Cited by 684Lipid metabolism and biosynthesisAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Influence of body fat distribution on free fatty acid metabolism in obesity.

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Jensen, M D, Haymond, M W, Rizza, R A, Cryer, P E, Miles, J M·1989·Journal of Clinical Investigation

Abstract

UNLABELLED: In order to determine whether differences in body fat distribution result in specific abnormalities of free fatty acid (FFA) metabolism, palmitate turnover, a measure of systemic adipose tissue lipolysis, was measured in 10 women with upper body obesity, 9 women with lower body obesity, and 8 nonobese women under overnight postabsorptive (basal), epinephrine stimulated and insulin suppressed conditions. RESULTS: Upper body obese women had greater (P less than 0.005) basal palmitate turnover than lower body obese or nonobese women (2.8 +/- 0.2 vs. 2.1 +/- 0.2 vs. 1.8 +/- 0.2 mumol.kg lean body mass (LBM)-1.min-1, respectively), but a reduced (P less than 0.05) net lipolytic response to epinephrine (59 +/- 7 vs. 79 +/- 5 vs. 81 +/- 7 mumol palmitate/kg LBM, respectively). Both types of obesity were associated with impaired suppression of FFA turnover in response to euglycemic hyperinsulinemia compared to nonobese women (P less than 0.005). These specific differences in FFA metabolism may reflect adipocyte heterogeneity, which may in turn affect the metabolic aberrations associated with different types of obesity. These findings emphasize the need to characterize obese subjects before studies.

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  1. Faloona, G., and R. H. Unger. 1974. Glucagon. In Methods of Hormone Radioimmunoassay. B. Jaffe and H. Behrman, editors. Aca- demic Press, Inc., New York. 317-330.
  2. Peake, G. T. 1974. Growth hormone. In Methods of Hormone Radioimmunoassay. B. Jaffe and H. Behrman, editors. Academic Press, New York. 103-121.

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Authors
Jensen, M. D., Haymond, M. W., Rizza, R. A., Cryer, P. E., & Miles, J. M.
Affiliations
  • Mayo Clinic (US)
  • Washington University in St. Louis (US)
Venue
Journal of Clinical Investigation
Published
1989-04-01
Volume
83
Issue
4
Pages
1168-1173
ISSN
0021-9738 (ISSN-L)
OpenAlex
W2087710728
Cited by
683
References
38
Citations by year
2026: 7 · 2025: 5 · 2024: 21 · 2023: 15 · 2022: 23 · 2021: 22 · 2020: 22 · 2019: 16 · 2018: 18 · 2017: 20 · 2016: 23 · 2015: 24 · 2014: 27 · 2013: 32 · 2012: 24
FWCI
5.49
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Mayo Foundation for Medical Education and Research
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK 26989, DK 29953, DK-38029)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
body fat distribution, upper body obesity, lower body obesity, free fatty acid metabolism, adipose tissue lipolysis, hyperinsulinemic-euglycemic clamp, adipocyte heterogeneity
MeSH terms
Adipose Tissue, Adult, Blood Glucose, Body Composition, Epinephrine, Fatty Acids, Nonesterified, Female, Humans, Infusions, Intravenous, Insulin, Kinetics, Obesity, Palmitates, Triglycerides

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