The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71
Open accessAbstract
Enterovirus 71 (EV71) is a major agent of hand, foot and mouth disease in children that can cause severe central nervous system disease and death. No vaccine or antiviral therapy is available. High-resolution structural analysis of the mature virus and natural empty particles shows that the mature virus is structurally similar to other enteroviruses. In contrast, the empty particles are markedly expanded and resemble elusive enterovirus-uncoating intermediates not previously characterized in atomic detail. Hydrophobic pockets in the EV71 capsid are collapsed in this expanded particle, providing a detailed explanation of the mechanism for receptor-binding triggered virus uncoating. These structures provide a model for enterovirus uncoating in which the VP1 GH loop acts as an adaptor-sensor for cellular receptor attachment, converting heterologous inputs to a generic uncoating mechanism, highlighting new opportunities for therapeutic intervention.
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Features and development of Coot
Emsley, P., Lohkamp, B., Scott, W. G., & Cowtan, K. (2010) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444910007493 · Cited by 29,915
Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination
Brünger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., et al. (1998) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444998003254 · Cited by 15,715
Structure of a human common cold virus and functional relationship to other picornaviruses
Rossmann, M. G., Arnold, E., Erickson, J. W., Frankenberger, E. A., Griffith, J. P., Hecht, H.-J., Johnson, J. E., Kamer, G., Luo, M., Mosser, A. G., et al. (1985) · Nature · doi:10.1038/317145a0 · Cited by 1,426
Three-Dimensional Structure of Poliovirus at 2.9 Å Resolution
Hogle, J. M., Chow, M., & Filman, D. J. (1985) · Science · doi:10.1126/science.2994218 · Cited by 1,260
Main-chain Bond Lengths and Bond Angles in Protein Structures
Laskowski, R. A., Moss, D. S., & Thornton, J. M. (1993) · Journal of Molecular Biology · doi:10.1006/jmbi.1993.1351 · Cited by 1,216
Kay, B. K., Williamson, M. P., & Sudol, M. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.2.231 · Cited by 1,215
Refinement of severely incomplete structures with maximum likelihood in BUSTER–TNT
Blanc, E., Roversi, P., Vonrhein, C., Flensburg, C., Lea, S. M., & Bricogne, G. (2004) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444904016427 · Cited by 717
An overview of the evolution of enterovirus 71 and its clinical and public health significance
McMinn, P. C. (2002) · FEMS Microbiology Reviews · doi:10.1016/s0168-6445(02)00070-0 · Cited by 699
Scavenger receptor B2 is a cellular receptor for enterovirus 71
Yamayoshi, S., Yamashita, Y., Li, J., Hanagata, N., Minowa, T., Takemura, T., & Koike, S. (2009) · Nature Medicine · doi:10.1038/nm.1992 · Cited by 517
Fricks, C. E., & Hogle, J. M. (1990) · Journal of Virology · doi:10.1128/jvi.64.5.1934-1945.1990 · Cited by 488
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The life cycle of non-polio enteroviruses and how to target it
Baggen, J., Thibaut, H. J., Strating, J. R. P. M., & van Kuppeveld, F. J. M. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0005-4 · Cited by 478
Structure Unifies the Viral Universe
Abrescia, N. G. A., Bamford, D. H., Grimes, J. M., & Stuart, D. I. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060910-095130 · Cited by 294
Self-citationRoom-temperature macromolecular serial crystallography using synchrotron radiation
Stellato, F., Oberthür, D., Liang, M., Bean, R., Gati, C., Yefanov, O., Barty, A., Burkhardt, A., Fischer, P., Galli, L., et al. (2014) · IUCrJ · doi:10.1107/s2052252514010070 · Cited by 256
Enterovirus 71 infection and vaccines
Yi, E.-J., Shin, Y.-J., Kim, J.-H., Kim, T.-G., & Chang, S.-Y. (2017) · Clinical and Experimental Vaccine Research · doi:10.7774/cevr.2017.6.1.4 · Cited by 203
Insight into the Life Cycle of Enterovirus-A71
Liu, Q., & Long, J.-E. (2025) · Viruses · doi:10.3390/v17020181 · Cited by 11
Metadata
- Authors
- Wang, X., Peng, W., Ren, J., Hu, Z., Xu, J., Lou, Z., Li, X., Yin, W., Shen, X., Porta, C., Walter, T. S., Evans, G., Axford, D., Owen, R., Rowlands, D. J., Wang, J., Stuart, D. I., Fry, E. E., & Rao, Z.
- Venue
- Nature Structural & Molecular Biology
- Published
- 2012-03-04
- Volume
- 19
- Issue
- 4
- Pages
- 424-429
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- OpenAlex
- W2157586119
- Cited by
- 395
- References
- 54
- FWCI
- 25.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wang, X., Peng, W., Ren, J., Hu, Z., Xu, J., Lou, Z., Li, X., Yin, W., Shen, X., Porta, C., Walter, T. S., Evans, G., Axford, D., Owen, R., Rowlands, D. J., Wang, J., Stuart, D. I., Fry, E. E., & Rao, Z. (2012). A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71. Nature Structural & Molecular Biology. https://doi.org/10.1038/nsmb.2255
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