach, M. L. (2011) · Psychology of Well-Being: Theory, Research and Practice · doi:10.1186/2211-1522-1-3 · Cited by 229 · see citing works
Self-citationNummenmaa, L., Hirvonen, J., Hannukainen, J. C., Immonen, H., Lindroos, M. M., Salminen, P., & Nuutila, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031089 · Cited by 220 · see citing works
Multiple roles for orexin/hypocretin in addiction
Mahler, S. V., Smith, R. J., Moorman, D. E., Sartor, G. C., & Aston-Jones, G. (2012) · Progress in Brain Research · doi:10.1016/b978-0-444-59489-1.00007-0 · Cited by 215 · see citing works
Endocannabinoids in Amygdala and Nucleus Accumbens Mediate Social Play Reward in Adolescent Rats
Trezza, V., Damsteegt, R., Manduca, A., Petrosino, S., Van Kerkhof, L. W. M., Pasterkamp, R. J., Zhou, Y., Campolongo, P., Cuomo, V., Di Marzo, V., et al. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.0114-12.2012 · Cited by 190 · see citing works
Neural vulnerability factors that increase risk for future weight gain
Stice, E., & Yokum, S. (2016) · Psychological Bulletin · doi:10.1037/bul0000044 · Cited by 179 · see citing works
Opioid system and human emotions
Nummenmaa, L., & Tuominen, L. (2018) · British Journal of Pharmacology · doi:10.1111/bph.13812 · Cited by 178 · see citing works
Kullmann, S., Heni, M., Veit, R., Scheffler, K., Machann, J., Häring, H.-U., Fritsche, A., & Preissl, H. (2015) · Diabetes Care · doi:10.2337/dc14-2319 · Cited by 175 · see citing works
A transdiagnostic perspective on social anhedonia
Barkus, E., & Badcock, J. C. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00216 · Cited by 165 · see citing works
Busetto, L., Bettini, S., Makaronidis, J., Roberts, C. A., Halford, J. C. G., & Batterham, R. L. (2021) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2021.01.002 · Cited by 159 · see citing works
van Bloemendaal, L., Veltman, D. J., ten Kulve, J. S., Groot, P. F. C., Ruhé, H. G., Barkhof, F., Sloan, J. H., Diamant, M., & Ijzerman, R. G. (2015) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12506 · Cited by 151 · see citing works
Devoto, F., Zapparoli, L., Bonandrini, R., Berlingeri, M., Ferrulli, A., Luzi, L., Banfi, G., & Paulesu, E. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.07.017 · Cited by 140 · see citing works
Putting desire on a budget: dopamine and energy expenditure, reconciling reward and resources
Beeler, J. A., Frazier, C. R. M., & Zhuang, X. (2012) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2012.00049 · Cited by 136 · see citing works
An evidence-based guide for obesity treatment in primary care.
Fitzpatrick, S. L., Wischenka, D., Appelhans, B. M., Pbert, L., Wang, M., Wilson, D. K., & Pagoto, S. L. (2016) · The American Journal of Medicine · doi:10.1016/j.amjmed.2015.07.015 · Cited by 125 · see citing works
Obesity and Eating Disorders in Children and Adolescents: The Bidirectional Link
Stabouli, S., Erdine, S., Suurorg, L., Jankauskienė, A., & Lurbe, E. (2021) · Nutrients · doi:10.3390/nu13124321 · Cited by 123 · see citing works
Maxwell, A. L., Gardiner, E., & Loxton, N. J. (2020) · European Eating Disorders Review · doi:10.1002/erv.2732 · Cited by 123 · see citing works
Psychopharmacological advances in eating disorders
Himmerich, H., & Treasure, J. (2018) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2018.1383895 · Cited by 119 · see citing works
A functional neuroimaging review of obesity, appetitive hormones and ingestive behavior
Burger, K. S., & Berner, L. A. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.04.025 · Cited by 110 · see citing works
Cameron, C. M., Wightman, R. M., & Carelli, R. M. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.08.006 · Cited by 109 · see citing works
Circadian rhythm of circulating levels of the endocannabinoid 2-arachidonoylglycerol
Hanlon, E. C., Tasali, E., Leproult, R., Stuhr, K. L., Doncheck, E., de Wit, H., Hillard, C. J., & Van Cauter, E. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-3455 · Cited by 101 · see citing works
Glucagon-Like Peptide-1 (GLP-1) in the Integration of Neural and Endocrine Responses to Stress
Diz-Chaves, Y., Herrera-Pérez, S., González-Matías, L. C., Lamas, J. A., & Mallo, F. (2020) · Nutrients · doi:10.3390/nu12113304 · Cited by 84 · see citing works
Response of neural reward regions to food cues in autism spectrum disorders
Cascio, C. J., Foss-Feig, J. H., Heacock, J. L., Newsom, C. R., Cowan, R. L., Benningfield, M. M., Rogers, B. P., & Cao, A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-9 · Cited by 76 · see citing works
The microbiota, the gut and the brain in eating and alcohol use disorders: A ‘Ménage à Trois’?
Temko, J. E., Bouhlal, S., Farokhnia, M., Lee, M. R., Cryan, J. F., & Leggio, L. (2017) · Alcohol and Alcoholism · doi:10.1093/alcalc/agx024 · Cited by 76 · see citing works
Food cue reactivity: Neurobiological and behavioral underpinnings
Kanoski, S. E., & Boutelle, K. N. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09724-x · Cited by 78 · see citing works
Boutelle, K. N., Manzano, M. A., & Eichen, D. M. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113018 · Cited by 61 · see citing works
Soussignan, R., Schaal, B., Rigaud, D., Royet, J.-P., & Jiang, T. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2010.12.007 · Cited by 62 · see citing works
Learning and the motivation to eat: forebrain circuitry.
Petrovich, G. D. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.04.059 · Cited by 57 · see citing works
Hermann, P., Gál, V., Kóbor, I., Kirwan, C. B., Kovács, P., Kitka, T., Lengyel, Z., Bálint, E., Varga, B., Csekő, C., et al. (2019) · NeuroImage: Clinical · doi:10.1016/j.nicl.2019.101803 · Cited by 46 · see citing works
Stievenard, A., Méquinion, M., Andrews, Z. B., Destée, A., Chartier-Harlin, M.-C., Viltart, O., & Vanbesien-Mailliot, C. C. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.11.021 · Cited by 39 · see citing works
Gutiérrez‐Martos, M., Girard, B., Mendonça‐Netto, S., Perroy, J., Valjent, E., Maldonado, R., & Martin, M. (2018) · Addiction Biology · doi:10.1111/adb.12541 · Cited by 35 · see citing works
Lyu, X., Du, J., Zhan, G., Wu, Y., Su, H., Zhu, Y., Jarskog, F., Zhao, M., & Fan, X. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00181 · Cited by 27 · see citing works
The importance of the hypothalamo-pituitary-adrenal axis as a therapeutic target in anorexia nervosa
Bou Khalil, R., Souaiby, L., & Farès, N. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.12.035 · Cited by 26 · see citing works
Towards a translational approach to food addiction: Implications for bulimia nervosa
Leslie, M., Lambert, E., & Treasure, J. (2019) · Current Addiction Reports · doi:10.1007/s40429-019-00264-0 · Cited by 9 · see citing works
Poghosyan, V., Ioannou, S., Al-Amri, K. M., Al-Mashhadi, S. A., Al-Mohammed, F., Al-Otaibi, T., & Al-Saeed, W. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.948063 · Cited by 8 · see citing works
Do GLP-1 Receptor Agonists Alter Brain Responses to Reward-Related Cues? A Systematic Review
Dang, V., Sambuco, N., Yammine, L., & Versace, F. (2026) · doi:10.64898/2026.01.31.702984 · Cited by 4 · see citing works
- Authors
- Berridge, K. C., Ho, C.-Y., Richard, J. M., & DiFeliceantonio, A. G.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Berridge, Kent C.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 1350
- Pages
- 43-64
- ISSN
- 0006-8993 (ISSN-L)
- PMC
- PMC2913163
- OpenAlex
- W2137060566
- Cited by
- 873
- References
- 255
- Citations by year
- 2026: 19 · 2025: 27 · 2024: 45 · 2023: 31 · 2022: 47 · 2021: 69 · 2020: 99 · 2019: 89 · 2018: 61 · 2017: 69 · 2016: 56 · 2015: 66 · 2014: 57 · 2013: 46 · 2012: 49
- FWCI
- 4.43
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- food reward, food liking, desire to eat, obesity, eating disorders, nucleus accumbens, ventral pallidum, opioid signaling, endocannabinoid signaling, orexin, mesolimbic dopamine system, glutamate signaling, limbic system
- MeSH terms
- Animals, Feeding and Eating Disorders, Brain, Feeding Behavior, Humans, Nerve Net, Obesity, Pleasure
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
