The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Molecular mechanisms for protein-encoded inheritance
Open accessAbstract
In prion inheritance and transmission, strains are phenotypic variants encoded by protein 'conformations'. However, it is unclear how a protein conformation can be stable enough to endure transmission between cells or organisms. Here we describe new polymorphic crystal structures of segments of prion and other amyloid proteins, which offer two structural mechanisms for the encoding of prion strains. In packing polymorphism, prion strains are encoded by alternative packing arrangements (polymorphs) of β-sheets formed by the same segment of a protein; in segmental polymorphism, prion strains are encoded by distinct β-sheets built from different segments of a protein. Both forms of polymorphism can produce enduring conformations capable of encoding strains. These molecular mechanisms for transfer of protein-encoded information into prion strains share features with the familiar mechanism for transfer of nucleic acid–encoded information into microbial strains, including sequence specificity and recognition by noncovalent bonds.
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Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD
Collinge, J., Sidle, K. C. L., Meads, J., Ironside, J., & Hill, A. F. (1996) · Nature · doi:10.1038/383685a0 · Cited by 1,735
Prions as adaptive conduits of memory and inheritance
Shorter, J., & Lindquist, S. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1616 · Cited by 555
Prions of fungi: inherited structures and biological roles
Wickner, R. B., Edskes, H. K., Shewmaker, F., & Nakayashiki, T. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1708 · Cited by 231
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Propagation of Tau aggregates and neurodegeneration
Goedert, M., Eisenberg, D. S., & Crowther, R. A. (2017) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-072116-031153 · Cited by 632
Self-citationGreen Rust: The Simple Organizing ‘Seed’ of All Life?
Russell, M. J. (2018) · Life · doi:10.3390/life8030035 · Cited by 101
Prions and protein-folding diseases: Review: Prions and protein-folding diseases
Norrby, E. (2011) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2011.02387.x · Cited by 75
Seidler, P. M., Boyer, D. R., Murray, K. A., Yang, T. P., Bentzel, M., Sawaya, M. R., Rosenberg, G., Cascio, D., Williams, C. K., Newell, K. L., et al. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.009688 · Cited by 70
Self-citationIntegrative Structural Biology in the Era of Accurate Structure Prediction
Masrati, G., Landau, M., Ben-Tal, N., Lupas, A., Kosloff, M., & Kosinski, J. (2021) · Journal of Molecular Biology · doi:10.1016/j.jmb.2021.167127 · Cited by 53
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Metadata
- Authors
- Wiltzius, J. J. W., Landau, M., Nelson, R., Sawaya, M. R., Apostol, M. I., Goldschmidt, L., Soriaga, A. B., Cascio, D., Rajashankar, K., & Eisenberg, D.
- Venue
- Nature Structural & Molecular Biology
- Published
- 2009-08-16
- Volume
- 16
- Issue
- 9
- Pages
- 973-978
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- OpenAlex
- W2155143852
- Cited by
- 259
- References
- 3
- FWCI
- 9.72
- Type
- journal article
- Language
- en
- Open access
- green
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- Wiltzius, J. J. W., Landau, M., Nelson, R., Sawaya, M. R., Apostol, M. I., Goldschmidt, L., Soriaga, A. B., Cascio, D., Rajashankar, K., & Eisenberg, D. (2009). Molecular mechanisms for protein-encoded inheritance. Nature Structural & Molecular Biology. https://doi.org/10.1038/nsmb.1643
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