The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
In vivo analysis of Yorkie phosphorylation sites
Open accessAbstract
The co-activator Yorkie (Yki) mediates transcriptional regulation effected by the Drosophila Fat–Warts (Wts)–Hippo (Hpo) pathways. Yki is inhibited by Wts-mediated phosphorylation, and a Wts phosphorylation site at Ser168 has been identified. Here we identify two additional Wts phosphorylation sites on Yki, and examine the respective contribution of all three sites to Yki nuclear localization and activity. Our results show that although Ser168 is the most critical site, all three phosphorylation sites influence Yki localization and activity in vivo, and can be sites of regulation by Wts. Thus, investigations of the role of Yki and its mammalian homolog Yes-associated protein (YAP) in development and oncogenesis should include evaluations of additional sites. The WW domains of Yki are not required for its phosphorylation, but instead are positively required for its activity. We also identify two potential sites of phosphorylation by an unknown kinase, which could influence phosphorylation of Ser168 by Wts, suggesting that there are additional mechanisms for regulating Yki/YAP activity.
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Zhao, B., Wei, X., Li, W., Udan, R. S., Yang, Q., Kim, J., Xie, J., Ikenoue, T., Yu, J., Li, L., et al. (2007) · Genes & Development · doi:10.1101/gad.1602907 · Cited by 3,092
Basu, S., Totty, N. F., Irwin, M. S., Sudol, M., & Downward, J. (2003) · Molecular Cell · doi:10.1016/s1097-2765(02)00776-1 · Cited by 843
Wu, S., Liu, Y., Zheng, Y., Dong, J., & Pan, D. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.01.007 · Cited by 640 · cited 2×
“One is the binding to 14-3-3 proteins; the other is the interaction with Sd/TEAD, which promotes nuclear localization (Goulev et al., 2008; Wu et al., 2008; Zhang et al., 2008; Zhao et al., 2008).”
BackgroundThe TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control
Zhang, L., Ren, F., Zhang, Q., Chen, Y., Wang, B., & Jiang, J. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.01.006 · Cited by 630
Cited by
The Hippo Signaling Pathway in Development and Cancer
Pan, D. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.09.011 · Cited by 2,269
A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF β-TRCP
Zhao, B., Li, L., Tumaneng, K., Wang, C.-Y., & Guan, K.-L. (2010) · Genes & Development · doi:10.1101/gad.1843810 · Cited by 1,418
Transduction of mechanical and cytoskeletal cues by YAP and TAZ
Halder, G., Dupont, S., & Piccolo, S. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3416 · Cited by 985
The YAP and TAZ transcription co-activators: Key downstream effectors of the mammalian Hippo pathway
Hong, W., & Guan, K.-L. (2012) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2012.05.004 · Cited by 493
Mechanosensitive mechanisms in transcriptional regulation
Mammoto, A., Mammoto, T., & Ingber, D. E. (2012) · Journal of Cell Science · doi:10.1242/jcs.093005 · Cited by 393
Metadata
- Authors
- Oh, H., & Irvine, K. D.
- Venue
- Oncogene
- Published
- 2009-03-30
- Volume
- 28
- Issue
- 17
- Pages
- 1916-1927
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2003111150
- Cited by
- 195
- References
- 4
- FWCI
- 6.49
- Type
- journal article
- Language
- en
- Open access
- green
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