The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Relationship Between Body Fat Mass and Free Fatty Acid Kinetics in Men and Women
Open accessAbstract
An increased release of free fatty acids (FFAs) into plasma likely contributes to the metabolic complications associated with obesity. However, the relationship between body fat and FFA metabolism is unclear because of conflicting results from different studies. The goal of our study was to determine the inter‐relationships between body fat, sex, and plasma FFA kinetics. We determined FFA rate of appearance (Ra) in plasma, by using stable isotopically labeled tracer techniques, during basal conditions in 106 lean, overweight, and obese, nondiabetic subjects (43 men and 63 women who had 7.0–56.0% body fat). Correlation analyses demonstrated: (i) no differences between men and women in the relationship between fat mass (FM) and total FFA Ra (µmol/min); (ii) total FFA Ra increased linearly with increasing FM (r = 0.652, P < 0.001); (iii) FFA Ra per kg FM decreased in a curvilinear fashion with increasing FM (r = −0.806; P < 0.001); (iv) FFA Ra in relationship to fat‐free mass (FFM) was greater in obese than lean subjects and greater in women than in men; and (v) abdominal fat itself was not an important determinant of total FFA Ra. We conclude that total body fat, not regional fat distribution or sex, is an important modulator of the rate of FFA release into plasma. Although increased adiposity is associated with a decrease in fatty acid release in relationship to FM, this downregulation is unable to completely compensate for the increase in FM, so total FFA Ra and FFA Ra with respect to FFM are greater in women than in men and in obese than in lean subjects.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
Healthy percentage body fat ranges: an approach for developing guidelines based on body mass index
Gallagher, D., Heymsfield, S. B., Heo, M., Jebb, S. A., Murgatroyd, P. R., & Sakamoto, Y. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.3.694 · Cited by 2,139
Splanchnic lipolysis in human obesity
Nielsen, S., Guo, Z., Johnson, C. M., Hensrud, D. D., & Jensen, M. D. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21047 · Cited by 933
Influence of body fat distribution on free fatty acid metabolism in obesity.
Jensen, M. D., Haymond, M. W., Rizza, R. A., Cryer, P. E., & Miles, J. M. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113997 · Cited by 683
Inflammation and the IKKβ/IκB/NF-κB axis in obesity- and diet-induced insulin resistance
Shoelson, S. E., Lee, J., & Yuan, M. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802501 · Cited by 474
Fatty acid—induced inflammation and insulin resistance in skeletal muscle and liver
Boden, G. (2006) · Current Diabetes Reports · doi:10.1007/s11892-006-0031-x · Cited by 276
Mittendorfer, B., Horowitz, J. F., & Klein, S. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00504.2001 · Cited by 154
Self-citationHorowitz, J. F., & Klein, S. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.278.6.e1144 · Cited by 138
Self-citationEnergy expenditure, sex, and endogenous fuel availability in humans
Nielsen, S., Guo, Z., Albu, J. B., Klein, S., O’Brien, P. C., & Jensen, M. D. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16253 · Cited by 129
Self-citationMenstrual cycle phase and oral contraceptive effects on triglyceride mobilization during exercise
Casazza, G. A., Jacobs, K. A., Suh, S.-H., Miller, B. F., Horning, M. A., & Brooks, G. A. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00050.2004 · Cited by 114
Cited by
Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications
Fabbrini, E., Sullivan, S., & Klein, S. (2010) · Hepatology · doi:10.1002/hep.23280 · Cited by 2,100
Self-citationChait, A., & den Hartigh, L. J. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00022 · Cited by 1,529
Why does obesity cause diabetes?
Klein, S., Gastaldelli, A., Yki-Järvinen, H., & Scherer, P. E. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2021.12.012 · Cited by 939
Self-citationFatty acids, obesity, and insulin resistance: Time for a reevaluation
Karpe, F., Dickmann, J. R., & Frayn, K. N. (2011) · Diabetes · doi:10.2337/db11-0425 · Cited by 896
Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease
Smith, G. I., Shankaran, M., Yoshino, M., Schweitzer, G. G., Chondronikola, M., Beals, J. W., Okunade, A. L., Patterson, B. W., Nyangau, E., Field, T., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci134165 · Cited by 771
Self-citation
Metadata
- Authors
- Mittendorfer, B., Magkos, F., Fabbrini, E., Mohammed, B. S., & Klein, S.
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2009-10
- Volume
- 17
- Issue
- 10
- Pages
- 1872-1877
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- OpenAlex
- W1982483611
- Cited by
- 192
- References
- 12
- FWCI
- 5.11
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Relationship Between Body Fat Mass and Free Fatty Acid Kinetics in Men and Women. https://app.cochat.ai/papers/10.1038/oby.2009.224
- The paper
- Mittendorfer, B., Magkos, F., Fabbrini, E., Mohammed, B. S., & Klein, S. (2009). Relationship Between Body Fat Mass and Free Fatty Acid Kinetics in Men and Women. Obesity. https://doi.org/10.1038/oby.2009.224
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
