Functional implications of genome topology

An integrated encyclopedia of DNA elements in the human genome

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Topological domains in mammalian genomes identified by analysis of chromatin interactions

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Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

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The Role of Chromatin during Transcription

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Mapping and analysis of chromatin state dynamics in nine human cell types

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Spatial partitioning of the regulatory landscape of the X-inactivation centre

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The accessible chromatin landscape of the human genome

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Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

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A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression

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Three-dimensional folding and functional organization principles of the Drosophila genome

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Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes

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Higher-Order Inter-chromosomal Hubs Shape 3D Genome Organization in the Nucleus

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Epigenetic regulation of ageing: linking environmental inputs to genomic stability

Benayoun, B. A., Pollina, E. A., & Brunet, A. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4048 · Cited by 610

Genome-wide Maps of Nuclear Lamina Interactions in Single Human Cells

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The 3D genome in transcriptional regulation and pluripotency

Gorkin, D. U., Leung, D., & Ren, B. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.05.017 · Cited by 391

Insulated Neighborhoods: Structural and Functional Units of Mammalian Gene Control

Hnisz, D., Day, D. S., & Young, R. A. (2016) · Cell · doi:10.1016/j.cell.2016.10.024 · Cited by 420

The Role of Chromosome Domains in Shaping the Functional Genome

Sexton, T., & Cavalli, G. (2015) · Cell · doi:10.1016/j.cell.2015.02.040 · Cited by 427

Noncoding Transcription by Alternative RNA Polymerases Dynamically Regulates an Auxin-Driven Chromatin Loop

Ariel, F., Jégu, T., Latrasse, D., Romero-Barrios, N., Christ, A., Benhamed, M., & Crespi, M. D. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.06.011 · Cited by 404

Transcription factors orchestrate dynamic interplay between genome topology and gene regulation during cell reprogramming

Stadhouders, R., Vidal, E., Serra, F., Stefano, B. D., Dily, F. L., Quilez, J., Gómez, A., Collombet, S., Berenguer, C., Cuartero, Y., et al. (2018) · Nature Genetics · doi:10.1038/s41588-017-0030-7 · Cited by 362

Nuclear architecture dictates HIV-1 integration site selection

Marini, B., Kertész‐Farkas, A., Ali, H., Lucic, B., Lisek, K., Manganaro, L., Pongor, S., Luzzati, R., Recchia, A., Mavilio, F., et al. (2015) · Nature · doi:10.1038/nature14226 · Cited by 360

Long noncoding RNAs: an emerging link between gene regulation and nuclear organization

Quinodoz, S. A., & Guttman, M. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.08.009 · Cited by 327

Comparison of computational methods for Hi-C data analysis

Forcato, M., Nicoletti, C., Pal, K., Livi, C. M., Ferrari, F., & Bicciato, S. (2017) · Nature Methods · doi:10.1038/nmeth.4325 · Cited by 314

Mouse Heterochromatin Adopts Digital Compaction States without Showing Hallmarks of HP1-Driven Liquid-Liquid Phase Separation

Erdel, F., Rademacher, A., Vlijm, R., Tünnermann, J., Frank, L., Weinmann, R., Schweigert, E., Yserentant, K., Hummert, J., Bauer, C., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.02.005 · Cited by 292

Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma

Jiang, S., Postovit, L., Cattaneo, A., Binder, E. B., & Aitchison, K. J. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00808 · Cited by 288

Long Non-Coding RNAs and their Biological Roles in Plants

Liu, X., Hao, L., Li, D., Zhu, L., & Hu, S. (2015) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2015.02.003 · Cited by 268

Long-Range Chromatin Interactions

Dekker, J., & Misteli, T. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019356 · Cited by 255

The role of transcription in shaping the spatial organization of the genome

van Steensel, B., & Furlong, E. E. M. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0114-6 · Cited by 247

Battles and hijacks: noncoding transcription in plants

Ariel, F., Romero-Barrios, N., Jégu, T., Benhamed, M., & Crespi, M. D. (2015) · Trends in Plant Science · doi:10.1016/j.tplants.2015.03.003 · Cited by 238

Gene Insertion Into Genomic Safe Harbors for Human Gene Therapy

Papapetrou, E. P., & Schambach, A. (2016) · Molecular Therapy · doi:10.1038/mt.2016.38 · Cited by 238

An Overview of Genome Organization and How We Got There: from FISH to Hi-C

Fraser, J., Williamson, I., Bickmore, W. A., & Dostie, J. (2015) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00006-15 · Cited by 232

Identification of alternative topological domains in chromatin

Filippova, D., Patro, R., Duggal, G., & Kingsford, C. (2014) · Algorithms for Molecular Biology · doi:10.1186/1748-7188-9-14 · Cited by 224

Replication timing and transcriptional control: beyond cause and effect — part III

Rivera‐Mulia, J. C., & Gilbert, D. M. (2016) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2016.03.022 · Cited by 214

Mechanisms and principles of homology search during recombination

Renkawitz, J., Lademann, C. A., & Jentsch, S. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3805 · Cited by 222

How retrotransposons shape genome regulation

Mita, P., & Boeke, J. D. (2016) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2016.01.001 · Cited by 217

Topologically associating domain boundaries that are stable across diverse cell types are evolutionarily constrained and enriched for heritability

McArthur, E., & Capra, J. A. (2021) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2021.01.001 · Cited by 207

Chromatin topology is coupled to Polycomb group protein subnuclear organization

Wani, A. H., Boettiger, A. N., Schorderet, P., Ergün, A., Munger, C., Sadreyev, R. I., Zhuang, X., Kingston, R. E., & Francis, N. J. (2016) · Nature Communications · doi:10.1038/ncomms10291 · Cited by 191

Cytoskeletal Control of Nuclear Morphology and Chromatin Organization

Ramdas, N. M., & Shivashankar, G. V. (2014) · Journal of Molecular Biology · doi:10.1016/j.jmb.2014.09.008 · Cited by 200

Simulated binding of transcription factors to active and inactive regions folds human chromosomes into loops, rosettes and topological domains

Brackley, C. A., Johnson, J., Kelly, S. L., Cook, P. R., & Marenduzzo, D. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw135 · Cited by 185

Mechanobiology of Tumor Growth

Chaudhuri, P. K., Low, B. C., & Lim, C. T. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00042 · Cited by 200

Chromosome conformation capture technologies and their impact in understanding genome function

Sati, S., & Cavalli, G. (2016) · Chromosoma · doi:10.1007/s00412-016-0593-6 · Cited by 195

Clustering of Tissue-Specific Sub-TADs Accompanies the Regulation of HoxA Genes in Developing Limbs

Berlivet, S., Paquette, D., Dumouchel, A., Langlais, D., Dostie, J., & Kmita, M. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1004018 · Cited by 170

Cis-regulatory chromatin loops arise before TADs and gene activation, and are independent of cell fate during early Drosophila development

Espinola, S. M., Götz, M., Bellec, M., Messina, O., Fiche, J.-B., Houbron, C., Dejean, M., Reim, I., Cardozo Gizzi, A. M., Lagha, M., et al. (2021) · Nature Genetics · doi:10.1038/s41588-021-00816-z · Cited by 174

Epigenomics

Wang, K., & Chang, H. Y. (2018) · Circulation Research · doi:10.1161/circresaha.118.310998 · Cited by 180

Nucleoporin-mediated regulation of cell identity genesPreprint

Ibarra, A., Benner, C. W., Tyagi, S., Cool, J., & Hetzer, M. W. (2016) · Genes & Development · doi:10.1101/gad.287417.116 · Cited by 163

Epigenetic regulation: A new frontier for biomedical engineers

Chen, Z., Li, S., Subramaniam, S., Shyy, J. Y.-J., & Chien, S. (2017) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071516-044720 · Cited by 163

Identification of hierarchical chromatin domains

Weinreb, C., & Raphael, B. J. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btv485 · Cited by 159

Cajal bodies are linked to genome conformation

Wang, Q., Sawyer, I. A., Sung, M.-H., Sturgill, D., Shevtsov, S. P., Pegoraro, G., Hakim, O., Baek, S., Hager, G. L., & Dundr, M. (2016) · Nature Communications · doi:10.1038/ncomms10966 · Cited by 164

Nuclear landscape of HIV-1 infection and integration

Lušić, M., & Siliciano, R. F. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.162 · Cited by 168

CRISPR-dCas9 and sgRNA scaffolds enable dual-colour live imaging of satellite sequences and repeat-enriched individual loci

Fu, Y., Rocha, P. P., Luo, V. M., Raviram, R., Deng, Y., Mazzoni, E. O., & Skok, J. A. (2016) · Nature Communications · doi:10.1038/ncomms11707 · Cited by 148

Multi-tiered Reorganization of the Genome during B Cell Affinity Maturation Anchored by a Germinal Center-Specific Locus Control Region

Bunting, K. L., Soong, T. D., Singh, R., Jiang, Y., Béguelin, W., Poloway, D. W., Swed, B. L., Hatzi, K., Reisacher, W., Teater, M., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.08.012 · Cited by 141

Genomic positional conservation identifies topological anchor point RNAs linked to developmental loci

Amaral, P., Leonardi, T., Han, N., Viré, E. A., Gascoigne, D. K., Arias‐Carrasco, R., Büscher, M., Pandolfini, L., Zhang, A., Pluchino, S., et al. (2018) · Genome biology · doi:10.1186/s13059-018-1405-5 · Cited by 136

Metazoan Nuclear Pores Provide a Scaffold for Poised Genes and Mediate Induced Enhancer-Promoter Contacts

Pascual‐García, P., Debo, B. M., Aleman, J. R., Talamas, J. A., Lan, Y., Nguyen, N., Won, K., & Capelson, M. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.02.020 · Cited by 130

Cycles in spatial and temporal chromosomal organization driven by the circadian clock

Aguilar‐Arnal, L., Hakim, O., Patel, V. R., Baldi, P., Hager, G. L., & Sassone‐Corsi, P. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2667 · Cited by 128

Soft X-Ray Tomography Reveals Gradual Chromatin Compaction and Reorganization during Neurogenesis In Vivo

Gros, M. A. L., Clowney, E. J., Magklara, A., Yen, A., Markenscoff-Papadimitriou, E., Colquitt, B. M., Myllys, M., Kellis, M., Lomvardas, S., & Larabell, C. A. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.060 · Cited by 125

Quantifying Genome-Editing Outcomes at Endogenous Loci with SMRT Sequencing

Hendel, A., Kildebeck, E., Fine, E. J., Clark, J. T., Punjya, N., Sebastiano, V., Bao, G., & Porteus, M. H. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.02.040 · Cited by 124

Protein Modeling: What Happened to the “Protein Structure Gap”?

Schwede, T. F. (2013) · Structure · doi:10.1016/j.str.2013.08.007 · Cited by 128

Trichoderma reesei complete genome sequence, repeat-induced point mutation, and partitioning of CAZyme gene clusters

Li, W.-C., Huang, C., Chen, C., Chuang, Y.-C., Tung, S., & Wang, T. (2017) · Biotechnology for Biofuels · doi:10.1186/s13068-017-0825-x · Cited by 117

Nongenetic functions of the genome

Bustin, M., & Misteli, T. (2016) · Science · doi:10.1126/science.aad6933 · Cited by 119

In the loop: promoter–enhancer interactions and bioinformatics

Mora, A., Sandve, G. K., Gabrielsen, O. S., & Eskeland, R. (2015) · Briefings in Bioinformatics · doi:10.1093/bib/bbv097 · Cited by 126

The BAF60 Subunit of the SWI/SNF Chromatin-Remodeling Complex Directly Controls the Formation of a Gene Loop at FLOWERING LOCUS C in Arabidopsis

Jégu, T., Latrasse, D., Delarue, M., Hirt, H., Domenichini, S., Ariel, F., Crespi, M. D., Bergounioux, C., Raynaud, C., & Benhamed, M. (2014) · The Plant Cell · doi:10.1105/tpc.113.114454 · Cited by 119

Orientation and repositioning of chromosomes correlate with cell geometry–dependent gene expression

Wang, Y., Nagarajan, M., Uhler, C., & Shivashankar, G. V. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-12-0825 · Cited by 117

ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration

Kidiyoor, G. R., Li, Q., Bastianello, G., Bruhn, C., Giovannetti, I., Adhil, M., Beznoussenko, G. V., Mironov, A., Raab, M., Piel, M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18580-9 · Cited by 111

Polycomb silencing: from linear chromatin domains to 3D chromosome folding

Cheutin, T., & Cavalli, G. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2013.11.016 · Cited by 102

Functional organization of the human 4D Nucleome

Chen, H., Chen, J., Muir, L. A., Ronquist, S., Meixner, W., Ljungman, M. E., Ried, T., Smale, S. T., & Rajapakse, I. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1505822112 · Cited by 105

Regulation of Cohesin-Mediated Chromosome Folding by Eco1 and Other Partners

Dauban, L., Montagne, R., Thierry, A., Lazar‐Stefanita, L., Bastié, N., Gadal, O., Cournac, A., Koszul, R., & Beckouët, F. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.01.019 · Cited by 116

Epigenomics in 3D: importance of long-range spreading and specific interactions in epigenomic maintenance

Jost, D., & Vaillant, C. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky009 · Cited by 84

Fractal dimension of chromatin: potential molecular diagnostic applications for cancer prognosis

Metze, K. (2013) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.2013.828889 · Cited by 97

Hi-C analysis: from data generation to integration

Pal, K., Forcato, M., & Ferrari, F. (2018) · Biophysical Reviews · doi:10.1007/s12551-018-0489-1 · Cited by 102

Chromosome territories and the global regulation of the genome

Fritz, A. J., Sehgal, N., Pliss, A., Xu, J., & Berezney, R. (2019) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22732 · Cited by 102

Integrating ChIP-seq with other functional genomics data

Jiang, S., & Mortazavi, A. (2018) · Briefings in Functional Genomics · doi:10.1093/bfgp/ely002 · Cited by 96

Cajal body function in genome organization and transcriptome diversity

Sawyer, I. A., Sturgill, D. M., Sung, M., Hager, G. L., & Dundr, M. (2016) · BioEssays · doi:10.1002/bies.201600144 · Cited by 87

Imaging Specific Genomic DNA in Living Cells

Chen, B., Guan, J., & Huang, B. (2016) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-062215-010830 · Cited by 77

Germline Progenitors Escape the Widespread Phenomenon of Homolog Pairing during Drosophila Development

Joyce, E. F., Apostolopoulos, N., Beliveau, B. J., & Wu, C.-T. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1004013 · Cited by 78

Understanding the 3D genome: Emerging impacts on human disease

Krumm, A., & Duan, Z. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.07.004 · Cited by 76

Nuclear matrix, nuclear envelope and premature aging syndromes in a translational research perspective

Cau, P., Navarro, C. L., Harhouri, K., Roll, P., Sigaudy, S., Kaspi, É., Perrin, S., Sandre‐Giovannoli, A. D., & Lévy, N. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.03.021 · Cited by 80

Computational Models of Large-Scale Genome Architecture

Rosa, A., & Zimmer, C. (2014) · International review of cytology · doi:10.1016/b978-0-12-800046-5.00009-6 · Cited by 78

Three-Dimensional Genome Organization and Function in Drosophila

Schwartz, Y. B., & Cavalli, G. (2017) · Genetics · doi:10.1534/genetics.115.185132 · Cited by 77

Inferring the physical properties of yeast chromatin through Bayesian analysis of whole nucleus simulations

Arbona, J., Herbert, S., Fabre, E., & Zimmer, C. (2017) · Genome biology · doi:10.1186/s13059-017-1199-x · Cited by 78

Put your 3D glasses on: plant chromatin is on show

Rodriguez‐Granados, N. Y., Ramirez-Prado, J. S., Veluchamy, A., Latrasse, D., Raynaud, C., Crespi, M. D., Ariel, F., & Benhamed, M. (2016) · Journal of Experimental Botany · doi:10.1093/jxb/erw168 · Cited by 73

Shaping epigenetic memory via genomic bookmarking

Michieletto, D., Chiang, M., Colì, D., Papantonis, A., Orlandini, E., Cook, P. R., & Marenduzzo, D. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx1200 · Cited by 72

Hormone-control regions mediate steroid receptor–dependent genome organizationPreprint

Dily, F. L., Vidal, E., Cuartero, Y., Quilez, J., Nacht, A. S., Vicent, G. P., Carbonell‐Caballero, J., Sharma, P., Villanueva‐Cañas, J. L., Ferrari, R., et al. (2018) · Genome Research · doi:10.1101/gr.243824.118 · Cited by 70

Reciprocal regulation of chromatin state and architecture byHOTAIRM1contributes to temporal collinearHOXAgene activation

Wang, X. Q. D., & Dostie, J. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw966 · Cited by 68

Signaling by Steroid Hormones in the 3D Nuclear Space

Dily, F. L., & Beato, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020306 · Cited by 76

Causes and consequences of nuclear gene positioning

Shachar, S., & Misteli, T. (2017) · Journal of Cell Science · doi:10.1242/jcs.199786 · Cited by 66

Gene Regulation in and out of Equilibrium

Wong, F. J., & Gunawardena, J. (2020) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-121219-081542 · Cited by 68

The interdependence of gene-regulatory elements and the 3D genome

Vermunt, M. W., Zhang, D., & Blobel, G. A. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201809040 · Cited by 72

The lncRNA MARS modulates the epigenetic reprogramming of the marneral cluster in response to ABA

Roulé, T., Christ, A., Hussain, N., Huang, Y., Hartmann, C., Benhamed, M., Gutierrez‐Marcos, J., Ariel, F., Crespi, M. D., & Blein, T. (2022) · Molecular Plant · doi:10.1016/j.molp.2022.02.007 · Cited by 65

Depletion of the Chromatin Looping Proteins CTCF and Cohesin Causes Chromatin Compaction: Insight into Chromatin Folding by Polymer Modelling

Tark‐Dame, M., Jerabek, H., Manders, E. M. M., Heermann, D. W., & DRIEL, R. V. (2014) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003877 · Cited by 60

Determining chromatin architecture with Micro Capture-C

Hamley, J. C., Li, H., Denny, N., Downes, D. J., & Davies, J. O. J. (2023) · Nature Protocols · doi:10.1038/s41596-023-00817-8 · Cited by 62

The 10-nm chromatin fiber and its relationship to interphase chromosome organization

Hansen, J. C., Connolly, M., McDonald, C. J., Pan, A., Pryamkova, A., Ray, K. P., Seidel, E., Tamura, S., Rogge, R. A., & Maeshima, K. (2017) · Biochemical Society Transactions · doi:10.1042/bst20170101 · Cited by 66

The fractal dimension of chromatin - a potential molecular marker for carcinogenesis, tumor progression and prognosis

Metze, K., Adam, R. L., & Florindo, J. B. (2019) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2019.1597707 · Cited by 62

Spectral identification of topological domains

Chen, J., Hero, A. O., & Rajapakse, I. (2016) · Bioinformatics · doi:10.1093/bioinformatics/btw221 · Cited by 59

A statistical model of ChIA-PET data for accurate detection of chromatin 3D interactions

Paulsen, J., Rødland, E. A., Holden, L., Holden, M., & Hovig, E. J. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku738 · Cited by 61

Diverse Non-genetic, Allele-Specific Expression Effects Shape Genetic Architecture at the Cellular Level in the Mammalian Brain

Huang, W.-C., Ferris, E., Cheng, T., Hörndli, C. S., Gleason, K., Tamminga, C. A., Wagner, J. D., Boucher, K. M., Christian, J. L., & Gregg, C. J. (2017) · Neuron · doi:10.1016/j.neuron.2017.01.033 · Cited by 59

Shaping epigenetic memory via genomic bookmarking

Michieletto, D., Chiang, M., Colì, D., Papantonis, A., Orlandini, E., Cook, P. R., & Marenduzzo, D. (2018) · Kölner Universitäts PublikationsServer (Universität zu Köln) · Cited by 59

The pluripotency factor Nanog regulates pericentromeric heterochromatin organization in mouse embryonic stem cellsPreprint

Novo, C. L., Tang, C., Ahmed, K., Djuric, U., Fussner, E., Mullin, N. P., Morgan, N. P., Hayre, J. K., Sienerth, A. R., Elderkin, S., et al. (2016) · Genes & Development · doi:10.1101/gad.275685.115 · Cited by 64

Macromolecular Topology Engineering

Qu, Z., Cheng, S. Z. D., & Zhang, W. (2021) · Trends in Chemistry · doi:10.1016/j.trechm.2021.02.002 · Cited by 60

Nuclear pores as versatile platforms for gene regulation

Pascual‐García, P., & Capelson, M. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2013.12.009 · Cited by 55

Quiescent Saccharomyces cerevisiae forms telomere hyperclusters at the nuclear membrane vicinity through a multifaceted mechanism involving Esc1, the Sir complex, and chromatin condensation

Laporte, D., Courtout, F., Tollis, S., & Sagot, I. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-01-0069 · Cited by 55

Chromatin structure in double strand break repair

Gospodinov, A. G., & Herceg, Z. (2013) · DNA repair · doi:10.1016/j.dnarep.2013.07.006 · Cited by 56

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