The DOI matches its Crossref record; 131 of the 132 references it cites were found in a registry or an index.
The phenotypic and genetic signatures of common musculoskeletal pain conditions
Open accessAbstract
Musculoskeletal pain conditions, such as fibromyalgia and low back pain, tend to coexist in affected individuals and are characterized by a report of pain greater than expected based on the results of a standard physical evaluation. The pathophysiology of these conditions is largely unknown, we lack biological markers for accurate diagnosis, and conventional therapeutics have limited effectiveness. Growing evidence suggests that chronic pain conditions are associated with both physical and psychological triggers, which initiate pain amplification and psychological distress; thus, susceptibility is dictated by complex interactions between genetic and environmental factors. Herein, we review phenotypic and genetic markers of common musculoskeletal pain conditions, selected based on their association with musculoskeletal pain in previous research. The phenotypic markers of greatest interest include measures of pain amplification and 'psychological' measures (such as emotional distress, somatic awareness, psychosocial stress and catastrophizing). Genetic polymorphisms reproducibly linked with musculoskeletal pain are found in genes contributing to serotonergic and adrenergic pathways. Elucidation of the biological mechanisms by which these markers contribute to the perception of pain in these patients will enable the development of novel effective drugs and methodologies that permit better diagnoses and approaches to personalized medicine.
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Cites
The Elements of Statistical Learning
Hastie, T., Tibshirani, R., & Friedman, J. (2009) · Springer Series in Statistics · doi:10.1007/978-0-387-84858-7 · Cited by 25,970
The McGill Pain Questionnaire: Major properties and scoring methods
Melzack, R. (1975) · Pain · doi:10.1016/0304-3959(75)90044-5 · Cited by 6,873
The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions
Gottesman, I. I., & Gould, T. D. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.4.636 · Cited by 5,615
Central sensitization: implications for the diagnosis and treatment of pain
Woolf, C. J. (2011) · Pain · doi:10.1016/j.pain.2010.09.030 · Cited by 4,771
Persistent postsurgical pain: risk factors and prevention
Kehlet, H., Jensen, T. S., & Woolf, C. J. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68700-x · Cited by 4,086
Core outcome domains for chronic pain clinical trials: IMMPACT recommendations
Turk, D. C., Dworkin, R. H., Allen, R. R., Bellamy, N., Brandenburg, N., Carr, D. B., Cleeland, C., Dionne, R., Farrar, J. T., Galer, B. S., et al. (2003) · Pain · doi:10.1016/j.pain.2003.08.001 · Cited by 3,510
Biological, clinical and population relevance of 95 loci for blood lipids
Teslovich, T. M., Musunuru, K., Smith, A. V., Edmondson, A. C., Stylianou, I. M., Koseki, M., Pirruccello, J. P., Ripatti, S., Chasman, D. I., Willer, C. J., et al. (2010) · Nature · doi:10.1038/nature09270 · Cited by 3,487
The biopsychosocial approach to chronic pain: Scientific advances and future directions.
Gatchel, R. J., Peng, Y. B., Peters, M. L., Fuchs, P. N., & Turk, D. C. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.4.581 · Cited by 3,392
The measurement of clinical pain intensity: a comparison of six methods
Jensen, M. P., Karoly, P., & Braver, S. (1986) · Pain · doi:10.1016/0304-3959(86)90228-9 · Cited by 3,275
A review of psychological risk factors in back and neck pain
Linton, S. J. (2000) · Spine · doi:10.1097/00007632-200005010-00017 · Cited by 1,776
Research works printed but not linked: 3
- Committee on Advancing Pain Research, Care and Education, Institute of Medicine. Relieving Pain in America: A Blueprint for Transforming Prevention, Care, Education, and Research, 1st edn (The National Academies Press, 2011).
- Slade, G. D. et al. Study methods, recruitment, sociodemographic findings, and demographic representativeness in the OPPERA study. J. Pain 12 (Suppl.), T12–T26 (2011). · DOI
- Diatchenko, L. et al. Three major haplotypes of the β2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder. Am. J. Med. Genet. Part B 141B, 449–462 (2006). · DOI
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Nociplastic pain: towards an understanding of prevalent pain conditions
Fitzcharles, M.-A., Cohen, S. P., Clauw, D. J., Littlejohn, G., Usui, C., & Häuser, W. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00392-5 · Cited by 1,253
The role of psychosocial processes in the development and maintenance of chronic pain
Edwards, R. R., Dworkin, R. H., Sullivan, M. D., Turk, D. C., & Wasan, A. D. (2016) · The Journal of Pain · doi:10.1016/j.jpain.2016.01.001 · Cited by 954
Evaluating psychosocial contributions to chronic pain outcomes
Meints, S. M., & Edwards, R. R. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.01.017 · Cited by 719
Individual differences in pain: understanding the mosaic that makes pain personal
Fillingim, R. B. (2016) · Pain · doi:10.1097/j.pain.0000000000000775 · Cited by 758
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Metadata
- Authors
- Diatchenko, L., Fillingim, R. B., Smith, S. B., & Maixner, W.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- University of Florida Health (US)
- Corresponding author
- Diatchenko, Luda
- Venue
- Nature Reviews Rheumatology
- Published
- 2013-04-02
- Volume
- 9
- Issue
- 6
- Pages
- 340-350
- ISSN
- 1759-4790 (ISSN-L)
- 1759-4804
- PMC
- PMC3991785
- OpenAlex
- W2002876517
- Cited by
- 241
- References
- 132
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 18 · 2023: 20 · 2022: 20 · 2021: 32 · 2020: 19 · 2019: 15 · 2018: 20 · 2017: 16 · 2016: 20 · 2015: 25 · 2014: 10 · 2013: 3
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Rheumatology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01ag033906-10)
- U.S. Public Health Service (1K12DSE022793)
- National Institute on Aging (R-01-AG-033906, AG033906, R37AG033906, P30AG028740)
- National Institute of Neurological Disorders and Stroke (P01NS045685)
- National Institute of Dental and Craniofacial Research (K12DE022793, R01-DE16558, U01DE017018, R01DE016558)
- Topics
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Keywords
- musculoskeletal pain, fibromyalgia, low back pain, phenotypic markers, genetic markers, pain amplification, psychological distress, pain catastrophizing, somatic awareness, psychosocial stress, genetic polymorphism, serotonergic pathways, adrenergic pathways, chronic pain, personalized medicine, biomarkers
- MeSH terms
- Animals, Chronic Disease, Genetic Markers, Humans, Phenotype, Musculoskeletal Pain
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