Molecular mechanisms of activity and derepression of alternative lengthening of telomeres
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Items 101–200 of 200
- Pathway choice in the alternative telomere lengthening in neoplasia is dictated by replication fork processing mediated by EXD2’s nuclease activityRonan Broderick, Veronica Cherdyntseva, Jadwiga Nieminuszczy, Eleni Dragona, Maria Kyriakaki, Theodora Evmorfopoulou, Sarantis Gagos, Wojciech Niedźwiedź · 2023 · Nature Communications
- Cell-to-Cell Heterogeneity in TrypanosomesVanessa Luzak, Lara López-Escobar, T. Nicolai Siegel, Luísa M. Figueiredo · 2021 · Annual Review of Microbiology
- ORCA/LRWD1 Regulates Homologous Recombination at ALT-Telomeres by Modulating Heterochromatin OrganizationRosaline Y.C. Hsu, Yo-Chuen Lin, Christophe E. Redon, Qinyu Sun, Deepak Kumar Singh, Yating Wang, Vasudha Aggarwal, Jaba Mitra, Abhijith V. Matur, Branden S. Moriarity et al. · 2020 · iScience
- RETRACTED: A subset of PARP inhibitors induces lethal telomere fusion in ALT-dependent tumor cellsJoydeep Mukherjee, Ajay Pandita, Kamalakar Chatla, Tor-Christian Aase Johannessen, Shigeo Ohba, Yongjian Tang, Cecilia L. Dalle Ore, Rolf Bjerkvig, Russell O. Pieper · 2021 · Science Translational Medicine · Retracted
- Genetic and Epigenetic Inheritance at TelomeresEvan H. Lister‐Shimauchi, Ben McCarthy, Michael J. Lippincott, Shawn Cameron Ahmed · 2022 · Epigenomes
- Pan-cancer analysis of telomere maintenance mechanismsMeline Hakobyan, Hans Binder, Arsen Arakelyan · 2024 · Journal of Biological Chemistry
- MNS16A tandem repeat minisatellite of human telomerase gene: functional studies in colorectal, lung and prostate cancerPhilipp Hofer, Cornelia Zöchmeister, Christian Behm, Stefanie Brezina, Andreas Baierl, Angelina Doriguzzi, Vanita Vanas, Klaus Holzmann, Hedwig Sutterlüty, Andrea Gsur · 2017 · Oncotarget
- Telomerase activity is required for the telomere G-overhang structure in Trypanosoma bruceiRanjodh Singh Sandhu, Bibo Li · 2017 · Scientific Reports
- γPNA FRET Pair Miniprobes for Quantitative Fluorescent In Situ Hybridization to Telomeric DNA in Cells and TissueAlexander Orenstein, April S. Berlyoung, Elizabeth E. Rastede, Ha Pham, Elise Fouquerel, Connor Murphy, Brian J. Leibowitz, Jian Yu, Tumul Srivastava, Bruce A. Armitage et al. · 2017 · Molecules
- An armadillo-domain protein participates in a telomerase interaction networkLadislav Dokládal, Eva Benková, David Honys, Nikoleta Dupľáková, Lan‐Ying Lee, Stanton B. Gelvin, Eva Sýkorová · 2018 · Plant Molecular Biology
- The Nucleosome Remodeling and Deacetylase Complex in Development and DiseaseJeannine M. Basta, Michael I. Rauchman · 2017 · Elsevier eBooks
- Karyotypic Flexibility of the Complex Cancer Genome and the Role of Polyploidization in Maintenance of Structural Integrity of Cancer ChromosomesChristina Raftopoulou, Fani‐Marlen Roumelioti, Eleni Dragona, S Gimelli, Frédérique Béna, Vassilis G. Gorgoulis, Stylianos E. Antonarakis, Sarantis Gagos · 2020 · Cancers
- Death domain-associated protein (DAXX) expression is associated with poor survival in metastatic high-grade serous carcinomaBen Davidson, Erin McFadden, Arild Holth, Marta Brunetti, Viví Ann Flørenes · 2020 · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin
- Changes in the Expression of Pre-Replicative Complex Genes in hTERT and ALT Pediatric Brain TumorsAurora Irene Idilli, Francesca Pagani, Emanuela Kerschbamer, Francesco Berardinelli, Manuel Bernabé‐García, María Luisa Cayuela, Silvano Piazza, Pietro Luigi Poliani, Emilio Cusanelli, Marina Mione · 2020 · Cancers
- RNAi drives nonreciprocal translocations at eroding chromosome ends to establish telomere-free linear chromosomesMartina Begnis, Manasi S. Apte, Hirohisa Masuda, Devanshi Jain, David Lee Wheeler, Julia Promisel Cooper · 2018 · Genes & Development
- ILF3 safeguards telomeres from aberrant homologous recombination as a telomeric R-loop readerChuanle Wang, Yan Y. Huang, Yue Yang, Ruofei Li, Yingying Li, Hongxin Qiu, Jiali Wu, Guang W. Shi, Wenbin Ma, Zhou Songyang · 2023 · Protein & Cell
- Multiple functions of the ALT favorite helicase, BLMShun Chang, Tan Jiang, Ren Bao, Yanduo Zhang, Jinkai Tong, Tongxin Jia, Jing Liu, Juhua Dan, Shuting Jia · 2025 · Cell & Bioscience
- Translin and Trax differentially regulate telomere-associated transcript homeostasisNatalia Gomez‐Escobar, Nasser Almobadel, Othman Rashed Alzahrani, Julia Feichtinger, Vicente Planells-Palop, Zafer Alshehri, Gerhard Thallinger, Jane A. Wakeman, Ramsay J. McFarlane · 2016 · Oncotarget
- Inhibition of LINE-1 retrotransposition represses telomere reprogramming during mouse 2-cell embryo developmentFang Wang, Isaac J. Chamani, Danxia Luo, Kasey Chan, Paula Andrea Navarro, David Lawrence Keefe · 2021 · Journal of Assisted Reproduction and Genetics
- ATRX modulates the escape from a telomere crisisHelene E. B. Geiller, Adam Harvey, Rhiannon E. Jones, Julia W. Grimstead, Kez Cleal, Eric A. Hendrickson, Duncan M. Baird · 2022 · PLoS Genetics
- TERRA expression is regulated by the telomere-binding proteins POT-1 and POT-2 inCaenorhabditis elegansCaterina Manzato, Luca Larini, Claudio Oss Pegorar, Maria Rosaria Dello Stritto, Katarína Juríková, Verena Jantsch, Emilio Cusanelli · 2023 · Nucleic Acids Research
- Gastroenteropancreatic neuroendocrine tumors: Epigenetic landscape and clinical implicationsHannah Stowe McMurry, Jaydira Del Rivero, Emerson Yu-sheng Chen, Adel Kardosh, Charles D. Lopez, Guillaume Joe Pegna · 2024 · Current Problems in Cancer
- Contributions of recombination and repair proteins to telomere maintenance in telomerase‐positive and negative Ustilago maydisEun Young Yu, Min Hsu, William K. Holloman, Neal F. Lue · 2017 · Molecular Microbiology
- Large-scale drug sensitivity, gene dependency, and proteogenomic analyses of telomere maintenance mechanisms in cancer cellsYangxiu Wu, Zhaoxiang Cai, Dale Cross, Jane R. Noble, Kelsy Prest, Jamie B. Littleboy, Scott B. Cohen, Baylee Edlundh, Jennifer M.S. Koh, Ran Xu et al. · 2025 · Nature Communications
- Chromosome extremities under the microscopy lens: molecular cytogenetics in telomere researchVeronica Cherdyntseva, Sarantis Gagos · 2020 · Current Opinion in Genetics & Development
- Epigenetics of Human TelomeresNicole Bettin, Mélina Vaurs, Anabelle Decottignies · 2025 · Cold Spring Harbor Perspectives in Biology
- SMARCAL1 is a targetable synthetic lethal therapeutic vulnerability in ATRX-deficient gliomas that use alternative lengthening of telomeresAlexandrea Brown, Laura M. Strickland, Elise N. Erman, Christopher J. Pirozzi, Justin Low, Bill H. Diplas, Emiley Gibson, Mariah Shobande, Taher Khambati, М.В. Крылова et al. · 2026 · Neuro-Oncology
- Transcriptome- and proteome-wide effects of a circular RNA encompassing four early exons of the spinal muscular atrophy genesDiou Luo, Eric William Ottesen, Ji Heon Lee, Ravindra Narayan Singh · 2024 · Scientific Reports
- Report from the 4th European Bone Sarcoma Networking meeting: focus on osteosarcomaSandra J. Strauss, Jakob Anninga, S. Rubina Baglio, Daniel Baumhoer, Sam Behjati, Stefan Bielack, Kjetil Boye, Javier Martín‐Broto, Anne‐Marie Cleton-Jansen, Andrea Degasperi et al. · 2018 · Clinical Sarcoma Research
- 2D gel electrophoresis reveals dynamics of t-loop formation during the cell cycle and t-loop in maintenance regulated by heterochromatin stateZepeng Zhang, Tianpeng Zhang, Yuanlong Ge, Mengfan Tang, Wenbin Ma, Qinfen Zhang, Shengzhao Gong, Woodring Erik Wright, Jerry W. Shay, Haiying Liu et al. · 2019 · Journal of Biological Chemistry
- Transcriptional regulation of telomeric repeat-containing RNA by acridine derivativesShuangshuang Kang, Jiaojiao Cao, Meiling Zhang, Xiaoya Li, Qian-Liang Guo, Huang Zeng, Zu‐Zhuang Wei, Xue Gong, Jing Wang, Bobo Liu et al. · 2021 · RNA Biology
- The hypomorphic TERT A1062T variant is associated with increased treatment-related toxicity in acute myeloid leukemiaAnna Both, Jürgen Krauter, Frédérik Damm, Felicitas R. Thol, Gudrun Göhring, Michael Heuser, Oliver Gerhard Ottmann, Michael Lübbert, Mohammed Amen Wattad, Lothar Kanz et al. · 2017 · Annals of Hematology
- Reciprocal impacts of telomerase activity and ADRN/MES differentiation state in neuroblastoma tumor biologyEun Young Yu, Syed S. Zahid, Sarah Aloe, Erik Falck-Pedersen, Xi Kathy Zhou, Nai‐Kong V. Cheung, Neal F. Lue · 2021 · Communications Biology
- Telomeric small RNAs in the genus CaenorhabditisStephen Frenk, Evan H. Lister‐Shimauchi, Shawn Cameron Ahmed · 2019 · RNA
- High serum gamma‐glutamyltransferase level after hepatitis C virus elimination is a risk factor for the development of hepatocellular carcinomaMiyako Murakawa, Mina Nakagawa, Hisaaki Nishimura, Shun Kaneko, Masato Miyoshi, Fukiko Kawai‐Kitahata, Sayuri Nitta, Jun Tsuchiya, Taro Shimizu, Keiya Watakabe et al. · 2024 · Hepatology Research
- Mutant ATRX: pathogenesis of ATRX syndrome and cancerKejia Yuan, Yan Hua Tang, Zexian Ding, Lei Peng, Jinghua Zeng, Huaying Wu, Qi Yi · 2024 · Frontiers in Molecular Biosciences
- Pancreatic neuroendocrine tumors G3 and pancreatic neuroendocrine carcinomas: differences in basic biology and treatmentMing-Yi Zhang, Du He, Shuang Zhang · 2020 · World Journal of Gastrointestinal Oncology
- Gametes deficient for Pot1 telomere binding proteins alter levels of telomeric foci for multiple generationsEvan H. Lister‐Shimauchi, Michael Dinh, Paul S. Maddox, Shawn Cameron Ahmed · 2021 · Communications Biology
- Inorganic elements in occupational settings: A review on the effects on telomere length and biologyVivian Francília Silva Kahl, Juliana da Silva · 2021 · Mutation Research/Genetic Toxicology and Environmental Mutagenesis
- Telomeres, Telomerase and CancerKazunori Tomita, Laura C. Collopy · 2017 · Elsevier eBooks
- Telomeric quadruplexes as therapeutic targetsSefan Asamitsu, Norifumi Shioda, Hiroshi Sugiyama · 2020 · Annual reports in medicinal chemistry
- Transcription as a double‐edged sword in genome maintenanceJian Ouyang · 2024 · FEBS Letters
- A unique telomere DNA expansion phenotype in human retinal rod photoreceptors associated with aging and diseaseW. Robert Bell, Alan Keith Meeker, Anthony J. Rizzo, Sumit Rajpara, Ian M. Rosenthal, Miguel Flores‐Bellver, Silvia Aparicio‐Domingo, Xiufeng Zhong, John R. Barber, Corinne E. Joshu et al. · 2018 · Brain Pathology
- Alternative Lengthening of Telomeres in the Budding Yeast Naumovozyma castelliiMarita Cohn, Ahu Karademir Andersson, Raquel Quintilla Mateo, Mirja Carlsson Möller · 2019 · G3 Genes Genomes Genetics
- Life and Death without Telomerase: The Saccharomyces cerevisiae ModelVeronica Martinez-Fernandez, Aurélia Barascu, Maria Teresa Teixeira · 2024 · Cold Spring Harbor Perspectives in Biology
- Novel role for Ddx39 in differentiation and telomere length regulation of embryonic stem cellsShanshan Nai, Meijie Wang, Jiao Yang, Bin Ling, Qiman Dong, Xiaoqiong Yang, Xiaoling Du, Man Lu, Lin Liu, Zhongbo Yu et al. · 2024 · Cell Death and Differentiation
- Nuclear Pore Complexes in DNA Repair and Telomere MaintenanceMarie‐Noëlle Simon, Alkmini Kalousi, Evi Soutoglou, Vincent Géli, Catherine Dargemont · 2018 · Springer eBooks
- Inhibition of the alternative lengthening of telomeres pathway by subtelomeric sequences in Saccharomyces cerevisiaeNathalie Grandin, Maria Eugenia Gallego, Charles I. White, Michel Charbonneau · 2020 · DNA repair
- Irreversible inhibition of TRF2TRFH recruiting functions by a covalent cyclic peptide induces telomeric replication stress in cancer cellsAlexander P. Sobinoff, Salvatore Di Maro, Ronnie Ren Jie Low, Rosaria Benedetti, Stefano Tomassi, Antonia D’Aniello, Rosita Russo, Ilaria Baglivo, Ugo Chianese, Paolo V. Pedone et al. · 2023 · Cell chemical biology
- Telomerase and alternative lengthening of telomeres coexist in the regenerating zebrafish caudal finsElena Martínez‐Balsalobre, Monique Anchelin, David Hernández-Silva, Marina Mione, Víctoriano Mulero, Francisca Alcaraz‐Pérez, Jesús García‐Castillo, María Luisa Cayuela · 2025 · EMBO Reports
- Epigenetic control of telomeric RNA maintains heterochromatin in telomerase-driven cancersJared D. W. Price, Frederick S Vizeacoumar, Omar Abuhussein, Vincent Maranda, Yue Zhang, Hironori Adachi, Kathryn Nguyen, Liliia Kyrylenko, Aline Rangel Pozzo, He Dong et al. · 2026 · Signal Transduction and Targeted Therapy
- The absence of telomerase leads to immune response and tumor regression in zebrafish melanomaBruno Lopes-Bastos, Joana Nabais, Tânia Ferreira, Giulia Allavena, Mounir El Maï, Malia Bird, Seniye Targen, Lorenzo Tattini, Da Kang, Jia‐Xing Yue et al. · 2024 · Cell Reports
- RADX Sustains POT1 Function at Telomeres to Counteract RAD51 Binding, which Triggers Telomere FragilityAnna‐Sophia Briod, Galina Glousker, Joachim Lingner · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Telomeric SUMO level influences the choices of APB formation pathways and ALT efficiencyRongwei Zhao, Xiaoyang Yu, Tafadzwa Chigumira, Meng Xu, Allison Wivagg, Rachel M. Lackner, Jayme Salsman, Graham Dellaire, Michael J. Matunis, David M. Chenoweth et al. · 2025 · The Journal of Cell Biology
- Subtelomeric elements provide stability to short telomeres in telomerase-negative cells of the budding yeast Naumovozyma castelliiRishi Kumar Jaiswal, Teresa Garibo Domingo, Héloïse Grunchec, Komudi Singh, Mehdi Pirooznia, Eran Elhaik, Marita Cohn · 2025 · Current Genetics
- ZNF827 pleiotropic cardiovascular risk locus involves regulation by nuclear factor-1Yingwei Liu, Lu Liu, Asraa Esmael, Alberto Tezza, Charlie London, Margaux‐Alison Fustier, Adrien B. Georges, Nabila Bouatia‐Naji · 2026 · Clinical Science
- Specific death of ALT cells through TSPYL5 depletionEloïse Claude, Harikleia Episkopou, Anabelle Decottignies · 2019 · Molecular & Cellular Oncology
- A transcriptome and literature guided algorithm for reconstruction of pathways to assess activity of telomere maintenance mechanismsLilit Nersisyan, Arsen Arakelyan · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
- Exercise to combat cancer: focusing on the endsJoshua Denham, Edward Bliss, Tracy M. Bryan, Brendan J. O’Brien, Dean E. Mills · 2024 · Physiological Genomics
- Amplification and Quantitation of Telomeric Extrachromosomal CirclesNathaniel J Robinson, William P. Schiemann · 2023 · BIO-PROTOCOL
- Toxicological Aspects of PROTACsRohini Pujari, Urvashi Soni · 2024 · Springer eBooks
- Expanding the chemotherapeutic potential of an established nucleoside analog with selective targeting of telomeraseTawna L. Whited, Derek J. Taylor · 2018 · Molecular & Cellular Oncology
- Biological Predictors of De Novo Tumors in Solid Organ Transplanted Patients During Oncological Surveillance: Potential Role of Circulating TERT mRNAMichela Cangemi, Stefania Zanussi, Enrica Rampazzo, Ettore Bidoli, Silvia Giunco, Rosamaria Tedeschi, Chiara Pratesi, Debora Martorelli, Mariateresa Casarotto, Ferdinando Martellotta et al. · 2021 · Frontiers in Oncology
- Telomere BiologyP. Logan Schuck, Stephanie M. Ackerson, Jason A. Stewart · 2022 · Elsevier eBooks
- Tabular foundation model predicts alternative lengthening of telomeres (ALT) and identifies SMARCAL1 as a target in ALT-driven cancersDeclan Bennett, Monika Wierdl, S Chakraborty, Jordan Johnson, Victoria Akingbehin, Daniel Estevez-Prado, Yuan Feng, Janeala J. Morsby, John Harper, Mohammad Ali Mohammad Nezhady et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Epigenetic dysregulation in brain tumors and neurodevelopmentMarco M. Hefti, Nadejda M. Tsankova · 2016 · Elsevier eBooks
- Telomere Biology and DiseaseJames N. Cooper, Neal S. Young · 2017 · Elsevier eBooks
- Small RNA-mediated genomic silencing promotes telomere stability in the absence of telomerase in C. elegansLu Lu, Ambika Bhattarai, Charlie Longtine, Stephen Frenk, Madelyn Garrison, Julie Seohyun Lee, Evan H. Lister-Shimauchi, Shawn Cameron Ahmed · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
- Stochastic Telomere Shortening and the Route to Limitless Replicative PotentialYusong Ye, Zhuoqin Yang, Jinzhi Lei · 2019 · Journal of Computational Biology
- Oncofetal HMGA2 as a key regulator of telomere stability through control of DNA topologyPriya Dharshana Ramani · 2018
- Morphogenesis of giant telomeric nuclear bodies in cancer cells with alternative lengthening of telomeresYuu Arimasu, Masachika Fujiwara, Jun Ishii, Tomohiro Chiba, Yuichi Terado, Yukiko Shishido‐Hara, Hiroshi Kamma · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- Clinical Relevance of Alternative Lengthening of Telomeres in CancerGuilherme G. da Silva, Karollyne S. Morais, Daniel da S. Arcanjo, Diêgo Madureira de Oliveira · 2020 · Current Topics in Medicinal Chemistry
- THE PML PROTEIN IS NOT ESSENTIAL FOR TELOMERE MAINTENANCE BY THE ALTERNATIVE LENGTHENING OF TELOMERES PATHWAY (ALT) AND ITS DELETION MODIFIES ALT BIOMARKERSWalter T. Barry · 2017
- Senescence and ImmortalizationRoger R. Reddel · 2015 · Springer eBooks
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- Faculty Opinions recommendation of Telomeres in cancer: tumour suppression and genome instability.Sharon A. Savage · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- RTEL-1 and DNA polymerase theta promote subtelomeric DNA synthesis and telomere fusion in C. elegansEvan H. Lister‐Shimauchi, Morgan M Brady, Stephen Frenk, Braxton Harris, Ana-Maria Leon Ortiz, Aylin Memili, Minh Nguyen, Simon J. Boulton, Shawn Cameron Ahmed · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Aging-related neoplasiaAna Bela Sarmento‐Ribeiro, Maria Filomena Botelho, Ana Cristina Gonçalves, Joana Barbosa Melo, Mafalda Laranjo, Raquel Alves, Joana Jorge, Ilda Patrícia Ribeiro, Salomé Pires, Ana Margarida Abrantes et al. · 2022 · Elsevier eBooks
- Telomere Length and CancerIsmail Ibrahim Al-Janabi · 2025 · Al-Rafidain Journal of Medical Sciences
- Investigating the physiological, metabolomic, and transcriptomic changes in response to telomerase deletion in Saccharomyces cerevisiaeTaizina Momtareen · 2025 · The Research Repository @ WVU (West Virginia University)
- Additional file 4 of TRIM28 inhibits alternative lengthening of telomere phenotypes by protecting SETDB1 from degradationChuanle Wang, Songyang, Zhou, Huang, Yan · 2021 · Figshare
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- ATRX loss promotes gliomagenesis by converged actions on neural differentiation and telomere maintenanceLibo Xu, Fei Li, Naiyan Wen, Caizhi Wu, Aonan Zhu, Yixuan Hou, Wenqi Wang, Yanying Zhao, Hongwu Zheng, Ling Zhang · 2026 · Cellular Signalling
- Single-stranded telomeric repeats segregate into spatial compartments within ALT-associated PML bodiesEmma S. Koeleman, Charlotte Kaplan, Maria Augusta do Rego Barros Fernandes Lima, Delia M. Braun, Caroline Knotz, Karsten Rippe · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Alternative lengthening of telomeres is dependent on RAD52 and RAD51 gene function in the budding yeast Naumovozyma castelliiHumberto Itriago, Marita Cohn · 2026 · G3 Genes Genomes Genetics
- Endocrine-disrupting chemical-induced gene networks confer coronary heart disease risk revealed by causal inference and single-cell analysesTao Yao, Yun-Lu Lin, Luo-Xiang Fang, Yu-Tian Wang, Lan-Feng Zhou, Ning Zhang, Gang Chen · 2026 · Food and Chemical Toxicology
- Integrative cross-tissue transcriptome-wide association and metabolomic analysis reveals novel genetic risk loci for aortic aneurysmHanxi Wang, 程俊傑, Jiali Yao, Wentao Jin, Wei Li · 2026 · Frontiers in Nutrition
- Deconstructing the Alternative Lengthening of Telomeres: Integromics Prioritizes Five Master Hubs Dictating Clinical Survival and Therapeutic VulnerabilitiesIsaac Armendáriz‐Castillo, Santiago Xavier Guerrero, Andrés Herrera-Yela, Jhommara Bautista, Andrés López‐Cortés · 2026 · Biology
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