The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing
Open accessAbstract
Constitutive heterochromatin in Arabidopsis thaliana is marked by repressive chromatin modifications, including DNA methylation, histone H3 dimethylation at Lys9 (H3K9me2) and monomethylation at Lys27 (H3K27me1). The enzymes catalyzing DNA methylation and H3K9me2 have been identified; alterations in these proteins lead to reactivation of silenced heterochromatic elements. The enzymes responsible for heterochromatic H3K27me1, in contrast, remain unknown. Here we show that the divergent SET-domain proteins ARABIDOPSIS TRITHORAX-RELATED PROTEIN 5 (ATXR5) and ATXR6 have H3K27 monomethyltransferase activity, and atxr5 atxr6 double mutants have reduced H3K27me1 in vivo and show partial heterochromatin decondensation. Mutations in atxr5 and atxr6 also lead to transcriptional activation of repressed heterochromatic elements. Notably, H3K9me2 and DNA methylation are unaffected in double mutants. These results indicate that ATXR5 and ATXR6 form a new class of H3K27 methyltransferases and that H3K27me1 represents a previously uncharacterized pathway required for transcriptional repression in Arabidopsis.
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Cites
Regulation of chromatin structure by site-specific histone H3 methyltransferases
Rea, S., Eisenhaber, F., O'Carroll, D., Strahl, B. D., Sun, Z.-W., Schmid, M., Opravil, S., Mechtler, K., Ponting, C. P., Allis, C. D., et al. (2000) · Nature · doi:10.1038/35020506 · Cited by 2,845 · cited 1×
“Results ATXR5 and ATXR6 function as H3K27 monomethyltransferases Histone lysine methylation is primarily catalyzed by SET-domain protein”
BackgroundWhole-Genome Analysis of Histone H3 Lysine 27 Trimethylation in Arabidopsis
Zhang, X., Clarenz, O., Cokus, S., Bernatavichute, Y. V., Pellegrini, M., Goodrich, J., & Jacobsen, S. E. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050129 · Cited by 767
Self-citation
Cited by
The Polycomb complex PRC2 and its mark in life
Margueron, R., & Reinberg, D. (2011) · Nature · doi:10.1038/nature09784 · Cited by 3,347
Comprehensive Analysis of Silencing Mutants Reveals Complex Regulation of the Arabidopsis Methylome
Stroud, H., Greenberg, M. V. C., Feng, S., Bernatavichute, Y. V., & Jacobsen, S. E. (2013) · Cell · doi:10.1016/j.cell.2012.10.054 · Cited by 873
Self-citationDu, J., Zhong, X., Bernatavichute, Y. V., Stroud, H., Feng, S., Caro, E., Vashisht, A. A., Terragni, J., Chin, H. G., Tu, A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.07.034 · Cited by 555
Self-citationFeng, S., Cokus, S. J., Schubert, V., Zhai, J., Pellegrini, M., & Jacobsen, S. E. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.07.008 · Cited by 349
Self-citationNic-Can, G. I., López-Torres, A., Barredo-Pool, F., Wrobel, K., Loyola-Vargas, V. M., Rojas-Herrera, R., & De-la-Peña, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072160 · Cited by 164
Metadata
- Authors
- Jacob, Y., Feng, S., LeBlanc, C. A., Bernatavichute, Y. V., Stroud, H., Cokus, S., Johnson, L. M., Pellegrini, M., Jacobsen, S. E., & Michaels, S. D.
- Venue
- Nature Structural & Molecular Biology
- Published
- 2009-06-07
- Volume
- 16
- Issue
- 7
- Pages
- 763-768
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- OpenAlex
- W2146543824
- Cited by
- 324
- References
- 2
- FWCI
- 7.32
- Type
- journal article
- Language
- en
- Open access
- green
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- Jacob, Y., Feng, S., LeBlanc, C. A., Bernatavichute, Y. V., Stroud, H., Cokus, S., Johnson, L. M., Pellegrini, M., Jacobsen, S. E., & Michaels, S. D. (2009). ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing. Nature Structural & Molecular Biology. https://doi.org/10.1038/nsmb.1611
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