Cited by 415Genomics and Chromatin DynamicsNuclear Structure and FunctionChromatin Remodeling and Cancer

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Functional implications of genome topology

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Cavalli, Giacomo, Misteli, Tom·2013·Nature Structural & Molecular Biology

DOI 10.1038/nsmb.2474PMC PMC6320674

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Abstract

Although genomes are defined by their sequence, the linear arrangement of nucleotides is only their most basic feature. A fundamental property of genomes is their topological organization in three-dimensional space in the intact cell nucleus. The application of imaging methods and genome-wide biochemical approaches, combined with functional data, is revealing the precise nature of genome topology and its regulatory functions in gene expression and genome maintenance. The emerging picture is one of extensive self-enforcing feedback between activity and spatial organization of the genome, suggestive of a self-organizing and self-perpetuating system that uses epigenetic dynamics to regulate genome function in response to regulatory cues and to propagate cell-fate memory.

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Authors: Cavalli, G., & Misteli, T.
Affiliations: Centre National de la Recherche Scientifique (FR)
National Institutes of Health (US)
Corresponding author: Cavalli, Giacomo
Misteli, Tom
ORCID: Cavalli, Giacomo
Misteli, Tom
Venue: Nature Structural & Molecular Biology
Publisher: Springer Science and Business Media LLC
Published: 2013-03
Volume: 20
Issue: 3
Pages: 290-299
ISSN: 1545-9985 (ISSN-L)
1545-9993
DOI: 10.1038/nsmb.2474
PMC: PMC6320674
OpenAlex: W2036663020
Cited by: 415
References: 136
Citations by year: 2026: 13 · 2025: 10 · 2024: 18 · 2023: 11 · 2022: 22 · 2021: 30 · 2020: 26 · 2019: 32 · 2018: 37 · 2017: 37 · 2016: 58 · 2015: 53 · 2014: 47 · 2013: 21
FWCI: 5.61
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Structural & Molecular Biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
HAL (submittedVersion)
Funders: National Institutes of Health
National Cancer Institute (ZIABC010309)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords: genome topology, 3D genome organization, nuclear organization, gene expression regulation, genome maintenance, epigenetic dynamics, self-organization, chromatin organization
MeSH terms: Cell Nucleus, Chromatin, DNA Repair, DNA Replication, Gene Expression Regulation, Models, Molecular, Transcription, Genetic, Genome, Epigenesis, Genetic

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