The DOI matches its Crossref record; 180 of the 180 references it cites were found in a registry or an index.
Behavioural phenotyping assays for mouse models of autism
Open accessAbstract
Autism is a heterogeneous neurodevelopmental disorder of unknown aetiology that affects 1 in 100-150 individuals. Diagnosis is based on three categories of behavioural criteria: abnormal social interactions, communication deficits and repetitive behaviours. Strong evidence for a genetic basis has prompted the development of mouse models with targeted mutations in candidate genes for autism. As the diagnostic criteria for autism are behavioural, phenotyping these mouse models requires behavioural assays with high relevance to each category of the diagnostic symptoms. Behavioural neuroscientists are generating a comprehensive set of assays for social interaction, communication and repetitive behaviours to test hypotheses about the causes of autism. Robust phenotypes in mouse models hold great promise as translational tools for discovering effective treatments for components of autism spectrum disorders.
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“The measures of sociability generated in the three chamber assay have been interpreted as an all-or-none result that should be restricted to comparison with a single experimental group, rather than a comparison between groups [7].”
From Behavioral Phenotyping of Juvenile Long-Evans and Sprague-Dawley Rats: Implications for Preclinical Models of Autism Spectrum Disorders (2016) · cites this paper as [7]
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In the citing paper
“The majority of ASD preclinical research has been carried out in mouse models that utilize standardized behavioral phenotyping tools to measure ASD-relevant deficits in social behavior, screen for repetitive behaviors and restricted interests, and evaluate associated symptoms, such as anxiety [7].”
From Behavioral Phenotyping of Juvenile Long-Evans and Sprague-Dawley Rats: Implications for Preclinical Models of Autism Spectrum Disorders (2016) · cites this paper as [7]
Experimental — accuracy not yet measuredIn the citing paper
“Mouse models of ASD, with deficits in up to three core behavioral domains, have begun to approximate ASDs in newly developed behavioral tasks, such as social approach, ultrasonic vocalizations and measurements of repetitive motor behaviors79.”
From Dendritic spine pathology in neuropsychiatric disorders (2011) · cites this paper as [79]
In the citing paper
“However, to date none of the various social and communication behaviors have been validated as robustly translatable from rodents to humans (Silverman et al., 2010).”
From Modeling Autism by SHANK Gene Mutations in Mice (2013) · cites this paper as Silverman et al., 2010
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Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
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Self-citationEpidemiology of Pervasive Developmental Disorders
Fombonne, E. (2009) · Pediatric Research · doi:10.1203/pdr.0b013e31819e7203 · Cited by 1,971
Advances in autism genetics: on the threshold of a new neurobiology
Abrahams, B. S., & Geschwind, D. H. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2346 · Cited by 1,866
Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism
Study, P. A. R. I. S., Jamain, S., Quach, H., Betancur, C., Råstam, M., Colineaux, C., Gillberg, I. C., Soderstrom, H., Giros, B., Leboyer, M., et al. (2003) · Nature Genetics · doi:10.1038/ng1136 · Cited by 1,851
Neuroligins and neurexins link synaptic function to cognitive disease
Südhof, T. C. (2008) · Nature · doi:10.1038/nature07456 · Cited by 1,849
Maternal Immune Activation Alters Fetal Brain Development through Interleukin-6
Smith, S. E. P., Li, J., Garbett, K., Mirnics, K., & Patterson, P. H. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2178-07.2007 · Cited by 1,605
A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome
Guy, J., Hendrich, B., Holmes, M., Martin, J. E., & Bird, A. (2001) · Nature Genetics · doi:10.1038/85899 · Cited by 1,558
Moy, S. S., Nadler, J. J., Perez, A., Barbaro, R. P., Johns, J. M., Magnuson, T. R., Piven, J., & Crawley, J. N. (2004) · Genes, Brain and Behavior · doi:10.1111/j.1601-1848.2004.00076.x · Cited by 1,522 · cited 1×
“We developed an automated three-chambered social approach task, which scores time spent in a side chamber with a novel mouse versus time spent in a side chamber with a non-social novel object, an inverted wire pencil cu”
MethodSelf-citation
Research works printed but not linked: 2
- Yang, M., Scattoni, M., Chadman, K., Silverman, J. & Crawley, J. N. in Autism Spectrum Disorders (eds Geschwind, D. & Dawson, G.) (Oxford Univ. Press, In the press.
- Yang, M., Perry, K., Weber, M. & Crawley, J. N. Social peers rescue autism-like phenotypes in adolescent BTBR T+Tf/J mice [abstract 328.7]. Proc. Neuroscience 2009 [online], (2009).
Cited by
Sorted by citations
Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283
Animal models of neuropsychiatric disorders
Nestler, E. J., & Hyman, S. E. (2010) · Nature Neuroscience · doi:10.1038/nn.2647 · Cited by 2,023
Dendritic spine pathology in neuropsychiatric disorders
Penzes, P., Cahill, M. E., Jones, K. A., VanLeeuwen, J.-E., & Woolfrey, K. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2741 · Cited by 1,523
Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice
Sharon, G., Cruz, N. J., Kang, D.-W., Gandal, M. J., Wang, B., Kim, Y.-M., Zink, E. M., Casey, C. P., Taylor, B. C., Lane, C. J., et al. (2019) · Cell · doi:10.1016/j.cell.2019.05.004 · Cited by 1,182
Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring
Buffington, S. A., Di Prisco, G. V., Auchtung, T. A., Ajami, N. J., Petrosino, J. F., & Costa-Mattioli, M. (2016) · Cell · doi:10.1016/j.cell.2016.06.001 · Cited by 1,163
Metadata
- Authors
- Silverman, J. L., Yang, M., Lord, C., & Crawley, J. N.
- Affiliations
- National Institute of Mental Health (US)
- University of Michigan (US)
- Corresponding author
- Crawley, Jacqueline N.
- Venue
- Nature Reviews Neuroscience
- Published
- 2010-07
- Volume
- 11
- Issue
- 7
- Pages
- 490-502
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC3087436
- OpenAlex
- W2098277878
- Cited by
- 1,462
- References
- 180
- Citations by year
- 2026: 52 · 2025: 74 · 2024: 109 · 2023: 77 · 2022: 116 · 2021: 121 · 2020: 125 · 2019: 108 · 2018: 113 · 2017: 94 · 2016: 101 · 2015: 91 · 2014: 78 · 2013: 66 · 2012: 75
- FWCI
- 4.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5rc1mh089721-02)
- National Institute of Mental Health (RC1 MH-089721, MH02179, R01MH089390, Z01MH002179, R01MH81873, 1RC1MH089721, ZIAMH002179, R01MH081873)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- autism spectrum disorder, mouse models of autism, behavioral phenotyping, behavioural assays, social interaction deficits, communication difficulties, repetitive behavior, candidate gene mutations, translational research, neurodevelopmental disorders
- MeSH terms
- Animals, Autistic Disorder, Disease Models, Animal, Diseases in Twins, Humans, Interpersonal Relations, Mutation, Phenotype, Social Behavior Disorders, Mice
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