Cited by 845Eating Disorders and BehaviorsRegulation of Appetite and ObesityNutrition, Health and Food Behavior

The DOI matches its Crossref record; 172 of the 173 references it cites were found in a registry or an index.

New insights into symptoms and neurocircuit function of anorexia nervosa

Open access

Kaye, Walter H., Fudge, Julie L., Paulus, Martin·2009·Nature Reviews Neuroscience

Open this paper in CoChat — free account Open PDF

Abstract

Individuals with anorexia nervosa have a relentless preoccupation with dieting and weight loss that results in severe emaciation and sometimes death. It is controversial whether such symptoms are secondary to psychosocial influences, are a consequence of obsessions and anxiety or reflect a primary disturbance of brain appetitive circuits. New brain imaging technology provides insights into ventral and dorsal neural circuit dysfunction - perhaps related to altered serotonin and dopamine metabolism - that contributes to the puzzling symptoms found in people with eating disorders. For example, altered insula activity could explain interoceptive dysfunction, and altered striatal activity might shed light on altered reward modulation in people with anorexia nervosa.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nrn2682

Cites

172 of 172 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
How do you feel — now? The anterior insula and human awareness
(Bud) Craig, A. D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2555 · Cited by 6,657 · cited 2×
“…of the entire body 143 and is crucial for the instantiation of the ‘self’ because it provides the link between cognitive and affective processes and the current body state 140–142, It is thought that altered interoceptive awareness might be a precipitating and reinforcing factor in AN 10,146–148 .”
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
How do you feel? Interoception: The sense of the physiological condition of the body
Craig, A. D. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn894 · Cited by 6,006
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127
Neural systems supporting interoceptive awareness
Critchley, H. D., Wiens, S., Rotshtein, P., Öhman, A., & Dolan, R. J. (2004) · Nature Neuroscience · doi:10.1038/nn1176 · Cited by 3,406 · cited 2×
“…of the entire body 143 and is crucial for the instantiation of the ‘self’ because it provides the link between cognitive and affective processes and the current body state 140–142, It is thought that altered interoceptive awareness might be a precipitating and reinforcing factor in AN 10,146–148 .”
Contributions of anterior cingulate cortex to behaviour
Devinsky, O., Morrell, M. J., & Vogt, B. A. (1995) · Brain · doi:10.1093/brain/118.1.279 · Cited by 3,377
Separate neural systems value immediate and delayed monetary rewards
McClure, S. M., Laibson, D. I., Loewenstein, G., & Cohen, J. D. (2004) · Science · doi:10.1126/science.1100907 · Cited by 3,089
Anterior Cingulate Conflict Monitoring and Adjustments in Control
Kerns, J. G., Cohen, J. D., MacDonald, A. W., Cho, R. Y., Stenger, V. A., & Carter, C. S. (2004) · Science · doi:10.1126/science.1089910 · Cited by 2,891
Risk and maintenance factors for eating pathology: A meta-analytic review.
Stice, E. M. (2002) · Psychological Bulletin · doi:10.1037/0033-2909.128.5.825 · Cited by 2,710

Flagged first, then by citations

Show all 173 references

1 of the 173 references couldn’t be matched to a known paper.

Sorted by citations

Gut feelings: the emerging biology of gut-brain communication
Mayer, E. A. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3071 · Cited by 1,726
Interoception and Mental Health: A Roadmap.
Khalsa, S. S., Adolphs, R., Cameron, O. G., Critchley, H. D., Davenport, P. W., Feinstein, J. S., Feusner, J. D., Garfinkel, S. N., Lane, R. D., Mehling, W. E., et al. (2018) · Biological psychiatry. Cognitive neuroscience and neuroimaging · doi:10.1016/j.bpsc.2017.12.004 · Cited by 1,453
Self-citation
The tempted brain eats: Pleasure and desire circuits in obesity and eating disorders
Berridge, K. C., Ho, C.-Y., Richard, J. M., & DiFeliceantonio, A. G. (2010) · Brain Research · doi:10.1016/j.brainres.2010.04.003 · Cited by 873
Eating disorders
Treasure, J. L., Claudino, A. M., & Zucker, N. L. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61748-7 · Cited by 661
Nothing tastes as good as skinny feels: the neurobiology of anorexia nervosa
Kaye, W. H., Wierenga, C. E., Bailer, U. F., Simmons, A. N., & Bischoff‐Grethe, A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.01.003 · Cited by 566
Self-citation
Medical complications of anorexia nervosa and bulimia
Westmoreland, P., Krantz, M. J., & Mehler, P. S. (2016) · The American Journal of Medicine · doi:10.1016/j.amjmed.2015.06.031 · Cited by 467
The insula: an underestimated brain area in clinical neuroscience, psychiatry, and neurology
Namkung, H., Kim, S.-H., & Sawa, A. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.02.002 · Cited by 462
Poor Cognitive Flexibility in Eating Disorders: Examining the Evidence using the Wisconsin Card Sorting Task
Tchanturia, K., Davies, H. A., Roberts, M., Harrison, A., Nakazato, M., Schmidt, U. H., Treasure, J. L., & Morris, R. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0028331 · Cited by 433
Can interoception improve the pragmatic search for biomarkers in psychiatry?
Khalsa, S. S., & Lapidus, R. C. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00121 · Cited by 366
The neuroendocrinology of the microbiota-gut-brain axis: a behavioural perspective
Cussotto, S., Sandhu, K. V., Dinan, T. G., & Cryan, J. F. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.04.002 · Cited by 326
Weight gain in anorexia nervosa does not ameliorate the faecal microbiota, branched chain fatty acid profiles and gastrointestinal complaints
Mack, I., Cuntz, U., Grämer, C., Niedermaier, S., Pohl, C., Schwiertz, A., Zimmermann, K., Zipfel, S., Enck, P., & Penders, J. (2016) · Scientific Reports · doi:10.1038/srep26752 · Cited by 313
Anorexia nervosa and obesity are associated with opposite brain reward response
Frank, G. K. W., Reynolds, J. R., Shott, M. E., Jappe, L., Yang, T. T., Tregellas, J. R., & O'Reilly, R. C. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.51 · Cited by 311
The Enigmatic Persistence of Anorexia Nervosa
Walsh, B. T. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.12081074 · Cited by 323
Anorexia nervosa
Treasure, J. L., Zipfel, S., Micali, N., Wade, T. D., Stice, E. M., Claudino, A. M., Schmidt, U. H., Frank, G., Bulik, C. M., & Wentz, E. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.74 · Cited by 302
The socio-emotional processing stream in Anorexia Nervosa
Oldershaw, A., Hambrook, D. G., Stahl, D. R., Tchanturia, K., Treasure, J. L., & Schmidt, U. H. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.11.001 · Cited by 286
An Update on Evidence-Based Psychosocial Treatments for Eating Disorders in Children and Adolescents
Lock, J. (2015) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2014.971458 · Cited by 281
A reward-centred model of anorexia nervosa: A focussed narrative review of the neurological and psychophysiological literature
O'Hara, C., Campbell, I. C., & Schmidt, U. H. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.02.012 · Cited by 271
Reward and the serotonergic system
Kranz, G. S., Kasper, S. F., & Lanzenberger, R. R. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.01.036 · Cited by 279
Increased Prefrontal and Parahippocampal Activation with Reduced Dorsolateral Prefrontal and Insular Cortex Activation to Food Images in Obesity: A Meta-Analysis of fMRI Studies
Brooks, S. J., Cedernaes, J., & Schiöth, H. B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060393 · Cited by 269
The Role of Affect in the Maintenance of Anorexia Nervosa: Evidence from a Naturalistic Assessment of Momentary Behaviors and Emotion
Engel, S., Wonderlich, S., Crosby, R., Mitchell, J., Crow, S., Peterson, C., Grange, D. L., Simonich, H. K., Cao, L., Lavender, J. M., et al. (2013) · Journal of Abnormal Psychology · doi:10.1037/a0034010 · Cited by 243
Dysregulation of brain reward systems in eating disorders: Neurochemical information from animal models of binge eating, bulimia nervosa, and anorexia nervosa
Avena, N. M., & Bocarsly, M. E. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.11.010 · Cited by 285
Alterations in brain structures related to taste reward circuitry in ill and recovered anorexia nervosa and in bulimia nervosa
Frank, G. K., Shott, M. E., Hagman, J. O., & Mittal, V. A. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.12101294 · Cited by 237
Increased neural processing of rewarding and aversive food stimuli in recovered anorexia nervosa
Cowdrey, F. A., Park, R. J., Harmer, C. J., & McCabe, C. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.05.028 · Cited by 233
Wiener klinische Wochenschrift
(2013) · Wiener klinische Wochenschrift · doi:10.1007/508.1613-7671 · Cited by 233
Differential neural responses to food images in women with bulimia versus anorexia nervosa
Brooks, S. J., O′Daly, O. G., Uher, R., Friederich, H.-C., Giampietro, V., Brammer, M., Williams, S. C. R., Schiöth, H. B., Treasure, J., & Campbell, I. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022259 · Cited by 231
Assessing body awareness and autonomic reactivity: Factor structure and psychometric properties of the Body Perception Questionnaire‐Short Form (BPQ‐SF)
Cabrera, A., Kolacz, J., Pailhez, G., Bulbena‐Cabre, A., Bulbena, A., & Porges, S. W. (2018) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.1596 · Cited by 224
Intuitive eating is associated with interoceptive sensitivity. Effects on body mass index
Herbert, B. M., Blechert, J., Hautzinger, M., Matthias, E., & Herbert, C. (2013) · Appetite · doi:10.1016/j.appet.2013.06.082 · Cited by 220
Bacterial ClpB heat-shock protein, an antigen-mimetic of the anorexigenic peptide α-MSH, at the origin of eating disorders
Tennoune, N., Chan, P., Breton, J., Legrand, R., Chabane, Y. N., Akkermann, K., Järv, A., Ouelaa, W., Takagi, K., Ghouzali, I., et al. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.98 · Cited by 218
Selective dysfunction of basal ganglia subterritories: From movement to behavioral disorders
Tremblay, L., Worbe, Y., Thobois, S., Sgambato, V., & Féger, J. (2015) · Movement Disorders · doi:10.1002/mds.26199 · Cited by 212
Incorporating positive body image into the treatment of eating disorders: A model for attunement and mindful self-care
Cook‐Cottone, C. P. (2015) · Body Image · doi:10.1016/j.bodyim.2015.03.004 · Cited by 207
Altered Insula Response to Sweet Taste Processing After Recovery From Anorexia and Bulimia Nervosa
Oberndorfer, T. A., Frank, G., Simmons, A. N., Wagner, A., McCurdy, D., Fudge, J. L., Yang, T. T., Paulus, M. P., & Kaye, W. H. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.11111745 · Cited by 200
Self-citation
Are extremes of consumption in eating disorders related to an altered balance between reward and inhibition?
Wierenga, C. E., Ely, A., Bischoff-Grethe, A., Bailer, U. F., Simmons, A. N., & Kaye, W. H. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00410 · Cited by 195
Self-citation
The role of psychosocial factors and psychiatric disorders in functional dyspepsia
Oudenhove, L. V., & Aziz, Q. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.10 · Cited by 195
Dysfunctions of leptin, ghrelin, BDNF and endocannabinoids in eating disorders: Beyond the homeostatic control of food intake
Monteleone, P., & Maj, M. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.10.021 · Cited by 199
New Insights in Anorexia Nervosa
Gorwood, P. A. P. M., Blanchet, C., Chartrel, N., Duclos, J., Déchelotte, P., Hanachi, M., Fetissov, S. O., Godart, N. T., Melchior, J., Ramoz, N., et al. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00256 · Cited by 206
Altered interoceptive awareness in anorexia nervosa: Effects of meal anticipation, consumption and bodily arousal
Khalsa, S. S., Craske, M. G., Li, W., Vangala, S., Strober, M., & Feusner, J. D. (2015) · International Journal of Eating Disorders · doi:10.1002/eat.22387 · Cited by 191
Neural basis of a multidimensional model of body image distortion in anorexia nervosa
Gaudio, S., & Quattrocchi, C. C. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.05.003 · Cited by 182
Advances in the treatment of anorexia nervosa: a review of established and emerging interventions
Brockmeyer, T., Friederich, H.-C., & Schmidt, U. H. (2017) · Psychological Medicine · doi:10.1017/s0033291717002604 · Cited by 198
Nutritional rehabilitation in anorexia nervosa: review of the literature and implications for treatment
Marzola, E., Nasser, J. A., Hashim, S. A., Shih, P.-A. B., & Kaye, W. H. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-290 · Cited by 180
Self-citation
Resistance to treatment and change in anorexia nervosa: a clinical overview
Daga, G. A., Amianto, F., Delsedime, N., Bacco, C. D., & Fassino, S. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-294 · Cited by 205
Hunger Does Not Motivate Reward in Women Remitted from Anorexia Nervosa
Wierenga, C. E., Bischoff‐Grethe, A., Melrose, A. J., Irvine, Z., Torres, L. A., Bailer, U. F., Simmons, A. N., Fudge, J. L., McClure, S. M., Ely, A. V., et al. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.09.024 · Cited by 184
Self-citation
Intolerance of uncertainty in eating disorders: a systematic review and meta-analysis
Brown, M., Robinson, L., Campione, G. C., Wuensch, K., Hildebrandt, T., & Micali, N. (2017) · European Eating Disorders Review · doi:10.1002/erv.2523 · Cited by 173
A systematic review of reviews of neurocognitive functioning in eating disorders: the state-of-the-literature and future directions.
Smith, K. E., Mason, T. B., Johnson, J. S., Lavender, J. M., & Wonderlich, S. A. (2018) · International Journal of Eating Disorders · doi:10.1002/eat.22929 · Cited by 170
Increased Capacity to Delay Reward in Anorexia Nervosa
STEINGLASS, J. E., Figner, B., Berkowitz, S. A., Simpson, H. B., Weber, E. U., & Walsh, B. T. (2012) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617712000446 · Cited by 182
Comorbid Psychiatric Disorders in Female Adolescents with First‐Onset Anorexia Nervosa
Bühren, K., Schwarte, R., Fluck, F., Timmesfeld, N., Krei, M., Egberts, K. M., Pfeiffer, E. F., Fleischhaker, C., Wewetzer, C., & Herpertz-Dahlmann, B. (2013) · European Eating Disorders Review · doi:10.1002/erv.2254 · Cited by 168
Neural Responses to Visual Food Cues: Insights from Functional Magnetic Resonance Imaging
García‐García, I., Narberhaus, A., Marqués‐Iturria, I., Garolera, M., Rădoi, A., Segura, B., Pueyo, R., Ariza, M., & Jurado, M. Á. (2013) · European Eating Disorders Review · doi:10.1002/erv.2216 · Cited by 166
Does a Shared Neurobiology for Foods and Drugs of Abuse Contribute to Extremes of Food Ingestion in Anorexia and Bulimia Nervosa?
Kaye, W. H., Wierenga, C. E., Bailer, U. F., Simmons, A. N., Wagner, A., & Bischoff‐Grethe, A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.01.002 · Cited by 171
Self-citation
Nonvisual Multisensory Impairment of Body Perception in Anorexia Nervosa: A Systematic Review of Neuropsychological Studies
Gaudio, S., Brooks, S. J., & Riva, G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110087 · Cited by 182
Deep-Brain Stimulation for Anorexia Nervosa
Wu, H., Dyck-Lippens, P. J. V., Santegoeds, R. G. C., van Kuyck, K., Gabriëls, L. A., Lin, G., Pan, G., Li, Y., Li, D., Zhan, S., et al. (2012) · World Neurosurgery · doi:10.1016/j.wneu.2012.06.039 · Cited by 163
Psilocybin therapy for females with anorexia nervosa: a phase 1, open-label feasibility study
Peck, S. K., Shao, S., Gruen, T., Yang, K. H., Babakanian, A., Trim, J., Finn, D. M., & Kaye, W. H. (2023) · Nature Medicine · doi:10.1038/s41591-023-02455-9 · Cited by 171
Self-citation
Attentional Processing of Food Pictures in Individuals with Anorexia Nervosa—An Eye-Tracking Study
Giel, K. E., Friederich, H.-C., Teufel, M., Hautzinger, M., Enck, P., & Zipfel, S. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.047 · Cited by 161
Altered Insula Activity during Visceral Interoception in Weight-Restored Patients with Anorexia Nervosa
Kerr, K. L., Moseman, S. E., Avery, J. A., Bodurka, J., Zucker, N. L., & Simmons, W. K. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.174 · Cited by 159
Disruption of Visuospatial and Somatosensory Functional Connectivity in Anorexia Nervosa
Favaro, A., Santonastaso, P., Manara, R., Bosello, R., Bommarito, G., Tenconi, E., & Salle, F. D. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.04.025 · Cited by 166
Neuroendocrinology and brain imaging of reward in eating disorders: A possible key to the treatment of anorexia nervosa and bulimia nervosa
Monteleone, A. M., Castellini, G., Volpe, U., Ricca, V., Lelli, L., Monteleone, P., & Maj, M. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.02.020 · Cited by 162
Reward processing in anorexia nervosa
Keating, C., Tilbrook, A. J., Rossell, S. L., Enticott, P. G., & Fitzgerald, P. B. (2012) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2012.01.036 · Cited by 161
The role of body image disturbance in the onset, maintenance, and relapse of anorexia nervosa: A systematic review
Glashouwer, K. A., van der Veer, R. M. L., Adipatria, F., de Jong, P. J., & Vocks, S. (2019) · Clinical Psychology Review · doi:10.1016/j.cpr.2019.101771 · Cited by 170
Altered Brain Reward Circuits in Eating Disorders: Chicken or Egg?
Frank, G. (2013) · Current Psychiatry Reports · doi:10.1007/s11920-013-0396-x · Cited by 153
A core eating network and its modulations underlie diverse eating phenomena
Chen, J., Papies, E. K., & Barsalou, L. W. (2016) · Brain and Cognition · doi:10.1016/j.bandc.2016.04.004 · Cited by 144
Neurocircuit function in eating disorders
Friederich, H., Wu, M., Simon, J. J., & Herzog, W. (2013) · International Journal of Eating Disorders · doi:10.1002/eat.22099 · Cited by 143
Neurobiological model of the persistence of anorexia nervosa
STEINGLASS, J. E., & Walsh, B. T. (2016) · Journal of Eating Disorders · doi:10.1186/s40337-016-0106-2 · Cited by 143
The intestinal microbiota and metabolites in patients with anorexia nervosa
Procházková, P., Roubalová, R., Dvořák, J., Kreisinger, J., Hill, M., Tlaskalová‐Hogenová, H., Tomášová, P., Pelantová, H., Cermakova, M., Kuzma, M., et al. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1902771 · Cited by 145
Cognitive Remediation Therapy for Eating Disorders: Development, Refinement and Future Directions
Tchanturia, K., & Lock, J. (2010) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_90 · Cited by 138
The perception of affective touch in anorexia nervosa
Crucianelli, L., Cardi, V., Treasure, J. L., Jenkinson, P. M., & Fotopoulou, A. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.01.078 · Cited by 138
Neurocircuity of Eating Disorders
Kaye, W. H., Wagner, A., Fudge, J. L., & Paulus, M. P. (2010) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_85 · Cited by 142
Self-citation
Altered insula activation during pain anticipation in individuals recovered from anorexia nervosa: Evidence of interoceptive dysregulation
Strigo, I. A., Matthews, S. C., Simmons, A. N., Oberndorfer, T. A., Klabunde, M., Reinhardt, L. E., & Kaye, W. H. (2012) · International Journal of Eating Disorders · doi:10.1002/eat.22045 · Cited by 137
Self-citation
Increased resting state functional connectivity in the default mode network in recovered anorexia nervosa
Cowdrey, F. A., Filippini, N., Park, R. J., Smith, S. M., & McCabe, C. (2012) · Human Brain Mapping · doi:10.1002/hbm.22202 · Cited by 145
Reward-related decision making in eating and weight disorders: A systematic review and meta-analysis of the evidence from neuropsychological studies
Wu, M., Brockmeyer, T., Hartmann, M., Skunde, M., Herzog, W., & Friederich, H. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.11.017 · Cited by 141
Psychological inflexibility and Symptom Expression in Anorexia Nervosa
Merwin, R. M., Timko, C. A., Moskovich, A. A., Ingle, K. K., Bulik, C. M., & Zucker, N. L. (2010) · Eating Disorders · doi:10.1080/10640266.2011.533606 · Cited by 131
Elevated cognitive control over reward processing in recovered female patients with anorexia nervosa
Ehrlich, S., Geisler, D., Ritschel, F., King, J. A., Seidel, M., Boehm, I., Breier, M., Clas, S., Weiss, J., Marxen, M., et al. (2015) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.140249 · Cited by 129
Eating disorders, gene–environment interactions and epigenetics
Campbell, I. C., Mill, J. S., Uher, R., & Schmidt, U. H. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.09.012 · Cited by 136
Increased resting state functional connectivity in the fronto-parietal and default mode network in anorexia nervosa
Boehm, I., Geisler, D., King, J. A., Ritschel, F., Seidel, M., Araujo, Y. I. D., Petermann, J., Lohmeier, H., Weiss, J., Walter, M., et al. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00346 · Cited by 131
Exposure therapy in eating disorders revisited
Koskina, A., Campbell, I. C., & Schmidt, U. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.11.010 · Cited by 127
A rat in the labyrinth of anorexia nervosa: Contributions of the activity‐based anorexia rodent model to the understanding of anorexia nervosa
Gutiérrez, E. (2013) · International Journal of Eating Disorders · doi:10.1002/eat.22095 · Cited by 127
Processing of Food, Body and Emotional Stimuli in Anorexia Nervosa: A Systematic Review and Meta‐analysis of Functional Magnetic Resonance Imaging Studies
Zhu, Y., Hu, X., Wang, J., Chen, J., Guo, Q., Li, C., & Enck, P. (2012) · European Eating Disorders Review · doi:10.1002/erv.2197 · Cited by 127
Labeling and defining severe and enduring anorexia nervosa: A systematic review and critical analysis
Broomfield, C., Stedal, K., Touyz, S., & Rhodes, P. (2017) · International Journal of Eating Disorders · doi:10.1002/eat.22715 · Cited by 126
Neuroscience and eating disorders: The allocentric lock hypothesis
Riva, G. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.10.039 · Cited by 126
Core psychopathology in anorexia nervosa and bulimia nervosa: A network analysis
Forrest, L. N., Jones, P. J., Ortiz, S. N., & Smith, A. R. (2018) · International Journal of Eating Disorders · doi:10.1002/eat.22871 · Cited by 125
Anorexia nervosa and the insula
Nunn, K., Frampton, I., Fuglset, T. S., Törzsök-Sonnevend, M., & Lask, B. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2010.10.038 · Cited by 122
Effects of short-term food deprivation on interoceptive awareness, feelings and autonomic cardiac activity
Herbert, B. M., Herbert, C., Pollatos, O., Weimer, K., Enck, P., Sauer, H., & Zipfel, S. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2011.09.004 · Cited by 121
Short-term metreleptin treatment of patients with anorexia nervosa: rapid on-set of beneficial cognitive, emotional, and behavioral effects
Milos, G. F., Antel, J., Kaufmann, L., Barth, N., Koller, A., Tan, S., Wiesing, U., Hinney, A., Libuda, L., Wabitsch, M., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00977-1 · Cited by 125
Grey matter abnormalities within cortico-limbic-striatal circuits in acute and weight-restored anorexia nervosa patients
Friederich, H.-C., Walther, S., Bendszus, M., Biller, A., Thomann, P., Zeigermann, S., Katus, T., Brunner, R., Zastrow, A., & Herzog, W. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.09.042 · Cited by 119
Who is The Fairest One of All? How Evolution Guides Peer and Media Influences on Female Body Dissatisfaction
Ferguson, C. J., Winegard, B. M., & Winegard, B. (2011) · Review of General Psychology · doi:10.1037/a0022607 · Cited by 134
A debate on current eating disorder diagnoses in light of neurobiological findings: is it time for a spectrum model?
Brooks, S. J., Rask‐Andersen, M., Benedict, C., & Schiöth, H. B. (2012) · BMC Psychiatry · doi:10.1186/1471-244x-12-76 · Cited by 120
Alterations in brain structure in adults with anorexia nervosa and the impact of illness duration
Fonville, L., Giampietro, V., Williams, S., Simmons, A., & Tchanturia, K. (2013) · Psychological Medicine · doi:10.1017/s0033291713002389 · Cited by 117
Reduced salience and default mode network activity in women with anorexia nervosa
Legget, K. T., Tregellas, J. R., Shott, M. E., & Frank, G. (2014) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.130046 · Cited by 119
Emotion processing deficits: A liability spectrum providing insight into comorbidity of mental disorders
Kret, M. E., & Ploeger, A. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.02.011 · Cited by 115
A Systematic Review of the Effects of Neuromodulation on Eating and Body Weight: Evidence from Human and Animal Studies
McClelland, J., Bozhilova, N. S., Campbell, I. C., & Schmidt, U. H. (2013) · European Eating Disorders Review · doi:10.1002/erv.2256 · Cited by 118
Anorexia Nervosa and a Lost Emotional Self: A Psychological Formulation of the Development, Maintenance, and Treatment of Anorexia Nervosa
Oldershaw, A., Startup, H. M., & Lavender, T. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.00219 · Cited by 131
Cognitive-Behavioral Flexibility in Anorexia Nervosa
Friederich, H., & Herzog, W. (2010) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_83 · Cited by 121
Resting-state synchrony between anterior cingulate cortex and precuneus relates to body shape concern in anorexia nervosa and bulimia nervosa
Lee, S., Kim, K. R., Ku, J. H., Lee, J.-H., Namkoong, K., & Jung, Y. (2013) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2013.11.004 · Cited by 112
An overview of trauma-informed care and practice for eating disorders
Brewerton, T. D. (2019) · Journal of Aggression, Maltreatment & Trauma · doi:10.1080/10926771.2018.1532940 · Cited by 111
Restraint of appetite and reduced regional brain volumes in anorexia nervosa: a voxel-based morphometric study
Brooks, S. J., Barker, G. J., O’Daly, O., Brammer, M. J., Williams, S., Benedict, C., Schiöth, H. B., Treasure, J. L., & Campbell, I. C. (2011) · BMC Psychiatry · doi:10.1186/1471-244x-11-179 · Cited by 110
Association of Brain Reward Learning Response With Harm Avoidance, Weight Gain, and Hypothalamic Effective Connectivity in Adolescent Anorexia Nervosa
Frank, G., DeGuzman, M. C., Shott, M. E., Laudenslager, M. L., Rossi, B., & Pryor, T. L. (2018) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2018.2151 · Cited by 112
Food matters: how the microbiome and gut–brain interaction might impact the development and course of anorexia nervosa
Herpertz‐Dahlmann, B., Seitz, J., & Baines, J. F. (2017) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-017-0945-7 · Cited by 115
Are Antipsychotics Effective for the Treatment of Anorexia Nervosa?
Kishi, T., Kafantaris, V., Sunday, S. R., Sheridan, E. M., & Correll, C. U. (2012) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12r07691 · Cited by 108
Abnormal reward circuitry in anorexia nervosa: A longitudinal, multimodal MRI study
Cha, J., Ide, J. S., Bowman, F. D., Simpson, H. B., Posner, J. E., & STEINGLASS, J. E. (2016) · Human Brain Mapping · doi:10.1002/hbm.23279 · Cited by 108
The Brain-Gut Axis in Health and Disease
Omran, Y. A., & Aziz, Q. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-0897-4_6 · Cited by 109
Out of my real body: cognitive neuroscience meets eating disorders
Riva, G. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00236 · Cited by 110
A systematic review of temporal discounting in eating disorders and obesity: Behavioural and neuroimaging findings
McClelland, J., Dalton, B., Kekic, M., Bartholdy, S., Campbell, I. C., & Schmidt, U. H. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.09.024 · Cited by 119
Core, social and moral disgust are bounded: A review on behavioral and neural bases of repugnance in clinical disorders
Vicario, C. M., Rafal, R. D., Martino, D., & Avenanti, A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.05.008 · Cited by 109

Authors: Kaye, W. H., Fudge, J. L., & Paulus, M.
Affiliations: University of California San Diego (US)
University of Rochester Medicine (US)
Corresponding author: Kaye, Walter H.
ORCID: Kaye, Walter H.
Fudge, Julie L.
Paulus, Martin
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2009-07-15
Volume: 10
Issue: 8
Pages: 573-584
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn2682
PMC: PMC13038070
OpenAlex: W2067637201
Cited by: 843
References: 173
Citations by year: 2026: 38 · 2025: 37 · 2024: 38 · 2023: 38 · 2022: 45 · 2021: 47 · 2020: 49 · 2019: 58 · 2018: 43 · 2017: 59 · 2016: 57 · 2015: 52 · 2014: 58 · 2013: 77 · 2012: 45
FWCI: 6.52
Type: journal article
Language: en
Open access: green
pmc.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Louis and Harold Price Foundation
Wellcome Trust (066122)
U.S. Public Health Service (018307, 001894, 020687, 016663, 046001, 063291, 042984)
National Institute of Mental Health (R01MH063291)
Topics: Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
Keywords: anorexia nervosa, eating disorders, neurocircuitry, neurotransmitter systems, serotonin, dopamine, reward processing, interoception, insula, striatum, appetite regulation, neuroimaging
MeSH terms: Animals, Anorexia Nervosa, Brain, Brain Mapping, Diagnostic Imaging, Dopamine, Humans, Neural Pathways, Serotonin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

New insights into symptoms and neurocircuit function of anorexia nervosa

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks