The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B
Open accessAbstract
The endosomal sorting complex required for transport (ESCRT) machinery, including ESCRT-III, localizes to the midbody and participates in the membrane-abscission step of cytokinesis. The ESCRT-III protein charged multivesicular body protein 1B (CHMP1B) is required for recruitment of the MIT domain–containing protein spastin, a microtubule-severing enzyme, to the midbody. The 2.5-Å structure of the C-terminal tail of CHMP1B with the MIT domain of spastin reveals a specific, high-affinity complex involving a noncanonical binding site between the first and third helices of the MIT domain. The structural interface is twice as large as that of the MIT domain of the VPS4–CHMP complex, consistent with the high affinity of the interaction. A series of unique hydrogen-bonding interactions and close packing of small side chains discriminate against the other ten human ESCRT-III subunits. Point mutants in the CHMP1B binding site of spastin block recruitment of spastin to the midbody and impair cytokinesis.
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Coot : model-building tools for molecular graphics
Emsley, P., & Cowtan, K. (2004) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444904019158 · Cited by 30,571
Parallels Between Cytokinesis and Retroviral Budding: A Role for the ESCRT Machinery
Carlton, J. G., & Martin-Serrano, J. (2007) · Science · doi:10.1126/science.1143422 · Cited by 764
Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis
Morita, E., Sandrin, V., Chung, H., Morham, S. G., Gygi, S. P., Rodesch, C. K., & Sundquist, W. I. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601850 · Cited by 724
Plasma membrane deformation by circular arrays of ESCRT-III protein filaments
Hanson, P. I., Roth, R., Lin, Y., & Heuser, J. E. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200707031 · Cited by 427
Cited by
Vietri, M., Radulovic, M., & Stenmark, H. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0177-4 · Cited by 962
Evolution of diverse cell division and vesicle formation systems in Archaea
Makarova, K. S., Yutin, N., Bell, S. D., & Koonin, E. V. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2406 · Cited by 228
Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III
Chang, C.-L., Weigel, A. V., Ioannou, M. S., Pasolli, H. A., Xu, C. S., Peale, D. R., Shtengel, G., Freeman, M., Hess, H. F., Blackstone, C., et al. (2019) · Journal of Cell Biology · doi:10.1083/jcb.201902061 · Cited by 206
Self-citationOxidation of F-actin controls the terminal steps of cytokinesis
Frémont, S., Hammich, H., Bai, J., Wioland, H., Klinkert, K., Rocancourt, M., Kikuti, C., Stroebel, D., Romet-Lemonne, G., Pylypenko, O., et al. (2017) · Nature Communications · doi:10.1038/ncomms14528 · Cited by 181
Centralspindlin: at the heart of cytokinesis
White, E. A., & Glotzer, M. (2012) · Cytoskeleton · doi:10.1002/cm.21065 · Cited by 168
Metadata
- Authors
- Yang, D., Rismanchi, N., Renvoisé, B., Lippincott-Schwartz, J., Blackstone, C., & Hurley, J. H.
- Venue
- Nature Structural & Molecular Biology
- Published
- 2008-11-09
- Volume
- 15
- Issue
- 12
- Pages
- 1278-1286
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- OpenAlex
- W2006463246
- Cited by
- 256
- References
- 4
- FWCI
- 6.44
- Type
- journal article
- Language
- en
- Open access
- green
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- Yang, D., Rismanchi, N., Renvoisé, B., Lippincott-Schwartz, J., Blackstone, C., & Hurley, J. H. (2008). Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B. Nature Structural & Molecular Biology. https://doi.org/10.1038/nsmb.1512
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