Why does obesity cause diabetes?

Obesity is associated with macrophage accumulation in adipose tissue

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The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function

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Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

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Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery

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β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

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Mechanisms of fatty acid-induced inhibition of glucose uptake.

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Prevalence of Hepatic Steatosis in An Urban Population in the United States: Impact of Ethnicity

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Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease

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Differential Significance of Plasma Visfatin Concentrations according to Adiposity in Children and Adolescents

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Mechanisms of Insulin Action and Insulin Resistance

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Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes

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Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications

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Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial

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Weight gain as a risk factor for clinical diabetes mellitus in women

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The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus

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Relation of Body Fat Distribution to Metabolic Complications of Obesity*

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Benefits of Modest Weight Loss in Improving Cardiovascular Risk Factors in Overweight and Obese Individuals With Type 2 Diabetes

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Bariatric Surgery versus Conventional Medical Therapy for Type 2 Diabetes

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Adipose-derived circulating miRNAs regulate gene expression in other tissues

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Adjustable Gastric Banding and Conventional Therapy for Type 2 Diabetes: A Randomized Controlled Trial

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Adipose tissue macrophage-derived exosomal miRNAs can modulate in vivo and in vitro insulin sensitivity

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Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol

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Glucolipotoxicity: fuel excess and β-cell dysfunction

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Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI

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Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial

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Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity

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Splanchnic lipolysis in human obesity

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Reversal of Nonalcoholic Hepatic Steatosis, Hepatic Insulin Resistance, and Hyperglycemia by Moderate Weight Reduction in Patients With Type 2 Diabetes

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Absence of an Effect of Liposuction on Insulin Action and Risk Factors for Coronary Heart Disease

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Hypoxia-Inducible Factor 1α Induces Fibrosis and Insulin Resistance in White Adipose Tissue

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Fatty acids, obesity, and insulin resistance: Time for a reevaluation

Karpe, F., Dickmann, J. R., & Frayn, K. N. (2011) · Diabetes · doi:10.2337/db11-0425 · Cited by 896 · see citing works

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

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Effects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology in Humans with Obesity

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Insulin Degradation: Progress and Potential

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Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance.

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Gluteofemoral body fat as a determinant of metabolic health

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Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease

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The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis.

Crewe, C., An, Y. A., & Scherer, P. E. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88883 · Cited by 732 · see citing works

Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling

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Metabolically healthy obesity: facts and fantasies

Smith, G. I., Mittendorfer, B., & Klein, S. (2019) · Journal of Clinical Investigation · doi:10.1172/jci129186 · Cited by 655 · see citing works

Alterations in Adipose Tissue and Hepatic Lipid Kinetics in Obese Men and Women With Nonalcoholic Fatty Liver Disease

Fabbrini, E., Mohammed, B. S., Magkos, F., Korenblat, K. M., Patterson, B. W., & Klein, S. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.038 · Cited by 631 · see citing works

Plasma Adiponectin Concentrations Predict Insulin Sensitivity of Both Glucose and Lipid Metabolism

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Can Diabetes Be Surgically Cured? Long-Term Metabolic Effects of Bariatric Surgery in Obese Patients with Type 2 Diabetes Mellitus

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Prevalence and associated factors of non‐alcoholic fatty liver disease in patients with type‐2 diabetes mellitus

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Insulin resistance causes inflammation in adipose tissue

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Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease

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Remission of human type 2 diabetes requires decrease in liver and pancreas fat content but is dependent upon capacity for β cell recovery

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Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction

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Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects.

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A multisite study of long-term remission and relapse of type 2 diabetes mellitus following gastric bypass

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Dichotomous effects of VEGF-A on adipose tissue dysfunction

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Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci

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Downregulation of Adipose Tissue Fatty Acid Trafficking in Obesity

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Metabolic Messengers: adiponectin

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Role of adipose tissue insulin resistance in the natural history of type 2 diabetes: results from the san antonio metabolism study

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Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes.

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Beta-cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) study

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Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication

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Skeletal muscle glycolysis, oxidation, and storage of an oral glucose load.

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Influence of obesity and type 2 diabetes on gluconeogenesis and glucose output in humans: a quantitative study.

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Contribution of Abnormal Muscle and Liver Glucose Metabolism to Postprandial Hyperglycemia in NIDDM

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Specific hepatic sphingolipids relate to insulin resistance, oxidative stress, and inflammation in nonalcoholic steatohepatitis

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AGA technical review on obesity

Klein, S., Wadden, T., & Sugerman, H. J. (2002) · Gastroenterology · doi:10.1053/gast.2002.35514 · Cited by 274 · see citing works

Intramyocellular Lipid Is Associated With Resistance to In Vivo Insulin Actions on Glucose Uptake, Antilipolysis, and Early Insulin Signaling Pathways in Human Skeletal Muscle

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Altered Extracellular Vesicle Concentration, Cargo, and Function in Diabetes

Freeman, D. W., Hooten, N. N., Eitan, E., Green, J., Mode, N. A., Bodogai, M., Zhang, Y., Lehrmann, E., Zonderman, A. B., Biragyn, A., et al. (2018) · Diabetes · doi:10.2337/db17-1308 · Cited by 254 · see citing works

Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation

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Causes and consequences of hypertriglyceridemia

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Opposite effects of short- and long-term fatty acid infusion on insulin secretion in healthy subjects

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Plasminogen activator inhibitor-1, adipose tissue and insulin resistance

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Surgical Removal of Omental Fat Does Not Improve Insulin Sensitivity and Cardiovascular Risk Factors in Obese Adults

Fabbrini, E., Tamboli, R. A., Magkos, F., Marks–Shulman, P. A., Eckhauser, A. W., Richards, W. O., Klein, S., & Abumrad, N. N. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.04.056 · Cited by 207 · see citing works

Effect of liver fat on insulin clearance

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Early and longer term effects of gastric bypass surgery on tissue-specific insulin sensitivity and beta cell function in morbidly obese patients with and without type 2 diabetes

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Relationship Between Body Fat Mass and Free Fatty Acid Kinetics in Men and Women

Mittendorfer, B., Magkos, F., Fabbrini, E., Mohammed, B. S., & Klein, S. (2009) · Obesity · doi:10.1038/oby.2009.224 · Cited by 192 · see citing works

Fatty Acids, Obesity and Insulin Resistance

Arner, P., & Rydén, M. (2015) · Obesity Facts · doi:10.1159/000381224 · Cited by 183 · see citing works

Fatty Acid Metabolism in the Liver, Measured by Positron Emission Tomography, Is Increased in Obese Individuals

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Renal glucose metabolism in normal physiological conditions and in diabetes

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Adiponectin Promotes Functional Recovery after Podocyte Ablation

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High-fat diet-induced β-cell proliferation occurs prior to insulin resistance in C57Bl/6J male mice

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Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans

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Glucolipotoxicity, β-Cells, and Diabetes: The Emperor Has No Clothes

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A Review of the Anti-Obesity Effects of Wild Edible Plants in the Mediterranean Diet and Their Active Compounds: From Traditional Uses to Action Mechanisms and Therapeutic Targets

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A novel evolutionary ensemble prediction model using harmony search and stacking for diabetes diagnosis

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