The DOI matches its Crossref record; 130 of the 131 references it cites were found in a registry or an index.
Exploring the origins of grey matter damage in multiple sclerosis
Open accessAbstract
Multiple sclerosis is characterized at the gross pathological level by the presence of widespread focal demyelinating lesions of the myelin-rich white matter. However, it is becoming clear that grey matter is not spared, even during the earliest phases of the disease. Furthermore, grey matter damage may have an important role both in physical and cognitive disability. Grey matter pathology involves both inflammatory and neurodegenerative mechanisms, but the relationship between the two is unclear. Histological, immunological and neuroimaging studies have provided new insight in this rapidly expanding field, and form the basis of the most recent hypotheses on the pathogenesis of grey matter damage.
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“Spinal cord pathology is an important determinant of permanent neurological disability with cardinal characteristics being inflammatory demyelination, synaptic, neuronal and axonal loss.6, 7, 8, 9, 10, 11”
From Neurite dispersion: a new marker of multiple sclerosis spinal cord pathology? (2017) · cites this paper as [7]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“Furthermore, most EAE models do not recapitulate the extensive grey matter pathology observed in patients, which show a demyelination pattern often characterized by chronic microglia activation, absence of leukocyte infiltration [46] and pronounced meningeal inflammation [156].”
From Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function (2022) · cites this paper as [46]
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Cites
1 retracted
Multiple Sclerosis and Epstein-Barr Virus
Levin, L. I., Munger, K. L., Rubertone, M. V., Peck, C. A., Lennette, E. T., Spiegelman, D. L., & Ascherio, A. (2003) · JAMA · doi:10.1001/jama.289.12.1533 · Cited by 166
RetractedResting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827
Microglia: a sensor for pathological events in the CNS
Kreutzberg, G. W. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10049-7 · Cited by 4,396
Noseworthy, J. H., Lucchinetti, C. F., Rodriguez, M., & Weinshenker, B. G. (2000) · New England Journal of Medicine · doi:10.1056/nejm200009283431307 · Cited by 3,016
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
The International Multiple Sclerosis Genetics Consortium & The Wellcome Trust Case Control Consortium 2 (2011) · Nature · doi:10.1038/nature10251 · Cited by 2,697
Self-citationImmunology of multiple sclerosis
Sospedra, M., & Martin, R. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115707 · Cited by 2,149
Self-citationCortical demyelination and diffuse white matter injury in multiple sclerosis
Kutzelnigg, A., Lucchinetti, C. F., Stadelmann, C., Brück, W., Rauschka, H., Bergmann, M., Schmidbauer, M., Parisi, J. E., & Lassmann, H. (2005) · Brain · doi:10.1093/brain/awh641 · Cited by 1,836
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Self-citationPeterson, J. W., Bö, L., Mörk, S., Chang, A., & Trapp, B. D. (2001) · Annals of Neurology · doi:10.1002/ana.1123 · Cited by 1,403
Aloisi, F. (2001) · Glia · doi:10.1002/glia.1106 · Cited by 1,310
Flagged first, then by citations
1 of the 131 references couldn’t be matched to a known paper.
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Items 401–413 of 413
Radfar, F., Shahidi, S., Farahani, H., Moghadasi, A. N., & Eskandrieh, S. (2026) · The Clinical Neuropsychologist · doi:10.1080/13854046.2026.2659074
Arashlow, F. T., Fekri, M., Salarvandian, S., Darfarin, K., Esmaeilpour, K., & Ebrahimi, R. (2026) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2026.107247
Saraste, M., Nikkilä, T., Matilainen, M., Hämäläinen, P., Wahlroos, S., Rajander, J., Snellman, A., Rinne, J., & Airas, L. M. (2026) · Multiple Sclerosis Journal · doi:10.1177/13524585261446839
Tensor-derived diffusion MRI metrics and NODDI in multiple sclerosis classification
Lasek, J., Mazur, W., Wnuk, M. A., Marona, M., Kaczówka, K., Słowik, A., & Krzyżak, A. T. (2026) · NeuroImage Clinical · doi:10.1016/j.nicl.2026.104057
Spatially Stereotyped Microgliosis Tracks Synaptic Pathology in the Demyelinated Superior ColliculusPreprint
McGrath, J. D., Shultz, J., Classe, M. J., Hannum, D. F., & Werneburg, S. (2026) · Research Square · doi:10.21203/rs.3.rs-9829260/v1
Sleep disturbance and cognitive impairment in multiple sclerosis: Clinical and imaging correlates
Sarhan, N. T., ELmotayam, A., AbdelHamid, G. A., Fawzy, H. M., Abdallah, A. A.-J., & Fathy, S. E. (2026) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2026.112145
Galazzo, I. B., Castellaro, M., Pizzini, F. B., Crescenzo, F., Amann, M., Al‐Araji, S., Bellenberg, B., Bianchi, A., Barkhof, F., Cortese, R., et al. (2026) · Brain Communications · doi:10.1093/braincomms/fcag225
Self-citationDong, Y., Yu, R., Ain, Q. U., Yan, G., Park, J. E., Dignean, R. A., Zandee, S., Klément, W., Larouche, S., Zheng, C., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-10050556/v1
Mechanisms of Epstein-Barr virus-associated autoimmunity: a comparative overview
Shabnam, F., & Khan, G. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1891373
Michaelson, N. M., Buathong, S., Treaba, C. A., Mayfield, J. D., Bhatt, A., Mainero, C., Klawiter, E. C., & Huang, S. Y. (2026) · Radiology · doi:10.1148/radiol.252139
Calabrese, M., Magliozzi, R., Tamanti, A., Ziccardi, S., Eccher, C., Biasi, P., Pizzini, F. B., & Marastoni, D. (2026) · Nature Reviews Neurology · doi:10.1038/s41582-026-01263-2
Self-citationNischal, S. A., Kale, K. M., Tourigny, K., Abuelem, M., Greene, G., Walsh, R., & Molnár, Z. (2026) · Journal of Anatomy · doi:10.1111/joa.70235
Xie, Y., Wu, S., Zhang, Y., Ju, C., Zhang, S., Wang, Y., Zhu, W., & Wang, M. (2026) · Journal of Neurology · doi:10.1007/s00415-026-14054-y
Metadata
- Authors
- Calabrese, M., Magliozzi, R., Ciccarelli, O., Geurts, J. J. G., Reynolds, R., & Martin, R.
- Affiliations
- University of Verona (IT)
- Istituto Superiore di Sanità (IT)
- University College London Hospitals NHS Foundation Trust (GB)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Hammersmith Hospital (GB)
- Corresponding author
- Calabrese, Massimiliano
- Venue
- Nature Reviews Neuroscience
- Published
- 2015-02-20
- Volume
- 16
- Issue
- 3
- Pages
- 147-158
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W1972438508
- Cited by
- 414
- References
- 131
- Citations by year
- 2026: 24 · 2025: 30 · 2024: 33 · 2023: 22 · 2022: 31 · 2021: 58 · 2020: 45 · 2019: 47 · 2018: 40 · 2017: 39 · 2016: 29 · 2015: 16
- FWCI
- 6.06
- Type
- journal article
- Language
- en
- Open access
- green
- pure.amsterdamumc.nl
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- UCL Discovery (University College London) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- National Science Foundation (2313255)
- Fondazione Italiana Sclerosi Multipla
- International Progressive MS Alliance
- Multiple Sclerosis Society
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Ministero della Salute (GR-2010-2313255, GR-2010)
- Universität Zürich
- Schweizerische Multiple Sklerose Gesellschaft
- Medical Research Council
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- multiple sclerosis, demyelination, neurodegeneration, neuroinflammation, white matter injury, cognitive disability, pathogenesis
- MeSH terms
- Animals, Cerebral Cortex, Humans, Inflammation, Multiple Sclerosis, White Matter, Gray Matter
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