Misteli, Tom

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature

Advanced Glycation End Products researchImmune Response and Inflammation

Cited by 4,221

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

Poulikakos, P. I., Persaud, Y., Janakiraman, M., Kong, X., Ng, C., Moriceau, G., Shi, H., Atefi, M., Titz, B., Gabay, M. T., et al. (2011) · Nature

Melanoma and MAPK PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 1,454

Ubiquitination regulates PTEN nuclear import and tumor suppression

Trotman, L. C., Wang, X., Alimonti, A., Chen, Z., Teruya-Feldstein, J., Yang, H., Pavletich, N. P., Carver, B. S., Cordon-Cardo, C., Erdjument-Bromage, H., et al. (2007) · Cell

PI3K/AKT/mTOR signaling in cancerUbiquitin and proteasome pathways

Cited by 748

Positional stability of single double-strand breaks in mammalian cells

Soutoglou, E., Dorn, J. F., Sengupta, K., Jasin, M., Nussenzweig, A., Ried, T., Danuser, G., & Misteli, T. (2007) · Nature Cell Biology

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 509

Repression of the Antioxidant NRF2 Pathway in Premature Aging

Kubben, N., Zhang, W., Wang, L., Voss, T. C., Yang, J., Qu, J., Liu, G.-H., & Misteli, T. (2016) · Cell

Nuclear Structure and FunctionGenetics, Aging, and Longevity in Model Organisms

Cited by 489

Extensive Heterogeneity and Intrinsic Variation in Spatial Genome Organization

Finn, E. H., Pegoraro, G., Brandão, H. B., Valton, A.-L., Oomen, M. E., Dekker, J., Mirny, L., & Misteli, T. (2019) · Cell

Genomics and Chromatin DynamicsNuclear Structure and Function

Cited by 459

Functional implications of genome topology

Cavalli, G., & Misteli, T. (2013) · Nature Structural & Molecular Biology

Genomics and Chromatin DynamicsNuclear Structure and Function

Cited by 415

3D Chromosome Regulatory Landscape of Human Pluripotent Cells

Ji, X., Dadon, D. B., Powell, B. E., Fan, Z. P., Borges-Rivera, D., Shachar, S., Weintraub, A. S., Hnisz, D., Pegoraro, G., Lee, T. I., et al. (2016) · Cell Stem Cell

Genomics and Chromatin DynamicsPluripotent Stem Cells Research

Cited by 400

Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases

Kubben, N., & Misteli, T. (2017) · Nature Reviews Molecular Cell Biology

Genetics, Aging, and Longevity in Model OrganismsNuclear Structure and Function

Cited by 320

The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks

Kruhlak, M., Crouch, E. E., Orlov, M., Montaño, C., Gorski, S. A., Nussenzweig, A., Misteli, T., Phair, R. D., & Casellas, R. (2007) · Nature

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 305

Activation of the Cellular DNA Damage Response in the Absence of DNA Lesions

Soutoglou, E., & Misteli, T. (2008) · Science

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 299

Long-Range Chromatin Interactions

Dekker, J., & Misteli, T. (2015) · Cold Spring Harbor Perspectives in Biology

Genomics and Chromatin DynamicsNuclear Structure and Function

Cited by 255

Activation of DNA Damage Response Signaling by Condensed Chromatin

Burgess, R. C., Burman, B., Kruhlak, M. J., & Misteli, T. (2014) · Cell Reports

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 198

DNA damage, chromatin, and transcription: the trinity of aging

Burgess, R. C., Misteli, T., & Oberdoerffer, P. (2012) · Current Opinion in Cell Biology

Genomics and Chromatin DynamicsDNA Repair Mechanisms

Cited by 72

The cell nucleus and aging: tantalizing clues and hopeful promises

Scaffidi, P., Gordon, L., & Misteli, T. (2005) · PLoS Biology

Nuclear Structure and FunctionGenetics, Aging, and Longevity in Model Organisms

Cited by 50

Genome instability in progeria: when repair gets old

Misteli, T., & Scaffidi, P. (2005) · Nature Medicine

Nuclear Structure and FunctionDNA Repair Mechanisms

Cited by 43

RNA-coupled CRISPR Screens Reveal ZNF207 as a Regulator of LMNA Aberrant Splicing in Progeria

Behera, A. K., Kim, J. J., Kordale, S., Damodaran, A. P., Kumari, B., Vidak, S., Dickson, E., Xiao, M.-S., Duncan, G., Andresson, T., et al. (2025) · Molecular Cell

RNA Research and SplicingNuclear Structure and Function

Cited by 6

RNA-coupled CRISPR screens reveal ZNF207 as a regulator of LMNA aberrant splicing in progeria

Behera, A. K., Kim, J. J., Kordale, S., Pekovic, F., Damodaran, A. P., Kumari, B., Vidak, S., Dickson, E., Xiao, M.-S., Duncan, G., et al. (2026) · Molecular Cell

RNA Research and SplicingNuclear Structure and Function

Cited by 6