The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Circadian Timing of Food Intake Contributes to Weight Gain
Open accessAbstract
Studies of body weight regulation have focused almost entirely on caloric intake and energy expenditure. However, a number of recent studies in animals linking energy regulation and the circadian clock at the molecular, physiological, and behavioral levels raise the possibility that the timing of food intake itself may play a significant role in weight gain. The present study focused on the role of the circadian phase of food consumption in weight gain. We provide evidence that nocturnal mice fed a high‐fat diet only during the 12‐h light phase gain significantly more weight than mice fed only during the 12‐h dark phase. A better understanding of the role of the circadian system for weight gain could have important implications for developing new therapeutic strategies for combating the obesity epidemic facing the human population today.
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“In mouse studies, feeding animals only during the rest (light) phase resulted in greater weight gain compared to feeding them during the active (dark) phase (55).”
From Meal timing and its role in obesity and associated diseases (2024) · cites this paper as [55]
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“The night eating syndrome in humans (33,34) and a shift of food intake from the active phase to the rest phase in laboratory rodents (35,36) have been associated with adverse metabolic consequences.”
From Circadian Misalignment Augments Markers of Insulin Resistance and Inflammation, Independently of Sleep Loss (2014) · cites this paper as [35]
In the citing paper
“Recent evidence from animal trials reported that eating at inappropriate circadian times may contribute to a poorer weight management and metabolic health [6,7,8].”
From Chronotype and Adherence to the Mediterranean Diet in Obesity: Results from the Opera Prevention Project (2020) · cites this paper as [6]
In the citing paper
“Emerging evidence from both rodent and human studies suggests that food consumption during habitual sleep or rest times (ie, evenings in humans) is associated with greater risk for obesity (49,50)”
From Social jetlag, chronotype, and cardiometabolic risk (2015) · cites this paper as [49]
In the citing paper
“The group fed during the light phase gained more weight, despite the absence of any significant differences in calorie intake or activity over the course of the experiment.”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [83]
In the citing paper
“These increases may have been due to lower energy expended via physical activity and greater food intake in the mice fed during the biological day, although neither of these observations reached statistical significance.”
From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Arble et al., 2009
In the citing paper
“Moreover, feeding mice for 6 weeks only during their biological day (normal rest phase) rather than biological night (normal active phase) increases their body fat percentage (statistical trend) and body mass (Arble et al., 2009).”
From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Arble et al., 2009
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Citations
Cites
Kopelman, P. G. (2000) · Nature · doi:10.1038/35007508 · Cited by 4,795
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485
Self-citationDamiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F., & Schibler, U. (2000) · Genes & Development · doi:10.1101/gad.183500 · Cited by 2,394
Adverse metabolic and cardiovascular consequences of circadian misalignment
Scheer, F. A. J. L., Hilton, M. F., Mantzoros, C. S., & Shea, S. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808180106 · Cited by 2,351
High-Fat Diet Disrupts Behavioral and Molecular Circadian Rhythms in Mice
Kohsaka, A., Laposky, A. D., Ramsey, K. M., Estrada, C., Joshu, C., Kobayashi, Y., Turek, F. W., & Bass, J. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.006 · Cited by 1,528
Self-citationElfhag, K., & Rössner, S. (2005) · Obesity Reviews · doi:10.1111/j.1467-789x.2005.00170.x · Cited by 1,343 · cited 1×
“Once gained, losing body weight by controlling energy intake through dieting and/or energy expenditure has proven to be di$cult over a prolonged period of time, making signi!cant and sustained weight loss challenging (14).”
Effects of poor and short sleep on glucose metabolism and obesity risk
Spiegel, K., Tasali, E., Leproult, R., & Van Cauter, E. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.23 · Cited by 857
Association between Eating Patterns and Obesity in a Free-living US Adult Population
Ma, Y. (2003) · American Journal of Epidemiology · doi:10.1093/aje/kwg117 · Cited by 725 · cited 3×
“5,8 In humans, phase delayed eating patterns of non breakfast eaters or patients with night eating syndrome, have suggested an association with increased BMI.”
Sleep and circadian rhythms: key components in the regulation of energy metabolism
Laposky, A. D., Bass, J., Kohsaka, A., & Turek, F. W. (2008) · FEBS Letters · doi:10.1016/j.febslet.2007.06.079 · Cited by 351
Colles, S. L., Dixon, J. B., & O'Brien, P. E. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803664 · Cited by 324
Research works printed but not linked: 1
- Arble DM, 2009, Sleep during phase restricted feeding in C57BL/6 mice, Sleep, 32, A61
Cited by
Sorted by citations
Hatori, M., Vollmers, C., Zarrinpar, A., DiTacchio, L., Bushong, E. A., Gill, S., Leblanc, M., Chaix, A., Joens, M., Fitzpatrick, J. A. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.019 · Cited by 1,986
Circadian integration of metabolism and energetics
Bass, J., & Takahashi, J. S. (2010) · Science · doi:10.1126/science.1195027 · Cited by 1,910
Self-citationJoint international consensus statement for ending stigma of obesity
Rubino, F., Puhl, R. M., Cummings, D. E., Eckel, R. H., Ryan, D. H., Mechanick, J. I., Nadglowski, J., Ramos Salas, X., Schauer, P. R., Twenefour, D., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0803-x · Cited by 1,152
“Additional evidence is now also available indicating other possible causes and contributors to obesity, including genetic 84 and epigenetic factors 85 , foodborne factors 86 , sleep deprivation and circadian dysrhythmia 87 , psychological stress, endocrine disruptors, medications, and intrauterine and intergenerationa…”
BackgroundBile acid signaling in metabolic disease and drug therapy
Li, T., & Chiang, J. Y. L. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008201 · Cited by 935
Impact of insufficient sleep on total daily energy expenditure, food intake, and weight gain
Markwald, R. R., Melanson, E. L., Smith, M. R., Higgins, J., Perreault, L., Eckel, R. H., & Wright, K. P. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216951110 · Cited by 810
Metadata
- Authors
- Arble, D. M., Bass, J., Laposky, A. D., Vitaterna, M. H., & Turek, F. W.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Turek, Fred W.
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2009-11
- Volume
- 17
- Issue
- 11
- Pages
- 2100-2102
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- PMC
- PMC3499064
- OpenAlex
- W2047324057
- Cited by
- 953
- References
- 13
- Citations by year
- 2026: 23 · 2025: 51 · 2024: 68 · 2023: 56 · 2022: 67 · 2021: 76 · 2020: 58 · 2019: 68 · 2018: 68 · 2017: 63 · 2016: 64 · 2015: 62 · 2014: 66 · 2013: 61 · 2012: 42
- FWCI
- 15.27
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- e-Publications@Marquette (Marquette University) (submittedVersion)
- Funders
- National Institute on Aging (P01AG011412, P01 AG114212)
- National Heart, Lung, and Blood Institute (T32HL007909)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Keywords
- circadian rhythm, meal timing, weight gain, high-fat diet, nocturnal feeding, light-dark cycle, circadian clock, energy regulation, mice
- MeSH terms
- Animals, Energy Intake, Circadian Rhythm, Dietary Fats, Eating, Male, Mice, Inbred C57BL, Motor Activity, Obesity, Time Factors, Weight Gain, Photoperiod, Mice
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