Increase in visfatin after weight loss induced by gastroplastic surgery
Abstract
OBJECTIVE: The recently described adipokine visfatin is produced in visceral fat and has been suggested to influence insulin resistance. To investigate whether visfatin concentrations are related to changes in body weight, this adipokine was measured in insulin-resistant severely obese patients before and after gastroplastic surgery. RESEARCH METHODS AND PROCEDURES: Visfatin, interleukin-6, high-sensitivity C-reactive protein, homeostasis model assessment of insulin resistance (HOMA-IR), and other clinical parameters were assessed in 36 severely obese subjects (28 female; mean age, 43 years) with a median BMI of 44.3 kg/m(2) (95% confidence interval, 43.3 to 48.1 kg/m(2)). RESULTS: After surgery, BMI decreased to a median of 31.9 kg/m(2) (30.1 to 35.1 kg/m(2)) (p < 0.0001). Median visfatin concentrations increased significantly after weight loss [70.9 ng/mL (61.4 to 75.6 ng/mL) vs. 86.4 ng/mL (79.4 to 89.8 ng/mL); p < 0.0005]. This increase correlated with the decrease of insulin and HOMA-IR and was associated with a reduction in plasma interleukin-6 and high-sensitivity C-reactive protein concentrations. DISCUSSION: Massive weight loss after gastroplastic surgery is accompanied by an increase in circulating concentrations of the novel adipokine visfatin. This increase correlates with the decrease in plasma insulin concentrations and HOMA-IR.
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Elderly people have higher basal levels of inflammation independently of disease status.
“Elderly people have higher basal levels of inflammation independently of disease status, and a considerable number of studies have been carried out in this population to assess associations between physical activity and inflammatory markers (190,223 -230) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [225]
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“Introduction Severe obesity is associated with an adverse cardiovascular risk profile including insulin resistance, hyperinsulinemia, and chronic subclinical inflammation, all of which are improved through weight loss after gastroplastic surgery (1).”
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Interleukin-6 is a negative regulator of visfatin gene expression in 3T3-L1 adipocytes
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Visfatin Is an Adipokine, But It Is Not Regulated by Thiazolidinediones
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Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works
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- Authors
- Krzyzanowska, K., Mittermayer, F., Krugluger, W., Kopp, H. P., & Schernthaner, G.
- Affiliations
- Medical University of Vienna (AT)
- Krankenanstalt Rudolfstiftung der Stadt Wien (AT)
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2006-11
- Volume
- 14
- Issue
- 11
- Pages
- 1886-1889
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- OpenAlex
- W2020352897
- Cited by
- 71
- References
- 12
- Citations by year
- 2024: 1 · 2020: 3 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 10 · 2012: 1
- FWCI
- 7.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- visfatin, bariatric surgery, weight loss, insulin resistance, adipokines, interleukin-6, C-reactive protein, HOMA-IR, plasma insulin
- MeSH terms
- Adult, C-Reactive Protein, Female, Humans, Insulin, Insulin Resistance, Male, Obesity, Morbid, Prospective Studies, Cohort Studies, Gastroplasty, Weight Loss, Interleukin-6, Body Mass Index, Cytokines, Treatment Outcome, Nicotinamide Phosphoribosyltransferase
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