The DOI matches its Crossref record; 186 of the 187 references it cites were found in a registry or an index.
Spreading of pathology in neurodegenerative diseases: a focus on human studies
Open accessAbstract
The progression of many neurodegenerative diseases is thought to be driven by the template-directed misfolding, seeded aggregation and cell-cell transmission of characteristic disease-related proteins, leading to the sequential dissemination of pathological protein aggregates. Recent evidence strongly suggests that the anatomical connections made by neurons - in addition to the intrinsic characteristics of neurons, such as morphology and gene expression profile - determine whether they are vulnerable to degeneration in these disorders. Notably, this common pathogenic principle opens up opportunities for pursuing novel targets for therapeutic interventions for these neurodegenerative disorders. We review recent evidence that supports the notion of neuron-neuron protein propagation, with a focus on neuropathological and positron emission tomography imaging studies in humans.
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“While still a contentious topic [46], there is now substantial evidence that also supports the idea that propagation of pathological tau species occurs between cells [47–50].”
From Glial contributions to neurodegeneration in tauopathies (2017) · cites this paper as [47]
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Metadata
- Authors
- Brettschneider, J., Tredici, K. D., Lee, V. M.-Y., & Trojanowski, J. Q.
- Affiliations
- Universität Ulm (DE)
- University of Pennsylvania (US)
- Corresponding author
- Trojanowski, John Q.
- Venue
- Nature Reviews Neuroscience
- Published
- 2015-01-15
- Volume
- 16
- Issue
- 2
- Pages
- 109-120
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC4312418
- OpenAlex
- W1973319971
- Cited by
- 790
- References
- 187
- Citations by year
- 2026: 40 · 2025: 64 · 2024: 50 · 2023: 54 · 2022: 63 · 2021: 78 · 2020: 79 · 2019: 86 · 2018: 83 · 2017: 88 · 2016: 70 · 2015: 35
- FWCI
- 11.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P30AG010124, P01AG017586)
- National Institute of Neurological Disorders and Stroke (P50NS053488)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
- Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- neurodegenerative diseases, protein aggregation, seeded aggregation, cell-to-cell transmission, neuropathology, positron emission tomography, therapeutic target
- MeSH terms
- Brain, Humans, Neurons, Disease Progression, Neurodegenerative Diseases
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