Obesity in 70‐Year‐Old Subjects as a Risk Factor for 15‐Year Coronary Heart Disease Incidence
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Objective: To investigate the role of obesity in general and waist circumference (WC) and BMI in particular as risk factors for 15‐year incidence of coronary heart disease (CHD) in the elderly. Research Methods and Procedures: This prospective study was based on 1597 (737 males and 860 females) 70‐year‐olds free from CHD and participants of three birth cohorts examined in 1971 to 1972 (Cohort I), 1976 to 1977 (Cohort II), and 1981 to 1982 (Cohort III) at Göteborg, Sweden. Fifteen‐year incidence of CHD (fatal and nonfatal) was ascertained from follow‐up examinations and registers. Relative risk (RR) for first ever CHD in reference to the lowest quartiles of WC and BMI was calculated from Cox regression. Results: In males, RRs for CHD in the highest WC and BMI quartiles were 1.36 [95% confidence interval (CI) 1.00 to 1.85] and 1.42 (95% CI 1.04 to 1.92), respectively, after adjustment for cohorts, smoking habits, diabetes, systolic blood pressure, and total cholesterol. In men, the risk associated with WC was independent of BMI. Neither WC nor BMI was related to CHD risk in females. After exclusion of first 5‐year all‐cause deaths, the adjusted RRs in the highest WC and BMI quartiles in males were 1.47 (95% CI 1.06 to 2.04) and 1.42 (1.04 to 1.92), respectively. In females, a significantly higher RR of 1.41 (95% CI 1.02 to 1.94) was observed in the second BMI quartile only after such exclusions. Discussion: WC, an indicator of both central and general obesity, appears to be a stronger predictor of CHD than BMI in elderly males, but in females, obesity was not a risk factor for CHD.
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Recent prospectively designed studies have found higher waist circumference increases cardiovascular disease risk in older adults.
“Recent prospectively designed studies have found higher WC increases CVD risk in older adults [27, 28]”
From Obesity pharmacotherapy in older adults: a narrative review of evidence (2025) · cites this paper as [27]
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Howard, B. V., Allison, D. B., Kumanyika, S., Pi-Sunyer, X., Lewis, C. E., McTigue, K. M., Burke, L. E., Poirier, P., & Eckel, R. H. (2009) · Cited by 1 · see citing works
Relationship between Obesity, Sarcopenia, Sarcopenic Obesity, and Dynapenia in the Elderly
Colón, C. J. P., & Jovet‐Toledo, G. G. (2021) · Translational Journal of the American College of Sports Medicine · doi:10.1249/tjx.0000000000000152
日本老年医学会「高齢者の生活習慣病管理ガイドライン」作成ワーキング (2018) · Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics · doi:10.3143/geriatrics.55.g1
- Authors
- Dey, D. K., & Lissner, L.
- Affiliations
- AstraZeneca (Sweden) (SE)
- Nordic School of Public Health (SE)
- Corresponding author
- Dey, Debashish K.
- ORCID
- Lissner, Lauren
- Venue
- Obesity Research
- Publisher
- Wiley
- Published
- 2003-07
- Volume
- 11
- Issue
- 7
- Pages
- 817-827
- ISSN
- 1071-7323 (ISSN-L)
- 1550-8528
- OpenAlex
- W2070980999
- Cited by
- 66
- References
- 40
- Citations by year
- 2024: 1 · 2021: 3 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 8 · 2013: 5 · 2012: 2
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Gun och Bertil Stohnes Stiftelse
- Stiftelsen Handlanden Hjalmar Svenssons
- Stiftelserna Wilhelm och Martina Lundgrens
- Vetenskapsrådet
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- obesity, waist circumference, body mass index, coronary artery disease, cardiovascular risk factors, older adults, sex differences, abdominal obesity, long-term incidence, birth cohort
- MeSH terms
- Aged, Body Constitution, Coronary Disease, Female, Humans, Male, Obesity, Prospective Studies, Risk Factors, Sweden, Body Mass Index
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