Molecular mechanisms of activity and derepression of alternative lengthening of telomeres
Abstract
Alternative lengthening of telomeres (ALT) involves homology-directed telomere synthesis. This multistep process is facilitated by loss of the ATRX or DAXX chromatin-remodeling factors and by abnormalities of the telomere nucleoprotein architecture, including altered DNA sequence and decreased TRF2 saturation. Induction of telomere-specific DNA damage triggers homology-directed searches, and NuRD-ZNF827 protein-protein interactions provide a platform for the telomeric recruitment of homologous recombination (HR) proteins. Telomere lengthening proceeds by strand exchange and template-driven DNA synthesis, which culminates in dissolution of HR intermediates.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A significant minority of cancers use alternative lengthening of telomeres (ALT) to maintain telomeres.
“Furthermore, although most human cancers (~90%) escape telomere crisis by activating telomerase56, a significant minority of cancers use an alternative telomere maintenance system, referred to as alternative lengthening of telomeres (ALT)161.”
From Telomeres in cancer: tumour suppression and genome instability (2017) · cites this paper as [161]
Cites
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
Schwartzentruber, J., Korshunov, A., Liu, X.-Y., Jones, D. T. W., Pfaff, E., Jacob, K., Sturm, D., Fontebasso, A. M., Quang, D.-A. K., Tönjes, M., et al. (2012) · Nature · doi:10.1038/nature10833 · Cited by 2,631 · see citing works
How Shelterin Protects Mammalian Telomeres
Palm, W., & de Lange, T. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.110306.130350 · Cited by 1,802 · see citing works
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
Greider, C. W., & Blackburn, E. H. (1989) · Nature · doi:10.1038/337331a0 · Cited by 1,643 · see citing works
Bryan, T. M., Englezou, A., Dalla-Pozza, L., Dunham, M. A., & Reddel, R. R. (1997) · Nature Medicine · doi:10.1038/nm1197-1271 · Cited by 1,292 · see citing works
Self-citationTelomere elongation in immortal human cells without detectable telomerase activity
Bryan, T. M., Englezou, A., Gupta, J., Bacchetti, S., & Reddel, R. R. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00098.x · Cited by 1,279 · see citing works
Self-citationSIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
Michishita, E., McCord, R. A., Berber, E., Kioi, M., Padilla-Nash, H., Damian, M., Cheung, P., Kusumoto, R., Kawahara, T. L. A., Barrett, J. C., et al. (2008) · Nature · doi:10.1038/nature06736 · Cited by 1,111 · see citing works
Altered Telomeres in Tumors with <i>ATRX</i> and <i>DAXX</i> Mutations
Heaphy, C. M., de Wilde, R. F., Jiao, Y., Klein, A. P., Edil, B. H., Shi, C., Bettegowda, C., Rodriguez, F. J., Eberhart, C. G., Hebbar, S., et al. (2011) · Science · doi:10.1126/science.1207313 · Cited by 1,083 · see citing works
Alternative lengthening of telomeres: models, mechanisms and implications
Cesare, A. J., & Reddel, R. R. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2763 · Cited by 1,022 · see citing works
Self-citationMammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication
Sfeir, A., Kosiyatrakul, S. T., Hockemeyer, D., MacRae, S. L., Karlseder, J., Schildkraut, C. L., & de Lange, T. (2009) · Cell · doi:10.1016/j.cell.2009.06.021 · Cited by 990 · see citing works
An alternative pathway for yeast telomere maintenance rescues est1− senescence
Lundblad, V., & Blackburn, E. H. (1993) · Cell · doi:10.1016/0092-8674(93)90234-h · Cited by 942 · see citing works
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
Denchi, E. L., & de Lange, T. (2007) · Nature · doi:10.1038/nature06065 · Cited by 880 · see citing works
Telomere maintenance by recombination in human cells
Dunham, M. A., Neumann, A. A., Fasching, C. L., & Reddel, R. R. (2000) · Nature Genetics · doi:10.1038/82586 · Cited by 879 · see citing works
Self-citationMechanism of homologous recombination: mediators and helicases take on regulatory functions
Sung, P., & Klein, H. L. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2008 · Cited by 697 · see citing works
Yeager, T. R., Neumann, A. A., Englezou, A., Huschtscha, L. I., Noble, J. R., & Reddel, R. R. (1999) · PubMed · Cited by 678 · see citing works
Self-citationThe epigenetic regulation of mammalian telomeres
Blasco, M. A. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2047 · Cited by 668 · see citing works
Homologous recombination and its regulation
Krejčí, L., Altmannová, V., Spirek, M., & Zhao, X. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks270 · Cited by 642 · see citing works
Lovejoy, C. A., Li, W., Reisenweber, S., Thongthip, S., Bruno, J., de Lange, T., De, S., Petrini, J. H. J., Sung, P. A., Jasin, M., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002772 · Cited by 629 · see citing works
Self-citation53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility
Dimitrova, N., Chen, Y.-C. M., Spector, D. L., & de Lange, T. (2008) · Nature · doi:10.1038/nature07433 · Cited by 572 · see citing works
García‐Cao, M., O’Sullivan, R. J., Peters, A. H. F. M., Jenuwein, T., & Blasco, M. A. (2003) · Nature Genetics · doi:10.1038/ng1278 · Cited by 557 · see citing works
Purification of Proteins Associated with Specific Genomic Loci
Déjardin, J., & Kingston, R. E. (2009) · Cell · doi:10.1016/j.cell.2008.11.045 · Cited by 545 · see citing works
Human RecQ Helicases in DNA Repair, Recombination, and Replication
Croteau, D. L., Popuri, V., Opresko, P. L., & Bohr, V. A. (2014) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060713-035428 · Cited by 535 · see citing works
Heaphy, C. M., Subhawong, A. P., Hong, S.-M., Goggins, M. G., Montgomery, E. A., Gabrielson, E., Netto, G. J., Epstein, J. I., Lotan, T. L., Westra, W. H., et al. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.06.018 · Cited by 516 · see citing works
Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors
Flynn, R. L., Cox, K. E., Jeitany, M., Wakimoto, H., Bryll, A. R., Ganem, N. J., Bersani, F., Pineda, J. R., Suvà, M. L., Benes, C. H., et al. (2015) · Science · doi:10.1126/science.1257216 · Cited by 504 · see citing works
Break-induced replication and telomerase-independent telomere maintenance require Pol32
Lydeard, J. R., Jain, S., Yamaguchi, M., & Haber, J. E. (2007) · Nature · doi:10.1038/nature06047 · Cited by 492 · see citing works
T-loops and the origin of telomeres
de Lange, T. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1359 · Cited by 461 · see citing works
Law, M. J., Lower, K. M., Voon, H. P. J., Hughes, J. R., Garrick, D., Viprakasit, V., Mitson, M., Gobbi, M. D., Marra, M. A., Morris, A. P., et al. (2010) · Cell · doi:10.1016/j.cell.2010.09.023 · Cited by 443 · see citing works
Wong, L. H., McGhie, J. D. R., Sim, M., Anderson, M. A., Ahn, S., Hannan, R. D., George, A. J., Morgan, K. A., Mann, J. R., & Choo, K. H. A. (2010) · Genome Research · doi:10.1101/gr.101477.109 · Cited by 415 · see citing works
Telomere-binding Protein TRF2 Binds to and Stimulates the Werner and Bloom Syndrome Helicases
Opresko, P. L., von Kobbe, C., Lainé, J., Harrigan, J. A., Hickson, I. D., & Bohr, V. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205396200 · Cited by 389 · see citing works
Interchromosomal Homology Searches Drive Directional ALT Telomere Movement and Synapsis
Cho, N. W., Dilley, R. L., Lampson, M. A., & Greenberg, R. A. (2014) · Cell · doi:10.1016/j.cell.2014.08.030 · Cited by 364 · see citing works
TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA
Flynn, R. L., Centore, R. C., O’Sullivan, R. J., Rai, R., Tse, A., Songyang, Z., Chang, S. S., Karlseder, J., & Zou, L. (2011) · Nature · doi:10.1038/nature09772 · Cited by 338 · see citing works
Coordinated actions of SLX1-SLX4 and MUS81-EME1 for Holliday junction resolution in human cells.
Wyatt, H. D. M., Sarbajna, S., Matos, J., & West, S. (2013) · Molecules and Cells · doi:10.1016/j.molcel.2013.08.035 · Cited by 327 · see citing works
Reversing Time: Origin of Telomerase
Nakamura, T., & Cech, T. R. (1998) · Cell · doi:10.1016/s0092-8674(00)81123-x · Cited by 318 · see citing works
Break-Induced Replication and Recombinational Telomere Elongation in Yeast
McEachern, M. J., & Haber, J. E. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133234 · Cited by 311 · see citing works
Clynes, D., Jelinska, C., Xella, B., Ayyub, H., Scott, C., Mitson, M., Taylor, S., Higgs, D. R., & Gibbons, R. J. (2015) · Nature Communications · doi:10.1038/ncomms8538 · Cited by 293 · see citing works
Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions
Cesare, A. J., Kaul, Z., Cohen, S. B., Napier, C. E., Pickett, H. A., Neumann, A. A., & Reddel, R. R. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1725 · Cited by 263 · see citing works
Self-citationRapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1
O’Sullivan, R. J., Arnoult, N., Lackner, D. H., Oganesian, L., Haggblom, C., Corpet, A., Almouzni, G., & Karlseder, J. (2014) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2754 · Cited by 259 · see citing works
Rogan, E. M., Bryan, T. M., Hukku, B., Maclean, K. N., Chang, A. C.-M., Moy, E. L., Englezou, A., Warneford, S., Dalla‐Pozza, L., & Reddel, R. R. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.9.4745 · Cited by 250 · see citing works
Self-citationUnusual Chromatin in Human Telomeres
Tommerup, H., Dousmanis, A., & de Lange, T. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.9.5777 · Cited by 232 · see citing works
Living with Genome Instability: Plant Responses to Telomere Dysfunction
Říha, K., McKnight, T. D., Griffing, L. R., & Shippen, D. E. (2001) · Science · doi:10.1126/science.1057110 · Cited by 226 · see citing works
The first molecular details of ALT in human tumor cells
Muntoni, A., & Reddel, R. R. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi266 · Cited by 226 · see citing works
Self-citationMcEachern, M. J., & Blackburn, E. H. (1996) · Genes & Development · doi:10.1101/gad.10.14.1822 · Cited by 224 · see citing works
Visualizing telomere dynamics in living mammalian cells using PNA probes
Molenaar, C., Wiesmeijer, K. C., Verwoerd, N. P., Khazen, S., Eils, R., Tanke, H. J., & Dirks, R. W. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg633 · Cited by 217 · see citing works
Telomerase and Retrotransposons: Which Came First?
Eickbush, T. H. (1997) · Science · doi:10.1126/science.277.5328.911 · Cited by 214 · see citing works
Alternative Lengthening of Telomeres is characterized by reduced compaction of telomeric chromatin
Episkopou, H., Drašković, I., Beneden, A. V., Tilman, G., Mattiussi, M., Gobin, M., Arnoult, N., Londoño‐Vallejo, A., & Decottignies, A. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku114 · Cited by 192 · see citing works
ATRX represses alternative lengthening of telomeres
Napier, C. E., Huschtscha, L. I., Harvey, A., Bower, K., Noble, J. R., Hendrickson, E. A., & Reddel, R. R. (2015) · Oncotarget · doi:10.18632/oncotarget.3846 · Cited by 182 · see citing works
Self-citationTRF2 Recruits RTEL1 to Telomeres in S Phase to Promote T-Loop Unwinding
Sarek, G., Vannier, J., Panier, S., Petrini, J. H. J., & Boulton, S. J. (2015) · Molecular Cell · doi:10.1016/j.molcel.2014.12.024 · Cited by 175 · see citing works
Draskovic, I., Arnoult, N., Steiner, V., Bacchetti, S., Lomonte, P., & Londoño-Vallejo, A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907689106 · Cited by 175 · see citing works
Biessmann, H., & Mason, J. M. (1997) · Chromosoma · doi:10.1007/s004120050225 · Cited by 170 · see citing works
Loss of ATRX leads to chromosome cohesion and congression defects
Ritchie, K., Seah, C., Moulin, J. M., Isaac, C. E., Dick, F. A., & Bérubé, N. G. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200706083 · Cited by 163 · see citing works
Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells
Conomos, D., Stutz, M. D., Hills, M., Neumann, A. A., Bryan, T. M., Reddel, R. R., & Pickett, H. A. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201207189 · Cited by 162 · see citing works
Self-citationImpaired germinal center reaction in mice with short telomeres
Herrera, E., Martínez‐A, C., & Blasco, M. A. (2000) · The EMBO Journal · doi:10.1093/emboj/19.3.472 · Cited by 144 · see citing works
Niida, H., Shinkai, Y., Hande, M. P., Matsumoto, T., Takehara, S., Tachibana, M., Oshimura, M., Lansdorp, P. M., & Furuichi, Y. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.4115-4127.2000 · Cited by 137 · see citing works
Alternative lengthening of telomeres in normal mammalian somatic cells
Neumann, A. A., Watson, C. M., Noble, J. R., Pickett, H. A., Tam, P. P. L., & Reddel, R. R. (2013) · Genes & Development · doi:10.1101/gad.205062.112 · Cited by 137 · see citing works
Self-citationMolecular characterization of inter-telomere and intra-telomere mutations in human ALT cells
Varley, H., Pickett, H. A., Foxon, J. L., Reddel, R. R., & Royle, N. J. (2002) · Nature Genetics · doi:10.1038/ng834 · Cited by 135 · see citing works
Self-citationRoles of SLX1–SLX4, MUS81–EME1, and GEN1 in avoiding genome instability and mitotic catastrophePreprint
Sarbajna, S., Davies, D. C., & West, S. C. (2014) · Genes & Development · doi:10.1101/gad.238303.114 · Cited by 134 · see citing works
MUS81-EME2 Promotes Replication Fork Restart
Pepe, A., & West, S. C. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.04.007 · Cited by 131 · see citing works
NuRD–ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination
Conomos, D., Reddel, R. R., & Pickett, H. A. (2014) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2877 · Cited by 129 · see citing works
Self-citationRecombinational Telomere Elongation Promoted by DNA Circles
Natarajan, S., & McEachern, M. J. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.13.4512-4521.2002 · Cited by 126 · see citing works
Maloisel, L., Fabre, F., & Gangloff, S. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01651-07 · Cited by 126 · see citing works
REV1 and polymerase ζ facilitate homologous recombination repair
Sharma, S., Hicks, J. K., Chute, C. L., Brennan, J. R., Ahn, J.-Y., Glover, T. W., & Canman, C. E. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr769 · Cited by 124 · see citing works
SLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with Telomeres
Wan, B., Yin, J., Horvath, K., Sarkar, J., Chen, Y., Wu, J., Wan, K., Lü, J., Gu, P., Yu, E. Y., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.08.017 · Cited by 117 · see citing works
Baird, D. M., Jeffreys, A. J., & Royle, N. J. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00227.x · Cited by 116 · see citing works
Lee, M., Hills, M., Conomos, D., Stutz, M. D., Dagg, R. A., Lau, L. M. S., Reddel, R. R., & Pickett, H. A. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1117 · Cited by 114 · see citing works
Self-citationNuclear-Receptor-Mediated Telomere Insertion Leads to Genome Instability in ALT Cancers
Marzec, P., Armenise, C., Pérot, G., Roumelioti, F., Basyuk, E. I., Gagos, S., Chibon, F., & Déjardin, J. (2015) · Cell · doi:10.1016/j.cell.2015.01.044 · Cited by 94 · see citing works
Unusual Chromatin in Human Telomeres
Tommerup, H., Dousmanis, A., & de Lange, T. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.9.5777-5785.1994 · Cited by 93 · see citing works
Immortalized cells with no detectable telomerase activity. A review.
Reddel, R. R., Bryan, T. M., & Murnane, J. P. (1997) · PubMed · Cited by 91 · see citing works
Self-citationLocalization-Dependent and -Independent Roles of SLX4 in Regulating Telomeres
Wilson, J. S. J., Tejera, Á. M., Castor, D., Toth, R. L., Blasco, M. A., & Rouse, J. W. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.07.033 · Cited by 88 · see citing works
Fasching, C. L., Neumann, A. A., Muntoni, A., Yeager, T. R., & Reddel, R. R. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1556 · Cited by 87 · see citing works
Self-citationInsertion of a Telomere Repeat Sequence into a Mammalian Gene Causes Chromosome Instability
Kilburn, A. E., Shea, M. J., Sargent, R. G., & Wilson, J. H. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.1.126-135.2001 · Cited by 86 · see citing works
Baird, D. M., Coleman, J., Rosser, Z. H., & Royle, N. J. (2000) · The American Journal of Human Genetics · doi:10.1086/302721 · Cited by 83 · see citing works
Bower, K., Napier, C. E., Cole, S. L., Dagg, R. A., Lau, L. M. S., Duncan, E. L., Moy, E. L., & Reddel, R. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050062 · Cited by 81 · see citing works
Self-citationMuntoni, A., Neumann, A. A., Hills, M., & Reddel, R. R. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn436 · Cited by 72 · see citing works
Self-citationSarkar, J., Wan, B., Yin, J., Vallabhaneni, H., Horvath, K., Kulikowicz, T., Bohr, V. A., Zhang, Y., Lei, M., & Liu, Y. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv522 · Cited by 65 · see citing works
Lee, J., Jeng, Y., Liau, J., Tsai, J., Hsu, H.-H., & Yang, C. (2015) · Modern Pathology · doi:10.1038/modpathol.2015.67 · Cited by 58 · see citing works
Bhattacharyya, S., Keirsey, J. K., Russell, B., Kavecansky, J., Lillard-Wetherell, K., Tahmaseb, K., Turchi, J. J., & Groden, J. L. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m900195200 · Cited by 58 · see citing works
Jiang, W.-Q., Zhong, Z.-H., Nguyen, A., Henson, J. D., Toouli, C., Braithwaite, A., & Reddel, R. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200810084 · Cited by 58 · see citing works
Self-citationMetabolism of DNA secondary structures at the eukaryotic replication fork
León-Ortiz, A. M., Svendsen, J. M., & Boulton, S. J. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.03.016 · Cited by 56 · see citing works
Zhao, W., & Sung, P. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv259 · Cited by 56 · see citing works
TRF1 and TRF2 binding to telomeres is modulated by nucleosomal organization
Galati, A., Micheli, E., Alicata, C., Ingegnere, T., Cicconi, A., Pusch, M. C., Giraud-Panis, M.-J. E., Gilson, É., & Cacchione, S. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv507 · Cited by 46 · see citing works
Cheng, C., Shtessel, L., Brady, M., & Ahmed, S. C. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119191109 · Cited by 33 · see citing works
Sakellariou, D., Chiourea, M., Raftopoulou, C., & Gagos, S. (2013) · Neoplasia · doi:10.1593/neo.131574 · Cited by 27 · see citing works
Organismal propagation in the absence of a functional telomerase pathway in Caenorhabditis elegans
Lackner, D. H., Raı́ces, M., Maruyama, H., Haggblom, C., & Karlseder, J. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.61 · Cited by 27 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Telomeres in cancer: tumour suppression and genome instability
Maciejowski, J., & de Lange, T. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.171 · Cited by 745 · see citing works
Regulation of human telomerase in homeostasis and disease
Roake, C. M., & Artandi, S. E. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0234-z · Cited by 341 · see citing works
Telomere-driven diseases and telomere-targeting therapies
Martínez, P., & Blasco, M. A. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201610111 · Cited by 257 · see citing works
“Reactivation of either telomerase activity or the alternative lengthening of telomeres (ALT) allows these premalignant cells to escape crisis, undergo unlimited divisions (immortalization), and evolve into a fully transformed cancerous state (Fig. 3 E; Pickett and Reddel, 2015; Shay, 2016).”
BackgroundProteolysis‐targeting chimeras in drug development: A safety perspective
Moreau, K., Coen, M., Zhang, A. X., Pachl, F., Castaldi, M. P., Dahl, G., Boyd, H., Scott, C., & Newham, P. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15014 · Cited by 229 · see citing works
Genetics and Epigenetics of Gastroenteropancreatic Neuroendocrine Neoplasms
Mafficini, A., & Scarpa, A. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00160 · Cited by 215 · see citing works
Role of the cGAS–STING pathway in cancer development and oncotherapeutic approaches
Khoo, L. T., & Chen, L. (2018) · The EMBO Reports · doi:10.15252/embr.201846935 · Cited by 204 · see citing works
The nucleosome remodeling and deacetylase complex in development and disease
Basta, J., & Rauchman, M. (2015) · Translational Research · doi:10.1016/j.trsl.2014.05.003 · Cited by 191 · see citing works
Functions, Regulation, and Therapeutic Implications of the ATR Checkpoint Pathway
Yazinski, S. A., & Zou, L. (2016) · Annual Review of Genetics · doi:10.1146/annurev-genet-121415-121658 · Cited by 173 · see citing works
The Emerging Roles of TERRA in Telomere Maintenance and Genome Stability
Bettin, N., Pegorar, C. O., & Cusanelli, E. (2019) · Cells · doi:10.3390/cells8030246 · Cited by 167 · see citing works
Roumelioti, F., Sotiriou, S. K., Katsini, V., Chiourea, M., Halazonetis, T. D., & Gagos, S. (2016) · EMBO Reports · doi:10.15252/embr.201643169 · Cited by 159 · see citing works
Extrachromosomal telomere repeat DNA is linked to ALT development via cGAS-STING DNA sensing pathway
Chen, Y., Shen, Y., Hsia, H.-Y., Tiang, Y. P., Sung, T.-L., & Chen, L. (2017) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3498 · Cited by 158 · see citing works
Kim, J. Y., Brosnan‐Cashman, J. A., An, S., Kim, S. J., Song, K. B., Kim, M. S., Kim, M.-J., Hwang, D. W., Meeker, A. K., Yu, E., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-1147 · Cited by 151 · see citing works
Telomere Loop Dynamics in Chromosome End Protection
Ly, D. V., Low, R. R. J., Frölich, S., Bartolec, T. K., Kafer, G. R., Pickett, H. A., Gaus, K., & Cesare, A. J. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.06.025 · Cited by 128 · see citing works
Self-citationLi, F., Deng, Z., Zhang, L., Wu, C., Jin, Y., Hwang, I., Vladimirova, O. V., Xu, L., Yang, L., Lu, B., et al. (2019) · The EMBO Journal · doi:10.15252/embj.201796659 · Cited by 126 · see citing works
Telomeres, aging, and cancer: the big picture
Lansdorp, P. M. (2022) · Blood · doi:10.1182/blood.2021014299 · Cited by 95 · see citing works
Yan, Y., Guo, G., Huang, J., Gao, M., Zhu, Q., Zeng, S., Gong, Z., & Xu, Z. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00960-9 · Cited by 88 · see citing works
Repair of DNA Breaks by Break-Induced Replication
Kockler, Z. W., Osia, B., Lee, R. H. C., Musmaker, K., & Malkova, A. (2021) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-081420-095551 · Cited by 86 · see citing works
ALT Positivity in Human Cancers: Prevalence and Clinical Insights
MacKenzie, D., Watters, A. K., To, J. T., Young, M. W., Muratori, J., Wilkoff, M. H., Abraham, R. G., Plummer, M. M., & Zhang, D. (2021) · Cancers · doi:10.3390/cancers13102384 · Cited by 85 · see citing works
Expression and differential regulation of human TERRA at several chromosome ends
Feretzaki, M., Nunes, P. R., & Lingner, J. (2019) · RNA · doi:10.1261/rna.072322.119 · Cited by 77 · see citing works
Telomere-related Markers for Cancer
Yuan, X., Dai, M., & Xu, D. (2020) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026620666200106145340 · Cited by 74 · see citing works
Schenkel, L. C., Kernohan, K. D., McBride, A., Ditta, R., Hodge, A., Ainsworth, P., Rodenhiser, D. I., Paré, G., Bérubé, N. G., Skinner, C. D., et al. (2017) · Epigenetics & Chromatin · doi:10.1186/s13072-017-0118-4 · Cited by 74 · see citing works
Bloom’s syndrome: Why not premature aging?
de Renty, C., & Ellis, N. A. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.05.010 · Cited by 72 · see citing works
Telomere Length Dynamics and the Evolution of Cancer Genome Architecture
Cleal, K., Norris, K., & Baird, D. M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020482 · Cited by 71 · see citing works
Repetitive RNAs as Regulators of Chromatin-Associated Subcompartment Formation by Phase Separation
Frank, L., & Rippe, K. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.04.015 · Cited by 68 · see citing works
Linking Telomere Regulation to Stem Cell Pluripotency
Liu, L. (2016) · Trends in Genetics · doi:10.1016/j.tig.2016.10.007 · Cited by 66 · see citing works
Deeg, K. I., Chung, I., Bauer, C., & Rippe, K. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2016.00186 · Cited by 65 · see citing works
Zhang, T., Zhang, Z., Shengzhao, G., Li, X., Liu, H., & Zhao, Y. B. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1007925 · Cited by 64 · see citing works
Lawlor, R. T., Veronese, N., Pea, A., Nottegar, A., Smith, L., Pilati, C., Demurtas, J., Fassan, M., Cheng, L., & Luchini, C. (2019) · BMC Cancer · doi:10.1186/s12885-019-5424-8 · Cited by 62 · see citing works
Understanding diversity in telomere dynamics
Monaghan, P., Eisenberg, D. T. A., Harrington, L. A., & Nussey, D. H. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0435 · Cited by 61 · see citing works
ATRX affects the repair of telomeric DSBs by promoting cohesion and a DAXX-dependent activity
Lovejoy, C. A., Takai, K., Huh, M. S., Picketts, D. J., & de Lange, T. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000594 · Cited by 61 · see citing works
Telomere Length Measurement by Molecular Combing
Kahl, V. F. S., Allen, J. A. M., Nelson, C. B., Sobinoff, A. P., Lee, M., Kilo, T., Vasireddy, R. S., & Pickett, H. A. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00493 · Cited by 59 · see citing works
Self-citationCleal, K., Jones, R. E., Grimstead, J. W., Hendrickson, E. A., & Baird, D. M. (2019) · Genome Research · doi:10.1101/gr.240705.118 · Cited by 59 · see citing works
RPA Stabilization of Single-Stranded DNA Is Critical for Break-Induced Replication
Ruff, P., Donnianni, R. A., Glancy, E., Oh, J., & Symington, L. S. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.12.003 · Cited by 57 · see citing works
Episkopou, H., Diman, A., Claude, E., Viceconte, N., & Decottignies, A. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.05.027 · Cited by 55 · see citing works
Highly Aggressive Metastatic Melanoma Cells Unable to Maintain Telomere Length
Viceconte, N., Dheur, M.-S., Majerová, E., Pierreux, C. E., Baurain, J., van Baren, N., & Decottignies, A. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.05.046 · Cited by 55 · see citing works
Nersisyan, L., Hopp, L., Loeffler‐Wirth, H., Galle, J., Loeffler, M., Arakelyan, A., & Binder, H. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01172 · Cited by 54 · see citing works
The macroH2A1.2 histone variant links ATRX loss to alternative telomere lengthening
Kim, J., Sun, C., Tran, A. D., Chin, P.-J., Ruiz, P. D., Wang, K., Gibbons, R. J., Gamble, M. J., Liu, Y., & Oberdoerffer, P. (2019) · Nature Structural & Molecular Biology · doi:10.1038/s41594-019-0192-3 · Cited by 49 · see citing works
DNA damage processing at telomeres: The ends justify the means
Fouquerel, E., Parikh, D., & Opresko, P. L. (2016) · DNA repair · doi:10.1016/j.dnarep.2016.05.022 · Cited by 48 · see citing works
Schaefer, T., Steiner, R., & Lengerke, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144902 · Cited by 48 · see citing works
Significance of TERT and ATRX mutations in glioma
Liu, J., Zhang, X., Xiao-ling, Y. A. N., Sun, M., Fan, Y., & Huang, Y. (2018) · Oncology Letters · doi:10.3892/ol.2018.9634 · Cited by 46 · see citing works
Carlton, P. M., Davis, R. E., & Ahmed, S. C. (2022) · Genetics · doi:10.1093/genetics/iyac014 · Cited by 46 · see citing works
Life and cancer without telomerase: ALT and other strategies for making sure ends (don’t) meet
Apte, M. S., & Cooper, J. P. (2016) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2016.1260090 · Cited by 44 · see citing works
Alternative Lengthening of Telomeres (ALT) in Tumors and Pluripotent Stem Cells
Zhao, S., Wang, F., & Liu, L. (2019) · Genes · doi:10.3390/genes10121030 · Cited by 41 · see citing works
Recagni, M., Bidzińska, J., Zaffaroni, N., & Folini, M. (2020) · Cancers · doi:10.3390/cancers12040949 · Cited by 41 · see citing works
Fogli, A., Demattei, M.-V., Corset, L., Vaurs‐Barrière, C., Chautard, E., Biau, J., Kémény, J., Godfraind, C., Pereira, B., Khallil, T., et al. (2017) · Journal of Neuro-Oncology · doi:10.1007/s11060-017-2585-7 · Cited by 38 · see citing works
Cimino-Reale, G., Gandellini, P., Santambrogio, F., Recagni, M., Zaffaroni, N., & Folini, M. (2017) · Journal of Hematology & Oncology · doi:10.1186/s13045-017-0510-3 · Cited by 36 · see citing works
Diagnosis and treatment of ALT tumors: is Trabectedin a new therapeutic option?
Pompili, L., Leonetti, C., Biroccio, A., & Salvati, E. (2017) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-017-0657-3 · Cited by 34 · see citing works
Lee, E. J., Hwang, I., Lee, J. Y., Park, J. N., Kim, K. C., Kim, G.-H., Kang, C.-M., Kim, I., Lee, S.-Y., & Kim, H.-S. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.12.015 · Cited by 34 · see citing works
Kim, K. Y., Kim, J. O., Kim, Y., Choi, J., Park, J. M., Han, K., Park, D., Park, Y. C., Kim, B. T., & Hong, K. (2021) · Hepatology · doi:10.1002/hep.32115 · Cited by 33 · see citing works
Zhou, J., Reddy, M. V., Wilson, B. K. J., Blair, D. A., Taha, A. J., Frampton, C. M., Eiholzer, R. A., Gan, P. Y. C., Ziad, F., Thotathil, Z., et al. (2017) · American Journal of Neuroradiology · doi:10.3174/ajnr.a5441 · Cited by 33 · see citing works
Evolving Linear Chromosomes and Telomeres: A C-Strand-Centric View
Lue, N. F. (2018) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2018.02.008 · Cited by 33 · see citing works
Novakovic, B., Napier, C. E., Vryer, R., Dimitriadis, E., Manuelpillai, U., Sharkey, A., Craig, J. M., Reddel, R. R., & Saffery, R. (2016) · Molecular Human Reproduction · doi:10.1093/molehr/gaw053 · Cited by 31 · see citing works
Self-citationTelomeres, Telomerase and Cancer
Lansdorp, P. M. (2022) · Archives of Medical Research · doi:10.1016/j.arcmed.2022.10.004 · Cited by 30 · see citing works
da Silva, M. S., Hovel-Miner, G. A., Briggs, E. M., Elias, M. C., & McCulloch, R. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1007321 · Cited by 30 · see citing works
Epigenetic Regulation of Telomere Maintenance for Therapeutic Interventions in Gliomas
Naderlinger, E., & Holzmann, K. (2017) · Genes · doi:10.3390/genes8050145 · Cited by 29 · see citing works
Simon, M., Churikov, D., & Géli, V. (2016) · FEMS Yeast Research · doi:10.1093/femsyr/fow085 · Cited by 28 · see citing works
Regulation of Telomere Homeostasis during Epstein-Barr virus Infection and Immortalization
Kamranvar, S. A., & Masucci, M. G. (2017) · Viruses · doi:10.3390/v9080217 · Cited by 28 · see citing works
Expression of tert Prevents ALT in Zebrafish Brain Tumors
Idilli, A. I., Cusanelli, E., Pagani, F., Kerschbamer, E., Berardinelli, F., Bernabe, M., Cayuela, M. L., Piazza, S., Poliani, P. L., & Mione, M. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00065 · Cited by 28 · see citing works
Denham, J. (2023) · Aging Cell · doi:10.1111/acel.13836 · Cited by 27 · see citing works
Functions of SUMO in the Maintenance of Genome Stability
Zilio, N., Eifler, K., & Ulrich, H. D. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-50044-7_4 · Cited by 27 · see citing works
Fanconi anemia proteins in telomere maintenance
Sarkar, J., & Liu, Y. (2016) · DNA repair · doi:10.1016/j.dnarep.2016.02.007 · Cited by 26 · see citing works
Timpano, S., & Picketts, D. J. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00885 · Cited by 26 · see citing works
Luo, Z., Liu, W., Sun, P., Wang, F., & Feng, X. (2020) · Briefings in Bioinformatics · doi:10.1093/bib/bbaa441 · Cited by 26 · see citing works
Güneş, Ç., Avila, A. I., & Rudolph, K. L. (2017) · Differentiation · doi:10.1016/j.diff.2017.12.004 · Cited by 26 · see citing works
ALT: A Multi-Faceted Phenomenon
Sommer, A., & Royle, N. J. (2020) · Genes · doi:10.3390/genes11020133 · Cited by 25 · see citing works
Assalve, G., Lunetti, P., Rocca, M. S., Cosci, I., Nisio, A. D., Ferlin, A., Zara, V., & Ferramosca, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26030993 · Cited by 24 · see citing works
Chebly, A., Ropio, J., Baldasseroni, L., Prochazkova‐Carlotti, M., Idrissi, Y., Ferrer, J., Farra, C., Beylot-Barry, M., Merlio, J., & Chevret, E. (2022) · Genes · doi:10.3390/genes13030539 · Cited by 24 · see citing works
Liu, H., Xu, C., Diplas, B. H., Brown, A., Strickland, L. M., Yao, H., Ling, J., McLendon, R. E., Keir, S. T., Ashley, D. M., et al. (2023) · Neuro-Oncology · doi:10.1093/neuonc/noad022 · Cited by 24 · see citing works
Telomere-lengthening mechanism revealed
Roake, C. M., & Artandi, S. E. (2016) · Nature · doi:10.1038/nature19483 · Cited by 24 · see citing works
Muraki, K., & Murnane, J. P. (2017) · Genes & Genetic Systems · doi:10.1266/ggs.17-00014 · Cited by 23 · see citing works
Synthetic lethality of cytolytic HSV-1 in cancer cells with ATRX and PML deficiency
Han, M., Napier, C. E., Frölich, S., Teber, E., Wong, T., Noble, J. R., Choi, E. H. Y., Everett, R. D., Cesare, A. J., & Reddel, R. R. (2019) · Journal of Cell Science · doi:10.1242/jcs.222349 · Cited by 23 · see citing works
Self-citationInhibition of p53 and/or AKT as a new therapeutic approach specifically targeting ALT cancers
Ge, Y., Wu, S., Zhang, Z., Li, X., Li, F., Yan, S., Liu, H., Huang, J., & Zhao, Y. B. (2019) · Protein & Cell · doi:10.1007/s13238-019-0634-z · Cited by 23 · see citing works
Slijepčević, P. (2016) · Cytogenetic and Genome Research · doi:10.1159/000447415 · Cited by 22 · see citing works
Telomere recombination pathways: tales of several unhappy marriages
Lue, N. F., & Yu, E. Y. (2016) · Current Genetics · doi:10.1007/s00294-016-0653-8 · Cited by 21 · see citing works
Measurement of Telomere Length in Colorectal Cancers for Improved Molecular Diagnosis
Balc’h, E. L., Grandin, N., Demattei, M.-V., Guyétant, S., Tallet, A., Pagès, J., Ouaïssi, M., Lecomte, T., & Charbonneau, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091871 · Cited by 21 · see citing works
TERT-mediated and ATRX-mediated Telomere Maintenance and Neuroblastoma
Duan, X., & Zhao, Q. (2017) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0000000000000840 · Cited by 21 · see citing works
Cabrera‐Andrade, A., López‐Cortés, A., Jaramillo-Koupermann, G., Paz‐y‐Miño, C., Pérez‐Castillo, Y., Munteanu, C. R., González‐Díaz, H., Pazos, A., & Tejera, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031053 · Cited by 21 · see citing works
Tumor suppressor functions of DAXX through histone H3.3/H3K9me3 pathway in pancreatic NETs
Ueda, H. R., Akiyama, Y., Shimada, S., Mogushi, K., Serizawa, M., Matsumura, S., Mitsunori, Y., Aihara, A., Ban, D., Ochiai, T., et al. (2018) · Endocrine Related Cancer · doi:10.1530/erc-17-0328 · Cited by 21 · see citing works
POLA network, Grandin, N., Pereira, B., Cohen, C., Billard, P., Dehais, C., Carpentier, C., Idbaïh, A., Bielle, F., Ducray, F., et al. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0833-0 · Cited by 20 · see citing works
In medio stat virtus : unanticipated consequences of telomere dysequilibrium
Harrington, L. A., & Pucci, F. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0444 · Cited by 20 · see citing works
The potential effect of melatonin on in vitro oocyte maturation and embryo development in animals
Nadri, P., Zahmatkesh, A., & Bakhtari, A. (2024) · Biology of Reproduction · doi:10.1093/biolre/ioae077 · Cited by 19 · see citing works
Choreographing the Double Strand Break Response: Ubiquitin and SUMO Control of Nuclear Architecture
Harding, S. M., & Greenberg, R. A. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00103 · Cited by 19 · see citing works
SLX4IP and telomere dynamics dictate breast cancer metastasis and therapeutic responsiveness
Robinson, N. J., Morrison-Smith, C. D., Gooding, A. J., Schiemann, B. J., Jackson, M. W., Taylor, D. J., & Schiemann, W. P. (2020) · Life Science Alliance · doi:10.26508/lsa.201900427 · Cited by 19 · see citing works
Abid, H. Z., McCaffrey, J., Raseley, K., YOUNG, E. A., Lassahn, K. A., Varapula, D. T., Riethman, H. C., & Xiao, M. (2020) · BMC Genomics · doi:10.1186/s12864-020-06901-7 · Cited by 19 · see citing works
Challenging endings: How telomeres prevent fragility
Glousker, G., & Lingner, J. (2021) · BioEssays · doi:10.1002/bies.202100157 · Cited by 19 · see citing works
TRIM28 inhibits alternative lengthening of telomere phenotypes by protecting SETDB1 from degradation
Wang, C., Songyang, Z., & Huang, Y. Y. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00660-y · Cited by 18 · see citing works
Ubiquitination and SUMOylation in Telomere Maintenance and Dysfunction
Yalçin, Z., Selenz, C., & Jacobs, J. J. L. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00067 · Cited by 18 · see citing works
RAD51 and RTEL1 compensate telomere loss in the absence of telomerase
Olivier, M., Charbonnel, C., Amiard, S., White, C. I., & Gallego, M. E. (2018) · Nucleic Acids Research · doi:10.1093/nar/gkx1322 · Cited by 18 · see citing works
Shedding light into the relevance of telomeres in human reproduction and male factor infertility†
Lopes, A. C., Oliveira, P. F., & Sousa, M. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy215 · Cited by 18 · see citing works
Clinicopathological and molecular characterization of chromophobe hepatocellular carcinoma
Kang, H. J., Oh, J., Kim, Y. W., Kim, W., An, J., Sung, C. O., Kim, J., Shim, J. H., Hwang, S., Yu, E., et al. (2021) · Liver International · doi:10.1111/liv.14975 · Cited by 18 · see citing works
To Fix or Not to Fix: Maintenance of Chromosome Ends Versus Repair of DNA Double-Strand Breaks
Casari, E., Gnugnoli, M., Rinaldi, C., Pizzul, P., Colombo, C. V., Bonetti, D., & Longhese, M. P. (2022) · Cells · doi:10.3390/cells11203224 · Cited by 17 · see citing works
MND1 enables homologous recombination in somatic cells primarily outside the context of replication
Koob, L., Friskes, A., van Bergen, L., Feringa, F. M., van den Broek, B., Koeleman, E. S., van Beek, E., Schubert, M., Blomen, V. A., Brummelkamp, T. R., et al. (2023) · Molecular Oncology · doi:10.1002/1878-0261.13448 · Cited by 17 · see citing works
Yu, Y., Jia, W., Lyu, Y., Su, D., Bai, M., Shen, J., Qiao, J., Han, T., Liu, W., Chen, J., et al. (2019) · Cell Discovery · doi:10.1038/s41421-019-0116-8 · Cited by 16 · see citing works
Telomerase-independent maintenance of telomere length in a vertebratePreprint
Yu, Q., Gates, P. B., Rogers, S., Mikičić, I., Elewa, A., Salomon, F., Lachnit, M., Caldarelli, A., Rodriguez, N. F., Cesare, A. J., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.25.485759 · Cited by 16 · see citing works
Telomere Maintenance Pathway Activity Analysis Enables Tissue- and Gene-Level Inferences
Nersisyan, L., Simonyan, A., Binder, H., & Arakelyan, A. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.662464 · Cited by 15 · see citing works
Alternative Lengthening of Telomeres and Chromatin Status
Udroiu, I., & Sgura, A. (2019) · Genes · doi:10.3390/genes11010045 · Cited by 15 · see citing works
Yu, E. Y., Cheung, N. V., & Lue, N. F. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01337-w · Cited by 15 · see citing works
In, S., Nunes, P. R., Fernandes, R. V., & Lingner, J. (2025) · The EMBO Journal · doi:10.1038/s44318-025-00502-4 · Cited by 14 · see citing works
Gunkel, M., Chung, I., Wörz, S., Deeg, K. I., Simon, R., Sauter, G., Jones, D., Korshunov, A., Rohr, K., Erfle, H., et al. (2016) · Methods · doi:10.1016/j.ymeth.2016.09.014 · Cited by 14 · see citing works
A critical role of telomere chromatin compaction in ALT tumor cell growth
Shi, G. W., Hu, Y., Zhu, X. Q., Jiang, Y., Pang, J., Wang, C., Huang, W., Zhao, Y. B., Ma, W., Liu, D., et al. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa224 · Cited by 14 · see citing works
- Authors
- Pickett, H. A., & Reddel, R. R.
- Affiliations
- The University of Sydney (AU)
- Corresponding author
- Pickett, Hilda A
- Reddel, Roger R
- Venue
- Nature Structural & Molecular Biology
- Published
- 2015-11
- Volume
- 22
- Issue
- 11
- Pages
- 875-880
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- OpenAlex
- W2193590034
- Cited by
- 203
- References
- 81
- Citations by year
- 2026: 14 · 2025: 10 · 2024: 12 · 2023: 10 · 2022: 13 · 2021: 22 · 2020: 27 · 2019: 24 · 2018: 20 · 2017: 28 · 2016: 20 · 2015: 2 · 2014: 1
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Structural & Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Keywords
- alternative lengthening of telomeres, telomere maintenance, homology-directed recombination, telomere synthesis, ATRX, DAXX, chromatin remodeling, TRF2, NuRD complex, strand exchange, telomere shortening, cancer cells
- MeSH terms
- DNA Helicases, Nuclear Proteins, Telomere, Telomere Homeostasis, Homologous Recombination
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review