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Transcriptional regulation of photoreceptor development and homeostasis in the mammalian retina
Open accessAbstract
In the developing vertebrate retina, diverse neuronal subtypes originate from multipotent progenitors in a conserved order and are integrated into an intricate laminated architecture. Recent progress in mammalian photoreceptor development has identified a complex relationship between six key transcription-regulatory factors (RORbeta, OTX2, NRL, CRX, NR2E3 and TRbeta2) that determine rod versus M cone or S cone cell fate. We propose a step-wise 'transcriptional dominance' model of photoreceptor cell fate determination, with the S cone representing the default state of a generic photoreceptor precursor. Elucidation of gene-regulatory networks that dictate photoreceptor genesis and homeostasis will have wider implications for understanding the development of nervous system function and for the treatment of neurodegenerative diseases.
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“Certain differentiation gene batteries composed of orthologous effector genes and the regulatory state drivers that activate them are known in all bilaterian animals investigated and even in cnidarians, e.g., in muscle cells (5) neurons (13), photoreceptor cells (14 -17), and neurosecretory cells (17).”
From Transphyletic conservation of developmental regulatory state in animal evolution (2011) · cites this paper as [16]
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Metadata
- Authors
- Swaroop, A., Kim, D., & Forrest, D.
- Affiliations
- National Institutes of Health (US)
- National Institute of Diabetes and Digestive and Kidney Diseases (US)
- Corresponding author
- Swaroop, Anand
- Venue
- Nature Reviews Neuroscience
- Published
- 2010-08
- Volume
- 11
- Issue
- 8
- Pages
- 563-576
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC11346175
- OpenAlex
- W2067470032
- Cited by
- 560
- References
- 154
- Citations by year
- 2026: 25 · 2025: 39 · 2024: 34 · 2023: 34 · 2022: 31 · 2021: 35 · 2020: 38 · 2019: 38 · 2018: 36 · 2017: 38 · 2016: 40 · 2015: 32 · 2014: 35 · 2013: 42 · 2012: 30
- FWCI
- 2.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Eye Institute (ZIAEY000473, Z01EY000450, ZIAEY000546)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- photoreceptor development, transcriptional regulation, retina, S-cones, rod photoreceptors, M-cones, transcription factors, RORβ, Otx2, NRL, CRX, NR2E3, TRbeta2, gene regulatory networks
- MeSH terms
- Animals, Homeostasis, Humans, Photoreceptor Cells, Retina, Retinal Diseases, Transcription, Genetic, Apoptosis, Neurogenesis
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