Sleep and circadian rhythms: key components in the regulation of energy metabolism
Abstract
In this review, we present evidence from human and animal studies to evaluate the hypothesis that sleep and circadian rhythms have direct impacts on energy metabolism, and represent important mechanisms underlying the major health epidemics of obesity and diabetes. The first part of this review will focus on studies that support the idea that sleep loss and obesity are "interacting epidemics." The second part will discuss recent evidence that the circadian clock system plays a fundamental role in energy metabolism at both the behavioral and molecular levels. These lines of research must be seen as in their infancy, but nevertheless, have provided a conceptual and experimental framework that potentially has great importance for understanding metabolic health and disease.
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Recent reports suggest that sleep problems, mood problems and obesity are "interacting epidemics".
“Indeed recent reports suggest that sleep problems, mood problems and obesity are “interacting epidemics” (Laposky et al., 2008).”
From Biological rhythms, higher brain function, and behavior: Gaps, opportunities, and challenges (2009) · cites this paper as Laposky et al., 2008
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- Authors
- Laposky, A. D., Bass, J., Kohsaka, A., & Turek, F. W.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Laposky, Aaron D.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2007-08-14
- Volume
- 582
- Issue
- 1
- Pages
- 142-151
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1970654981
- Cited by
- 351
- References
- 74
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 15 · 2023: 15 · 2022: 13 · 2021: 20 · 2020: 15 · 2019: 21 · 2018: 13 · 2017: 20 · 2016: 26 · 2015: 15 · 2014: 24 · 2013: 24 · 2012: 19
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (P01AG011412)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- sleep, circadian rhythm, circadian clock, energy metabolism, obesity, diabetes mellitus, sleep deprivation, metabolic health, metabolic disorders
- MeSH terms
- Animals, Circadian Rhythm, Energy Metabolism, Humans, Obesity, Sleep, Sleep Deprivation
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