The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition
Open accessAbstract
The Notch receptor and its ligands are key components in a core metazoan signaling pathway that regulates the spatial patterning, timing and outcome of many cell-fate decisions. Ligands contain a disulfide-rich Delta/Serrate/LAG-2 (DSL) domain required for Notch trans-activation or cis-inhibition. Here we report the X-ray structure of a receptor binding region of a Notch ligand, the DSL-EGF3 domains of human Jagged-1 (J-1DSL-EGF3). The structure reveals a highly conserved face of the DSL domain, and we show, by functional analysis of Drosophila melanogster ligand mutants, that this surface is required for both cis- and trans-regulatory interactions with Notch. We also identify, using NMR, a surface of Notch-1 involved in J-1DSL-EGF3 binding. Our data imply that cis- and trans-regulation may occur through the formation of structurally distinct complexes that, unexpectedly, involve the same surfaces on both ligand and receptor.
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Bray, S. J. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.94 · Cited by 1,012
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Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation
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Roles of Glycosylation in Notch Signaling
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Metadata
- Authors
- Cordle, J., Johnson, S., Zi Yan Tay, J., Roversi, P., Wilkin, M. B., de Madrid, B. H., Shimizu, H., Jensen, S., Whiteman, P., Jin, B., Redfield, C., Baron, M., Lea, S. M., & Handford, P. A.
- Venue
- Nature Structural & Molecular Biology
- Published
- 2008-07-27
- Volume
- 15
- Issue
- 8
- Pages
- 849-857
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- OpenAlex
- W2129096575
- Cited by
- 264
- References
- 48
- FWCI
- 7.07
- Type
- journal article
- Language
- en
- Open access
- green
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- Cordle, J., Johnson, S., Zi Yan Tay, J., Roversi, P., Wilkin, M. B., de Madrid, B. H., Shimizu, H., Jensen, S., Whiteman, P., Jin, B., Redfield, C., Baron, M., Lea, S. M., & Handford, P. A. (2008). A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition. Nature Structural & Molecular Biology. https://doi.org/10.1038/nsmb.1457
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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